Journal of Ophthalmic & Vision Research最新文献

{"title":"Individual and Combined Effects of Diabetes and Glaucoma on Total Macular Thickness and Ganglion Cell Complex Thickness: A Cross-sectional Analysis.","authors":"Dhruven Shah, Rita Dhamankar, Vijay Shetty, Suhas S Haldipurkar, Prakash Chipade, Shabnam Tanwar, Prachi Sankhe, Devendra Venkatramani, Paresh Mhatre, Maninder Singh Setia","doi":"10.18502/jovr.v17i4.12303","DOIUrl":"10.18502/jovr.v17i4.12303","url":null,"abstract":"<p><strong>Purpose: </strong>Presence of diabetes in glaucoma patients may influence findings while documenting the progression of glaucoma. We conducted the study to compare individual and combined effects of diabetes and glaucoma on macular thickness and ganglion cell complex thickness.</p><p><strong>Methods: </strong>The present study is a cross-sectional analysis of 172 eyes of 114 individuals. The groups were categorized according to the following conditions: glaucoma, diabetes mellitus, both glaucoma and diabetes (`both' group), and none of these conditions (`none' group). Patients with diabetes did not have diabetic retinopathy (DR). We compared retinal nerve fiber layer (RNFL) thickness, ganglion cell complex (GCC) thickness, foveal loss of volume (FLV), and global loss of volume (GLV) among the groups. We used random effects multivariate analysis to adjust for potential confounders.</p><p><strong>Results: </strong>The mean (SD) age of these individuals was 60.7 (10.1) years. The total average RNFL and GCC were significantly lower in the glaucoma group (RNFL: -36.27, 95% confidence intervals [CI]: -42.79 to -29.74; P <math><mo><</mo></math> 0.05, and GCC: -26.24, 95% CI: -31.49 to -20.98; P <math><mo><</mo></math> 0.05) and the `both' group (RNFL: -24.74, 95% CI: -32.84 to -16.63; P <math><mo><</mo></math> 0.05, and GCC: -17.92, 95% CI: -24.58 to -11.26; P <math><mo><</mo></math> 0.05) as compared with the `none' group. There were no significant differences in the average RNFL values and total average GCC between the diabetes group and the `none' group. The values of FLV and GLV were significantly higher in the `glaucoma' group and the `both' group as compared with the `none' group. The foveal values were not significantly different across these four groups. Among the glaucoma cases, 25% were mild, 30% were moderate, and 45% were severe; there was no significant difference in the proportion of severity of glaucoma between the `glaucoma only' and `both' groups (p=0.32). After adjusting for severity and type of glaucoma, there were no statistically significant differences in the values of average RNFL (6.6, 95% CI: -1.9 to 15.2; P=0.13), total average GCC (3.6, -95% CI: -2.4 to 9.6; P=0.24), and GLV (-3.9, 95% CI: -9.5 to 1.6; P=0.16) in the `both group' as compared with the glaucoma only group.</p><p><strong>Conclusion: </strong>We found that diabetes with no DR did not significantly affect the retinal parameters in patients with glaucoma. Thus, it is less likely that thickness of these parameters will be overestimated in patients with glaucoma who have concurrent diabetes without retinopathy.</p>","PeriodicalId":16586,"journal":{"name":"Journal of Ophthalmic & Vision Research","volume":"17 4","pages":"505-514"},"PeriodicalIF":1.6,"publicationDate":"2022-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9806304/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10509232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retinal Pigment Epithelium Transplantation: Past, Present, and Future.","authors":"Ayyad Zartasht Khan,&nbsp;Tor Paaske Utheim,&nbsp;Jon Roger Eidet","doi":"10.18502/jovr.v17i4.12325","DOIUrl":"10.18502/jovr.v17i4.12325","url":null,"abstract":"<p><p>Retinal pigment epithelium (RPE) is a monolayer of cells situated between photoreceptors and the underlying choroid. It is essential for normal retinal function. Damaged RPE is associated with diseases such as age-related macular degeneration, Stargardt's macular dystrophy, and retinitis pigmentosa. RPE cells can easily be visualized <i>in vivo</i>, sustainable <i>in vitro</i>, and differentiated from stem cells with a relatively straightforward protocol. Due to these properties and the clinical significance of this epithelium in various retinal diseases, RPE transplantation as a treatment modality has gained considerable interest in the last decade. This paper presents the main techniques for RPE transplantation and discusses recent clinically relevant publications.