Journal of Oral Pathology & Medicine最新文献

{"title":"Prevalence of Oral Potentially Malignant Disorders in Smokeless Tobacco Users With or Without Areca Nut: A Meta-Analysis.","authors":"Gowri Sivaramakrishnan, Kannan Sridharan","doi":"10.1111/jop.70045","DOIUrl":"https://doi.org/10.1111/jop.70045","url":null,"abstract":"<p><strong>Background: </strong>Smokeless tobacco (SLT) use is a major global risk factor for oral potentially malignant disorders (OPMDs). However, the differential impact of SLT product composition, particularly tobacco-only versus combined tobacco-areca nut products, on OPMD prevalence remains inadequately characterized.</p><p><strong>Objective: </strong>To compare the pooled prevalence of OPMDs between users of tobacco-only SLT and users of SLT containing both tobacco and areca nut.</p><p><strong>Methods: </strong>This study was conducted following PRISMA guidelines. Electronic databases (PUBMED, Cochrane, Scopus, Embase, Web of Science) were searched until December 15, 2024. Included studies reported OPMD prevalence among current SLT users with a clear product description. Areca nut-only products were excluded. Two reviewers independently screened studies, extracted data, and assessed quality (Newcastle-Ottawa scale). Pooled prevalence estimates were calculated using random-effects models in R software due to anticipated heterogeneity. Sensitivity analysis (leave-one-out) was performed.</p><p><strong>Results: </strong>Thirty-three studies (62 680 SLT users: 5058 tobacco-only; 57 622 tobacco-areca nut) were included. Overall OPMD prevalence was significantly higher among SLT with areca nut users (16.3%, 95% CI) compared to tobacco-only SLT users (10.4%, 95% CI). Tobacco-areca nut use showed markedly high prevalence of oral submucous fibrosis (OSMF) (33%) and dysplasia (16%), especially in endemic regions like India (88.8% OPMD prevalence in this subgroup). Tobacco-only SLT use was predominantly associated with leukoplakia (18%) and lichen planus/lichenoid reactions (15%). A critical limitation was the high proportion of non-specific OPMD diagnoses (27% overall, 38% in tobacco-areca nut users), hindering precise estimates of specific conditions. Sensitivity analyses confirmed result robustness.</p><p><strong>Conclusions: </strong>This meta-analysis demonstrates a substantial global burden of OPMDs among SLT users, with distinct risk profiles driven by product composition. Tobacco-areca nut SLT poses the highest risk (especially for OSMF and dysplasia), while tobacco-only SLT remains a significant independent risk factor (primarily for leukoplakia and lichenoid reaction). The high prevalence, particularly with combined products in regions like South Asia, underscores the urgent need for targeted public health interventions. Future research must prioritize precise product classification and standardized OPMD diagnosis to improve risk assessment.</p>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating Temporomandibular Disorder Severity: A Four-Dimensional Model.","authors":"Adrian Ujin Yap, Jie Lei, Chengge Liu, Zhiwei Huang, Kai-Yuan Fu","doi":"10.1111/jop.70050","DOIUrl":"https://doi.org/10.1111/jop.70050","url":null,"abstract":"<p><strong>Background: </strong>This study developed and tested a multi-dimensional model for evaluating the severity of temporomandibular disorders (TMDs) based on the five core symptoms (5Ts) of the Diagnostic Criteria for TMDs (DC/TMD).</p><p><strong>Methods: </strong>Study participants were sourced from a university hospital. The 5Ts screener was expanded to include the dimensions of duration, frequency, intensity, and interference with daily activities (5Ts-4D). The 5Ts-4D, along with the Graded Chronic Pain Scale (GCPS), Jaw Functional Limitation Scale-8 (JFLS-8), and Oral Health Impact Profile for TMDs (OHIP-TMD), was administered to individuals with no (NT), intra-articular (IT), pain-related (PT), and combined (CT) TMDs as determined using the DC/TMD methodology and diagnostic algorithms. Reliability and validity testing were carried out thereafter (α = 0.05).