Journal of Oral Pathology & Medicine最新文献

{"title":"Investigation of the Telomere Length in PERI-Implant Oral Mucosa Cells.","authors":"Fernando Costa Giffoni, Thaís Ellen Chaves Gomes, Priscila Nazaré de Souza, Paula Valente E Silva, Luiz Alexandre Viana Magno, Amanda Lage Cândido, Marcelo Faria Lasmar, Sebastião Guilherme de Oliveira Neto, Marcus Vinicius Lucas Ferreira, Thiago Moreira Gonçalves Araujo, Luara Isabela Dos Santos, Bruno Ramos Chrcanovic, Ricardo Santiago Gomez, Roberta Rayra Martins-Chaves","doi":"10.1111/jop.70061","DOIUrl":"https://doi.org/10.1111/jop.70061","url":null,"abstract":"<p><strong>Background: </strong>The biological effects of dental implants on peri-implant tissues have been widely investigated. Recent reports of oral squamous cell carcinoma (OSCC) cases adjacent to dental implants have raised concerns regarding the potential impact of implant materials on cellular aging and oncogenic transformation. Telomeres, which protect chromosome ends, undergo progressive shortening and play a critical role in cellular senescence and tumorigenesis. However, the impact of dental implants on telomere length in peri-implant mucosa remains unclear.</p><p><strong>Objective: </strong>This study aimed to compare telomere length in mucosa adjacent to dental implants with that of gingival tissue associated with healthy teeth.</p><p><strong>Methods: </strong>A paired cross-sectional study was conducted with 16 patients who had dental implants for at least 1 year. Swabs were collected from the peri-implant mucosa and healthy gingival mucosa of the same patient. Telomere length was assessed using quantitative PCR, with the relative telomere-to-single-copy-gene ratio (T/C) calculated using the 2^-∆∆Cq method.</p><p><strong>Results: </strong>Telomere length in the peri-implant mucosa was not significantly different from that in the healthy gingival mucosa (p = 0.117).</p><p><strong>Conclusion: </strong>These findings suggest that dental implants do not alter telomere length in adjacent mucosal cells.</p>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145040498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical, Radiographic and Histopathological Analysis of Cemento-Ossifying Fibromas and Fibro-Osseous Lesions of the Oral and Maxillofacial Region: A 53-Year Retrospective Study and Update of Current Concepts.","authors":"Hannah Gil de Farias Morais, Débora Frota Colares, Maurília Raquel de Souto Medeiros, Caio César da Silva Barros, Everton Freitas de Morais, Márcia Cristina da Costa Miguel, Roseana de Almeida Freitas","doi":"10.1111/jop.70059","DOIUrl":"https://doi.org/10.1111/jop.70059","url":null,"abstract":"<p><strong>Background: </strong>Fibro-osseous lesions (FOL) of the jawbones and cemento-ossifying fibroma (COF) represent a heterogeneous group of lesions with overlapping histopathological features and variability in biological behavior. Thus, this study aimed to evaluate the clinical, radiographic, and histopathological characteristics of FOLs (cemento-osseous dysplasia-COD, fibrous dysplasia-FD, ossifying fibroma-OF) as well as COF, diagnosed at a reference center in oral pathology over 53 years.</p><p><strong>Methods: </strong>Sex, age, symptoms, clinical diagnosis, time of evolution, anatomical site, size of the lesion, and radiographic characteristics were collected from all cases of lesions previously diagnosed as FOLs.</p><p><strong>Results: </strong>Among 19 600 cases of oral and maxillofacial lesions diagnosed at our center, 156 (0.8%) had a histological diagnosis of FOL, with COD being the most common (37.2%). Radiographically, most cases presented as unilocular lesions (64.3%) (p = 0.034) with mixed radiolucency (53.8%). COD and COF frequently exhibited well-defined borders. Additionally, 50% of COD cases displayed a cotton-wool appearance, while half of FDs appeared as ground-glass opacifications. Histopathologically, a significantly high frequency of lamellar bone was observed in all types of FOL (p = 0.0001). In contrast, peritrabecular clefting was significantly found in FDs, and cementum-like tissue in CODs and COFs (p < 0.05). Lesional bone fusing with the normal adjacent bone was more significantly observed in COD and FD (p = 0.001).</p><p><strong>Conclusion: </strong>A definitive and accurate diagnosis of FOL is achievable when cases are individually investigated, and all clinical, radiographic, and histopathologic features are analyzed.