Journal of Oral Pathology & Medicine最新文献

{"title":"Bibliometrics-Based Mapping of Research on the Role of miRNAs in Oral Cancer.","authors":"Yujing Wang, Rujie Shi, Baisheng Wang, Kun Li","doi":"10.1111/jop.70037","DOIUrl":"10.1111/jop.70037","url":null,"abstract":"<p><strong>Background: </strong>MiRNAs have essential research value and broad clinical application prospects in oral cancer.</p><p><strong>Aims: </strong>We provided a comprehensive understanding of trends, current features, and priorities in the field of miRNA and oral cancer research based on bibliometrics.</p><p><strong>Materials and methods: </strong>Reference records were obtained from the Web of Science core collection and analyzed using CiteSpace 6.2.4, VOSviewer 1.6.20, and GraphPad Prism 8.</p><p><strong>Results: </strong>Results showed that between 2008 and 2024, a total of 1149 publications in the database were retrieved to study the role of miRNAs in oral cancer. The annual number of publications showed an increasing trend from year to year, peaking in 2021. Among them, China (470 articles), China Medical University (37 articles), and the journal Oral Oncology demonstrated the highest research productivity in terms of countries (regions), institutions, and journals.</p><p><strong>Discussion: </strong>Keywords and cited literature indicate that the current research focus is mainly on microenvironmentally- derived miRNAs as potential diagnostic and therapeutic targets for oral cancer. Recent studies have gradually focused on the experimental study of drug delivery systems of miRNAs in treating oral cancer, which may become one of the important research directions in the future.</p><p><strong>Conclusions: </strong>Thus, by searching the literature in the field of miRNAs and oral cancer from the Web of Science core collection and performing bibliometric analysis, the development of research and research hotspots in the last two decades was mapped out. This will provide valuable references and guidelines for relevant scholars and researchers to explore the direction in future research endeavors.</p>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using Quantitative Masticatory Dysfunction to Inform Pain Management in Trigeminal Neuralgia Through Electromyographic Monitoring.","authors":"Alessia Riente, Alessio Abeltino, Cassandra Serantoni, Michele Maria De Giulio, Giada Bianchetti, Mariaconsiglia Santantonio, Giulio Cesare Passali, Stefano Capezzone, Rosita Esposito, Marco De Spirito, Giuseppe Maulucci","doi":"10.1111/jop.70035","DOIUrl":"https://doi.org/10.1111/jop.70035","url":null,"abstract":"<p><strong>Background: </strong>Trigeminal neuralgia (TN) is a rare and debilitating condition characterized by severe, episodic facial pain, with an incidence of about five individuals per 100 000 annually, predominantly affecting women aged 50-70 years. TN is often difficult to diagnose; leading to underestimation or misdiagnosis and prolonged patient suffering.</p><p><strong>Objective: </strong>This study aimed to assess masticatory dysfunction in individuals with and without TN using an electromyographic device (\"Chewing\") and evaluate its potential to quantify pain-related dysfunction and inform treatment approaches.</p><p><strong>Methods: </strong>This observational study assessed masticatory dysfunction in TN patients and healthy controls using \"Chewing\" device. Masticatory behavior was monitored with apple and carrot as test foods, and parameters such as chewing time, number of chews, and chewing force were recorded. Participants were clustered based on masticatory patterns using an unsupervised learning approach.</p><p><strong>Results: </strong>Two distinct clusters of masticatory behavior emerged from the analysis. Cluster 1, representing 27.5% of TN1 patients, was characterized by prolonged chewing duration, a greater number of chewing cycles, and reduced chewing force compared to Cluster 0. Specifically, during apple mastication, Cluster 1 showed a 24% increase in chewing time (p = 0.02), a twofold increase in the number of chews (p < 0.001), and a 50% reduction in chewing force (p < 0.001). When chewing carrots, the number of chews increased by 57% (p < 0.001), while chewing force decreased by 64% (p < 0.001). Chewing frequency was also significantly higher in Cluster 1 for both food types (p < 0.001). Furthermore, a higher prevalence of TN1 patients was found in Cluster 1 compared to Cluster 0 (χ² = 4.53, p = 0.05), suggesting an association between altered masticatory behavior and trigeminal neuralgia. Nonetheless, the presence of some TN1 patients in Cluster 0 indicates that masticatory function may remain intact in certain individuals, possibly due to milder pain symptoms or the development of compensatory coping strategies.