</p><p><strong>Results: </strong>Among the 324 participants, 13.6% had NT, while 42.9%, 15.7%, and 27.8% were diagnosed with IT, PT, and CT, respectively. The 5Ts-4D demonstrated good internal consistency (Cronbach's alpha = 0.83-0.95) and moderate-to-good test-retest reliability (ICC = 0.51-0.97) across various symptom-dimension combinations. It also showed robust known-group differences (PT, CT, IT>NT) and convergent validity, with strong correlations between global TMD severity, JFLS-8, and OHIP-TMD (r_s = 0.68-0.78).</p><p><strong>Conclusions: </strong>The 5Ts-4D, with its strong reliability and robust validity, holds promise as a straightforward tool for evaluating TMD symptoms and severity, thereby contributing to more effective management of TMD patients.</p>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Positive Feedback Loop Between SPP1⁺Macrophages and Tumor Cells Promotes Head and Neck Squamous Cell Carcinoma Progression.","authors":"Chun Liu, Chuwen Li, Kun Wu, Haiyan Guo, Jianjun Zhang","doi":"10.1111/jop.70049","DOIUrl":"https://doi.org/10.1111/jop.70049","url":null,"abstract":"<p><strong>Background: </strong>Emerging research has identified SPP1⁺macrophages as playing a critical role in head and neck squamous cell carcinoma (HNSCC). However, the specific mechanism by which SPP1⁺macrophages promote HNSCC progression remains poorly understood.</p><p><strong>Methods: </strong>The interaction of SPP1 and CD44 between SPP1⁺macrophages and tumor cells was detected by multiplex immunohistochemical staining of tissue sections, co-immunoprecipitation, and immunocytochemistry after co-culture. Flow cytometry, reverse transcription-polymerase chain reaction, and spheroid-formation assay were used to detect the stemness of tumor cells. Migration ability of tumor cells was analyzed by Transwell and wound-healing assays. In addition, the PI3K/Akt pathway was verified by western blot. The expression of soluble CD44 and SPP1 in serum was detected by enzyme-linked immunosorbent assay, and the expression of SPP1 in macrophages was detected by flow cytometry, western blot, and reverse transcription-polymerase chain reaction.</p><p><strong>Results: </strong>SPP1 and CD44 formed an interaction between SPP1⁺macrophages and tumor cells in HNSCC. SPP1⁺macrophages released SPP1 to regulate stemness and metastasis characteristics of tumor cells via the SPP1-CD44 axis. Soluble CD44 upregulated SPP1 expression in macrophages and thus, SPP1 and CD44 formed a positive feedback loop between SPP1⁺macrophages and tumor cells in HNSCC.</p><p><strong>Conclusions: </strong>SPP1-CD44 upregulates stemness and migration abilities of tumor cells in HNSCC. SPP1-CD44 forms an interaction and a positive feedback loop in SPP1⁺macrophages and tumor cells in HNSCC.</p>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic Heterogeneity Confers Differences in the Tumor Microenvironment of Aggressive Types of Melanomas.","authors":"Juliana de Souza do Nascimento, João Figueira Scarini, Erika Said Abu Egal, Marcelo Brum Corrêa, Rodrigo Ribas Dias Dos Reis, Luciana Schultz Amorim, Rachel Martins Marinho Robim, Clóvis Antônio Lopes Pinto, Patricia Maria Peresi, Ana Lucia Noronha Francisco, Felipe Paiva Fonseca, Luiz Paulo Kowalski, Román Carlos, Fernanda Viviane Mariano, Albina Altemani","doi":"10.1111/jop.70042","DOIUrl":"https://doi.org/10.1111/jop.70042","url":null,"abstract":"<p><strong>Background: </strong>Melanoma affects skin and mucosa and can be particularly aggressive when the lesion is an advanced cutaneous tumor or located in the sinonasal or oral mucosa. Reprogramming of energy metabolism has been defined as a hallmark of cancer; so this study aimed to verify the expression of proteins related to metabolism and cellular proliferation.</p><p><strong>Methods: </strong>Immunohistochemical analysis with antibodies adipophilin, FASN, GLUT-1, HIF-1α, and Ki-67 was performed in a series of 28 sinonasal melanomas (SM), 16 oral melanomas (OM), and 39 cutaneous melanomas (CM). For CM, 25 cases with matched lymph node metastases were analyzed, while 17 mucosal and 15 cutaneous melanocytic nevi served as controls.