</p>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145030097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-Related Differences in Histone Acetylation and Tumor Development in a 4-Nitroquinoline 1-Oxide and Ethanol-Induced Oral Squamous Cell Carcinoma Mouse Model.","authors":"Wender Rodrigues Nazário, Anaíra Ribeiro Guedes Fonseca Costa, Débora de Oliveira Santos, Nayara Rúbio Diniz Del Nero, Tamiris Sabrina Rodrigues, Luiza Diniz Ferreira Borges, Carlos Ueira-Vieira, Sérgio Vitorino Cardoso, Adriano Mota Loyola, Paulo Rogério de Faria","doi":"10.1111/jop.70062","DOIUrl":"https://doi.org/10.1111/jop.70062","url":null,"abstract":"<p><strong>Background: </strong>Oral squamous cell carcinoma (OSCC) is one of the most frequent head and neck cancers. The 4-nitroquinoline 1-oxide (4NQO) mouse model of oral carcinogenesis is a well-established model to investigate the mechanism behind OSCC development, including epigenetic alterations. Studies have shown that histone acetylation is a key regulator of gene expression and may play a role in such a tumor. This study investigates the acetylation of H3K9, H3K14, and H3K27 and the KAT2A gene expression in a sex-based approach in a 4NQO/ethanol (EtOH)-induced OSCC mouse model.</p><p><strong>Methods: </strong>A total of 120 C57Bl/6J mice (60 males and 60 females) were divided into four groups (n = 15). In the first 10 weeks, they were treated with 5 mg/mL propylene glycol (PPG) or 100 μg/mL 4NQO in drinking water, followed by either sterilized water or 8% EtOH for 15 weeks. After euthanasia, tongues were analyzed histopathologically. Immunohistochemistry and qPCR were also employed to study the histones and gene expression.</p><p><strong>Results: </strong>Female mice showed increased H3K9ac and H3K14ac expression from normal mucosa to dysplasia, followed by decreased expression in OSCC. H3K9ac and H3K14ac expression in males was lower in the 4NQO/EtOH group. H3K27ac was higher in dysplastic lesions compared to OSCC, particularly in females. Comparatively, females had higher H3K9ac and H3K14ac expression in the 4NQO/EtOH group than males. KAT2A expression was lower in females treated with PPG/EtOH and 4NQO/H₂O than in males.</p><p><strong>Conclusion: </strong>Our results indicate that H3 acetylation and KAT2A gene expression may play a key role in oral carcinogenesis on a sex-related basis.</p>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145030030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hedgehog Components Are Present in Polymorphous Adenocarcinoma of the Salivary Gland Regardless of PRKD1 Mutation and Tissue Invasion.","authors":"Dandara Andrade De Santana, Cecília Vitória Lima De Oliveira, Flávia Caló De Aquino Xavier, Manoela Domingues Martins, Bruno Cunha Pires, Tercio Guimarães Reis, Patrícia Ramos Cury, Clarissa Araújo Gurgel, Maria Cristina Teixeira Cangussu, Daniel Araki Ribeiro, Victor Coutinho Bastos, Carolina Cavalieri Gomes, Jean Nunes Dos Santos","doi":"10.1111/jop.70057","DOIUrl":"https://doi.org/10.1111/jop.70057","url":null,"abstract":"<p><strong>Purpose: </strong>Polymorphous adenocarcinoma of the salivary gland is characterized by cellular uniformity associated with a variety of morphological growth patterns, a fact that makes its diagnosis challenging. Therefore, the identification of genetic alterations and signaling pathways emerges as a tool for elucidation of the pathogenesis of this tumor and accurate differential diagnosis. The aim of this study was to assess mutations in the PRKD1 gene and in protein components of the HH pathway (SHH, IHH, SMO, and GLI-1) in cases of polymorphous adenocarcinoma of the salivary gland.</p><p><strong>Methods: </strong>Sanger sequencing was used to interrogate hotspot mutations in PRKD1 exon 15 and immunohistochemistry to analyze the protein expression of PRKD1, SHH, IHH, SMO, and GLI-1.</p><p><strong>Results: </strong>The PRKD1 c.2130A>C/T hotspot mutation was detected in 50% of the sequenced samples. A previously unreported variant, c.2110C>T resulting in p.His704Tyr, was identified in one case, while 100% of the samples carried the intronic variation rs2273813, regardless of tissue invasion (perineural, lymphovascular, fat, bone, muscle, and mucous acini). Immunostaining revealed significant results for several associations between PRKD1, IHH, SMO, and GLI-1. In contrast, SHH immunoexpression did not correlate with the expression of the other proteins.</p><p><strong>Conclusion: </strong>The PRKD1 E710D hotspot mutation and protein expression of PRKD1 and HH components (SHH, IHH, SMO, and GLI-1) were detected in PAC regardless of tissue invasion, although HH proteins contributed to the morphogenesis of this rare oral cancer. Additionally, the positive correlation between the expression of PRKD1 and HH pathway components (IHH, SMO, and GLI-1) suggests a possible interaction between these proteins, independent of the HH pathway ligand.