Bruno Fortaleza de A Ferreira, Gustavo Sakuno, Juliana Mika Kato, Rodolfo Bonatti, Álvaro Fernandes Ferreira, Aloisio Fumio Nakashima, Yoshitaka Nakashima
{"title":"Combined Brilliant and Trypan Blue As Vital Dyes for Chromovitrectomy.","authors":"Bruno Fortaleza de A Ferreira, Gustavo Sakuno, Juliana Mika Kato, Rodolfo Bonatti, Álvaro Fernandes Ferreira, Aloisio Fumio Nakashima, Yoshitaka Nakashima","doi":"10.18502/jovr.v19i2.7652","DOIUrl":"10.18502/jovr.v19i2.7652","url":null,"abstract":"<p><p>Brilliant blue 0.05% and trypan blue 0.1% were mixed in a proportion of 1:1 in a 1-mL syringe. This combination produced a waterfall effect with the fast sinking of the dye to the posterior pole and little diffusion through the vitreous cavity. Therefore, it can effectively stain the internal limiting membrane and the epiretinal membrane with a good contrast during surgeries for a macular hole, myopic foveoschisis, and macular pucker.</p>","PeriodicalId":16586,"journal":{"name":"Journal of Ophthalmic & Vision Research","volume":"19 2","pages":"264-266"},"PeriodicalIF":1.6,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11267129/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141759220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Whiplash Maculopathy Following Parachute Injury.","authors":"Parveen Sen, Harshit Vaidya","doi":"10.18502/jovr.v19i2.7442","DOIUrl":"10.18502/jovr.v19i2.7442","url":null,"abstract":"<p><strong>Purpose: </strong>To report subtle yet important macular changes following a whiplash injury.</p><p><strong>Case report: </strong>We report an unusual case of a healthy young male presenting with a three-month history of a drop in vision in both eyes following an accident while crash-landing from a parachute. There was no direct ocular injury. Fundus examination revealed a bilateral well-defined area of retinal pigment epithelium (RPE) alterations over the macula with no other obvious retinal abnormality. Optical coherence tomography (OCT) examination revealed outer retinal layer defects with nearly intact inner retina.</p><p><strong>Conclusion: </strong>This case highlights the importance of fundus evaluation and reviewing patient's visual symptoms in otherwise inapparent ocular trauma.</p>","PeriodicalId":16586,"journal":{"name":"Journal of Ophthalmic & Vision Research","volume":"19 2","pages":"260-263"},"PeriodicalIF":1.6,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11267134/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141759301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effect of Induced Myopia on the Vestibulo-ocular Reflex Evaluated by Ocular Vestibular Evoked Myogenic Potential.","authors":"Mahdi Mazloom, Javad Heravian Shandiz, Sadegh Jafarzadeh, Jamshid Jamali, Hamed Momeni-Moghaddam","doi":"10.18502/jovr.v19i2.10910","DOIUrl":"10.18502/jovr.v19i2.10910","url":null,"abstract":"<p><strong>Purpose: </strong>The possible effects of refractive errors on vestibulo-ocular reflex (VOR) has been a conflicting issue. The aim of this study was to evaluate the effects of induced myopia on VOR using the ocular Vestibular Evoked Myogenic Potential (oVEMP).</p><p><strong>Methods: </strong>In this cross-sectional quasi-experimental study, 35 emmetropic and normal subjects with the mean age of 23.89 <math><mo>±</mo></math> 3.93 (range, 20-40 years) without any ocular, nervous system, and vestibular disorders, underwent the oVEMP test in the comprehensive rehabilitation center of Mashhad University of Medical Sciences. The oVEMP was performed under five different conditions of testing binocularly, monocularly, and when myopia was induced with the use of spherical lenses of +1.00, +3.00, and +5.00 diopters, respectively. There were 2 to 5 min of rest with closed eyes after each condition to avoid adaptation, fatigue, and any other sources of bias. Mean latencies of oVEMP waves (N1 and P1) and amplitudes of N1-P1 complex were measured.</p><p><strong>Results: </strong>There was no significant difference between the right and left sides (<i>P</i> <math><mo>></mo></math> 0.05). The induced myopia significantly increased the N1 and P1 latencies using lenses of +1.00, +3.00, and +5.00 diopters but the amplitudes of N1-P1 complex were not influenced by the different amounts of induced myopia. There was no significant difference among the different conditions of induced myopia either (<i>P</i> <math><mo>></mo></math> 0.05).</p><p><strong>Conclusion: </strong>Induced myopia could affect the VOR due to prolonging the latencies of oVEMP waves. However, the amplitudes were not affected and the effects of multiple degrees of induced myopia were not significantly different.</p>","PeriodicalId":16586,"journal":{"name":"Journal of Ophthalmic & Vision Research","volume":"19 2","pages":"219-226"},"PeriodicalIF":1.6,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11267135/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141759222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Camille Yvon, Bhupendra Patel, John Ng, Marcus T Altman, Raman Malhotra
