Journal of Ophthalmic & Vision Research最新文献_第9页

Star of the Diabetic Macular Show: Stellate Nonhereditary Idiopathic Foveomacular Retinoschisis (SNIFR). 糖尿病黄斑展明星：星状非遗传性特发性中央黄斑视网膜裂（SNIFR）。

IF 1.6

Journal of Ophthalmic & Vision Research Pub Date : 2025-05-05 eCollection Date: 2025-01-01 DOI: 10.18502/jovr.v20.15125

Cory A Christensen, Neha Gupta, Mark P Breazzano

引用次数: 0

Successful Use of Upadacitinib, a Selective JAK Inhibitor, in the Treatment of Two Cases of Recalcitrant Chronic Uveitis. 选择性JAK抑制剂Upadacitinib成功治疗顽固性慢性葡萄膜炎2例

IF 1.4

Journal of Ophthalmic & Vision Research Pub Date : 2025-05-05 eCollection Date: 2025-01-01 DOI: 10.18502/jovr.v20.14952

Diego Dominguez, Sawyer Vaclaw, Cynthia K McClard, Matlock A Jeffries, Jila Noori

{"title":"Successful Use of Upadacitinib, a Selective JAK Inhibitor, in the Treatment of Two Cases of Recalcitrant Chronic Uveitis.","authors":"Diego Dominguez, Sawyer Vaclaw, Cynthia K McClard, Matlock A Jeffries, Jila Noori","doi":"10.18502/jovr.v20.14952","DOIUrl":"10.18502/jovr.v20.14952","url":null,"abstract":"Purpose: Immunomodulatory agents, including conventional immunosuppressive treatment and biologics, are the mainstay of treating chronic uveitis. Janus kinase (JAK) inhibitors, one of the newest biologics, have shown successful outcomes in treating autoimmune diseases such as rheumatoid arthritis and inflammatory bowel diseases by suppressing the JAK/signal transducers and transcription (STAT) pathway. We present two cases of recalcitrant chronic uveitis with significant improvement in intraocular inflammation by using upadacitinib, a selective JAK1 inhibitor.Case reports: The first case is a 59-year-old female with HLA-B27-positive Chron's disease and chronic anterior and intermediate uveitis who experienced an improvement in visual acuity, anterior chamber and vitreous inflammation, and cystoid macular edema on upadacitinib. The second patient is a 71-year-old female with birdshot chorioretinopathy, intolerant of initially used systemic immunosuppressive agents who showed significant improvement in vitreous inflammation, retinal phlebitis, and choroiditis after treatment with upadacitinib.Conclusion: Utilizing JAK inhibitors such as upadacitinib in treating uveitis, whether in isolated forms or in the context of systemic autoimmune diseases, may require further evaluation by controlled cohort studies.","PeriodicalId":16586,"journal":{"name":"Journal of Ophthalmic & Vision Research","volume":"20 ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12258069/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144675034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A New Complementary Touch for the Temporal Inverted Internal Limiting Membrane Flap Technique. 颞部倒置内限制膜瓣技术的一种新的补充方法。

IF 1.6

Journal of Ophthalmic & Vision Research Pub Date : 2025-05-05 eCollection Date: 2025-01-01 DOI: 10.18502/jovr.v20.14516

Levent Karabas, Ecem Önder Tokuç, Sevim Ayça Seyyar, Özlem Şahin

引用次数: 0

Effect of Occupational Exposure to Low-frequency Electromagnetic Fields on Cataract Development. 职业接触低频电磁场对白内障发展的影响。

IF 1.5

Journal of Ophthalmic & Vision Research Pub Date : 2025-04-25 eCollection Date: 2025-01-01 DOI: 10.18502/jovr.v20.12281

Mohammad Hosein Validad, Monireh Mahjoob, Masoud Pishjo, Mostafa Diani, Tahereh Rakhshandadi