</p>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145033571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AARS1 Implicates Malignancy and Immune Infiltration in Head and Neck Squamous Cell Carcinoma, Serving as a Prognostic Predictor.","authors":"Shengkai Chen, Yuanhe You, Fangxing Zhu, Zhiyuan Zhang, Jianbo Shi, Zhuowei Tian","doi":"10.1111/jop.70058","DOIUrl":"https://doi.org/10.1111/jop.70058","url":null,"abstract":"<p><strong>Background: </strong>The aberrant expression of AARS1 has been linked to tumor progression in various cancers. However, its role and underlying mechanisms in head and neck squamous cell carcinoma (HNSCC) remain unclear.</p><p><strong>Methods: </strong>We validated AARS1 expression using databases and cell lines. Prognostic significance was assessed via Kaplan-Meier and Cox analyses. CCK-8, colony formation, wound healing, and flow cytometry evaluated the effects of AARS1 on HNSCC malignancy. Immune cell infiltration and immune checkpoint associations with AARS1 were analyzed using TIMER, CIBERSORT, MCPCOUNTER, and QUANTISEQ. Subsequently, histological staining and western blotting were performed to verify the identified relationship between AARS1 and immune suppression in HNSCC.</p><p><strong>Results: </strong>AARS1 was significantly upregulated in HNSCC tissues and cell lines. High AARS1 expression predicted poor overall survival (OS), disease-specific survival (DSS), and progression-free interval (PFI). Silencing AARS1 inhibited cell proliferation, migration, and resistance to apoptosis. In the AARS1 high-expression group, decreased CD8⁺ T cell infiltration was observed, along with increased expression of Siglec-15 and ITPRIPL1. These findings suggest that AARS1 might contribute to immune evasion and tumor progression in HNSCC.</p><p><strong>Conclusion: </strong>Elevated AARS1 expression correlates with poor prognosis, malignant behaviors, and immune infiltration in HNSCC, indicating that AARS1 may serve as a potential therapeutic target.</p>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145023610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Function of Hsa_circ_0001862 Regulating miR-23a-IRF1/PPP2R5E Axis to Oral Squamous Cell Carcinoma Development.","authors":"Xue Liu, Hui Xiong, Xuefeng Wang, Lina Li, Chang Liu, Feng Huo, Yadong Tao","doi":"10.1111/jop.70013","DOIUrl":"https://doi.org/10.1111/jop.70013","url":null,"abstract":"<p><strong>Backgrounds: </strong>Head and neck cancer is among the top ten cancers worldwide, with most lesions in the oral cavity. Oral squamous cell carcinoma accounts for more than 90% of all oral malignancies and is a significant public health concern. Circular RNA and micro RNA, as non-coding RNA, plays an important role in the development of tumor transmission.</p><p><strong>Aims: </strong>This study attempted to explore the pathogenesis of oral squamous cell carcinoma from the perspective of non-coding RNA.</p><p><strong>Materials & methods: </strong>We found that miR-23a was abnormally elevated in oral squamous cell carcinoma tissues. Taking this as an entry point, we searched for the circRNA and downstream target genes of miR-23a's upstream function through bioinformatics prediction. We determined the direct targeting relationship between miR-23a and hsa_circ_0001862, as well as the downstream target genes IRF1 and PPP2R5E, by dual luciferase reporter experiments. We used a series of cell phenotype experiments, such as CCK8, colony formation, scratch and trans-well assays, to verify the influence of each of the above genes on the tongue squamous cell line Tca-8113.</p><p><strong>Results: </strong>Hsa_circ_0001862 regulates the expression level of miR-23a through sponging. In the occurrence and development of tongue squamous cell carcinoma, the expression level of miR-23a is abnormally increased, which can promote the occurrence and development of tongue squamous cell carcinoma by down-regulating the expression level of its target genes IRF1 and PPP2R5E.</p><p><strong>Discussion: </strong>The identification of this signaling pathway provides a practical basis for early detection, early diagnosis and early treatment of oral squamous cell carcinoma.</p><p><strong>Conclusion: </strong>The regulatory mechanism of hsa_circ_0001862-miR-23a-IRF1/PPP2R5E axis on the OSCC and the function of downstream target genes that play specific roles.</p>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145023526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatments to Avoid Ranula Recurrence: A Network Meta-Analysis.","authors":"Marina Rocha Fonseca Souza, Moisés Willian Aparecido Gonçalves, Roberta Rayra Martins-Chaves, Rachel Alvarenga-Brant, Bruno Chrcanovic, Long Ge, Honghao Lai, Ricardo Santiago Gomez, Carolina Castro Martins-Pfeifer","doi":"10.1111/jop.70041","DOIUrl":"https://doi.org/10.1111/jop.70041","url":null,"abstract":"<p><strong>Background: </strong>Oral and plunging ranulas require effective treatment strategies to minimize recurrence; yet no consensus exists on the most effective approach.