</p><p><strong>Results: </strong>SM showed an increased frequency of undifferentiated cells, necrotic areas, and marked expression of adipophilin in comparison to OM. In metastatic CM, a significant increase of FASN expression was detected. However, the frequency of expression of this protein was not significantly different between primary tumors and their metastasis. Concerning adipophilin expression in CM with or without metastasis, no significant difference was found, whereas the Ki-67 proliferative index was significantly lower in metastatic tumors. Benign melanocytic lesions showed lower expression of all markers.</p><p><strong>Conclusion: </strong>SM and OM show marked differences in metabolic phenotype alterations since SM are more frequently positive for adipophilin. In CM, the marked expression of FASN in metastatic tumors suggests that these proteins probably contribute to disease progression.</p>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Costs-Outcome Description Arising From Side Effects due the Over-Prescription of Antibiotics in Oral Healthcare in Chile.","authors":"Rodrigo J Mariño, Carlos Zaror, Pablo Cantú, Gerardo Espinoza","doi":"10.1111/jop.70044","DOIUrl":"https://doi.org/10.1111/jop.70044","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study is to investigate the financial consequences of immediate side effects of antibiotic over-prescription in dentistry from a societal perspective; to improve resource allocation and antibiotic prescribing practices.</p><p><strong>Methods: </strong>A cost-outcome description study was conducted, employing a decision tree model to estimate the costs arising from antibiotic over-prescription in oral healthcare. The model is based on a review of the relevant literature regarding current antibiotic prescribing practices in dentistry. It estimated the annual antibiotic prescription from 31 233 registered dentists in Chile (i.e., 1 624 428 prescriptions), with 55% of these considered unnecessary. Direct costs from a societal perspective were evaluated over a one-year time horizon, including medical services, lost income, and transportation costs. A sensitivity analysis was performed to assess the robustness of the findings.</p><p><strong>Results: </strong>The total societal cost of antibiotic over-prescription in dentistry was estimated at CLP: 8545478768 (USD: 9519516), including CLP: 3275870238 (USD: 3649263) for unnecessary prescriptions, and CLP: 5269608530 (USD:5870253) for adverse reactions. The sensitivity analysis indicated that variations in the percentage of unnecessary prescriptions significantly influenced the overall costs, ranging from CLP: 6991755356 (USD: 7788695) to CLP: 10099202180 (USD: 11250337).</p><p><strong>Conclusion: </strong>The study evaluated the economic burden of antibiotic over-prescription in oral healthcare, in terms of adverse reactions, highlighting the need for better prescribing practices. It suggested that significant cost-savings (USD: 9.5 million) could be achieved by reducing unnecessary antibiotic prescriptions. By addressing this challenge, we can not only alleviate the financial burden on society but also contribute to the global fight against antimicrobial resistance.</p>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytological and Genotoxic Effects of Systemic Isotretinoin on Oral Mucosa Cells.","authors":"Alinda Uslu, Hanife Guler Donmez","doi":"10.1111/jop.70048","DOIUrl":"https://doi.org/10.1111/jop.70048","url":null,"abstract":"<p><strong>Background: </strong>Despite its widespread use in acne vulgaris treatment, the potential cytological and genotoxic effects of systemic isotretinoin on oral mucosal cells remain poorly understood. This study aimed to investigate the cytological and genotoxic effects of systemic isotretinoin on oral mucosal cells.