{"title":"Oculoplastic Conditions in Covid-19 Patients: Case Series and Literature Review.","authors":"Camille Yvon, Bhupendra Patel, John Ng, Marcus T Altman, Raman Malhotra","doi":"10.18502/jovr.v19i2.10908","DOIUrl":"10.18502/jovr.v19i2.10908","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate oculoplastic conditions in patients diagnosed with coronavirus disease 2019 (COVID-19) seen at ophthalmology departments of three tertiary referral centers in the United Kingdom and the United States, and review of the literature.</p><p><strong>Methods: </strong>Retrospective multicenter case series studied over 18 months.</p><p><strong>Results: </strong>A total of four patients developed eyelid, orbital, or lacrimal gland pathology within four weeks of testing positive for COVID-19. All were male, and the mean age at presentation was 49 (range, 31-58 years). Suspected diagnoses included anterior idiopathic orbital inflammation, facial angioedema, dacryoadenitis, and anophthalmic socket inflammation. Three patients recovered fully and one patient recovered partially (mean 2.7 weeks) from ocular manifestations with steroids hastening recovery.</p><p><strong>Conclusion: </strong>Adnexal manifestations of COVID-19 include self-limiting orbital inflammation and eyelid lymphedema.</p>","PeriodicalId":16586,"journal":{"name":"Journal of Ophthalmic & Vision Research","volume":"19 2","pages":"235-245"},"PeriodicalIF":1.6,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11267130/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141759296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sara Sardari, Mehdi Khabazkhoob, Ebrahim Jafarzadehpur, Akbar Fotouhi
{"title":"The Repeatability of Axial Length Measurements Using a Scheimpflug-based System.","authors":"Sara Sardari, Mehdi Khabazkhoob, Ebrahim Jafarzadehpur, Akbar Fotouhi","doi":"10.18502/jovr.v18i4.14551","DOIUrl":"10.18502/jovr.v18i4.14551","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the repeatability of Pentacam AXL as a Scheimpflug-based system or measuring axial length according to the age, sex, lens type, axial length value, and type of cataract.</p><p><strong>Methods: </strong>The present study was conducted using multistage cluster sampling in Tehran, Iran. Ocular biometry was performed, using the Pentacam AXL, by an experienced optometrist on all the participants. The axial length (AL) measurements were taken thrice, with a gap of 10 minutes. To evaluate the repeatability, the intraclass correlation coefficient (ICC) and the repeatability coefficient (RC) were calculated. To determine the significant difference in the repeatability index among study variables, the tolerance index (TI) was calculated.</p><p><strong>Results: </strong>In this report, 897 eyes of 677 individuals aged between 20 and 91 years (mean <math><mo>±</mo></math> SD: 64.90 <math><mo>±</mo></math> 13.62 years) were reported. The ICC of the axial length measurements was 0.981 for all cases. Based on the within-subject standard deviation, the RC was 0.401. The ICC was 0.976 and 0.985 in men and women, respectively. The TI showed better RC of measurements among females. The ICC decreased from 0.999 in participants under 40 years to 0.973 in individuals over 60 years of age. The TI showed a decrease in RC with advancing age. The RC was worse in eyes with nuclear cataracts; the RC was also worse in the first quartile of the signal-to-noise ratio (SNR) compared to the other SNR quartiles.</p><p><strong>Conclusion: </strong>The Scheimpflug-based systemPentacam AXL had high repeatability in measuring axial length. Some variables such as male gender, older age, and nuclear cataract were associated with reduced repeatability of the measurements. A higher SNR was associated with better repeatability of the axial length measurements.</p>","PeriodicalId":16586,"journal":{"name":"Journal of Ophthalmic & Vision Research","volume":"18 4","pages":"396-404"},"PeriodicalIF":2.