Journal of Oral Pathology & Medicine最新文献

{"title":"Oral and Pancreatobiliary Microbiota in Cancer: A Systematic Review of Compositional Alterations and Their Clinical Implications","authors":"Esperouz Fariba,&nbsp;Villani Rosanna,&nbsp;Ciavarella Domenico,&nbsp;Serviddio Gaetano,&nbsp;Lorusso Mauro,&nbsp;Lo Russo Lucio","doi":"10.1111/jop.70172","DOIUrl":"10.1111/jop.70172","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Associations between microbial dysbiosis and malignancies of the pancreatobiliary system have been described in recent studies. As a result of the limited number of studies that have been done specifically on the malignancies of the biliary tract, information regarding oral, biliary and tumour-related microbial alterations was combined to provide an overview of the microbial changes that may occur.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Studies that involved observations on the composition or presence of dysbiosis of the microbiota from oral (saliva, oral rinse, dental plaque) or other non-oral specimens (bile, pancreatic tissue, duodenal tissue and bacteria-derived extracellular vesicles from plasma) in patients with pancreatobiliary malignancies were considered. The risk of bias was evaluated using the Newcastle-Ottawa Scale (NOS) for case–control study designs and the JBI Checklist for cross-sectional studies.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>There were a total of 16 studies involving 1426 participants that were conducted using both case–control and cross-sectional study designs. Samples were collected from saliva, oral wash, bile, pancreatic and duodenal tissues and bacterial extracellular vesicles isolated from plasma samples. The most common method used was 16S rRNA sequencing, and two used shotgun metagenomics. In all the studies, patients with pancreatobiliary cancers, especially PDAC, had a significantly higher abundance of opportunistic microbes like Streptococcus, Veillonella, Fusobacterium, Prevotella and a lower abundance of commensal bacteria like Neisseria and Corynebacterium. There was overlap of microbial profile in the oral cavity and tumour/bile compartments in a few studies.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Although the current data is preliminary and observational in nature, there are consistent findings linking microbiota dysbiosis with cancers of the pancreatobiliary region within both oral and non-oral body sites. Causality has not been established yet. The use of microbial signatures as a basis for biomarker development is a promising research direction.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":"55 9","pages":"1008-1018"},"PeriodicalIF":2.3,"publicationDate":"2026-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jop.70172","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148536186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of the Chemokine (C–C Motif) Ligand 5 (CCL5) in Oral Lichen Planus and Oral Lichenoid Lesions: A Systematic Review","authors":"Edward Rampersaud,&nbsp;Huda Moutaz Asmael Al-Azzawi,&nbsp;Massimo Aria,&nbsp;Karolin Hijazi,&nbsp;Antonio Celentano,&nbsp;Giulio Fortuna","doi":"10.1111/jop.70163","DOIUrl":"10.1111/jop.70163","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>RANTES, a chemokine involved in regulating inflammatory responses, has been implicated in the pathogenesis of various diseases, including oral lichen planus (OLP). In this condition, the interaction between C–C motif ligand 5 (CCL5) and CC motif chemokine receptor 5 (CCR5) may contribute to the destruction of basal keratinocytes and an imbalance of Th1 cells, leading to chronic inflammation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This systematic review aimed to evaluate expression of the CCL5 in the serum and relevant cell types of patients with oral lichen planus and oral lichenoid lesions (OLLs) compared to controls.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We searched the following databases: Medline (Ovid), CENTRAL (Cochrane Library), Embase (Ovid), CINAHL (EBSCO), and Web of Science Core Collection, up to May 2026. Study quality and risk of bias were assessed using the Joana Briggs Institute tools.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Five studies (227 participants) met the inclusion criteria. The findings indicated a marked upregulation of CCL5 in the serum, T-lymphocytes, and fibroblasts of OLP/OLL patients compared to controls. However, these results were weakened by high risk of bias in statistical analysis, reporting, and confounding factors, along with significant heterogeneity in methodology and diagnostic criteria.