</p><p><strong>Conclusions: </strong>\"Chewing\" device successfully quantified and differentiated masticatory patterns, providing valuable insights into functional adaptations. Subgrouping TN patients by masticatory behavior may guide personalized treatment strategies and improve patient outcomes.</p>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144855532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of Fluconazole Resistance and Susceptibility on Candida-Streptococci Aggregation Dynamics.","authors":"Maribasappa Karched, Asma Hanif, Radhika G Bhardwaj, Mai E Khalaf, Muawia A Qudeimat","doi":"10.1111/jop.70034","DOIUrl":"https://doi.org/10.1111/jop.70034","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the interaction between fluconazole-resistant (Flu-R) and -susceptible dose-dependent (Flu-SDD) isolates of Candida albicans and Candida glabrata with oral streptococci, exploring autoaggregation, coaggregation, and the impact of streptococcal biofilm-secreted components on Candida biofilms.</p><p><strong>Methods: </strong>Autoaggregation and coaggregation of Candida Flu-R and Flu-SDD isolates with streptococci (S. mutans, S. gordonii, and S. sanguinis) were assessed using an optical density assay. The inhibitory effects of streptococcal biofilm-secreted components on Candida biofilms were examined, quantifying biofilm inhibition by crystal violet staining and assessing viability through 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Statistical analysis of the data was done by one-way ANOVA, considering a p-value of < 0.05 as significant.</p><p><strong>Results: </strong>Flu-R C. albicans exhibited higher autoaggregation (71%) than Flu-SDD (62%), both surpassing Streptococcus spp. (32%-49%). Flu-R and Flu-SDD C. glabrata had less autoaggregation ability than C. albicans (p < 0.05). Coaggregation increased steadily, with Flu-SDD C. albicans exhibiting the highest coaggregation with S. mutans (69% ± 8% at 2 h). Flu-R strains showed significant coaggregation differences with streptococcal species (p-values 0.05-< 0.001). Biofilm inhibition was significant in Candida Flu-R and Flu-SDD isolates treated with streptococcal biofilm supernatants. Supernatants of all three streptococcal species decreased Flu-R C. albicans viability (1.15-2.15-fold).</p><p><strong>Conclusions: </strong>Fluconazole susceptibility/resistance significantly influences aggregation and biofilm formation with oral streptococci. Streptococcal biofilm supernatants hinder Candida strains' growth and viability, suggesting implications for colonization, biofilm formation, and oral infections.</p>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144855531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling Novel DSPP Variants and Dental Phenotypes in Dentinogenesis Imperfecta.","authors":"Angkana Boonyakanog, Thanakorn Theerapanon, Tanit Arunratanothai, Somchai Yodsanga, Nond Rojvachiranonda, Lakshman Samaranayake, Wuttichart Kamolvisit, Vorasuk Shotelersuk, Thantrira Porntaveetus","doi":"10.1111/jop.70030","DOIUrl":"https://doi.org/10.1111/jop.70030","url":null,"abstract":"<p><strong>Background: </strong>Variants in the dentin sialophosphoprotein (DSPP) gene are known to cause hereditary dentin disorders, including dentinogenesis imperfecta (DGI), which is characterized by abnormal dentin development and structure. However, the full spectrum of clinical manifestations and the impact of specific variants remain to be fully elucidated.</p><p><strong>Methods: </strong>Oral and radiological examinations were conducted on eight patients from two families. Physical characterization of deciduous DGI teeth and matched controls was performed. Exome and Sanger sequencing were employed for variant detection.