Journal of Oral Pathology & Medicine最新文献

{"title":"Patient Education and Levels of Disease-Specific Information Needs Among Individuals With Oral Epithelial Dysplasia.","authors":"Waleed Alamoudi, Abdullah Alsoghair, Richeal Ni Riordain, Stefano Fedele, Stephen Porter","doi":"10.1111/jop.13642","DOIUrl":"https://doi.org/10.1111/jop.13642","url":null,"abstract":"<p><strong>Background: </strong>Oral epithelial dysplasia (OED) is a histological diagnosis that carries an increased risk of the individual developing oral squamous cell carcinoma. We assessed the information needs (IN) and explored the sources of education used by individuals with OED using a validated OED-specific measurement.</p><p><strong>Methods: </strong>A total of 102 adults with OED from the oral medicine clinic of a dental hospital in Central London were selected using convenience sampling. A cross-sectional survey was conducted in which participants completed the 33-item Oral Epithelial Dysplasia Informational Needs Questionnaire (ODIN-Q), which assessed IN and gathered perspectives on patient education.</p><p><strong>Results: </strong>Approximately two-thirds of the participants (n = 66, 64%) reported meeting the IN, whereas the remaining participants (n = 36, 35%) did not. The mean and median total scores from the questionnaire were 2.43 (± 0.38) and 2.6, respectively, indicating a low sufficient level of IN. Most participants (n = 80, 78%) preferred one-on-one meetings as the primary mode of obtaining information, followed by written materials (n = 64, 62%), audiovisual resources (n = 24, 23%), and group discussions (n = 8, 0.7%).</p><p><strong>Conclusions: </strong>Some topics were insufficiently met, necessitating additional educational efforts, such as risk factors and lifestyle modifications, physical and psychological impacts, awareness of potential complications, and seeking medical and psychological support. Sex and degree of dysplasia were associated with the levels of IN. These findings may guide future longitudinal research on OED IN assessment, support the creation of tailored educational tools, and facilitate further evaluation of the psychometric properties of the ODIN-Q.</p>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143998722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral Health in Individuals with Severe Mental Illness on Second-Generation Antipsychotics-A Scoping Review.","authors":"Dileep Sharma, Oliver Higgins, Aleksander Sawicki, Poornima Ramamurthy, Belinda Field, Paul Hussein, Kiran Singh, Sarbin Ranjitkar","doi":"10.1111/jop.13639","DOIUrl":"https://doi.org/10.1111/jop.13639","url":null,"abstract":"<p><strong>Introduction: </strong>There has been a significant increase in antipsychotic usage, particularly belonging to second-generation antipsychotics (SGAs), in the management of severe mental illnesses (SMIs) over the past few decades, but their impact on oral health is unclear. This review evaluated the oral side effects of the SGAs used in managing SMIs.</p><p><strong>Methods: </strong>A PRISMA-guided scoping review was conducted, using predefined criteria and relevant word combination in Medline (PubMed), Embase, Scopus and Cochrane databases. Eligible studies were assessed for study type, population demographics, antipsychotic medication usage, oral diseases and conditions, and their outcomes. Primary outcomes were explicitly studied oral conditions or diseases, and secondary outcomes were broader oral or general \"treatment-emergent adverse effects.\"</p><p><strong>Results: </strong>Twelve studies met the inclusion criteria for the primary outcomes and 13 for the secondary outcomes. The most reported primary outcomes were salivary gland dysfunction (hypofunction, three studies; hypersalivation, two studies), dental caries (positive association, three studies; no association, one study), and periodontal disease (five studies). Secondary outcomes included dysgeusia and oral hypoesthesia (six studies).</p><p><strong>Discussion: </strong>SGAs significantly compromise oral health, particularly through salivary gland and sensory dysfunction, highlighting the need for up-to-date guidelines on routine oral screening and preventive care.</p>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144004424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Burning Mouth Syndrome: Unlocking the Future of Pharmacological Treatment","authors":"Daniela Adamo","doi":"10.1111/jop.13641","DOIUrl":"https://doi.org/10.1111/jop.13641","url":null,"abstract":"","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":"54 5","pages":"251-262"},"PeriodicalIF":2.7,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143950158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of the Edmonton-33: A Patient-Reported Outcome Instrument in Head and Neck Oncology at Baseline and Subacute Phases Post-Treatment.","authors":"K Zhang, H Khan, H Seikaly, A Nichols, K Fung, S D MacNeil, A Mendez","doi":"10.1111/jop.13640","DOIUrl":"https://doi.org/10.1111/jop.13640","url":null,"abstract":"<p><strong>Background: </strong>Patient-reported outcomes (PRO), which prioritize patient perspectives, are highly valuable for patient-centered care in Head and Neck Oncology. The objective of this study was to explore the longitudinal validity of the Edmonton-33 (E-33), a PRO instrument for assessing head and neck functions in swallowing, chewing, dry mouth, and speech.