Journal of Neural Transmission最新文献_第3页

Abnormal iron metabolism in the zona incerta in Parkinson's disease mice. 帕金森病小鼠不动带铁代谢异常。

IF 3.2 4区医学

Journal of Neural Transmission Pub Date : 2025-06-01 Epub Date: 2025-03-22 DOI: 10.1007/s00702-025-02913-3

Minxia Xiu, Yanhong Liu, Zhaobo Wang, Jing Zhang, Yaying Shi, Junxia Xie, Limin Shi

{"title":"Abnormal iron metabolism in the zona incerta in Parkinson's disease mice.","authors":"Minxia Xiu, Yanhong Liu, Zhaobo Wang, Jing Zhang, Yaying Shi, Junxia Xie, Limin Shi","doi":"10.1007/s00702-025-02913-3","DOIUrl":"10.1007/s00702-025-02913-3","url":null,"abstract":"Parkinson's disease (PD) is characterized by the loss of dopaminergic neurons in the substantia nigra (SN) and abnormal iron metabolism. While most of the current studies have focused on nigral iron deposition, there is still limited research into the role of iron in other brain regions. The zona incerta (ZI) is a heterogeneous subthalamic region and has extensive connections with the basal ganglia nucleus. Clinically, the ZI has been recognized as a new therapeutic target for PD. Deep brain stimulation of the ZI has been reported to relieve motor symptoms and experimental heat pain in patients with PD. The aim of the present study is to evaluate changes in iron levels in the ZI. Two neurotoxins, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 6-hydroxydopamine (6-OHDA), were used to prepare PD mice. By immunostaining, we first measured the success of MPTP or 6-OHDA injury. We found that the expressions of tyrosine hydroxylase were decreased after MPTP or 6-OHDA treatment. Secondly, we observed the changes of iron metabolism using Perls' iron staining and western blots. Our results showed that the numbers of iron-positive cells were significantly increased in the SN and ZI of MPTP/6-OHDA-treated mice. Moreover, the expression levels of ferritin and divalent metal transporter 1 (DMT1) in the ZI were also increased in the PD group. Glutathione peroxidase 4 (GPX4), a marker of ferroptosis, was also detected. Western blots revealed that MPTP significantly down-regulated the level of GPX4 in the ZI. As glial cells activation and neuroinflammation play important roles in the ion deposition, we finally investigated the microglial and astrocyte activation and inflammatory factors. These results suggested increased iron levels and inflammation may be present in the ZI in PD mice.","PeriodicalId":16579,"journal":{"name":"Journal of Neural Transmission","volume":" ","pages":"845-857"},"PeriodicalIF":3.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143677163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microstructural imaging of brain changes in schizophrenia via quantitative T1 (qT1): a preliminary comparison of two acquisition protocols. 通过定量T1 （qT1）对精神分裂症患者大脑变化的显微结构成像：两种获取方案的初步比较。

IF 3.2 4区医学

Journal of Neural Transmission Pub Date : 2025-06-01 Epub Date: 2025-04-05 DOI: 10.1007/s00702-025-02899-y

George Nader, Setare Safara, Kimberly L Desmond, Philip Gerretsen, Ariel Graff, Vincenzo De Luca

{"title":"Microstructural imaging of brain changes in schizophrenia via quantitative T1 (qT1): a preliminary comparison of two acquisition protocols.","authors":"George Nader, Setare Safara, Kimberly L Desmond, Philip Gerretsen, Ariel Graff, Vincenzo De Luca","doi":"10.1007/s00702-025-02899-y","DOIUrl":"10.1007/s00702-025-02899-y","url":null,"abstract":"Schizophrenia spectrum disorders (SSD) are a complex group of illnesses, and their pathophysiology remains unclear. Recent developments in neuroimaging techniques provided useful quantitative measures, such as quantitative T1 mapping (qT1) that is susceptible to tissue-level, microscopic changes. However, it is important to identify the most sensitive, accurate, and reliable imaging protocol, given the complex nature of SSD. We compared structural brain changes in a pilot sample of 15 SSD patients and 7 healthy controls, cross-sectionally, and using two different qT1 mapping protocols. Our findings showed a global elevation in qT1 values in SSD patients, that was statistically significant in the lateral ventricles, thalamus, caudate, and hippocampus (p < 0.01). Moreover, the two acquisition protocols were differently modulated by demographic factors, such as age, sex, and education, which further illustrates the importance of protocol selection. In conclusion, this investigation revealed microstructural tissue changes in subcortical regions in SSD patients, providing further insights into the pathophysiology of the illness.","PeriodicalId":16579,"journal":{"name":"Journal of Neural Transmission","volume":" ","pages":"887-895"},"PeriodicalIF":3.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protective effect of formononetin in chronic unpredictable stress (CUS) linked to parkinson disease. 刺芒柄花素在与帕金森病相关的慢性不可预测应激（CUS）中的保护作用。