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10794809/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139512982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Impact of COVID-19 on Ophthalmology Practice: Changes and Controversies in Endophthalmitis Risk.","authors":"Mohammad Riazi","doi":"10.18502/jovr.v18i3.13771","DOIUrl":"10.18502/jovr.v18i3.13771","url":null,"abstract":"","PeriodicalId":16586,"journal":{"name":"Journal of Ophthalmic & Vision Research","volume":"18 3","pages":"249-251"},"PeriodicalIF":2.0,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10432926/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10106043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Risk of Induction of Corneal Neovascularization with Topical Erythropoietin: An Animal Safety Study.","authors":"Sepehr Feizi, Mozhgan Rezaei Kanavi, Mohammad Abolhosseini, Seyed-Mohamadmehdi Moshtaghion, Hamed Esfandiari","doi":"10.18502/jovr.v18i3.13772","DOIUrl":"10.18502/jovr.v18i3.13772","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the pro-angiogenic effect of topical erythropoietin on cornea in chemical burn-injured rabbit eyes.</p><p><strong>Methods: </strong>The corneal alkali-burn injury was induced in 10 eyes of 10 rabbits using filter paper saturated with 1.0 mol sodium hydroxide. The eyes were categorized into the treatment group (<i>n</i> = 5) that received topical erythropoietin (3000 IU/mL) every 8 hr for one month versus the control group (<i>n</i> = 5) that received normal saline every 8 hr for one month. All eyes were treated with topical ciprofloxacin every 8 hr until corneal re-epithelialization was complete. Corneal epithelial defects, stromal opacity, and neovascularization were evaluated after the injury. At the conclusion of the study, the rabbits were euthanized and their corneas were submitted to histopathological examination.</p><p><strong>Results: </strong>Baseline characteristics including the rabbits' weight and the severity of corneal injury were comparable in two groups. Time to complete corneal re-epithelialization was 37 days in the treatment group and 45 days in the control group (<i>P</i> = 0.83). There was no significant difference between the groups in the rate of epithelial healing or corneal opacification. Clinical and microscopic corneal neovascularization was observed in one eye (20%) in the treatment group and two eyes (40%) in the control group (<i>P</i> = 0.49).</p><p><strong>Conclusion: </strong>Recombinant human erythropoietin administered topically did not induce vessel formation in rabbit corneas after chemical burn.</p>","PeriodicalId":16586,"journal":{"name":"Journal of Ophthalmic & Vision Research","volume":"18 3","pages":"252-259"},"PeriodicalIF":2.0,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11082528/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140912499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Quaternary Knot Technique: Suture Knot Burial without Scleral Flap or Incision for Trans-scleral Fixation.","authors":"Levent Dogan, Ibrahim Edhem Yilmaz","doi":"10.18502/jovr.v18i3.13784","DOIUrl":"https://doi.org/10.18502/jovr.v18i3.13784","url":null,"abstract":"<p><p>Despite the introduction of novel sutureless posterior chamber intraocular lens (IOL) fixation techniques, some conditions still require suture-assisted scleral fixation. If the scleral fixation suture knot is left directly under the conjunctiva, it may become exposed, resulting in an increased risk of endophthalmitis. To avoid this problem, we offer a new alternative, simple, and safe way for burying the end of the suture using knots in this report.</p>","PeriodicalId":16586,"journal":{"name":"Journal of Ophthalmic & Vision Research","volume":"18 3","pages":"342-347"},"PeriodicalIF":2.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10432925/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10106036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dhanwini Rudraprasad, Jaishree Gandhi, Poonam Naik, Milind N Naik, Chenchu Naidu, Dilip Kumar Mishra, Joveeta Joseph
{"title":"A Novel and Low-cost Approach for Intravitreal Injection in an Experimental Model of Endophthalmitis.","authors":"Dhanwini Rudraprasad, Jaishree Gandhi, Poonam Naik, Milind N Naik, Chenchu Naidu, Dilip Kumar Mishra, Joveeta Joseph","doi":"10.18502/jovr.v18i3.13775","DOIUrl":"https://doi.org/10.18502/jovr.v18i3.13775","url":null,"abstract":"<p><strong>Purpose: </strong>Animal models are necessary in understanding the pathogenesis of endophthalmitis and are also necessary to assist the development of new therapeutics for this sight-threatening ocular inflammation. Hamilton syringes are usually preferred to inject pathogens when performing experiments on test subjects, however, this method has technical and financial disadvantages. In this study, we report the findings and assess the related benefits of applying a novel low-cost intravitreal injection technique to initiate endophthalmitis in a mouse model while using the Eppendorf tip and a 26G needle.