</p><p><strong>Results: </strong>All patients exhibited opalescent teeth with bulbous crowns and pulpal obliteration. A copper-beaten skull appearance was detected in one proband, indicating craniosynostosis and necessitating immediate medical intervention. Ultrastructural analyses revealed a dark and red-yellow tone in deciduous DGI teeth. DGI dentin exhibited decreased mineral density, hardness, and elastic modulus, along with disruption of dentinal tubules, the dentinoenamel junction, and mineral contents. Two novel heterozygous frameshift variants in DSPP, c.2317del and c.3555del, were identified in families A and B, respectively, both located in exon 5, expected to alter the repeating sequence pattern of the dentin phosphoprotein (DPP) protein.</p><p><strong>Conclusion: </strong>This study identifies two novel frameshift variants in the DPP region associated with compromised dentin properties, composition, and ultrastructure. These findings expand the genotype and phenotype spectra of DSPP-DGI, highlighting the crucial role of dentists not only in addressing dental diseases but also in contributing to broader medical interventions.</p>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144835356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CD44 and Snail1 Expression Predicts Poor Prognosis of Oral Squamous Cell Carcinoma.","authors":"Cintia Eliza Marques, Everton Freitas de Morais, Bruno Cesar da Costa, Fábio Haach Téo, Ana Lúcia Carrinho Ayroza Rangel, Ricardo D Coletta, Lívia Maris Ribeiro Paranaiba Dias","doi":"10.1111/jop.70032","DOIUrl":"https://doi.org/10.1111/jop.70032","url":null,"abstract":"<p><strong>Background: </strong>Oral squamous cell carcinoma (OSCC) remains a challenging malignancy with poor 5-year survival rates due to diagnosis at an advanced stage and a high likelihood of recurrence and metastasis. These aggressive traits may be influenced by cancer stem cells (CSC) and epithelial-mesenchymal transition (EMT).</p><p><strong>Methods: </strong>This study investigated the prognostic significance of the CSC marker CD44 and EMT-related proteins (Snail1, Snail2, E-cadherin, N-cadherin) in 132 OSCCs using immunohistochemistry. The comprehensive survival analysis included univariate and multivariate (stepwise method) Cox regression for disease-specific survival (DSS) and disease-free survival (DFS), Kaplan-Meier curves based on log-rank testing, and receiver operating characteristic (ROC) analysis to assess the predictive accuracy of the markers.</p><p><strong>Results: </strong>High CD44 expression independently predicted worse DSS (HR = 2.74, 95% CI 1.44-5.23, p = 0.003) and DFS (HR = 2.22, 95% CI 1.16-4.23, p = 0.01), and Snail1 was significantly associated with poor DSS (HR = 2.62, 95% CI 1.37-5.03, p = 0.004). The combined expression of CD44 and Snail1 improved the discrimination of worse outcomes compared to markers individually. The presence of lymphovascular invasion (HR = 8.68, 95% CI 3.81-19.75, p < 0.0001) and a positive surgical margin (< 5 mm; HR = 4.45, 95% CI 1.99-9.96, p = 0.0003) were also independently associated with DSS.</p><p><strong>Conclusions: </strong>The results of this study highlight the prognostic significance of CD44 and Snail1 in OSCC, emphasizing their potential interplay in tumor aggressiveness.</p>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144835400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tackling (Oral) Health Disinformation: Not as Easy as It Seems","authors":"Nicola Cirillo","doi":"10.1111/jop.70033","DOIUrl":"10.1111/jop.70033","url":null,"abstract":"","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":"54 8","pages":"609-612"},"PeriodicalIF":2.3,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144835401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Mandibular Trabecular Bone by Fractal Analysis on Digital Panoramic Radiograph in Patients with Inherited Bleeding Disorder.","authors":"Muhammed Abdullah Çege, Öykü Öztürk Gündoğdu, Zühre Kaya, Zühre Akarslan, Dilek Aynur Çankal","doi":"10.1111/jop.70036","DOIUrl":"https://doi.org/10.1111/jop.70036","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to assess mandibular trabecular bone health in patients with inherited bleeding disorders using fractal analysis (FA) on digital panoramic radiographs (DPR).