Journal of Neural Transmission最新文献

{"title":"Sitagliptin attenuates L-dopa-induced dyskinesia by regulating mitochondrial proteins and neuronal activity in a 6-OHDA-induced mouse model of Parkinson's disease.","authors":"Hye-Yeon Park, Young-Kyoung Ryu, Ga Seul Lee, Jun Go, Ju-Eun Kim, Kyeong-Seon Min, Chul-Ho Lee, Jeong Hee Moon, Kyoung-Shim Kim","doi":"10.1007/s00702-025-02907-1","DOIUrl":"https://doi.org/10.1007/s00702-025-02907-1","url":null,"abstract":"<p><p>L-dopa-induced dyskinesia (LID) is an incapacitating complication of long-term administration of L-dopa therapy that commonly affects patients with Parkinson's disease (PD) due to the widespread use of the causative drug. Herein, we investigated the therapeutic potential of sitagliptin, a drug used to treat type 2 diabetes mellitus, to treat LID. 6-hydroxydopamine (6-OHDA) was unilaterally injected into the left side of the substantia nigra pas compacta to induce a mouse model of PD. After four weeks of 6-OHDA induction, L-dopa was administered with or without sitagliptin for 11 consecutive days. LID was monitored using abnormal involuntary movement (AIM) scoring, conducted on days 5 and 10 of L-dopa treatment. Comparative proteomic analysis was performed on the 6-OHDA-lesioned striatum by comparing groups treated with vehicle + L-dopa and sitagliptin + L-dopa. Sitagliptin combined with L-dopa significantly attenuated AIM scores in 6-OHDA-lesioned mice. Proteomic analysis following sitagliptin treatment showed an increase in proteins involved in mitochondrial function regulation and a decrease in proteins associated with cytoskeleton function regulation. Changes in the expression of Ndufb2, a subunit of NADH: ubiquinone oxidoreductase (complex I), and Arc, an immediate early gene (IEG), which showed the most significant increase and decrease, respectively, were validated using western blotting and RT-PCR analysis. These findings suggest that sitagliptin may have therapeutic potential by enhancing mitochondrial functions and suppressing neuronal activity in the striatum, thereby mitigating the incapacitating complications associated with long-term L-dopa use in patients with PD.</p>","PeriodicalId":16579,"journal":{"name":"Journal of Neural Transmission","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143649263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antinociceptive properties of intravesical/needle-free administration of abobotulinumtoxinA in a rodent model of chronic visceral pain: in vivo and histological evidence.","authors":"Céline Augé, Mathieu Vogt, Vincent Martin, Stéphane Lezmi, Xavier Gamé, Philippe Lluel, Jacquie Maignel","doi":"10.1007/s00702-025-02906-2","DOIUrl":"https://doi.org/10.1007/s00702-025-02906-2","url":null,"abstract":"<p><p>While interstitial cystitis along with bladder pain syndrome (IC/BPS) is still poorly treated, published clinical evidence suggests that onabotulinumtoxinA (natural botulinum neurotoxin type A (BoNT/A)) intradetrusor injections is efficient in IC/BPS. However, as bladder instillation could be a safer and more convenient administration route, we aimed to investigate the effect of BoNT/A needle-free administration in an IC/BPS rodent model. Cyclophosphamide (CYP) was used to induce IC/BPS in rats. The resulting symptoms mimicked the main key features of human non-ulcerative IC/BPS. AbobotulinumtoxinA (aboBoNT-A) or reference compounds used in the clinic were delivered as a single intravesical administration into the bladder via the urethra. Visceral allodynia and hyperalgesia were assessed at the abdominal level with von Frey filaments before and after bladder pain induction. The levels of BoNT/A-cleaved SNAP25 (c-SNAP25), total SNAP25 (SNAP25^N-ter), beta-3 tubulin and CGRP in bladders were also quantified using immunohistochemistry (IHC), as well as the histopathological lesions. AboBoNT-A was well tolerated up to 30 U/rat. Allodynia and hyperalgesia were significantly decreased after aboBoNT-A dosing, with higher efficacy compared to references. c-SNAP25 IHC levels were low and similar in the detrusor for the 3 aboBoNT-A groups. Neither CYP or aboBoNT-A induced any change in the amount of SNAP25, beta-3 tubulin or CGRP. Some CYP-induced histopathological lesions showed a trend in improvement under aboBoNT-A. AboBoNT-A displayed analgesic properties that could translate into better therapies for visceral pain. Interestingly, intravesical (needle-free) administration seems like a promising and reproducible route for botulinum toxin therapy in patients with IC/BPS.