IF 3.2 4区医学

Journal of Neural Transmission Pub Date : 2025-05-16 DOI: 10.1007/s00702-025-02939-7

Tanvi Dayanand Pingale, Girdhari Lal Gupta

{"title":"Protective effect of formononetin in chronic unpredictable stress (CUS) linked to parkinson disease.","authors":"Tanvi Dayanand Pingale, Girdhari Lal Gupta","doi":"10.1007/s00702-025-02939-7","DOIUrl":"https://doi.org/10.1007/s00702-025-02939-7","url":null,"abstract":"Formononetin [FMN] belongs to the member of class 7-hydroxyisoflavones possesses anti-oxidant and anti-inflammatory activity. However, its efficacy in chronic unpredictable stress (CUS) associated with Parkinson disease (PD) is not evaluated. In a current study the effect of FMN on CUS associated with PD was screened to examine efficacy using different behavioral, biochemical and immuno-histochemical evaluation. During the study, CUS associated with PD was induced in mice by administering rotenone followed by exposure to different mild stressors. Animals showing CUS linked to PD were included in the study and treated daily with FMN (5, 10 & 20 mg/kg) by intraperitoneal route. After the treatment, animals evaluated for behavioral, biochemical parameters and immunohistochemistry analysis. Treatment with FMN was effective in alleviating core symptoms of chronic stress linked to PD and improved cognitive function, gait abnormality and impairment in co-ordination of CUS + ROT model. FMN showed dose dependent reduction in IL- 1β, TNF- α, IL- 6 concentration. FMN increasing the levels of dopamine, norepinephrine and serotonin. Immunohistochemical study revealed that the expression of α-synuclein reduced which helps to improve CUS linked to Parkinson's. Furthermore, expression of BDNF and BCL-2 found to be improved after FMN treatment and helps in elevation of dopamine levels thereby surviving neuronal system. Study findings revealed that formononetin is effective in the treatment of chronic unpredictable stress linked to Parkinson's, however further clinical investigation is required to evaluate its effect in human.","PeriodicalId":16579,"journal":{"name":"Journal of Neural Transmission","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuroimaging in advanced Parkinson's disease: insights into pathophysiology, biomarkers, and personalized therapies. 晚期帕金森病的神经影像学：病理生理学、生物标志物和个性化治疗的见解

IF 3.2 4区医学

Journal of Neural Transmission Pub Date : 2025-05-12 DOI: 10.1007/s00702-025-02942-y

Nils Schröter, Sergiu Groppa, Michel Rijntjes, Gabriel Gonzalez-Escamilla, Horst Urbach, Wolfgang H Jost, Alexander Rau

