Biomarkers in Peri-Implant Crevicular Fluid of Healthy Implants and Those With Peri-Implant Diseases: A Systematic Review and Meta-Analysis

IF 2.7 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Oral Pathology & Medicine Pub Date : 2025-03-18 DOI:10.1111/jop.13612

Gerardo La Monaca, Nicola Pranno, Romeo Patini, Antonella Polimeni, Massimo Cordaro, Maria Paola Cristalli

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引用次数: 0

Abstract

Introduction

Several biomarkers in peri-implant crevicular fluid have been studied to diagnose peri-implant diseases with inconclusive results. This systematic review and meta-analysis aimed to comprehensively compare data on the levels of biological components in peri-implant crevicular fluid collected from healthy and diseased implants to identify reliable biomarkers for diagnosing and monitoring peri-implant disease.

Materials and Methods

The search strategy included studies comparing biomarker levels in peri-implant crevicular fluid between healthy and diseased implants through electronic databases (MEDLINE/PubMed, Embase, Cochrane Library), grey literature, and hand-searching relevant journals and reference lists of pertinent papers. A two-stage screening was performed in duplicate and independently. In the first stage, titles and abstracts that fulfilled eligibility criteria were screened. In the second stage, a full-text analysis was conducted to verify eligibility. All articles meeting the inclusion criteria underwent data extraction and quality assessment. Meta-analyses were conducted on studies with similar comparisons and outcome measures.

Results

After screening the titles and abstracts, out of 100 potentially relevant papers identified for full-text evaluation, 49 were excluded, 51 were included in the qualitative analysis, and 18 were included in the quantitative synthesis. Among 96 biomarkers assessed, the most studied were pro-inflammatory cytokines (IL-1ß, IL-6, TNF-α, and IL-17), osteoclastogenic-related factors (RANK, RANKL, and OPG), anti-inflammatory cytokines (IL-10), chemokines (IL-8, MIP-1α/CCL3, and MIP-3α/CCL-20), and enzymes (MMP-8, Cat-K, AST, and ALT).

Conclusions

Meta-analyses comparing data from healthy patients and those with peri-implantitis or mucositis and between patients with mucositis and those with peri-implantitis showed a moderate predictive value of IL-1ß, VEGF, cortisol, and sRANKL/OPG for peri-implantitis.

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健康种植体和有种植体周围疾病的种植体周围沟液中的生物标志物：系统综述和荟萃分析

介绍：研究了种植体周围沟液中的几种生物标志物用于诊断种植体周围疾病，但结果不确定。本系统综述和荟萃分析旨在全面比较从健康和患病种植体收集的种植体周围沟液中生物成分水平的数据，以确定诊断和监测种植体周围疾病的可靠生物标志物。材料和方法：检索策略包括通过电子数据库（MEDLINE/PubMed, Embase, Cochrane Library），灰色文献，手工检索相关期刊和相关论文的参考文献列表，比较健康和病变种植体种植体周围沟液中生物标志物水平的研究。两个阶段的筛选进行了重复和独立。在第一阶段，对符合资格标准的标题和摘要进行筛选。在第二阶段，进行全文分析以验证资格。所有符合纳入标准的文章都进行了数据提取和质量评估。对具有相似比较和结果测量的研究进行meta分析。结果：筛选标题和摘要后，筛选出100篇可能相关的论文进行全文评价，排除49篇，51篇纳入定性分析，18篇纳入定量综合。在评估的96个生物标志物中，研究最多的是促炎因子（IL-1ß、IL-6、TNF-α和IL-17）、破骨相关因子（RANK、RANKL和OPG）、抗炎因子（IL-10）、趋化因子（IL-8、MIP-1α/CCL3和MIP-3α/ ccl20）和酶（MMP-8、Cat-K、AST和ALT）。结论：荟萃分析比较了健康患者与种植周炎或粘膜炎患者以及粘膜炎患者与种植周炎患者之间的数据，结果显示IL-1ß、VEGF、皮质醇和sRANKL/OPG对种植周炎的预测价值中等。

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来源期刊

Journal of Oral Pathology & Medicine 医学-病理学

CiteScore

5.90

自引率

6.10%

发文量

121

审稿时长

4-8 weeks

期刊介绍： The aim of the Journal of Oral Pathology & Medicine is to publish manuscripts of high scientific quality representing original clinical, diagnostic or experimental work in oral pathology and oral medicine. Papers advancing the science or practice of these disciplines will be welcomed, especially those which bring new knowledge and observations from the application of techniques within the spheres of light and electron microscopy, tissue and organ culture, immunology, histochemistry and immunocytochemistry, microbiology, genetics and biochemistry.