</p><p><strong>Methods: </strong>This study involved 59 adult patients (18 female, 41 male) with squamous cell carcinoma (SCC) of the oral cavity. Participants provided consent and completed the E-33 and other PRO instruments before and after surgical and radiation treatment at months 3 (n = 18), 6 (n = 18), and 9 (n = 16). Data were collected (from June 2021 to August 2024) and analyzed for correlation between domains of the E-33 and their domain-specific, previously validated counterparts before treatment (baseline) and after treatment (Months 3, 6, and 9).</p><p><strong>Results: </strong>There were statistically significant correlations (p < 0.05) between all E-33 domains and their domain-specific counterparts at baseline and at post-treatment month 6. At Months 3 and 9 post-treatment, there were partial correlations between E-33 domains and some domain-specific counterparts.</p><p><strong>Conclusion: </strong>The E-33 demonstrates validity pre-treatment and post-treatment at subacute timepoint (Months 6) for capturing data on swallowing, chewing, dry mouth, and speech, similar to other previously validated instruments. This validity is limited at the more acute timepoint of 3 months post-treatment and the later timepoint of 9 months post-treatment. Additional data are needed to further explore the long-term validity at further longitudinal timepoints at 1 and 2 years post-treatment.</p>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143970618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of LncRNA UCA1 in OSCC CAFs: PD-L1 Upregulation and Tumor Progression.","authors":"Nisha Zhu, Mengxiang Zhao, Yong Fu, Xingxing Zhao, Sufeng Zhao, Antonio Celentano, Liang Ding, Qingang Hu, Yanhong Ni","doi":"10.1111/jop.13631","DOIUrl":"https://doi.org/10.1111/jop.13631","url":null,"abstract":"<p><strong>Objectives: </strong>Characterize LncUCA1 expression in OSCC cancer-associated fibroblasts (CAFs), investigate immune regulation by high LncUCA1 CAFs, and assess their impact on tumor malignancy in vitro.</p><p><strong>Materials and methods: </strong>Transcriptome sequencing identified upregulated genes in matched CAFs and normal fibroblasts (NFs) from OSCC patients. Clinical outcomes were evaluated in 21 OSCC patients. LncUCA1's effect on PD-L1 expression in CAFs was assessed by flow sorting and qRT-PCR. Co-culture experiments evaluated CAFs' impact on CD8⁺ T cell proliferation and immunosuppression. Matrigel contraction and CCK8 assays explored CAFs' matrix contraction and proliferation. Direct co-culture analyzed CAFs' effect on OSCC proliferation. Transwell assays examined CAFs' impact on tumor cell migration and invasion.</p><p><strong>Results: </strong>LncUCA1 was significantly upregulated in CAFs compared to NFs. Higher LncUCA1 expression correlated with advanced tumor stage and shorter overall survival. LncUCA1 positively correlated with PD-L1 expression and activated the JAK2/STAT3 pathway in CAFs. Co-culture experiments showed high LncUCA1 CAFs inhibited CD8⁺ T cell proliferation and enhanced immunosuppression. LncUCA1 overexpression enhanced matrix contraction but significantly promoted proliferation, migration, and invasion of OSCC cells.</p><p><strong>Conclusions: </strong>LncUCA1 upregulation in CAFs drives PD-L1 expression, inhibits CD8⁺ T cell proliferation, and promotes immunosuppression. High LncUCA1 CAFs also enhance OSCC proliferation, migration, and invasion.</p>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144000150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral Mucosal Alterations: Prevalence and Associated Factors Among 31-Year-Old Adults From a Brazilian Birth Cohort.","authors":"Karine Duarte da Silva, Letícia Regina Morello Sartori, Bernardo Lessa Horta, Flávio Fernando Demarco, Marcos Britto Correa, Sandra Beatriz Chaves Tarquinio","doi":"10.1111/jop.13638","DOIUrl":"https://doi.org/10.1111/jop.13638","url":null,"abstract":"<p><strong>Background: </strong>Population-based studies on the prevalence of oral mucosal alterations and sociodemographic and behavioral predictors are scarce. The aim of this study was to assess the prevalence of oral mucosal alterations and associated factors in 31-year-old individuals from a Brazilian birth cohort.</p><p><strong>Methods: </strong>Adults from the oral health substudy were included. At the age of 31, information was collected on oral mucosal alterations, including clinical diagnosis, site, size, and self-reported onset time through a clinical examination. After descriptive analyses, associations between independent variables and the presence of potentially malignant oral disorders, developmental alterations, and parulis were tested. Poisson regression models were used to estimate the prevalence ratio of oral mucosal alterations according to sociodemographic, behavioral, and oral health-related variables.