{"title":"Neuroimaging in advanced Parkinson's disease: insights into pathophysiology, biomarkers, and personalized therapies.","authors":"Nils Schröter, Sergiu Groppa, Michel Rijntjes, Gabriel Gonzalez-Escamilla, Horst Urbach, Wolfgang H Jost, Alexander Rau","doi":"10.1007/s00702-025-02942-y","DOIUrl":"https://doi.org/10.1007/s00702-025-02942-y","url":null,"abstract":"Advanced Parkinson's disease (APD) represents a late stage of Parkinson's disease and is characterized by complex motor and non-motor symptoms that are less responsive to oral dopaminergic therapies. While APD has a relevant impact on patients' quality of life and requires intensified treatment, consistent diagnostic criteria have only recently been proposed. The precise pathophysiology underlying the symptoms of APD remains poorly understood, making early prognostication and intervention difficult. Neuroimaging has emerged as a promising tool for elucidating the mechanisms driving APD, identifying biomarkers for disease staging, and predicting therapeutic response. Techniques such as molecular imaging and magnetic resonance imaging provide insight into molecular and structural changes associated with the progression of PD, including protein aggregation, neuroinflammation, and regional neurodegeneration. While positron emission tomography imaging of alpha-synuclein and other pathologies offers avenues for staging and differential diagnosis, advanced magnetic resonance imaging approaches have the potential for capturing subtle microstructural changes i.e. through neuromelanin-sensitive or diffusion-weighted imaging. However, the majority of imaging studies has focused on early Parkinson's disease, leaving their applicability to APD uncertain. Future research should prioritize the validation of neuroimaging findings in well-defined APD cohorts and extend their use to predict clinical milestones such as motor fluctuations, dyskinesia, and cognitive decline. These efforts are essential to advance personalized therapeutic strategies and bridge the gap between research and clinical management of APD.","PeriodicalId":16579,"journal":{"name":"Journal of Neural Transmission","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143997092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mild behavioral impairment in idiopathic REM sleep behavior disorder and Lewy body disease continuum. 特发性快速眼动睡眠行为障碍与路易体病连续体的轻度行为障碍。

IF 3.2 4区医学

Journal of Neural Transmission Pub Date : 2025-05-01 Epub Date: 2025-01-09 DOI: 10.1007/s00702-024-02877-w

Bora Jin, Eun Jin Yoon, Kyung Ah Woo, Seoyeon Kim, Seungmin Lee, Ryul Kim, Jung Hwan Shin, Yu Kyeong Kim, Jee-Young Lee

{"title":"Mild behavioral impairment in idiopathic REM sleep behavior disorder and Lewy body disease continuum.","authors":"Bora Jin, Eun Jin Yoon, Kyung Ah Woo, Seoyeon Kim, Seungmin Lee, Ryul Kim, Jung Hwan Shin, Yu Kyeong Kim, Jee-Young Lee","doi":"10.1007/s00702-024-02877-w","DOIUrl":"10.1007/s00702-024-02877-w","url":null,"abstract":"To investigate the clinical impact of mild behavioral impairment (MBI) in a predefined cohort with Lewy body disease (LBD) continuum. Eighty-four patients in the LBD continuum participated in this study, including 35 patients with video-polysomnography-confirmed idiopathic REM sleep behavior disorder (iRBD) and 49 clinically established LBD. Evaluations included the Movement Disorder Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS), neuropsychological tests, and MBI Checklist (MBI-C). We examined the clinical associates of MBI-C and its diagnostic values in predicting disease severity and cognitive impairment across the LBD continuum. Participants were classified into 19 cognitively normal (CN), 45 mild cognitive impairment (MCI), and 20 dementia groups. Median MBI-C total scores were 1.0, 8.0, and 18.5 for CN, MCI, and dementia groups, respectively, with a significant increasing trend (p < 0.001). The MBI-C total score demonstrated significant correlations with the MDS-UPDRS part 1 (r = 0.504, p < 0.001) and total scores (r = 0.508, p < 0.001). Furthermore, significant correlations were observed between MBI-C and cognitive performances in frontal/executive (DSC: r = -0.314, p = 0.006; TMT-B: r = -0.338, p = 0.003) and attentional (TMT-A: r = -0.343, p = 0.002) domains. A cutoff 5.0 effectively differentiated the MCI from CN groups (area under the curve (AUC = 0.74). Furthermore, the MBI-C effectively discriminated the iRBD patients with high phenoconversion risk against those with low-risk (cut-off 4.0, AUC = 0.72). The MBI-C may be a useful screening questionnaire reflecting clinical severity across the LBD continuum. Longitudinal studies are needed to determine its value in monitoring disease progression in prodromal LBD.","PeriodicalId":16579,"journal":{"name":"Journal of Neural Transmission","volume":" ","pages":"637-644"},"PeriodicalIF":3.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12043749/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142950331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Severity of anhedonia is associated with hyper-synchronization of the salience-default mode network in non-clinical individuals: a resting state EEG connectivity study. 在非临床个体中，快感缺乏的严重程度与显著性默认模式网络的高度同步有关：一项静息状态脑电图连通性研究。

IF 3.2 4区医学

Journal of Neural Transmission Pub Date : 2025-05-01 Epub Date: 2025-02-15 DOI: 10.1007/s00702-025-02894-3

