颌骨骨内腺样囊性癌的临床病理特征:系统综述。

IF 2.3 3区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE
Luccas Lavareze, João Figueira Scarini, Reydson Alcides de Lima-Souza, Talita de Carvalho Kimura, Rogério de Oliveira Gondak, Erika Said Abu Egal, Albina Altemani, Fernanda Viviane Mariano
{"title":"颌骨骨内腺样囊性癌的临床病理特征:系统综述。","authors":"Luccas Lavareze, João Figueira Scarini, Reydson Alcides de Lima-Souza, Talita de Carvalho Kimura, Rogério de Oliveira Gondak, Erika Said Abu Egal, Albina Altemani, Fernanda Viviane Mariano","doi":"10.1111/jop.70063","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>We aimed to evaluate the clinicopathological features, survival rate, and potential prognostic markers of the jaws' primary intraosseous adenoid cystic carcinoma (PIACC).</p><p><strong>Materials and methods: </strong>MEDLINE/PubMed, Scopus, and Embase searches were performed with the keywords \"adenoid cystic carcinoma,\" and \"jaw,\" or \"maxilla,\" or \"mandible.\" We included articles that evaluated cases diagnosed as PIACC in jaws. Studies with insufficient demographic data, inconclusive histopathologic diagnosis, and appropriate follow-up were excluded. The Joanna Briggs Institute tool was used to assess the risk of bias.</p><p><strong>Results: </strong>Fifty-five PIACC comprising 27 studies met the inclusion criteria. The mean age of the patients was 56.4 ± 19.6 years with no sex predilection. PIACC showed a strong predilection for the mandible (69.1%), mainly in the posterior segment (40%). The patients presented symptoms in 87.3% of cases. Radiographically, PIACC presented as an ill-defined radiolucent lesion (40%). Most cases showed a cribriform pattern (32.7%). PIACC with a solid growth pattern presented a lower disease-free survival (DFS) (p = 0.040). The 2- and 5-year overall survival rates were 57.9% and 53.8%, respectively. Distant metastases were seen in 3.6% of the patients and were related to a lower DFS (p = 0.043).</p><p><strong>Conclusion: </strong>PIACC is a rare neoplasm of the jaws with an incidence in the fifth and sixth decades of life and no sex predilection. The posterior mandible was affected in most cases. Solid growth patterns and distant metastases are prognostic factors for a lower DFS.</p>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":""},"PeriodicalIF":2.3000,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Clinicopathological Profile of Intraosseous Adenoid Cystic Carcinoma of the Jaws: A Systematic Review.\",\"authors\":\"Luccas Lavareze, João Figueira Scarini, Reydson Alcides de Lima-Souza, Talita de Carvalho Kimura, Rogério de Oliveira Gondak, Erika Said Abu Egal, Albina Altemani, Fernanda Viviane Mariano\",\"doi\":\"10.1111/jop.70063\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>We aimed to evaluate the clinicopathological features, survival rate, and potential prognostic markers of the jaws' primary intraosseous adenoid cystic carcinoma (PIACC).</p><p><strong>Materials and methods: </strong>MEDLINE/PubMed, Scopus, and Embase searches were performed with the keywords \\\"adenoid cystic carcinoma,\\\" and \\\"jaw,\\\" or \\\"maxilla,\\\" or \\\"mandible.\\\" We included articles that evaluated cases diagnosed as PIACC in jaws. Studies with insufficient demographic data, inconclusive histopathologic diagnosis, and appropriate follow-up were excluded. The Joanna Briggs Institute tool was used to assess the risk of bias.</p><p><strong>Results: </strong>Fifty-five PIACC comprising 27 studies met the inclusion criteria. The mean age of the patients was 56.4 ± 19.6 years with no sex predilection. PIACC showed a strong predilection for the mandible (69.1%), mainly in the posterior segment (40%). The patients presented symptoms in 87.3% of cases. Radiographically, PIACC presented as an ill-defined radiolucent lesion (40%). Most cases showed a cribriform pattern (32.7%). PIACC with a solid growth pattern presented a lower disease-free survival (DFS) (p = 0.040). The 2- and 5-year overall survival rates were 57.9% and 53.8%, respectively. Distant metastases were seen in 3.6% of the patients and were related to a lower DFS (p = 0.043).</p><p><strong>Conclusion: </strong>PIACC is a rare neoplasm of the jaws with an incidence in the fifth and sixth decades of life and no sex predilection. The posterior mandible was affected in most cases. Solid growth patterns and distant metastases are prognostic factors for a lower DFS.</p>\",\"PeriodicalId\":16588,\"journal\":{\"name\":\"Journal of Oral Pathology & Medicine\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.3000,\"publicationDate\":\"2025-09-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Oral Pathology & Medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1111/jop.70063\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"DENTISTRY, ORAL SURGERY & MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Oral Pathology & Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1111/jop.70063","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
引用次数: 0