</p>","PeriodicalId":16579,"journal":{"name":"Journal of Neural Transmission","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-motor fluctuations in Parkinson's disease: frequency and clinical correlate.","authors":"Baig Ilyas Mirza Mujahid, Vikram V Holla, Nitish Kamble, Ravi Yadav, Pramod Kumar Pal, Rohan R Mahale","doi":"10.1007/s00702-025-02908-0","DOIUrl":"https://doi.org/10.1007/s00702-025-02908-0","url":null,"abstract":"<p><p>Non-motor symptoms (NMS) occur in 60-97% of Parkinson's disease (PD) patients. NMS show fluctuations over the course of the day referred to as non-motor fluctuations (NMF). To assess the frequency, severity, predictors and effect of the NMF on the quality of life in PD patients. This was a cross-sectional, hospital based, single-centre study. A total of 150 patients with PD were recruited. NMF was assessed using the MDS-Non-motor rating scale (MDS-NMS) and the Non-motor fluctuation assessment questionnaire (NoMoFA). The mean age at presentation and age at onset was 51.3 ± 10.8 years and 44.6 ± 11.1 years respectively and male predominance (75.3%). The mean duration of parkinsonism was 5.3 ± 3.7 years. Motor fluctuations (MF) were seen in 97 patients. A total of 143 patients (95.3%) had at least single NMS. Depression, cognition and pain was the most common NMS domain. NMF was seen in 57 patients (39.8%). NMF occurred in 50.5% in PD patients with MF. Pain was the most frequent NMS which showed NMF followed by fatigue, anxiety and depression. Pain had greater degree of change from ON to OFF period as compared to other NMS domains. NMF was associated with longer disease duration, higher levodopa dose and longer levodopa intake, greater motor severity, MF, higher NMS burden and poor quality of life. NMF is seen in association with MF. Pain, anxiety, depression and fatigue was the common NMS showing NMF. Pain had a large degree of fluctuation in the severity.</p>","PeriodicalId":16579,"journal":{"name":"Journal of Neural Transmission","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stress in lockdown: exploring the interplay and effects of cortisol and psychological distress in parent-child dyads.","authors":"Alexe Bilodeau-Houle, Félix Duplessis-Marcotte, Catherine Raymond, Rachel Primiani, Marie-France Marin","doi":"10.1007/s00702-025-02898-z","DOIUrl":"https://doi.org/10.1007/s00702-025-02898-z","url":null,"abstract":"<p><p>During the COVID-19 pandemic, some children experienced psychological distress. Moreover, pandemic-related stressors were associated with changes in hair cortisol concentrations (HCC) in youth. Research has shown that parental distress influenced children's well-being during the pandemic, but it remains unclear whether parental distress is associated with children's HCC during the pandemic. Furthermore, as some preliminary evidence suggests that children's HCC may predict their emotional response to the pandemic, it is essential to assess whether children's HCC provides insight into their susceptibility to developing symptoms associated with stress-related psychopathologies. The present study aimed to (1) examine the association between parental pandemic-related distress and children's HCC; (2) investigate the moderating role of parental distress on the association between parent and child HCC; and (3) explore the association between children's HCC and their distress longitudinally. In June 2020, 71 parent-child (8-15 y/o) dyads provided a hair sample to assess pre-pandemic HCC (December 2019-March 2020) and pandemic HCC (March-June 2020) in Quebec, Canada. Post-traumatic stress, anxiety, depression, and stress symptoms were also assessed in dyads every three months from June 2020 to March 2021. Results showed that parental stress symptoms and HCC were positively associated with children's HCC during the pandemic. Moreover, children's pre-pandemic and pandemic HCC were independently negatively associated with children's anxiety symptoms during the pandemic. These results provide evidence of an association between parental physiological and psychological stress and their children's HCC during the pandemic and suggest that HCC may help identify youth at risk of developing anxiety symptoms during chronic stressful events.