Claudio Imperatori, Giorgia Allegrini, Aurelia Lo Presti, Giuseppe A Carbone, Mauro Adenzato, Benedetto Farina, Rita B Ardito

{"title":"Severity of anhedonia is associated with hyper-synchronization of the salience-default mode network in non-clinical individuals: a resting state EEG connectivity study.","authors":"Claudio Imperatori, Giorgia Allegrini, Aurelia Lo Presti, Giuseppe A Carbone, Mauro Adenzato, Benedetto Farina, Rita B Ardito","doi":"10.1007/s00702-025-02894-3","DOIUrl":"10.1007/s00702-025-02894-3","url":null,"abstract":"Anhedonia is a core transnosographic symptom in several neuropsychiatric disorders. Recently, the Triple Network (TN) model has been proposed as a useful neurophysiological paradigm for conceptualizing anhedonia, providing new insights to clinicians and researchers. Despite this, the relationship between the functional dynamics of TN and the severity of anhedonia has been relatively understudied in non-clinical samples, especially in the resting state (RS) condition. Therefore, in the current study, we investigated this relationship using electroencephalography (EEG) functional connectivity. Eighty-two participants (36 males; mean age: 24.28 ± 7.35 years) underwent RS EEG recording with eyes-closed and completed the Beck Depression Inventory-derived 4-item anhedonia scale (BDI-Anh4) and the Brief Symptoms Inventory (BSI). EEG data on functional connectivity were analyzed using the exact low-resolution electromagnetic tomography (eLORETA). A significant positive correlation was observed between the BDI-Anh4 total score and salience-default mode network connectivity in the beta frequency band (r = 0.409; p = 0.010). The results of the hierarchical linear regression analysis also showed that this connectivity pattern was positively and independently associated (β = 0.358; p < 0.001) with the BDI-Anh4 total score and explained an additional 11% of the anhedonia variability. The association between anhedonia severity and increased salience-default mode network synchronization detected in the current study may reflect difficulty disengaging from internal/self-related mental contents, which consequently impairs the processing of other stimuli, including rewarding stimuli.","PeriodicalId":16579,"journal":{"name":"Journal of Neural Transmission","volume":" ","pages":"731-741"},"PeriodicalIF":3.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12043527/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Compound heterozygous TMEM67 biallelic variants including a novel frameshift mutation in two Filipino adolescent siblings with Joubert syndrome. 复合杂合TMEM67双等位基因变异包括一个新的移码突变在两个菲律宾青少年兄弟姐妹Joubert综合征。

IF 3.2 4区医学

Journal of Neural Transmission Pub Date : 2025-05-01 Epub Date: 2025-01-23 DOI: 10.1007/s00702-025-02885-4

Khloe L Kruzette Solijon, Roi O Engkong, Barbra Charina V Cavan, Leslee Y Ong, Yi-Hsuan Chen, Han-I Lin, Chin-Hsien Lin, Gerard Saranza

{"title":"Compound heterozygous TMEM67 biallelic variants including a novel frameshift mutation in two Filipino adolescent siblings with Joubert syndrome.","authors":"Khloe L Kruzette Solijon, Roi O Engkong, Barbra Charina V Cavan, Leslee Y Ong, Yi-Hsuan Chen, Han-I Lin, Chin-Hsien Lin, Gerard Saranza","doi":"10.1007/s00702-025-02885-4","DOIUrl":"10.1007/s00702-025-02885-4","url":null,"abstract":"Joubert Syndrome (JS) is a congenital cerebellar ataxia typically inherited in an autosomal recessive pattern, although rare X-linked inheritance can occur. It is characterized by hypotonia evolving into ataxia, global developmental delay, oculomotor apraxia, breathing dysregulation, and multiorgan involvement. To date, there are 40 causative genes implicated in JS, all of which encode proteins of the primary cilium. Primary cilia play a crucial role in the normal development and function of many organs, including parts of the brain (cerebellum and brainstem), kidneys, and the retina. This likely explains the multiorgan involvement seen in JS. In this report, we present the first genetically confirmed case of JS in two Filipino adolescent siblings who had early onset ataxia, hepatomegaly, and global developmental delay. A cranial CT scan revealed the Molar Tooth Sign (MTS). Whole Exome Sequencing (WES), performed via buccal swab, showed biallelic pathogenic variants at NM_153704.6:c.2086 C > T (NP_714915.3:p.Leu696Phe) and NM_153704.6:c.431del (NP_714915.3:p.Leu144CysfsTer19) in TMEM67, which are associated with Joubert Syndrome 6 (OMIM:610688) in a compound heterozygous state. The prevalence of NM_153704.6:c.2086 C > T (NP_714915.3:p.Leu696Phe) in TMEM67 variant is very rare (< 0.001%), and the NM_153704.6:c.431del (NP_714915.3:p.Leu144CysfsTer19) has not been recorded. This case contributes valuable information to the expanding knowledge of JS and its related disorders.","PeriodicalId":16579,"journal":{"name":"Journal of Neural Transmission","volume":" ","pages":"655-661"},"PeriodicalIF":3.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TMEM119-positive microglial cells in cerebrospinal fluid, a potential new marker for neuroinflammatory response after aneurysmal subarachnoid hemorrhage. 脑脊液中 TMEM119 阳性的小胶质细胞--动脉瘤性蛛网膜下腔出血后神经炎症反应的潜在新标记。