摘要

目的:探讨颌骨原发性骨内腺样囊性癌(PIACC)的临床病理特征、生存率和潜在预后指标。材料和方法:使用关键词“腺样囊性癌”和“颌骨”或“上颌骨”或“下颌骨”进行MEDLINE/PubMed, Scopus和Embase搜索。我们纳入了评估颌骨中诊断为PIACC病例的文章。排除了人口统计资料不足、组织病理学诊断不确定和适当随访的研究。乔安娜布里格斯研究所的工具被用来评估偏见的风险。结果:55项PIACC包括27项研究符合纳入标准。患者平均年龄56.4±19.6岁,无性别偏好。PIACC对下颌骨有强烈的偏好(69.1%),主要在后段(40%)。87.3%的患者出现症状。放射学上,PIACC表现为界限不清的放射透明病变(40%)。以筛网型居多(32.7%)。固定生长模式的PIACC无病生存期(DFS)较低(p = 0.040)。2年和5年总生存率分别为57.9%和53.8%。3.6%的患者出现远处转移,并与较低的DFS相关(p = 0.043)。结论:PIACC是一种罕见的颌骨肿瘤,多发于五六十岁,无性别倾向。后下颌骨在大多数情况下受到影响。固体生长模式和远处转移是低DFS的预后因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Clinicopathological Profile of Intraosseous Adenoid Cystic Carcinoma of the Jaws: A Systematic Review.

Objectives: We aimed to evaluate the clinicopathological features, survival rate, and potential prognostic markers of the jaws' primary intraosseous adenoid cystic carcinoma (PIACC).

Materials and methods: MEDLINE/PubMed, Scopus, and Embase searches were performed with the keywords "adenoid cystic carcinoma," and "jaw," or "maxilla," or "mandible." We included articles that evaluated cases diagnosed as PIACC in jaws. Studies with insufficient demographic data, inconclusive histopathologic diagnosis, and appropriate follow-up were excluded. The Joanna Briggs Institute tool was used to assess the risk of bias.

Results: Fifty-five PIACC comprising 27 studies met the inclusion criteria. The mean age of the patients was 56.4 ± 19.6 years with no sex predilection. PIACC showed a strong predilection for the mandible (69.1%), mainly in the posterior segment (40%). The patients presented symptoms in 87.3% of cases. Radiographically, PIACC presented as an ill-defined radiolucent lesion (40%). Most cases showed a cribriform pattern (32.7%). PIACC with a solid growth pattern presented a lower disease-free survival (DFS) (p = 0.040). The 2- and 5-year overall survival rates were 57.9% and 53.8%, respectively. Distant metastases were seen in 3.6% of the patients and were related to a lower DFS (p = 0.043).

Conclusion: PIACC is a rare neoplasm of the jaws with an incidence in the fifth and sixth decades of life and no sex predilection. The posterior mandible was affected in most cases. Solid growth patterns and distant metastases are prognostic factors for a lower DFS.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
5.90
自引率
6.10%
发文量
121
审稿时长
4-8 weeks
期刊介绍: The aim of the Journal of Oral Pathology & Medicine is to publish manuscripts of high scientific quality representing original clinical, diagnostic or experimental work in oral pathology and oral medicine. Papers advancing the science or practice of these disciplines will be welcomed, especially those which bring new knowledge and observations from the application of techniques within the spheres of light and electron microscopy, tissue and organ culture, immunology, histochemistry and immunocytochemistry, microbiology, genetics and biochemistry.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信