</p><p><strong>Methods: </strong>The 18-hr culture of clinical isolates of bacteria (<i>Staphylococcus aureus</i> and <i>Pseudomonas aeruginosa</i>) and fungus (<i>Aspergillus flavus</i> and <i>Candida albicans</i>) were resuspended to a final concentration of 10,000 colony forming units (CFU)/1 µL which were separately injected intravitreally into C57BL/6 mice (6-8 weeks) using a 0.1-2.5µL pipette attached to the modified Eppendorf tip with a 26G needle. The contralateral eye served as vehicle/uninjected control. Disease progression was determined by assessing the corneal haze, opacity, bacterial burden, and retinal histology of the eyes used in the model. Following euthanization, bacteria-infected mice were enucleated after 24 hr of the initial injection, and fungus-infected mice after 72 hr.</p><p><strong>Results: </strong>Of the 50 mice injected, the modified technique was successful in 48 mice. Two mice were excluded due to cataract formed by accidental injury to the lens. The experimental endophthalmitis mice model successfully mimicked the natural clinical course. Clinical assessment and histopathology confirmed the influx of inflammatory cells into the posterior segment of the eye along with dissolution of retinal architecture.</p><p><strong>Conclusion: </strong>Our novel method of injection using a modified Eppendorf tip and 26G needle yielded a cost-effective mouse model of clinical endophthalmitis, resulting in reproducible infection for understanding various aspects of its pathobiology.</p>","PeriodicalId":16586,"journal":{"name":"Journal of Ophthalmic & Vision Research","volume":"18 3","pages":"272-282"},"PeriodicalIF":2.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10432928/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10106035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Intraocular Pressure Values using IcareⓇ Rebound Tonometer and Correlation with Postconceptional Age in Premature Infants.","authors":"Catarina Monteiro, Maria Vivas, Júlio Almeida, Mário Ramalho, Mafalda Mota, Susana Teixeira, Isabel Prieto","doi":"10.18502/jovr.v18i3.13774","DOIUrl":"https://doi.org/10.18502/jovr.v18i3.13774","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimedto determine a normative range of intraocular pressure (IOP) values measured with Icare rebound tonometer in premature infants and evaluate IOP variation over time and its correlation with the progression of postconceptional age (PCA). By doing so, we also evaluated advantages of this IOP-measuring method in this population when compared to more traditional methods.</p><p><strong>Methods: </strong>We conducted a single-center prospective study that included premature infants (gestational age <math><mo>≤</mo></math>32 weeks) who were admitted to the neonatal intensive care unit (NICU) in Hospital Professor Doutor Fernando Fonseca. The study took place between January and December 2021. IOP was measured using Icare tonometer on the occasion of the first retinopathy of prematurity (ROP) screening requested by the NICU and again after a two-week interval if PCA was still <math><mo>≤</mo></math>37 weeks. IOP measurements were stopped at 37 weeks or if the infant was discharged. The evaluated outcomes were mean IOP values and their correlation with PCA.</p><p><strong>Results: </strong>Thirty-four eyes of 17 preterm infants with a mean gestational age of 29.4 <math><mo>±</mo></math> 2.3 weeks and a mean birth weight of 1222.9 <math><mo>±</mo></math> 361.9 gr were evaluated. The mean IOP registered was 16.1 <math><mo>±</mo></math> 6.4 mmHg, with a median value of 15.3 mmHg. The top 90<math><msup><mrow></mrow><mrow><mi>t</mi><mi>h</mi></mrow></msup></math> percentile was 22.1 mmHg and the bottom 10<math><msup><mrow></mrow><mrow><mi>t</mi><mi>h</mi></mrow></msup></math> percentile was 9.0 mmHg. The average IOP reduction was 4.8 <math><mo>±</mo></math> 6.7 mmHg (<i>P</i> = 0.0019) within the two-week interval of PCA.</p><p><strong>Conclusion: </strong>The mean IOP in premature infants was 16.1 <math><mo>±</mo></math> 6.4 mmHg and this value significantly decreased by 4.8 <math><mo>±</mo></math> 6.7 mmHg every two weeks of PCA.</p>","PeriodicalId":16586,"journal":{"name":"Journal of Ophthalmic & Vision Research","volume":"18 3","pages":"267-271"},"PeriodicalIF":2.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10432930/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10046630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}