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>CCL5 may play a role in the pathogenesis of OLP/OLLs by promoting T-cell infiltration, correlating positively with disease severity, and presenting itself as a potential therapeutic target. However, the low-quality evidence due to the high risk of bias identified in the majority of included studies highlights the need for further research to confirm the immunomodulatory role of CCL5 in OLP/OLLs pathogenesis.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":"55 9","pages":"983-993"},"PeriodicalIF":2.3,"publicationDate":"2026-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148376018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TMD Symptom Characteristics and Their Four-Dimensional Impact on Oral Health-Related Quality of Life","authors":"Adrian Ujin Yap,&nbsp;Zhi-Wei Huang,&nbsp;Cheng-Ge Liu,&nbsp;Kai Yuan Fu,&nbsp;Jie Lei","doi":"10.1111/jop.70165","DOIUrl":"10.1111/jop.70165","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>This study examined how temporomandibular disorder (TMD) symptoms impact the four dimensions of Oral Health-related Quality of Life (OHRQoL) and identified symptom determinants contributing to high jaw disability and low OHRQoL.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Participants with pain-related (PT), intra-articular (IT), and combined TMD (CT) symptoms completed the Five TMD Symptoms-4D Screener, Jaw Functional Limitation Scale-8, and Oral Health Impact Profile for TMDs. TMD symptoms and impact were each assessed in four dimensions: duration-S1, frequency-S2, intensity-S3, and interference-S4; oral function-I1, orofacial pain-I2, orofacial esthetics-I3, and psychosocial impact-I4. Data were analyzed using the chi-squared test, nonparametric methods, and logistic regression (<i>α</i> = 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among the 272 participants (mean age 31.3 years), 5.5%, 18.0%, and 76.5% had PT, IT, and CT symptoms, respectively. Significant differences in global TMD severity (CT &gt; IT/PT), duration (IT &gt; CT &gt; PT), frequency (IT &gt; CT &gt; PT), intensity (IT/CT &gt; PT), jaw disability (PT/CT &gt; IT), and global OHIP (PT/CT &gt; IT) scores were observed. Additionally, significant differences were identified in I1 (CT &gt; IT), I2 (PT/CT &gt; IT), and I4 (PT/CT &gt; IT) dimensions. Symptom-impact dimension correlations varied based on the type of TMD symptoms. PT, CT, and S4 were significantly associated with both high jaw functional limitation and low OHRQoL (ORs = 3.78–47.06).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>TMD pain and symptom interference were key determinants of reduced OHRQoL, underscoring the need for symptom-specific assessment and individualized care.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":"55 9","pages":"1034-1044"},"PeriodicalIF":2.3,"publicationDate":"2026-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148404929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Micronucleus Frequency Test in Epithelial Cells Desquamated From the Oral Mucosa of Patients With Fanconi Anemia","authors":"Bárbara Soldatelli Ballardin,&nbsp;Pâmela Olivia de Moura,&nbsp;Pedro Leonardo Czmola de Lima,&nbsp;Juliana Lucena Schussel,&nbsp;Cassius Carvalho Torres-Pereira","doi":"10.1111/jop.70166","DOIUrl":"10.1111/jop.70166","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Fanconi anemia (FA) is a rare genetic disorder predisposing patients to oral squamous cell carcinoma (OSCC). Hematopoietic stem cell transplantation (HSCT) corrects bone marrow failure but may increase the risk of malignancies. Exfoliative cytology and the micronucleus (MN) test provide noninvasive assessment of genomic instability.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To compare relative frequency of micronuclei (RFMN) in intact mucosa and OPMD lesions in FA patients, and to evaluate its correlation with time post-HSCT.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Forty-six FA patients were included: Group 1 (FA without HSCT, <i>n</i> = 14), Group 2 (FA post-HSCT without OPMD, <i>n</i> = 13), and Group 3 (FA post-HSCT with OPMD, <i>n</i> = 19). Exfoliative cytology samples were collected from buccal mucosa and OPMD lesions. MNs were manually counted to calculate RFMN. Nonparametric tests were applied to compare groups and the Wilcoxon signed-rank test for intraindividual comparisons. Spearman's correlation and linear regression were used to evaluate associations with age and time.