</p><p><strong>Methods: </strong>Thirty-five patients with hereditary bleeding disorders (hemophilia A or B, and von Willebrand disease (VWD)) and 35 healthy controls were included. Data were collected on factor levels, inhibitor status, bleeding history, factor replacement therapy, vitamin D use, and calcium supplementation. Using ImageJ software, FA was performed from the determined regions in the mandible via DPR: ROI-1 (condylar region), ROI-2 (mandibular angle) and ROI-3 (molar region). Each region was independently evaluated by a radiologist and a maxillofacial surgeon trained in FA.</p><p><strong>Results: </strong>Of the patients, 23 (65%) had severe hemophilia, 3 (8%) had type III VWD, 5 (15%) had moderate hemophilia, and 4 (12%) had type I VWD. Interobserver agreement for FA measurements in the condyle, angle, and molar areas was almost perfect (Kw = 0.992-0.993). In these three regions, no statistically significant differences in mean FA values were found between patients and controls, regardless of age or gender (p > 0.05). However, four high-risk patients-one with severe hemophilia B with inhibitors, two with type III VWD, and one with severe hemophilia A on an on-demand regimen-displayed significantly lower mean FA values in the condylar region compared to controls (p < 0.05). These findings suggest that while most patients with inherited bleeding disorders may not show marked alterations in mandibular trabecular bone structure, some high-risk individuals could have compromised bone health detectable via FA.</p><p><strong>Conclusion: </strong>This preliminary study indicates that FA may be a valuable tool for identifying at-risk patients with inherited bleeding disorders. Larger studies are needed to confirm these preliminary findings.</p>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144835399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deciphering NOTCH1 as a Biomarker in Adenoid Cystic Carcinoma: Insights From a Systematic Review With Meta-Analysis","authors":"Isabela de Sousa Slivar,&nbsp;Bruno de Andrade Zanesco,&nbsp;Manoela Domingues Martins,&nbsp;Leandro Luongo Matos,&nbsp;Fábio Daumas Nunes,&nbsp;Lauren Frenzel Schuch,&nbsp;Vivian Petersen Wagner","doi":"10.1111/jop.70028","DOIUrl":"10.1111/jop.70028","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Most studies suggest that NOTCH1 alterations are associated with prognosis in adenoid cystic carcinoma (ACC), but findings remain fragmented. We conducted an integrative analysis to evaluate the prognostic value of NOTCH1-related biomarkers in ACC.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A comprehensive search was conducted across multiple databases. Inclusion criteria comprised studies examining NOTCH1-related features at ACC diagnosis and their relation with survival outcomes. Meta-analysis was performed on studies sharing similar methodology.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Twelve studies met the eligibility criteria. NOTCH1 mutational status, Notch1 immunoexpression, and NICD1 immunoexpression were associated either with overall, disease-free or progression-free survival. Methodological disparities hindered integration of results. Meta-analyses of HRs were conducted with 2 studies for each index factor, revealing a 2.31-fold increased risk of death for primary ACC cases with NOTCH1 mutations, a 2.6-fold increased risk of death for those exhibiting positive NICD1 expression and a 1.91-fold heightened risk of disease recurrence for cases with high Notch1 expression.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This comprehensive review underscores the prognostic relevance of NOTCH1 in ACC, indicating its potential as a valuable risk stratification tool.