</p>","PeriodicalId":16586,"journal":{"name":"Journal of Ophthalmic & Vision Research","volume":"17 4","pages":"574-580"},"PeriodicalIF":2.0,"publicationDate":"2022-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9806312/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10565536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ocular Manifestations in Patients with Sensorineural Hearing Loss.","authors":"Haniah A Zaheer, Deepika C Parameswarappa, Myra A Zaheer, Jay Chhablani, Preeti Patil-Chhablani","doi":"10.18502/jovr.v17i4.12321","DOIUrl":"10.18502/jovr.v17i4.12321","url":null,"abstract":"<p><p>Identification of ocular manifestations in patients with sensorineural hearing loss (SNHL) can have a large impact on the outcome and treatment of pediatric patients. Due to the common co-incidence of ocular manifestations and SNHL in children, both ophthalmologic and hearing loss screening and routine examinations must be conducted to minimize adverse outcomes and worsening of pathology. Early evaluation and diagnosis is imperative for intervention and further development of the patient. Co-incidence requires a thorough evaluation that includes a comprehensive history, examination, and diagnostic testing. In this article, a literature review was conducted to analyze the presentations of various diseases and syndromes, such as Alport Syndrome, Waardenburg Syndrome, Norrie Disease, Usher Disease, Stickler Syndrome, Marfan Syndrome, Congenital Rubella, and Hereditary Optic Neuropathies. We divided the various ocular pathologies into anterior and posterior segment presentations and associated systemic findings for better understanding. Additionally, this review aims to include an update on the management of patients with both ocular and hearing loss manifestations.</p>","PeriodicalId":16586,"journal":{"name":"Journal of Ophthalmic & Vision Research","volume":"17 4","pages":"551-573"},"PeriodicalIF":1.6,"publicationDate":"2022-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9806326/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10514376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abnormal Visual Function: An Under-recognized Risk Factor of Road Traffic Injuries.","authors":"Hassan Hashemi,&nbsp;Payam Nabovati,&nbsp;Abbasali Yekta,&nbsp;Ali Borojerdi,&nbsp;Hamidreza Fallahkohan,&nbsp;Farhad Rezvan,&nbsp;Mehdi Khabazkhoob","doi":"10.18502/jovr.v17i4.12306","DOIUrl":"https://doi.org/10.18502/jovr.v17i4.12306","url":null,"abstract":"<p><strong>Purpose: </strong>To determine the relationship between road accidents with visual acuity, refractive errors, visual field, and contrast sensitivity.</p><p><strong>Methods: </strong>This population-based case-control study was conducted on roads leading to Tehran Province, Iran. The case group comprised drivers who had met with accidents and were at fault for the accident. The cases were selected in an ongoing manner (incidence cases). The controls were drivers who were the opposing victims in the same. After an initial interview, optometric and ophthalmic examinations including the measurement of visual acuity, refraction, visual field assessment, contrast sensitivity measurement, and slit lamp biomicroscopy were performed for all study participants.</p><p><strong>Results: </strong>In this study, 281 and 204 individuals were selected for the case and control groups. The mean uncorrected visual acuity was 0.05 <math><mo>±</mo></math> 0.12 and 0.037 <math><mo>±</mo></math> 0.10 logMAR in the case and control groups, respectively (<i>P</i> = 0.095). Of the participants in the case and control groups, 32.8% and 23% had a visual field defect in at least one eye, respectively (adjusted odds ratios [aOR] = 1.63, 95% confidence interval [CI]: 1.08-2.48; <i>P</i> = 0.021). Moreover, 16.2% of the cases and 8.3% of the controls had visual field defects in both eyes (aOR = 2.13, 95% CI: 1.17-3.86; <i>P</i> = 0.012). Contrast sensitivity was worse in the case group in all spatial frequencies under non-glare conditions. However, under glare conditions, the contrast sensitivity was significantly worse in the case group only in the spatial frequency of 12 cycles per degree (cpd).</p><p><strong>Conclusion: </strong>Reduced contrast sensitivity, especially under non-glare conditions, and visual field defects are risk factors that influence the prevalence of road accidents. It is strongly advised that special attention be paid to these visual functions in legal assessments to apply the necessary interventions in individuals with these types of disorders.