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>RFMN in OPMD lesions (Group 3) was significantly higher than in the integrous mucosa of the same patients (median 8 MN/1000 cells, IQR 4–13; ~3.7-fold increase; <i>p</i> = 0.001). No significant differences were observed between Groups 1 and 2 in integrous mucosa. RFMN in integrous mucosa positively correlated with time post-HSCT (<i>ρ</i> = 0.694, <i>p</i> &lt; 0.001), independent of age and GVHD presence.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>FA patients, particularly post-HSCT with OPMD, exhibited markedly increased genomic instability. RFMN increases over time, including time post-HSCT, emphasizing the need for vigilant long-term oral monitoring in this high-risk population.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":"55 9","pages":"1045-1051"},"PeriodicalIF":2.3,"publicationDate":"2026-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jop.70166","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148421804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic Value of Selected Epithelial-Mesenchymal Transition and Immune Checkpoint Markers in Predicting Malignant Transformation of Oral Leukoplakia.","authors":"Jiveswara Vijiakumar, Thomas George Kallarakkal, Lee Peng Karen-Ng, Samadara Siriwardena, Wanninayake Mudiyanselage Tilakaratne","doi":"10.1111/jop.70187","DOIUrl":"https://doi.org/10.1111/jop.70187","url":null,"abstract":"<p><strong>Aim: </strong>This study investigates the prognostic potential of epithelial-mesenchymal transition (EMT) markers (E-cadherin, N-cadherin, Twist) and immune checkpoint markers (PD-1, PD-L1) in predicting malignant transformation (MT) of oral leukoplakia (OL).</p><p><strong>Methodology: </strong>Immunohistochemistry (IHC) was performed on 56 OL tissue samples, categorized equally into progressive (transformed to higher-grade dysplasia or OSCC within 3 years) and non-progressive groups. Expression levels of E-cadherin, N-cadherin, Twist, PD-1, and PD-L1 were systematically assessed.</p><p><strong>Results: </strong>Progressive OL cases showed descriptive trends of lower E-cadherin expression, higher N-cadherin and Twist expression compared with non-progressive cases; however, these EMT-marker differences were not statistically significant. PD-1 expression was significantly higher in progressive OL (p = 0.038) compared with non-progressive OL. When stratified into non-progressive, dysplasia-progressive, and OSCC-progressive subsets, PD-L1 expression demonstrated significant variation (p = 0.018). Higher PD-1 expression was significantly associated with progressive OL in males (p = 0.02) and correlated with a shorter time to progression (τb = 0.456, p = 0.004).</p><p><strong>Conclusion: </strong>The findings suggest that immune checkpoint markers, particularly PD-1 and PD-L1, may be associated with progression in OL and may warrant further validation as adjunctive prognostic markers.</p>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149069790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clarifications Regarding Methodological Aspects of Micronucleus Assessment in Oral Epithelial Cells in Fanconi Anemia.","authors":"Bárbara Soldatelli Ballardin, Pâmela Olivia de Moura, Pedro Leonardo Czmola de Lima, Juliana Lucena Schussel, Cassius Carvalho Torres-Pereira","doi":"10.1111/jop.70185","DOIUrl":"https://doi.org/10.1111/jop.70185","url":null,"abstract":"","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149069620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral Cell Cytogenetic Biomarkers for Monitoring Genomic Instability in Fanconi Anemia.","authors":"Raquel Alves Sales, Gabriel Carvalhal de Aguiar, Daniel Vitor de Souza, Daniel Araki Ribeiro","doi":"10.1111/jop.70184","DOIUrl":"https://doi.org/10.1111/jop.70184","url":null,"abstract":"","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149069812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Papilliferous Keratoameloblastoma: What Is It, and Who Coined the Eponym?","authors":"Fumio Ide, Shinnichi Sakamoto, Michiko Nishimura, Yuji Miyazaki, Kentaro Kikuchi","doi":"10.1111/jop.70183","DOIUrl":"https://doi.org/10.1111/jop.70183","url":null,"abstract":"","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149039426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Infrared and Dual-Wavelength Photobiomodulation Therapy on Mandibular Bone Healing Following Radiotherapy and Tooth Extraction: An Experimental Study.","authors":"Göksal Keldal, Sefa Çolak, Asiye Yancı, Gülhan Güler Avcı, Rutkay Fırat Bulut, Bilal Bahar, Yunus Balel, Fikret Gevrek","doi":"10.1111/jop.70186","DOIUrl":"https://doi.org/10.1111/jop.70186","url":null,"abstract":"<p><strong>Background: </strong>Osteoradionecrosis (ORN) is a serious complication of head and neck radiotherapy characterized by impaired bone healing. Infrared photobiomodulation therapy (IR-PBMT) and dual-wavelength photobiomodulation therapy (Dual-PBMT) have been proposed as non-invasive approaches to enhance bone regeneration.