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":"54 8","pages":"647-657"},"PeriodicalIF":2.3,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jop.70028","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144821631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of Vitamin D Level on Oral Health Status in Adult Hypophosphatasia.","authors":"Florian Dudde, Dominik Fildebrandt, Paul Kock, Karin Petz, Ralf Smeets, Martin Gosau, Michael Amling, Thomas Beikler, Florian Barvencik","doi":"10.1111/jop.70039","DOIUrl":"https://doi.org/10.1111/jop.70039","url":null,"abstract":"<p><strong>Aim: </strong>Vitamin D deficiency is common in hypophosphatasia (HPP) patients. However, its impact on oral health is unclear. Therefore, the purpose of this study was to investigate the relationship between Vitamin D levels and oral health in adults with hypophosphatasia.</p><p><strong>Materials and methods: </strong>In this retrospective study, oral health and bone metabolism in HPP patients were examined. The Decayed/Missing/Filled Teeth (DMFT) index, clinical attachment level (CAL), probing pocket depth (PPD), and periodontal screening index (PSI) were among the metrics used to evaluate oral health.</p><p><strong>Results: </strong>The average age of the 48 HPP patients in the study was 42.21 (±15.78) years. A mean Vitamin D level of 29 μg/L was used to divide the participants into two groups. Compared to patients with Vitamin D levels above 29 μg/L, those with levels below this threshold showed noticeably worse oral health, as evidenced by higher PSI, PPD, decayed tooth count, and periodontitis severity index.</p><p><strong>Conclusion: </strong>The results imply that adults with HPP who have low Vitamin D levels have worse oral health. To potentially improve oral health, it is crucial to diagnose and treat Vitamin D deficiency in HPP patients, as it is a known risk factor for periodontitis in the general population.</p>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144821632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inside the Fire. Exploring the Impact of Anxiety, Depression, and Sleep Disturbances on Pain Perception in Burning Mouth Syndrome: A Cross-Sectional Study of 200 Patients.","authors":"Antonietta Argiuolo, Federica Canfora, Benedetta Muzii, Cristina D'Antonio, Daniela D'Auria, Amerigo Giudice, Gennaro Musella, Luca D'Aniello, Massimo Aria, Nelson Mauro Maldonato, Michele Davide Mignogna, Daniela Adamo","doi":"10.1111/jop.70026","DOIUrl":"https://doi.org/10.1111/jop.70026","url":null,"abstract":"<p><strong>Background: </strong>This study investigates how anxiety, depression, and sleep disturbances affect pain perception and clinical impairment in burning mouth syndrome (BMS).</p><p><strong>Methods: </strong>A cross-sectional survey was conducted on 200 BMS patients. The Hamilton Rating Scale for Depression (HAM-D) and Anxiety (HAM-A), Epworth Sleepiness Scale (ESS), Pittsburgh Sleep Quality Index (PSQI), Visual Analogue Scale (VAS), and short form of McGill pain questionnaire (SF-MPQ) were used. The Clinical Global Impressions Severity of Illness (CGI-S) assessed illness severity, and comorbidities were analyzed via the Age-Adjusted Charlson Comorbidity Index (AACCI). Correlation tests and path analyses explored relationships among psychological factors, sleep quality, and BMS severity.</p><p><strong>Results: </strong>Pain intensity (VAS) correlated significantly with anxiety (HAM-A, ρ = 0.25, p < 0.05), depression (HAM-D, ρ = 0.15, p < 0.05), and shorter sleep duration (ρ = -0.19, p < 0.05). Path analyses revealed that anxiety significantly increased pain intensity (β = 0.24, p < 0.05), indirectly influencing clinical severity (CGI-S: β = 0.07, p < 0.05). Depression strongly impacted poor sleep quality (PSQI, β = 0.33, p < 0.05). Shorter sleep duration affected both sleep quality (β = -0.46, p < 0.05) and clinical outcomes (CGI-S, β = -0.17, p < 0.05). Pain quality (SF-MPQ) showed weaker, non-significant associations with psychological factors.</p><p><strong>Conclusions: </strong>Anxiety amplifies pain intensity, while depression worsens sleep quality, exacerbating clinical outcomes. Shorter sleep duration further contributes to worse outcomes. These findings emphasize the need for tailored interventions targeting psychological distress and sleep disturbances to improve pain management and quality of life in BMS patients.</p>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144821633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}