</p>","PeriodicalId":16586,"journal":{"name":"Journal of Ophthalmic & Vision Research","volume":"17 4","pages":"529-535"},"PeriodicalIF":2.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9806314/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10509238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Torpedo Retinopathy or Chorioretinopathy?","authors":"Mahmoud Dehghan,&nbsp;Ramin Nourinia,&nbsp;Sahba Fekri,&nbsp;Seyed-Hossein Abtahi","doi":"10.18502/jovr.v17i4.12345","DOIUrl":"https://doi.org/10.18502/jovr.v17i4.12345","url":null,"abstract":"This is a Letter to the Editor and does not have an abstract. Please download the PDF or view the article HTML.","PeriodicalId":16586,"journal":{"name":"Journal of Ophthalmic & Vision Research","volume":"17 4","pages":"605-606"},"PeriodicalIF":2.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9806320/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10509240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Influence of Near Vision Tasks on Intraocular Pressure in Normal Subjects and Glaucoma Patients.","authors":"Mohammad Pakravan,&nbsp;Azadeh Samaeili,&nbsp;Hamed Esfandiari,&nbsp;Kiana Hassanpour,&nbsp;Sadid Hooshmandi,&nbsp;Shahin Yazdani,&nbsp;Farideh Sharifipour,&nbsp;Azadeh Doozandeh,&nbsp;Bahram Einollahi,&nbsp;Parastou Pakravan,&nbsp;Mohammad Hasan Shahriari,&nbsp;Bahareh Kheiri","doi":"10.18502/jovr.v17i4.12350","DOIUrl":"https://doi.org/10.18502/jovr.v17i4.12350","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the effect of static accommodative tasks on intraocular pressure (IOP) of glaucomatous and normal eyes.</p><p><strong>Methods: </strong>Four groups of subjects categorized as primary open-angle glaucoma (POAG), primary angle-closure suspects (PACS), normal age-matched controls, and normal young adults (NYA; age <math><mo><</mo></math> 40 years) were enrolled. The baseline IOPs were measured after the subjects were looking at a distant target for 15 min. Static accommodation was obtained by execution of near vision tasks (reading at 33 cm in daylight [300 lux] for 60 min). IOPs were measured at 15, 30, 45, and 60 min intervals while accommodating and then measured again after 15 min of relaxing accommodation while looking at a distant target.</p><p><strong>Results: </strong>One-hundred and eighteen eyes of 98 subjects were recruited. The study groups consisted of the following categories: 25 POAG (46 eyes), 24 PACS (47 eyes), 25 matched controls (50 eyes), and 24 NYA (48 eyes). Within all groups, the mean IOP decreased throughout the accommodation period at all time points. Maximum IOP reduction after accommodation was detected at the 30-min time among the POAG subjects, at the 45-min time in the PACS and matched control groups, and at 15 min after the relaxation of accommodation in the NYA group. IOP reduction levels showed no statistically significant difference among POAG, PACS, and the normal matched groups in their response to accommodation. However, NYA had significantly lower IOP and greater IOP reduction after the resting period (relaxation of accommodation).</p><p><strong>Conclusion: </strong>Static accommodative tasks can significantly reduce IOP in normal, POAG, and PACS individuals. Encouraging glaucoma patients to practice periodical near vision tasks could be viewed as an adjunctive measure for glaucoma management.</p>","PeriodicalId":16586,"journal":{"name":"Journal of Ophthalmic & Vision Research","volume":"17 4","pages":"497-504"},"PeriodicalIF":2.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9806325/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10514373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multicolor Imaging Highlights Xerophthalmic Fundus.","authors":"Fatemeh Abdi,&nbsp;Amin Zand,&nbsp;Arzhang Gordiz,&nbsp;Tahmineh Motevasseli","doi":"10.18502/jovr.v17i4.12341","DOIUrl":"https://doi.org/10.18502/jovr.v17i4.12341","url":null,"abstract":"This is a Photo Essay and does not have an abstract. Please download the PDF or view the article HTML.","PeriodicalId":16586,"journal":{"name":"Journal of Ophthalmic & Vision Research","volume":"17 4","pages":"592-595"},"PeriodicalIF":2.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9806306/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10565543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unvalidated Cerebrospinal Fluid Pressure Equations Should not Be Used for Research.","authors":"David Fleischman,&nbsp;Hanspeter E Killer","doi":"10.18502/jovr.v17i4.12343","DOIUrl":"https://doi.org/10.18502/jovr.v17i4.12343","url":null,"abstract":"This is a Letter to the Editor and does not have an abstract. Please download the PDF or view the article HTML.","PeriodicalId":16586,"journal":{"name":"Journal of Ophthalmic & Vision Research","volume":"17 4","pages":"601-602"},"PeriodicalIF":2.