IF 3.2 4区医学

Journal of Neural Transmission Pub Date : 2025-05-01 Epub Date: 2025-02-04 DOI: 10.1007/s00702-025-02886-3

Andrea Cattaneo, Julia Messinger, Kevin Lamllari, Helmut Heinsen, Michael K Schuhmann, Christoph Wipplinger, Vera Nickl, Mario Löhr, Ekkehard Kunze, Christian Stetter, Thomas Linsenmann, Michael Bohnert, Ralf-Ingo Ernestus, Johann Zwirner, Benjamin Ondruschka, Camelia-Maria Monoranu, Simone Bohnert

{"title":"TMEM119-positive microglial cells in cerebrospinal fluid, a potential new marker for neuroinflammatory response after aneurysmal subarachnoid hemorrhage.","authors":"Andrea Cattaneo, Julia Messinger, Kevin Lamllari, Helmut Heinsen, Michael K Schuhmann, Christoph Wipplinger, Vera Nickl, Mario Löhr, Ekkehard Kunze, Christian Stetter, Thomas Linsenmann, Michael Bohnert, Ralf-Ingo Ernestus, Johann Zwirner, Benjamin Ondruschka, Camelia-Maria Monoranu, Simone Bohnert","doi":"10.1007/s00702-025-02886-3","DOIUrl":"10.1007/s00702-025-02886-3","url":null,"abstract":"Aneurysmal subarachnoid hemorrhage (aSAH) is a debilitating condition with significant morbidity and mortality rates. Despite advancements in treatment, understanding the underlying pathophysiology, particularly the inflammatory response, remains crucial for improving patient outcomes. In this study, we investigated the presence of transmembrane protein 119 (TMEM119) of microglial cells in cerebrospinal fluid (CSF) as a potential marker for neuroinflammation following aSAH. CSF samples were collected from aSAH patients, pathological and healthy controls, processed, and analyzed using immunocytochemistry. TMEM119-positive microglial cells were consistently identified in the CSF of aSAH patients, exhibiting amoeboid morphology and intense staining. Importantly, microglial cells were detected as early as the first day post-bleeding, persisting throughout the acute phase in some cases. Analysis of consecutive samples revealed varying trends in microglial cell numbers, with a peak during the initial phase followed by a gradual decline. Our findings suggest that microglia may migrate into the CSF following aSAH, potentially serving as an early predictor of inflammatory-related CNS damage. This study underscores the importance of understanding neuroinflammatory processes in aSAH and opens avenues for further research on the role of microglia in CNS disorders by liquid biopsy.","PeriodicalId":16579,"journal":{"name":"Journal of Neural Transmission","volume":" ","pages":"689-698"},"PeriodicalIF":3.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12043730/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143189445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Action impulsivity and attention deficits in patients at an early stage of Huntington disease. 亨廷顿病早期患者的行动冲动和注意力缺陷。

IF 3.2 4区医学

Journal of Neural Transmission Pub Date : 2025-05-01 Epub Date: 2025-03-03 DOI: 10.1007/s00702-025-02888-1

Sacha Brohée, Stephan Grimaldi, Laure Spieser, Nathalie Baril, Thierry Hasbroucq, Frédérique Fluchere, Jean-Philippe Azulay, Franck Vidal, Marianne Vaugoyeau