</p><p><strong>Results: </strong>Oral mucosal alterations had an identified prevalence of 33.5% (n = 535). The five most prevalent clinical diagnoses were exostosis (18.6%), coated tongue (12.4%), parulis (10.2%), benign oral brownish pigmentation (10.2%), and fissured tongue (9.7%). The tongue was the most common site (29.7%), followed by vestibule or gums (24.3%). In the multivariate analysis, individuals who consumed alcohol frequently had a two-fold increase in oral mucosal alterations prevalence compared to non-users (PR = 2.03; 95% CI = 1.17-3.52). Low schooling and tobacco and alcohol consumption were associated with a higher prevalence of oral potentially malignant disorders and parulis (p value ≤ 0.05).</p><p><strong>Conclusions: </strong>There was a high prevalence (33.5%) of oral mucosal alterations, mainly developmental. Prevalence was associated with socioeconomic, behavioral, and oral health-related variables, highlighting the need for comprehensive and multidisciplinary approaches to risk factors to prevent oral diseases.</p>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144025315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mucosamin Spray for the Prevention of Oral Mucositis in Cancer Patients Receiving Chemotherapy: A Retrospective Cohort Study","authors":"Giuseppe Colella,&nbsp;Ciro Emiliano Boschetti,&nbsp;Francesca Farina,&nbsp;Maria Luisa Colella,&nbsp;Antonio Vicidomini,&nbsp;Nicola Cirillo","doi":"10.1111/jop.13636","DOIUrl":"https://doi.org/10.1111/jop.13636","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>It has been suggested that hyaluronic acid can prevent oral mucositis in patients receiving cancer treatment. We aimed to compare the efficacy of a commercial preparation of sodium hyaluronate spray supplemented with a pool of amino acids (Mucosamin) to standard oral care (SOC) in the prevention of chemotherapy-induced oral mucositis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In this retrospective cohort study, consecutive cancer patients who had received chemotherapy without prior or concomitant radiotherapy at a tertiary care University Hospital in Naples, Italy, were eligible for inclusion. The exposure of interest was the use of Mucosamin spray prior to commencing the prescribed cycle of chemotherapy. The primary endpoint of the study was the onset of oral mucositis in both groups during and after their chemotherapy regimens. The secondary endpoint was to determine the severity of pain for patients who developed oral mucositis in either group.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A reduction was observed in the incidence of mucositis in patients who had used Mucosamin prophylactically (4%, 2/57) compared to SOC (33%, 16/49), with an effect size <i>ϕ</i> of 0.39. Patients in the Mucosamin group experienced a significant risk reduction (RR = 0.11; 95% CI 0.03–0.44). The use of Mucosamin resulted in an absolute risk reduction of 29.14%, and the number needed to treat to prevent one additional case of mucositis was 3.43.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Discussion</h3>\u0000 \u0000 <p>Our results show that cancer patients receiving Mucosamin spray prior to the commencement of chemotherapy are at a reduced risk of developing oral mucositis compared to those receiving care as usual.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":"54 5","pages":"397-400"},"PeriodicalIF":2.7,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jop.13636","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143949889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global Insights of Oral Submucous Fibrosis: Concerns About Betel Nut and Oral Cancer","authors":"Siyao You,&nbsp;Jianjun Wu,&nbsp;Sicen Lai,&nbsp;Hua Tu,&nbsp;Xinyan Cui,&nbsp;Qiao Yi,&nbsp;Qiuyun Guo","doi":"10.1111/jop.13637","DOIUrl":"https://doi.org/10.1111/jop.13637","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Oral submucous fibrosis (OSF) is a chronic progressive fibrosis of oral mucosa, with the possibility of eventually progressing to oral cancer, remaining unclear pathogenesis, and a lack of targeted therapies. This study aims to analyze current research progress from a bibliometric perspective to guide the way forward.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Documents in the Web of Science Core Collection database from 1999 to August 31, 2023 were thoroughly searched using a given query. After selection, years of publishing, countries, institutions, authors, journals, and keywords were analyzed using bibliometric software.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The bibliometric results of 1522 documents show that India and China were the most productive countries in this field. Central South University has published the most papers. The <i>Journal of Oral Pathology &amp; Medicine</i> and <i>Oral Oncology</i> were the leading journals. Betel nut, oral cancer, malignant transformation, and fibroblast were the main focuses during recent study periods. We also analyzed differences between studies in betel chewing and nonchewing areas. Notably, scholars pay more attention to the pathogenesis of OSF in the former, while the relationship between OSF and cancer is more concerning in the latter, such as in the United Kingdom and the United States.