</p><p><strong>Objectives: </strong>This systematic review evaluated several treatments for the recurrence of oral and plunging ranulas.</p><p><strong>Methodology: </strong>A comprehensive search was conducted in five bibliographic databases and gray literature. Randomized and non-randomized studies were included if they investigated treatment approaches for oral or plunging ranulas. Two independent reviewers screened studies, extracted data, and assessed the risk of bias. The primary outcome was recurrence of (1) oral and (2) plunging ranula. For each type of ranula, a random-model frequentist network meta-analysis (NMA) was established for seven treatment strategies: enucleation, micromarsupialization, marsupialization, marsupialization with packing, partial sublingual gland excision, sublingual gland excision, and sublingual gland excision plus submandibular gland excision. A minimal important difference (MID) and the GRADE approach for NMA were used for interpretation of data.</p><p><strong>Results: </strong>Eighteen studies were included (all non-randomized-14 for oral ranula and six for plunging ranula). No treatment demonstrated clear superiority in preventing recurrence. Certainty of evidence was low to very low for oral ranulas and very low for plunging ranulas, primarily due to the risk of bias, imprecision, and intransitivity.</p><p><strong>Conclusions: </strong>Given the low certainty of evidence, no single treatment can be considered superior to others. Future research should prioritize longer follow-up randomized controlled trials.</p>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145023602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Clinicopathological Study of Marginal Gingival Leukoplakia.","authors":"Daniel Lobato Ferreira Ferraz, Caique Mariano Pedroso, Hélen Kaline Farias Bezerra, Alan Roger Dos Santos-Silva, Pablo Agustin Vargas, Marcio Ajudarte Lopes","doi":"10.1111/jop.70052","DOIUrl":"https://doi.org/10.1111/jop.70052","url":null,"abstract":"<p><strong>Background: </strong>Marginal gingival leukoplakias are relatively uncommon and rarely discussed in the scientific literature. Studies suggest they are distinct from other leukoplakias due to aggressive behavior and a strong association with proliferative verrucous leukoplakia. This study aimed to evaluate the clinicopathological characteristics of patients diagnosed with marginal gingival lesions.</p><p><strong>Methods: </strong>This retrospective study analyzed 32 patients diagnosed with marginal gingival leukoplakia. Clinicopathological data were extracted. K-means clustering and principal component analyses identified subgroups within the dataset. Histopathological findings were assessed by two oral pathologists using World Health Organization criteria for grading oral epithelial dysplasia.</p><p><strong>Results: </strong>The lesions predominantly affected older individuals (mean age: 60.4 years), 16 men and 16 women, and exhibited multifocality in 75% of cases. Proliferative verrucous leukoplakia was diagnosed in 24 patients (75%), and most lesions were homogeneous (84.4%). Thirteen patients were treated (three scalpel, eight laser, two both), while 19 underwent \"wait and see.\" Over a 95.4-month average follow-up, 11 recurrences (73.3%) were noted: four after scalpel (80%) and seven after laser excision (70%). Malignant transformation occurred in three cases. The most common histopathological feature was hyperkeratosis (n = 24), and eight cases showed mild, one moderate, and two severe epithelial dysplasia. Cluster analysis revealed five subgroups.</p><p><strong>Conclusion: </strong>Marginal gingival leukoplakias demonstrate significant heterogeneity but seem to be strongly associated with proliferative verrucous leukoplakia. Recurrence is a common outcome, and laser excision might be a better option for lesion control. Close monitoring remains essential for early intervention and improved outcomes.