{"title":"Effect of Occupational Exposure to Low-frequency Electromagnetic Fields on Cataract Development.","authors":"Mohammad Hosein Validad, Monireh Mahjoob, Masoud Pishjo, Mostafa Diani, Tahereh Rakhshandadi","doi":"10.18502/jovr.v20.12281","DOIUrl":"10.18502/jovr.v20.12281","url":null,"abstract":"Purpose: Cataracts are the second leading cause of visual impairment worldwide. This study aimed to examine the impact of occupational exposure to low-frequency electromagnetic fields on cataract development.Methods: One hundred employees of Zahedan Electricity Company participated in this study. They were assigned to four groups based on their level of exposure: regular, operational, operator personnel, and non-exposure. Based on LOCS III grading, the risk of developing different types of cataracts (i.e., nuclear, posterior subcapsular, and cortical) was evaluated for all participants.Results: The frequency of cataracts was 62.2% in the exposure group (which includes three subgroups: the regular, operational, and operator personnel) and 53.8% in the non-exposure group. There was a significant difference between the study groups in terms of nuclear opacity grading (P = 0.003). The correlation between nuclear and posterior subcapsular cataract grading and work experience duration in the exposure group was statistically significant (P <math><mo><</mo></math> 0.018).Conclusion: This study's findings indicate that exposure to low-frequency electromagnetic fields such as power lines, power plants, and power distribution posts may be a risk factor for cataract development, particularly nuclear cataracts.","PeriodicalId":16586,"journal":{"name":"Journal of Ophthalmic & Vision Research","volume":"20 ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12094108/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Practice, Challenges, and the Future of Ophthalmic Genetics in Saudi Arabia. 沙特阿拉伯眼科遗传学的临床实践、挑战和未来。

IF 1.5

Journal of Ophthalmic & Vision Research Pub Date : 2025-04-02 eCollection Date: 2025-01-01 DOI: 10.18502/jovr.v20.15890

Basamat AlMoallem, Ghadah Alsuwailem, Nadeef Alqahtani, Layan Alshammari, Abeer Alkhodier

{"title":"Clinical Practice, Challenges, and the Future of Ophthalmic Genetics in Saudi Arabia.","authors":"Basamat AlMoallem, Ghadah Alsuwailem, Nadeef Alqahtani, Layan Alshammari, Abeer Alkhodier","doi":"10.18502/jovr.v20.15890","DOIUrl":"10.18502/jovr.v20.15890","url":null,"abstract":"Purpose: Ophthalmic genetics is vital for diagnosing and managing inherited eye disorders, contributing to personalized treatments.Methods: This cross-sectional study assessed 131 healthcare professionals in Saudi Arabia through an online questionnaire to evaluate clinical practices, referral patterns, and challenges in genetic ophthalmology.Results: Our study showed that 61.7% of participants reported the availability of ophthalmic genetics services in their hospitals, with an equal percentage referring patients to genetic specialists. However, significant barriers were identified, including limited budgets for genetic testing (69.6%), a lack of trained physicians (70.9%), low community awareness (50.6%), and a perceived lack of treatment options (27.8%). Additionally, concerns about patient access to genetic testing (54.3%) and genetic counseling (50.6%) were highlighted.Conclusion: This is the first study on ophthalmic genetics in Saudi Arabia, and its findings emphasize the need for policy reforms and targeted interventions. Proposed solutions include innovative financial models for genetic testing, expanded training programs for healthcare providers, and public awareness campaigns to improve access to genetic services. Addressing these challenges can enhance early diagnosis, treatment strategies, and patient outcomes in ophthalmic genetics.","PeriodicalId":16586,"journal":{"name":"Journal of Ophthalmic & Vision Research","volume":"20 ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12013457/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144025902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Presumed Tubercular Multifocal Choroiditis. 推测为结核性多灶性脉络膜炎。

IF 1.6

Journal of Ophthalmic & Vision Research Pub Date : 2024-12-31 eCollection Date: 2024-12-01 DOI: 10.18502/jovr.v19i4.11199

Masoud Soheilian, Pejvak Azadi

引用次数: 0

Pharmacological Treatment of Presbyopia Using Pilocarpine 1.25% Eye Drops. 1.25%匹罗卡品滴眼液治疗老花眼的药理作用。

