Tissue Biomarkers for Predicting the Risk of Oral Cancer in Patients Diagnosed With Oral Leukoplakia: A Systematic Review of the Past 4 Years

IF 2.3 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Oral Pathology & Medicine Pub Date : 2025-04-08 DOI:10.1111/jop.13632

Luís Monteiro, Elia Rocha, Sara Ferreira, Filomena Salazar, José Júlio Pacheco, Saman Warnakulasuriya

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引用次数: 0

Abstract

Background

Oral potentially malignant disorders may precede the development of oral cancer, and biomarkers are being investigated for their risk assessment. We aim to provide updated information on tissue biomarkers related to the risk of malignant transformation (MT) in patients with oral leukoplakia (OL) published during the last four years.

Methods

A search strategy was developed using the electronic databases PubMed, EBSCO, and Cochrane Library to search for articles related to this topic (published from 2020 to 2024) (CRD42024527395).

Results

Of the 1385 articles identified, 14 were included, with a combined sample of 1479 patients of whom 216 suffered MT. There were 30 different biomarkers evaluated of which Bmi-1, CD3/CD8, Ki-67, p16, and DNA ploidy were evaluated in more than one study. Of the 9 studies with multivariate analysis, Bmi-1, Tipe-2, copy number alteration, DcR2, and Ki-67, PTHrP, podoplanin (PDPN), and BubR1/Mad2 biomarkers presented independent significant value on MT. In one study, adding DNA ploidy status to the grade of dysplasia increased the model's predictive power.

Conclusion

Although heterogeneity continues to exist, this systematic review reconfirms the role of biomarkers previously described such as PDPN and DNA ploidy and some new additional biomarkers.

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预测口腔白斑患者口腔癌风险的组织生物标志物：过去4年的系统综述

背景：口腔潜在恶性疾病可能先于口腔癌的发展，生物标志物正在被研究用于其风险评估。我们的目标是提供在过去四年中发表的与口腔白斑（OL）患者恶性转化（MT）风险相关的组织生物标志物的最新信息。方法：采用PubMed、EBSCO和Cochrane Library电子数据库制定检索策略，检索与本主题相关的文章（发表时间为2020 - 2024）（CRD42024527395）。结果：在鉴定的1385篇文章中，14篇纳入了1479例患者的综合样本，其中216例患有MT。有30种不同的生物标志物被评估，其中Bmi-1、CD3/CD8、Ki-67、p16和DNA倍性在不止一项研究中被评估。在9项多变量分析的研究中，Bmi-1、Tipe-2、拷贝数改变、DcR2、Ki-67、PTHrP、podoplanin （PDPN）和BubR1/Mad2生物标志物对MT具有独立的显著价值。在一项研究中，将DNA倍体状态加入到发育不良的等级中增加了模型的预测能力。结论：尽管异质性仍然存在，但本系统综述再次证实了先前描述的生物标志物（如PDPN和DNA倍体）和一些新的额外生物标志物的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Oral Pathology & Medicine 医学-病理学

CiteScore

5.90

自引率

6.10%

发文量

121

审稿时长

4-8 weeks

期刊介绍： The aim of the Journal of Oral Pathology & Medicine is to publish manuscripts of high scientific quality representing original clinical, diagnostic or experimental work in oral pathology and oral medicine. Papers advancing the science or practice of these disciplines will be welcomed, especially those which bring new knowledge and observations from the application of techniques within the spheres of light and electron microscopy, tissue and organ culture, immunology, histochemistry and immunocytochemistry, microbiology, genetics and biochemistry.