</p>","PeriodicalId":16579,"journal":{"name":"Journal of Neural Transmission","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical neurovascular coupling through cerebrovascular reserve and cognitive function.","authors":"Mami Ishikawa, Takashi Kobari, Taiki Ishikawa, Gen Kusaka","doi":"10.1007/s00702-025-02905-3","DOIUrl":"https://doi.org/10.1007/s00702-025-02905-3","url":null,"abstract":"<p><p>Neurovascular coupling ensures that cerebral blood flow (CBF) is proportionally matched to neural activity. In patients with chronic cerebral hypoperfusion, this may be clinically assessed through multiple regression analysis with cognitive function and the cerebrovascular reserve (CVR) as key factors. Cognitive function (based on neuropsychological testing using the Neurobehavioral Cognitive Status Examination [COGNISTAT]) and cerebrovascular risk factors, including CBF, CVR (as evaluated using N-isopropyl-p-¹²³I-iodoamphetamine single-photon emission computed tomography with acetazolamide challenge), and periventricular hyperintensity (PVH) grade, were investigated in 65 patients with steno-occlusive disease of a main cerebral artery. Multiple regression analysis was performed between COGNISTAT scores and other factors in 41 patients with a vascular mild cognitive impairment pattern on COGNISTAT and a proportionally variable CVR range. Additionally, we examined subgroups based on HbA1c, PVH grade, and lipid values, as well as 10 patients who underwent anastomosis surgery. The multiple regression analysis of COGNISTAT scores and CVR showed statistically significant relationships in the 41 patients and all subgroups (adjusted R² > 0.45). The high HbA1c and high PVH grade groups exhibited lower standardized partial regression coefficients (SPRCs) for CVR compared with the lower groups (0.187, 0.203 vs. 0.230, 0.254, respectively). After anastomosis surgery, both COGNISTAT scores and CVR significantly improved while their relationship was maintained (SPRC = 0.224, p = 0.0092, adjusted R² = 0.457). A significant regression relationship was found between cognitive function and CVR, indicating a potential causal relationship based on clinical neurovascular coupling function that may vary depending on HbA1c level and PVH grade.</p>","PeriodicalId":16579,"journal":{"name":"Journal of Neural Transmission","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Botulinum toxin effects on biochemical biomarkers related to inflammation-associated head and neck chronic conditions: a systematic review of clinical research.","authors":"Ines Novo Pereira, Sara Durão, Haidar Hassan, Ana Cristina Braga, André Mariz Almeida, Ana Cristina Manso, Ricardo Faria-Almeida, Giancarlo De la Torre Canales","doi":"10.1007/s00702-024-02869-w","DOIUrl":"https://doi.org/10.1007/s00702-024-02869-w","url":null,"abstract":"<p><p>Botulinum toxin type A (BoNT) has emerged as a potential alternative to conventional therapies to many debilitating chronic diseases characterised by inflammatory states. However, the biological rationale remains ambiguous. Our review aimed to systematically assessed which biochemical biomarkers have been reported in clinical research to evaluate BoNT analgesic and mood-lifting effects in head and neck chronic conditions related to inflammation. We searched databases and registries between inception and September 29, 2023. Of the nine included studies, there were concerns about risk of bias for six studies. The leading biomarker with five studies was the calcitonin gene-related peptide (CGRP), followed by serotonin with two studies. Oxidative stress biomarkers were only reported in one study. Several important players in inflammatory processes and different immune cell classes have been evaluated in four studies. There was only one trial measuring changes in beta Tubulin and SNAP-25, and another study evaluating cutaneous neuropeptide substance-P. After BoNT, a significant effect was reported in six studies, including decrease in plasma levels of CGRP in chronic migraine and trigeminal