</p><p><strong>Methods: </strong>Buccal smear samples were collected from isotretinoin users (n = 20) and controls (n = 20). Cytomorphometric analyses (cell diameter (CD), nuclear diameter (ND), nuclear area (NA), cell area (CA), ND/CD, and NA/CA ratios) and cytological evaluations (nuclear degenerations, binucleation, perinuclear halos) were conducted using Papanicolaou staining. Micronucleus (MN) testing was performed on Feulgen-stained samples.</p><p><strong>Results: </strong>CD, ND, CA, and NA were significantly higher in the isotretinoin group (p < 0.05), while the ND/CD ratio was reduced (p < 0.05). MN scores and the presence of micronucleated cells (MNed cells) were significantly increased in isotretinoin users (p < 0.05), indicating genotoxic effects. The isotretinoin group showed a lower mean pH (5.8) than controls (6.7) (p < 0.001). No significant differences were linked to isotretinoin duration (less than 6 months (6<) vs. 6 months or more (6≥)) (p > 0.05).</p><p><strong>Conclusions: </strong>Isotretinoin use induces cytological changes, including increased cell and nuclear sizes, and genotoxic effects, as evidenced by elevated MN formation. Monitoring oral mucosal alterations in isotretinoin users may provide insights into potential side effects.</p>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Syzygium Cumini Extract Induced Reactive Oxygen Species-Mediated Apoptosis in Human Oral Squamous Carcinoma Cells\".","authors":"","doi":"10.1111/jop.70047","DOIUrl":"https://doi.org/10.1111/jop.70047","url":null,"abstract":"","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HPV-Vaccine and Reduced Odds Ratio for Oral and Oropharyngeal Cancer in Both Genders.","authors":"J Katz, H Gao, A I Garcia","doi":"10.1111/jop.70016","DOIUrl":"https://doi.org/10.1111/jop.70016","url":null,"abstract":"<p><strong>Background: </strong>Human papillomavirus-related cancer inflicts significant morbidity and mortality in adults. Real-life data on the effectiveness of a vaccine are scarce. The purpose of the study was to assess the association between human papillomavirus vaccination and oral and oropharyngeal cancer.</p><p><strong>Methods: </strong>Queries used de-identified data from patients attending the University of Florida Gainesville Health Center for malignant neoplasm of the oral cavity and pharynx for patients diagnosed between October 2015 and September 2022.</p><p><strong>Results: </strong>From a hospital population of 1 743 953 patients, 4 131 (0.23%) patients (1228 females and 2903 males) had oropharyngeal cancer. Males were likelier to have oral or oro/oropharyngeal cancer (Odds Ratio = 2.5; p < 0.0001). 56 654 (37 479 females and 19 175 males) were vaccinated, mostly Human papillomavirus 9-VALENT (53%). The vaccine was associated with a reduced odds ratio for oral/oropharyngeal cancer (Odds ratio 0.008, p < 0.0001) that remained low after adjustments for smoking status and alcohol abuse. When stratified by oropharyngeal and oral only, oral pharyngeal had a lower odds ratio with vaccination (0.01, 95%CI 0.00-0.06) compared to the oral cavity (0.03, 95% CI 0.01-0.10). There were also differences in the odds ratio with other risk factors such as gender, race, smoking, and alcohol abuse.</p><p><strong>Conclusions: </strong>Human papillomavirus vaccination is associated with a reduced odds ratio for oral and oropharyngeal cancer.</p>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Investigation of the Differences in Cortactin, MT1-MMP, TKS4, and TKS5 Immunoexpression Between Central and Peripheral Giant Cell Granulomas.","authors":"Bernardo da Fonseca Orcina, Ezequiel Azevedo Schemmfelnnig, Rebeka Camille Carvalho Chamon, Douglas Magno Guimarães, Maria Sueli da Silva Kataoka, Sérgio de Melo Alves Júnior, Sandra Beatriz Chaves Tarquinio, Ana Carolina Uchoa Vasconcelos, Ana Paula Neutzling Gomes, João de Jesus Viana Pinheiro, Adriana Etges","doi":"10.1111/jop.70040","DOIUrl":"10.1111/jop.70040","url":null,"abstract":"<p><strong>Background: </strong>Central giant cell granuloma (CGCG) is a benign and locally confined osteolytic lesion that occasionally exhibits aggressive behavior, while the peripheral giant cell granuloma (PGCG) is a reactive lesion with localized proliferation. Both lesions present similar histological characteristics.