</p><p><strong>Methods: </strong>Twenty-nine male Wistar-Albino rats were included. An experimental protocol designed to induce mandibular ORN was performed using a single 35 Gy radiation dose followed by mandibular molar extraction. Animals were allocated to four groups: control, radiotherapy plus extraction (RT + EX), RT + EX + IR-PBMT, and RT + EX + Dual-PBMT. IR-PBMT was performed using a 940 nm diode laser, whereas Dual-PBMT combined 632-650 nm red and 904-940 nm infrared wavelengths. Both PBMT protocols were applied extraorally for 14 consecutive days. Bone samples were evaluated histopathologically and immunohistochemically for alkaline phosphatase (ALP), bone morphogenetic protein-2 (BMP-2), osteonectin (ONC), and tartrate-resistant acid phosphatase (TRAP).</p><p><strong>Results: </strong>The RT + EX group exhibited severe inflammation and tissue destruction, whereas both PBMT-treated groups showed reduced inflammation and partial epithelialization. Osteogenic marker expression was significantly lower and TRAP expression was significantly higher in the RT + EX group than in the control group (p < 0.05). Compared with the RT + EX group, both IR-PBMT and Dual-PBMT significantly increased ALP, BMP-2, and ONC expression and reduced TRAP expression (p < 0.05). ALP expression was significantly higher in the Dual-PBMT group than in the IR-PBMT group, whereas no significant differences between the two protocols were observed for BMP-2, ONC, or TRAP.</p><p><strong>Conclusion: </strong>Both IR-PBMT and Dual-PBMT improved the evaluated histological and bone-remodeling parameters following radiotherapy and tooth extraction. Because the control animals did not undergo tooth extraction, comparisons with the control group should be interpreted cautiously. Although Dual-PBMT produced a greater increase in ALP expression, the findings do not demonstrate the overall superiority of one PBMT protocol over the other. Both approaches may represent promising adjunctive strategies for mitigating radiation-associated impairment of mandibular bone healing.</p>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149012041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circ_STIL Affects Ferroptosis by Sponging miR-338-3p in Oral Squamous Cell Carcinoma.","authors":"Mengxing Qi, Yongzhi Liu, Meng Ma, Dongsheng Zhang","doi":"10.1111/jop.70180","DOIUrl":"https://doi.org/10.1111/jop.70180","url":null,"abstract":"<p><strong>Background: </strong>Ferroptosis is pivotal in cancer onset and progression, which can be mediated by non-coding RNAs.</p><p><strong>Objectives: </strong>This study examined the expression profile of circSTIL/miR-338-3p in oral squamous cell carcinoma (OSCC) patients. Its regulatory mechanism in ferroptosis and OSCC cells was also examined.</p><p><strong>Materials and methods: </strong>Fifty OSCC tissue samples were collected to profile gene expression and validate clinical relevance. Functional assays in OSCC cell lines explored how circSTIL and miR-338-3p modulation affect proliferation and migration. Ferroptosis was assessed by quantifying intracellular Fe²⁺, ROS, and MDA, while ferroptosis-related key proteins' levels were measured via western blot. Potential target genes were predicted via online databases, with their functions and pathways analyzed using GO and KEGG enrichment analysis.</p><p><strong>Results: </strong>circSTIL was significantly upregulated in OSCC tumor samples, with its expression levels correlated with tumor size, lymph node metastasis status, and histological grade. Knockdown of circSTIL notably impaired the migratory and invasive capacities of OSCC cells, concurrently initiating ferroptotic cell death. Mechanistically, circSTIL functions as a sponge for miR-338-3p. Silencing miR-338-3p partially reversed the role of si-circSTIL against the malignant behavior of tumor cells, with GPX4 as its direct target.</p><p><strong>Conclusion: </strong>circSTIL/miR-338-3p axis plays a key role in the malignant progression of OSCC and ferroptosis. GPX4 may function as the key target in this regulatory network.</p>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148912515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}