neuralgia; serotonin decrease when collected from human tears in refractory intractable dry eye disease and increase in peripheral blood platelets in painful cervical dystonia associated to depression and anxiety; decrease in plasma concentration of markers of oxidative damage to proteins and increase in biomarkers for antioxidant power; decrease in expression of gene sets involved in inflammatory pathways and immune cells classes in the periosteum and metalloproteinase-9 molecule in the tears. BoNT seems to affect some biomarkers present in chronic inflammatory conditions. However, the certainty evidence found was very low to moderate. This study is registered on PROSPERO (CRD42023432131).</p>","PeriodicalId":16579,"journal":{"name":"Journal of Neural Transmission","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A structured framework for emotion-cognition dynamics: Implications for assessment and intervention.","authors":"Vahid Nejati","doi":"10.1007/s00702-025-02903-5","DOIUrl":"https://doi.org/10.1007/s00702-025-02903-5","url":null,"abstract":"<p><p>This paper presents a novel framework for understanding the interaction between cognitive and emotional processes, recognizing the complex and dynamic relationship between these two constructs. The framework categorizes cognitive functions into four distinct categories: Cold Cognition, Hot Cognition, Warm Cognition, and Cool Cognition. By distinguishing between the style of processing (intuitive vs. analytical) and the content of information (emotional vs. non-emotional), the framework provides a model for both assessment and intervention. For assessment, it helps categorize cognitive and emotional processes, enabling targeted evaluations based on specific processing styles and content. For interventions, it supports the development of training programs that address processing styles in relation to the target function, improving the effectiveness of therapeutic and developmental strategies. Overall, this framework has the potential to advance both theoretical understanding and practical applications in cognitive and emotional assessment and training.</p>","PeriodicalId":16579,"journal":{"name":"Journal of Neural Transmission","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of inflammatory biomarker levels in neurodegenerative proteinopathies: a case-control study.","authors":"Sarah E V Cook, Kateřina Menšíková, Dorota Koníčková, Hedvika Šlanhofová, Kateřina Klíčová, Milan Raška, Jana Zapletalová, David Friedecký, Petr Kaňovský","doi":"10.1007/s00702-025-02902-6","DOIUrl":"https://doi.org/10.1007/s00702-025-02902-6","url":null,"abstract":"<p><p>While diagnostic criteria have been established and validated for most neurodegenerative diseases, the considerable overlap between individual nosological entities remains a significant diagnostic challenge. Increasing evidence suggests that neurodegeneration is often initiated by inflammation within the central nervous system. The identification of inflammation could serve as a first signal of the pathophysiological process. As such, validated biological markers (\"biomarkers\") of neuroinflammation are critically important. This study aimed to assess the presence and levels of inflammatory biomarkers in three neurodegenerative diseases: Lewy body diseases (LBD), multiple system atrophy (MSA), and 4-repeat tauopathies (4RT). A total of 83 LBD, 24 MSA, and 31 4RT patients were included, with 83 control subjects for comparison. Six immune-related proteins were analysed in cerebrospinal fluid (CSF) and blood serum (serum): C3 complement, C4 complement, haptoglobin, transferrin, orosomucoid, and β2 microglobulin (β2M). ANCOVA statistical analysis revealed significantly lower levels of several inflammatory biomarkers in LBD (CSF: transferrin, C3 complement, orosomucoid; Serum: orosomucoid, β2M) and MSA (CSF: transferrin, C3 complement, C4 complement, orosomucoid) compared to controls. Significant differences were also observed between the synucleinopathy patient groups (LBD and MSA) and 4RT in serum levels of C3 complement. Additionally, the CSF/serum quotients for transferrin (LBD and MSA) and C3 complement (LBD) were significantly lower in disease relative to controls. These findings suggest that inflammatory processes may play a role in the pathophysiology of neurodegenerative proteinopathies, warranting further research to confirm these associations. The identification of potential fluid biomarkers would then represent a promising step forward in the field.