Global Insights of Oral Submucous Fibrosis: Concerns About Betel Nut and Oral Cancer

IF 2.7 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Oral Pathology & Medicine Pub Date : 2025-04-09 DOI:10.1111/jop.13637

Siyao You, Jianjun Wu, Sicen Lai, Hua Tu, Xinyan Cui, Qiao Yi, Qiuyun Guo

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引用次数: 0

Abstract

Background

Oral submucous fibrosis (OSF) is a chronic progressive fibrosis of oral mucosa, with the possibility of eventually progressing to oral cancer, remaining unclear pathogenesis, and a lack of targeted therapies. This study aims to analyze current research progress from a bibliometric perspective to guide the way forward.

Methods

Documents in the Web of Science Core Collection database from 1999 to August 31, 2023 were thoroughly searched using a given query. After selection, years of publishing, countries, institutions, authors, journals, and keywords were analyzed using bibliometric software.

Results

The bibliometric results of 1522 documents show that India and China were the most productive countries in this field. Central South University has published the most papers. The Journal of Oral Pathology & Medicine and Oral Oncology were the leading journals. Betel nut, oral cancer, malignant transformation, and fibroblast were the main focuses during recent study periods. We also analyzed differences between studies in betel chewing and nonchewing areas. Notably, scholars pay more attention to the pathogenesis of OSF in the former, while the relationship between OSF and cancer is more concerning in the latter, such as in the United Kingdom and the United States.

Conclusion

Findings from this study provide an overview of the current research and reveal the future hotspot of the OSF research. It suggests that exploring the pathogenesis and mechanisms of malignant transformation in OSF will be a focal point in future research. Advancements in the prevention and treatment of OSF could significantly enhance patients' quality of life and reduce mortality associated with oral cancer.

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口腔粘膜下纤维化的全球洞察：槟榔和口腔癌的担忧

口腔黏膜下纤维化（Oral mucous fibrosis， OSF）是一种慢性进行性口腔黏膜纤维化，最终发展为口腔癌的可能性较大，发病机制尚不清楚，且缺乏靶向治疗。本研究旨在从文献计量学的角度分析目前的研究进展，以指导未来的研究方向。方法采用给定查询对Web of Science Core Collection数据库1999年至2023年8月31日的文献进行全面检索。选择后，使用文献计量软件分析出版年份、国家、机构、作者、期刊和关键词。结果1522篇文献的计量结果表明，印度和中国是该领域最具生产力的国家。中南大学发表的论文最多。口腔病理学杂志；《医学》和《口腔肿瘤学》是主要期刊。槟榔、口腔癌、恶性转化和成纤维细胞是最近研究的主要焦点。我们还分析了槟榔咀嚼区和非咀嚼区研究之间的差异。值得注意的是，前者的学者更关注OSF的发病机制，而后者，如英国和美国，则更关注OSF与癌症的关系。本研究的结果对目前的研究进行了概述，并揭示了未来OSF研究的热点。因此，探讨OSF恶性转化的发病机制将是今后研究的重点。口腔癌的预防和治疗进展可显著提高患者的生活质量，降低口腔癌相关的死亡率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Oral Pathology & Medicine 医学-病理学

CiteScore

5.90

自引率

6.10%

发文量

121

审稿时长

4-8 weeks

期刊介绍： The aim of the Journal of Oral Pathology & Medicine is to publish manuscripts of high scientific quality representing original clinical, diagnostic or experimental work in oral pathology and oral medicine. Papers advancing the science or practice of these disciplines will be welcomed, especially those which bring new knowledge and observations from the application of techniques within the spheres of light and electron microscopy, tissue and organ culture, immunology, histochemistry and immunocytochemistry, microbiology, genetics and biochemistry.