</p>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145000788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral and Maxillofacial Pathology in Latin America and the Caribbean: A Comprehensive Survey of Recognition, Training, and Practice.","authors":"Leonor Victoria González-Pérez, Cristina Saldivia-Siracusa, Ana Carolina Prado Ribeiro E Silva, Lady Paola Aristizábal Arboleda, Karen Patricia Domínguez Gallagher, Anna Luiza Damaceno Araújo, Pablo Agustin Vargas, María Luisa Paparella, Ana Verónica Ortega Pinto, Wilfredo Alejandro González-Arriagada, Claudia Patricia Peña-Vega, Roberto Gerber-Mora, Gilda Lucia García Heredia, Florence Juana Maria Cuadra Zelaya, Ileana Del Rosario Hurtado Castillo, Arvind Babu Rajendra Santosh, Adalberto Mosqueda-Taylor, Erick Antonio Castillo Gurdián, María Del Carmen González Galván, Wilson Delgado Azañero, Helen Rivera, Ronell Bologna-Molina, Mariana Villarroel-Dorrego, Janeth Liliam Flores Ramos, Carlos Alberto Gaidos Nates, Patricia Reiván Ortiz, Claudette Arambu Turcios, Erick Martínez Cruz, Loyden Evan Ken, Keith D Hunter, Alan Roger Santos-Silva","doi":"10.1111/jop.70051","DOIUrl":"https://doi.org/10.1111/jop.70051","url":null,"abstract":"<p><strong>Background: </strong>Oral and maxillofacial pathology (OMFP) is a dental specialty that studies the causes, processes, and effects of diseases in the oral and maxillofacial area, while also contributing to diagnosis and treatment. Its recognition, training, and professional practice vary across the globe. This study aimed to explore the training and professional development of OMFP in Latin America and the Caribbean (LAC), including important issues such as specialty recognition, service regulation, postgraduate education, number of specialists, career opportunities, and perceived barriers.</p><p><strong>Methods: </strong>An observational, cross-sectional study was conducted, where senior professionals in OMFP from 21 LAC countries were invited to complete a self-administered questionnaire via the REDCap web platform.</p><p><strong>Results: </strong>Experts from 21 countries reported recognition of OMFP as a dental specialty in 76.2% of the countries, with 61.9% offering it as an independent program distinct from oral medicine. Specific regulations for practice were present in 52.4% of the countries, and 33.3% offered postgraduate programs, mainly combining other specialties. The professional activities of participants were diverse, including roles in private practice, universities, research, laboratories, and hospitals. However, 61.9% of participants identified the lack of recognition for multidisciplinary teams as a significant barrier to their practice.</p><p><strong>Conclusion: </strong>This groundbreaking study provides an overview of key aspects of training, practice, and recognition of OMFP in 21 LAC countries. The findings demonstrate significant variation both within the region and when compared to global studies, providing a crucial foundation for future research in this area.</p>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144992659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Nd-YAG Laser Versus Epidermal Growth Factor Injection on Salivary Pain Mediators in Myogenic Temporomandibular Disorders (A Randomized Clinical Trial).","authors":"Passant Osama Qataya, Azza Mohamed Zaki, Fatma Amin, Ahmed Swedan, Hagar Elkafrawy","doi":"10.1111/jop.70053","DOIUrl":"https://doi.org/10.1111/jop.70053","url":null,"abstract":"<p><strong>Background: </strong>Myogenic temporomandibular disorder (MTMD) is a complex disorder of the masticatory apparatus. Many nonsurgical treatments have been introduced for treating MTMD chronic pain. The aim of this study is to test the effect of Nd-YAG laser versus epidermal growth factor (EGF) on painful chronic MTMD through monitoring pain scores and salivary pain mediators' levels.</p><p><strong>Materials and methods: </strong>Twenty-seven patients with chronic painful MTMD, refractory to conventional treatments, were included in this study. Group I (n = 13) was treated using Nd-YAG Laser. Group II (n = 14) was treated by intramuscular EGF injections. Pain score using the numerical rating scale (NRS, 0-10), salivary nerve growth factor (NGF, mg/dL), and salivary glutamate (Glu, mg/dL) were measured at baseline (day 0), 1, and 3 months.</p><p><strong>Results: </strong>NRS decreased significantly in both groups at 1 and 3 months compared to baseline. However, group II patients only showed a significant increase in NRS at 3 months compared to 1 month. In response to both treatments, NGF levels decreased significantly at 1 month compared to baseline. However, NGF levels at 3 months were significantly higher than baseline in both test groups. Glu levels showed a significant decrease in group II patients only at 1 and 3 months compared to baseline.</p><p><strong>Conclusion: </strong>The results of this clinical trial have shown, for the first time, that Nd-YAG laser and EGF intramuscular injection can offer effective non- to minimally invasive treatment options for pain alleviation in chronic MTMD. Salivary NGF is a promising noninvasive sensitive biomarker for chronic painful MTMD. EGF intramuscular injection had a direct effect on salivary Glu levels.</p><p><strong>Trial registration: </strong>This clinical trial was registered at ClinicalTrials.gov. Identifier: NCT06044974.</p>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}