{"title":"Action impulsivity and attention deficits in patients at an early stage of Huntington disease.","authors":"Sacha Brohée, Stephan Grimaldi, Laure Spieser, Nathalie Baril, Thierry Hasbroucq, Frédérique Fluchere, Jean-Philippe Azulay, Franck Vidal, Marianne Vaugoyeau","doi":"10.1007/s00702-025-02888-1","DOIUrl":"10.1007/s00702-025-02888-1","url":null,"abstract":"Huntington's disease (HD) is characterized by a combination of motor, cognitive, and neuropsychiatric impairments. Among them, impulsivity and attention deficits are clinical features usually described in HD, impacting the quality of life of patients and their caregivers. Twenty early-stage HD patients (PHD) and 20 age and gender-matched control participants (CP) performed a \"Simon\" reaction time (RT) task allowing us to explore action impulsivity and attention deficits. Surface EMG recordings aimed at revealing the presence and characterizing the nature of impulsivity in PHD. Correlational analyses between error rates or chronometric data, and clinical or neuropsychological data were examined. (1) Analysis of the accuracy and EMG patterns revealed no difference between PHD and CP, indicating absence of motor impulsivity at the early stage of HD. (2) Chronometric indices revealed a general slowing of information processing in PHD, involving central information processing but sparing the latest stages of motor execution, consistent with performed correlational analysis. (3) Sequential analysis of RT patterns showed a failure to allocate attention appropriately. These indices of attentional deficits nicely correlated with performance in neuropsychological tests exploring attentional processes. (1) Central information processing slows down at the early stage of HD but the latest steps of motor execution are unaffected. (2) In the progression of HD, attentional deficits typically should appear first among dysexecutive problems, without significant action impulsivity.","PeriodicalId":16579,"journal":{"name":"Journal of Neural Transmission","volume":" ","pages":"645-654"},"PeriodicalIF":3.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of diabetes mellitus type two on incidence and progression of Parkinson's disease: a systematic review of longitudinal patient cohorts. 2型糖尿病对帕金森病发病率和进展的影响：一项纵向患者队列的系统回顾

IF 4 4区医学

Journal of Neural Transmission Pub Date : 2025-05-01 Epub Date: 2025-01-23 DOI: 10.1007/s00702-025-02882-7

Olga Stockmann, Lan Ye, Stephan Greten, David Chemodanow, Florian Wegner, Martin Klietz

{"title":"Impact of diabetes mellitus type two on incidence and progression of Parkinson's disease: a systematic review of longitudinal patient cohorts.","authors":"Olga Stockmann, Lan Ye, Stephan Greten, David Chemodanow, Florian Wegner, Martin Klietz","doi":"10.1007/s00702-025-02882-7","DOIUrl":"10.1007/s00702-025-02882-7","url":null,"abstract":"Parkinson's disease (PD) is a chronic neurodegenerative disease of the elderly. Patients suffer from progressive motor and non-motor symptoms. Further, PD patients often present geriatric features like multimorbidity and polypharmacotherapy. A frequent comorbidity of PD patients is diabetes mellitus type two (T2DM). In the last decade growing evidence emerged on the impact of T2DM on PD. Of the present review was to analyze the impact of T2DM on PD incidence and progression in patient cohorts. A systematic review of the literature was performed via PubMed and Google Scholar. Studies on longitudinal PD patient cohorts with at least 10 patients per group were included. The diabetic state of the patient had to be determined. In total, 15 studies were analyzed for this review. According to most of the included studies T2DM increases the risk of developing PD significantly. Disease progression is augmented by T2DM both for motor and cognitive impairments. Some studies also point out a correlation of motor worsening and diabetic status measured by the serum HbA1c level. In relation to biomarkers, PD patients with diabetes have higher neurofilament light chain and Tau level but lower Amyloid beta level. T2DM seems to be a risk factor for the development and progression of PD. PD patients should be screened for T2DM and treatment should be initiated promptly. There is still a lack of knowledge about the molecular mechanisms leading to interactions of these diseases.","PeriodicalId":16579,"journal":{"name":"Journal of Neural Transmission","volume":" ","pages":"627-635"},"PeriodicalIF":4.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12043777/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143023709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0