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9806303/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10509235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ciliary Body Schwannoma: A Case Report and Literature Review.","authors":"Haythem El Mokh,&nbsp;Néjib Ben Yahia,&nbsp;Mustapha Bouziri,&nbsp;Walid Gattoufi,&nbsp;Abdelmajid Khabir","doi":"10.18502/jovr.v17i4.12339","DOIUrl":"https://doi.org/10.18502/jovr.v17i4.12339","url":null,"abstract":"<p><strong>Purpose: </strong>To present a case of intraocular schwannoma arising from the ciliary body with description of histological and immunophenotypic characteristics.</p><p><strong>Case report: </strong>A 32-year-old woman who was followed for glaucoma of the left eye and chronic renal failure at the stage of hemodialysis presented with buphthalmos and two weeks of blurry vision of the left eye. A magnetic resonance imaging exam was performed suspecting melanoma. Enucleation was rapidly performed. The histological examination after HE (Hematoxylin and Eiosin) and HEA50 (Hematoxylin and polychromatic solution EA 50) staining showed proliferation of mesenchymal monomorphic fusiform cells with eosinophilic cytoplasm and small oval nuclei which showed a tendency toward palisading. Some parts of the tumor were hypercellular with a fascicular arrangement (Antoni A pattern); other parts were weakly cellular with a myxoid arrangement (Antoni B pattern). Several Verocay bodies and a lot of hemorrhagic suffusions were described. Mitotic figures were very rare. Immunohistochemistry staining showed that tumor cells were positive for PS100 and vimentin.</p><p><strong>Conclusion: </strong>Although ciliary body schwannoma is extremely rare, it should be considered in the differential diagnosis of intraocular tumors.</p>","PeriodicalId":16586,"journal":{"name":"Journal of Ophthalmic & Vision Research","volume":"17 4","pages":"581-586"},"PeriodicalIF":2.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9806316/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10509236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of Donor Thickness on Visual Acuity in Descemet's Stripping Automated Endothelial Keratoplasty.","authors":"Tomislav Kuzman,&nbsp;Ana Meter,&nbsp;Miro Kalauz,&nbsp;Sanja Masnec,&nbsp;Ivan Škegro,&nbsp;Ivana Jonjić","doi":"10.18502/jovr.v17i4.12296","DOIUrl":"https://doi.org/10.18502/jovr.v17i4.12296","url":null,"abstract":"<p><strong>Purpose: </strong>Conventional Descemet's Stripping Automated Endothelial Keratoplasty (DSAEK) is a corneal transplantation procedure where the patient's inner dysfunctional layer is replaced with donor lamella. The data currently present in the literature about the correlation between lamellar thickness and visual acuity is sometimes contradictory and lacks clarity.</p><p><strong>Methods: </strong>Study included 55 eyes that underwent the conventional DSAEK procedure. Patients had no other comorbidities that could affect visual acuity. Data about lamellar thickness and visual acuity were measured six months after surgery with anterior segment optical coherent tomography (A5-OCT).</p><p><strong>Results: </strong>The results show that visual acuity before surgery improved from 0.82 to 0.25 logMAR after surgery. Better visual acuity of 0.20 logMAR was achieved with postoperative lamellas thinner than 124 μm, while statistically significantly lower visual acuity of 0.29 logMAR was gained with postoperative lamellas thicker than 124 μm.</p><p><strong>Conclusion: </strong>Our results suggest that the goal after conventional DSAEK is to have postoperative lamellas thinner than 124 μm in the eye, as this will result in better postoperative visual acuity. This value represents the optimal thickness for conventional DSAEK surgery that could minimize tissue loss for eye banks and surgeons may experience fewer problems during surgery, while obtaining good final visual acuity.</p>","PeriodicalId":16586,"journal":{"name":"Journal of Ophthalmic & Vision Research","volume":"17 4","pages":"462-469"},"PeriodicalIF":2.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9806308/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10565541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}