IF 1.6

Journal of Ophthalmic & Vision Research Pub Date : 2024-12-31 eCollection Date: 2024-12-01 DOI: 10.18502/jovr.v19i4.14578

Seyed Abolghasem Mousavi, Zhale Rajavi, Hamideh Sabbaghi, Saeid Abdi, Nafeeseh Montazerin, Bahareh Kheiri, Azadeh Haseli-Mofrad, Kourosh Sheibani, Hemn Baghban Jaldian

{"title":"Pharmacological Treatment of Presbyopia Using Pilocarpine 1.25% Eye Drops.","authors":"Seyed Abolghasem Mousavi, Zhale Rajavi, Hamideh Sabbaghi, Saeid Abdi, Nafeeseh Montazerin, Bahareh Kheiri, Azadeh Haseli-Mofrad, Kourosh Sheibani, Hemn Baghban Jaldian","doi":"10.18502/jovr.v19i4.14578","DOIUrl":"10.18502/jovr.v19i4.14578","url":null,"abstract":"Purpose: To assess the efficiency and safety of pilocarpine eye drop 1.25% analogue (IR- Pilo) in comparison with its original brand-name drug (Vuity).Methods: In this non-randomized comparative study, 75 patients with presbyopia aged 40 to 60 years were enrolled. The right eyes of these patients received either IR-Pilo (n = 45) or Vuity (n = 30) and their contralateral eyes served as controls. Refractive errors, distance best-corrected visual acuity (BCVA), near vision, amplitude of accommodation, pupil size, and intraocular pressure (IOP) were measured before and 1 to 2 hours after instillation of the eye drop.Results: The mean refractive error was stable, except for a small myopic shift in the Vuity group. There was no significant change in distance BCVA. Near vision improved significantly in both intervention groups (P <math><mo><</mo></math> 0.001) with preference for IR-Pilo (4 vs 2.3). Furthermore, a higher amplitude of accommodation and pupil constriction occurred after instillation of both drops, with a higher effect associated with IR-Pilo. However, IOP did not change significantly post intervention.Conclusion: IR-Pilo and Vuity eye drops had comparable results; both were effective and led to stable distance vision and improved near vision. Both ophthalmic drugs were safe and none of them were associated with significant adverse effects.","PeriodicalId":16586,"journal":{"name":"Journal of Ophthalmic & Vision Research","volume":"19 4","pages":"468-475"},"PeriodicalIF":1.6,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11795009/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143364524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-term Results of Topical Insulin Treatment for Persistent Corneal Epithelial Defects. 外用胰岛素治疗持续性角膜上皮缺损的远期疗效。

IF 1.6

Journal of Ophthalmic & Vision Research Pub Date : 2024-12-31 eCollection Date: 2024-12-01 DOI: 10.18502/jovr.v19i4.13977

Júlio Almeida, Tomás R Costa, Maria Vivas, Catarina Monteiro, Fernando T Vaz, Diana Silva, Cristina Vendrell, Isabel Prieto

