Clinicopathological Study of Oncocytomas of Head and Neck Region: A Systematic Review

IF 2.3 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Oral Pathology & Medicine Pub Date : 2025-08-06 DOI:10.1111/jop.70022

João Paulo Gonçalves de Paiva, Laura Borges Kirschnick, Daniela Giraldo Roldán, Manoela Domingues Martins, Alan Roger Santos-Silva, Ciro Dantas Soares, Jacks Jorge

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引用次数: 0

Abstract

Background

Salivary gland oncocytomas are infrequent benign salivary gland tumors with few reported cases.

Aims

This study aimed to systematically review case reports and case series studies on oncocytomas in the head and neck region.

Materials & Methods

Electronic searches were performed in PubMed, Scopus, Web of Science, Embase, and LILACS databases. The risk of bias was assessed using the Joanna Briggs Institute—University of Adelaide tool for case reports and case series.

Results

A total of 99 studies (145 cases) were included. Oncocytomas predominantly affected women, typically presenting as solitary, asymptomatic parotid masses in patients over 51 years of age. Some cases reported multiple or bilateral tumors, occasionally associated with other salivary gland lesions. Histologically, the tumors were primarily composed of eosinophilic oncocytes with minimal pleomorphism, arranged in diverse architectural patterns. Immunohistochemical analysis revealed positivity for PTAH, antimitochondrial antigen, CK5/6, CK8/18, CK10/13, CK19, EMA, along with a low Ki67 index, while being negative for S100 and actin. Surgical excision was the primary treatment, with rare instances of recurrence.

Conclusion

Oncocytoma is a rare, benign neoplasm that most commonly arises in the parotid gland, with a predilection for female patients. Complete surgical excision constitutes the standard treatment and is associated with an excellent prognosis.

Abstract Image

查看原文本刊更多论文

头颈部肿瘤细胞瘤的临床病理研究：系统综述。

背景：唾液腺癌细胞瘤是罕见的良性唾液腺肿瘤，报道病例很少。目的：本研究旨在系统回顾头颈部肿瘤的病例报告和病例系列研究。材料与方法：在PubMed、Scopus、Web of Science、Embase和LILACS数据库中进行电子检索。使用乔安娜布里格斯研究所-阿德莱德大学的案例报告和案例系列工具评估偏倚风险。结果：共纳入99项研究（145例）。肿瘤细胞瘤主要影响女性，典型表现为孤立的，无症状的腮腺肿块，患者年龄超过51岁。一些病例报告多发性或双侧肿瘤，偶尔伴有其他唾液腺病变。组织学上，肿瘤主要由嗜酸性肿瘤细胞组成，具有最小的多形性，排列成不同的结构模式。免疫组化分析显示PTAH、抗线粒体抗原、CK5/6、CK8/18、CK10/13、CK19、EMA阳性，Ki67指数低，S100和actin阴性。手术切除是主要的治疗方法，很少有复发的情况。结论：嗜酸细胞瘤是一种罕见的良性肿瘤，常见于腮腺，多见于女性患者。完全手术切除是标准的治疗方法，预后良好。

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来源期刊

Journal of Oral Pathology & Medicine 医学-病理学

CiteScore

5.90

自引率

6.10%

发文量

121

审稿时长

4-8 weeks

期刊介绍： The aim of the Journal of Oral Pathology & Medicine is to publish manuscripts of high scientific quality representing original clinical, diagnostic or experimental work in oral pathology and oral medicine. Papers advancing the science or practice of these disciplines will be welcomed, especially those which bring new knowledge and observations from the application of techniques within the spheres of light and electron microscopy, tissue and organ culture, immunology, histochemistry and immunocytochemistry, microbiology, genetics and biochemistry.