</p><p><strong>Objective: </strong>To compare the immunoexpression of the main invadopodia-related proteins in CGCG and PGCG in the jaws.</p><p><strong>Methods: </strong>30 CGCG and 12 PGCG biopsied at the oral and maxillofacial pathology departments of three universities were evaluated. The expression of cortactin, MT1-MMP, TKS4, and TKS5, in spindle-shaped and polygonal mononuclear cells (SPMC) and multinucleated giant cells (MGC) was observed through immunohistochemistry, and the labeled areas were semi-automatically detected by an image processing software equipped with an efficient color detection plugin. The percentages of labeled areas in MGC and SPMC for both lesions were statistically compared at a significance level of p < 0.05.</p><p><strong>Results: </strong>The expressions of all evaluated proteins in MGC were significantly higher for CGCG than PGCG (p < 0.05). Regarding SPMC, only the expressions of cortactin and TKS5 were significantly higher expressed in CGCG than in PGCG (p < 0.05).</p><p><strong>Conclusion: </strong>The significantly higher expressions of cortactin (MGC, SPMC), TKS4 (MGC), TKS5 (MGC, SPMC), and MT1-MMP (MGC) in CGCG may partially explain its greater invasiveness/aggressiveness.</p>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Network Analysis of Anxiety and Depression Symptoms in Individuals With Oral Lichen Planus and Evaluation of Salivary Biomarkers: A New Approach.","authors":"Alessandra Laís Pinho Valente Pires, Adriana Mendonça da Silva, Murilo Cruz, Ynara Bosco de Oliveira Lima-Arsati, Franco Arsati, Rodrigo Tripodi Calumby, Jean Nunes Dos Santos, Gabriela Botelho Martins, Valéria Souza Freitas","doi":"10.1111/jop.70038","DOIUrl":"10.1111/jop.70038","url":null,"abstract":"<p><strong>Objective: </strong>To estimate the network structure of 21 symptoms of anxiety and depression in individuals diagnosed with oral lichen planus (OLP) and compare it with salivary biomarkers, cortisol and alpha-amylase.</p><p><strong>Materials and methods: </strong>A case-control study was conducted with 21 OLP cases and 21 controls matched by sex and age. Beck Anxiety and Depression Inventories were administered, and salivary cortisol and alpha-amylase levels were determined. Descriptive analysis used the Mann-Whitney U test to compare participants' responses and the Benjamini-Hochberg Method to control the False Discovery Rate (FDR). Network analysis was performed using regularized partial correlation network models.</p><p><strong>Results: </strong>A significant association was found between anxiety (p = 0.001) and depression (p = 0.004) scores and OLP. The \"shaky/unsteady\" symptom was most central in the anxiety network for OLP patients, while \"feelings of punishment\" and \"self-criticism\" were central in the depression network. Weak correlations were observed between cortisol and alpha-amylase in anxiety and depressive symptoms. Cortisol awekening response (CAR) had a negative correlation with alpha-amylase awakening response (AAR) (-0.54), as like AAR and Faint/lightheaded (-0.57) in anxiety network. Anxiety network structures did not differ between groups (p = 0.18), but the depression network was more connected in controls than in OLP cases (overall strength 69.29 vs. 27.35, p < 0.000).</p><p><strong>Conclusion: </strong>This study reveals the distinct network structures of anxiety and depression symptoms in OLP patients, highlighting a new methodological approach to exploring symptom configurations. When exploring the relationship with cortisol and alpha-amylase, weak relationships were found between them. The findings may prompt further network studies involving biomarkers and their interaction with anxiety and depression.</p>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}