{"title":"Long-term Results of Topical Insulin Treatment for Persistent Corneal Epithelial Defects.","authors":"Júlio Almeida, Tomás R Costa, Maria Vivas, Catarina Monteiro, Fernando T Vaz, Diana Silva, Cristina Vendrell, Isabel Prieto","doi":"10.18502/jovr.v19i4.13977","DOIUrl":"10.18502/jovr.v19i4.13977","url":null,"abstract":"Purpose: To evaluate the effects of topical insulin in patients with persistent corneal epithelial defects that are refractory to the standard treatment.Methods: A retrospective, hospital-based, clinical study was performed on 17 eyes of 16 patients with different types of refractory persistent epithelial defects who were treated with topical insulin. The treatment was continued until the defect either was resolved or persisted after three months. Patients' demographic information, etiology, comorbidities, and clinical data were reviewed. The rate of epithelial healing was considered as the primary outcome measure.Results: Neurotrophic keratitis was the most common cause of persistent epithelial defects (58.8%), and within this category, herpetic eye disease was the main comorbidity (44.4%). The mean follow-up time was 17.91 months. Eleven out of fifteen eyes (77.3%) had complete improvement and only one patient did not respond to the treatment. The mean time of reepithelization for the eyes with full recovery was 31.27 days (ranging from 6 to 61 days). The best-corrected visual acuity improved significantly after treatment (P <math><mo><</mo></math> 0.005), and there were no reports of complications or side effects during the study period.Conclusion: Our results suggest that topical insulin, due to its good safety profile, availability, and affordability, could be a good therapeutic alternative for persistent epithelial defects.","PeriodicalId":16586,"journal":{"name":"Journal of Ophthalmic & Vision Research","volume":"19 4","pages":"397-404"},"PeriodicalIF":1.6,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11795001/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143364470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum Oxidative Stress-related Biomarkers in Ocular Hypertension and Glaucoma. 高眼压和青光眼的血清氧化应激相关生物标志物。

IF 1.6

Journal of Ophthalmic & Vision Research Pub Date : 2024-12-31 eCollection Date: 2024-12-01 DOI: 10.18502/jovr.v19i4.15011

Mine Esen Baris, Onur Furundaoturan, Meltem Kocamanoğlu, Seray Şahin, Yasemin Akçay, Suzan Güven Yılmaz

{"title":"Serum Oxidative Stress-related Biomarkers in Ocular Hypertension and Glaucoma.","authors":"Mine Esen Baris, Onur Furundaoturan, Meltem Kocamanoğlu, Seray Şahin, Yasemin Akçay, Suzan Güven Yılmaz","doi":"10.18502/jovr.v19i4.15011","DOIUrl":"10.18502/jovr.v19i4.15011","url":null,"abstract":"Purpose: To evaluate the serum levels of oxidative stress-related molecules in patients with ocular hypertension (OHT) and primary open-angle glaucoma (POAG) compared with healthy controls.Methods: Treatment-naive patients with no known systemic diseases and with OHTand POAG diagnosis were recruited for the study. Also, age- and gender-matched healthy volunteers with no ocular and systemic diseases were included as controls. None of the participants were under any topical or systemic treatment or vitamin/antioxidant supplements. Smokers were excluded from the study. Serum levels of total antioxidant capacity (TAC), ascorbic acid, protein carbonyls (PCs), advanced glycation end products (AGEs), neuronal pentraxin 2 (NPTX2), and <math><mi>β</mi></math> -amyloid precursor protein(A <math><mi>β</mi></math> ) were analyzed.Results: A total of 90 patients (30 in each group) were included in the study. There was no statistically significant difference between the study groups in terms of age and gender distribution. Serum levels of TAC (1.47 <math><mo>±</mo></math> 0.11 mmole/L) were significantly higher in patients with OHT compared to controls (1.40 <math><mo>±</mo></math> 0.11 mmole/L) and patients with POAG (1.30 <math><mo>±</mo></math> 0.08 mmole/L) (P <math><mo><</mo></math> 0.05). However, there was no significant difference between the study groups in terms of serum levels of ascorbic acid, PCs, AGEs, NPTX2, and A <math><mi>β</mi></math> .Conclusion: Serum levels of TAC were significantly higher in patients with OHT. This elevated level might contribute to the protection of the optic nerve even in the presence of increased intraocular pressure.","PeriodicalId":16586,"journal":{"name":"Journal of Ophthalmic & Vision Research","volume":"19 4","pages":"433-439"},"PeriodicalIF":1.6,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11795014/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143364940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New Sight for Old: Commentary On the Use of Pilocarpine for Presbyopia. 以旧换新：匹罗卡品治疗老花眼述评。

IF 1.4

Journal of Ophthalmic & Vision Research Pub Date : 2024-12-31 eCollection Date: 2024-12-01 DOI: 10.18502/jovr.v19i4.17786

Cameron F Parsa

引用次数: 0