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Findings from this study provide an overview of the current research and reveal the future hotspot of the OSF research. It suggests that exploring the pathogenesis and mechanisms of malignant transformation in OSF will be a focal point in future research. Advancements in the prevention and treatment of OSF could significantly enhance patients' quality of life and reduce mortality associated with oral cancer.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":"54 5","pages":"380-391"},"PeriodicalIF":2.7,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143950133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tissue Biomarkers for Predicting the Risk of Oral Cancer in Patients Diagnosed With Oral Leukoplakia: A Systematic Review of the Past 4 Years","authors":"Luís Monteiro,&nbsp;Elia Rocha,&nbsp;Sara Ferreira,&nbsp;Filomena Salazar,&nbsp;José Júlio Pacheco,&nbsp;Saman Warnakulasuriya","doi":"10.1111/jop.13632","DOIUrl":"10.1111/jop.13632","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Oral potentially malignant disorders may precede the development of oral cancer, and biomarkers are being investigated for their risk assessment. We aim to provide updated information on tissue biomarkers related to the risk of malignant transformation (MT) in patients with oral leukoplakia (OL) published during the last four years.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A search strategy was developed using the electronic databases PubMed, EBSCO, and Cochrane Library to search for articles related to this topic (published from 2020 to 2024) (CRD42024527395).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of the 1385 articles identified, 14 were included, with a combined sample of 1479 patients of whom 216 suffered MT. There were 30 different biomarkers evaluated of which Bmi-1, CD3/CD8, Ki-67, p16, and DNA ploidy were evaluated in more than one study. Of the 9 studies with multivariate analysis, Bmi-1, Tipe-2, copy number alteration, DcR2, and Ki-67, PTHrP, podoplanin (PDPN), and BubR1/Mad2 biomarkers presented independent significant value on MT. In one study, adding DNA ploidy status to the grade of dysplasia increased the model's predictive power.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Although heterogeneity continues to exist, this systematic review reconfirms the role of biomarkers previously described such as PDPN and DNA ploidy and some new additional biomarkers.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":"54 5","pages":"283-289"},"PeriodicalIF":2.7,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nonmetastatic Lymph Node Histological Architecture Is Associated With Metastasis, Recurrence, and Survival in Oral Squamous Cell Carcinoma","authors":"Katherine Sabando-Criollo,&nbsp;Michelle Shanut Fernández-Cuya,&nbsp;Carlo Lozano-Burgos,&nbsp;René Martínez-Flores,&nbsp;Wilfredo Alejandro González-Arriagada","doi":"10.1111/jop.13628","DOIUrl":"10.1111/jop.13628","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Oral squamous cell carcinoma (OSCC) is a common cancer, with a high propensity for regional lymph node metastasis (LnM), resulting in 5-year survival rates of only 40%–50%. The premetastatic niche (PMN), a modified lymph node microenvironment preparing for future metastasis, is poorly understood. This study analyzes the histomorphological features of nonmetastatic lymph nodes from OSCC patients, stratified by the presence or absence of regional cervical LnM.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This cohort study examined 424 nonmetastatic lymph nodes, preserved in paraffin blocks, from 45 OSCC patients. Histological analysis was performed using hematoxylin and eosin staining to evaluate architectural features, specifically capsule and trabeculae thickness, subcapsular and medullary sinus ectasia, fibrosis, follicular organization, and hyperplasia. Logistic regression models were used to assess the relationships between these features and LnM, recurrence, and survival.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Our analysis revealed that intense medullary ectasia was associated with an increased risk of lymph node metastasis (LnM) (OR = 1.63; 95% CI: 0.99–2.67; <i>p</i> = 0.051), whereas follicular hyperplasia appeared protective (OR = 0.27; 95% CI: 0.15–0.5; <i>p</i> &lt; 0.001). Nonvisible sinusoidal trabeculae suggested a higher risk of recurrence (OR = 2.18; 95% CI: 0.99–4.81; <i>p</i> = 0.05). Disorganized lymphoid follicles (OR = 1.91; 95% CI: 0.97–3.77; <i>p</i> = 0.059), focal subcapsular ectasia (OR = 4.4; 95% CI: 1.34–14.37; <i>p</i> = 0.014) and marked subcapsular ectasia (OR = 3.2; 95% CI: 1.06–9.63; <i>p</i> = 0.038) correlated with decreased survival. Conversely, follicular hyperplasia (OR = 0.38; 95% CI: 0.19–0.74; <i>p</i> = 0.005) and medullary fibrosis (OR = 0.13; 95% CI: 0.02–0.67; <i>p</i> = 0.015) were associated with improved survival.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>These results highlight the potential clinical significance of follicular hyperplasia in lymph nodes. Patients exhibiting this feature may have a more favorable prognosis, characterized by increased survival and decreased risk of lymph node metastasis, regardless of concurrent alterations in other lymph node architecture.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":"54 5","pages":"371-379"},"PeriodicalIF":2.7,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}