</p>","PeriodicalId":16579,"journal":{"name":"Journal of Neural Transmission","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Action impulsivity and attention deficits in patients at an early stage of Huntington disease.","authors":"Sacha Brohée, Stephan Grimaldi, Laure Spieser, Nathalie Baril, Thierry Hasbroucq, Frédérique Fluchere, Jean-Philippe Azulay, Franck Vidal, Marianne Vaugoyeau","doi":"10.1007/s00702-025-02888-1","DOIUrl":"https://doi.org/10.1007/s00702-025-02888-1","url":null,"abstract":"<p><p>Huntington's disease (HD) is characterized by a combination of motor, cognitive, and neuropsychiatric impairments. Among them, impulsivity and attention deficits are clinical features usually described in HD, impacting the quality of life of patients and their caregivers. Twenty early-stage HD patients (PHD) and 20 age and gender-matched control participants (CP) performed a \"Simon\" reaction time (RT) task allowing us to explore action impulsivity and attention deficits. Surface EMG recordings aimed at revealing the presence and characterizing the nature of impulsivity in PHD. Correlational analyses between error rates or chronometric data, and clinical or neuropsychological data were examined. (1) Analysis of the accuracy and EMG patterns revealed no difference between PHD and CP, indicating absence of motor impulsivity at the early stage of HD. (2) Chronometric indices revealed a general slowing of information processing in PHD, involving central information processing but sparing the latest stages of motor execution, consistent with performed correlational analysis. (3) Sequential analysis of RT patterns showed a failure to allocate attention appropriately. These indices of attentional deficits nicely correlated with performance in neuropsychological tests exploring attentional processes. (1) Central information processing slows down at the early stage of HD but the latest steps of motor execution are unaffected. (2) In the progression of HD, attentional deficits typically should appear first among dysexecutive problems, without significant action impulsivity.</p>","PeriodicalId":16579,"journal":{"name":"Journal of Neural Transmission","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effectiveness of non-invasive brain stimulation in treatment of major depressive disorder (MDD): a systematic review and transfer analysis.","authors":"Vahid Nejati, Azin Sarraj Khorrami, Zahra S Vaziri, Fatemeh Shahri, Maryam Yazdchi, Vahid Abdolmanafi, Saeed Paydarfard, Aida Golshan","doi":"10.1007/s00702-024-02852-5","DOIUrl":"10.1007/s00702-024-02852-5","url":null,"abstract":"<p><p>This study aimed to analyze the transferability of non-invasive brain stimulation (NIBS) interventions in individuals with major depressive disorder (MDD) based on the FIELD model (Function, Implementation, Ecology, Level, and Duration), encompassing function, implement, ecology, level, and duration. A systematic search of electronic databases yielded a total of 21 eligible studies, comprising 12 transcranial direct current stimulation (tDCS) and 9 transcranial magnetic stimulation (TMS) trials, involving 1029 individuals with MDD. The meta-analysis of effect sizes revealed positive transfer effects across all domains of the FIELD model, suggesting that NIBS interventions have potential efficacy in improving various facets of MDD. The subgroup analysis highlighted that bilateral dlPFC stimulation exhibited the highest effect size for transferability, indicating greater transferability for rTMS, a higher dose of stimulation, and the integration of additional interventions. Additionally, the study discusses the implications of bilateral dorsolateral prefrontal cortex (dlPFC) stimulation and the integration of complementary therapies for optimizing treatment efficacy.</p>","PeriodicalId":16579,"journal":{"name":"Journal of Neural Transmission","volume":" ","pages":"369-385"},"PeriodicalIF":3.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142710399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}