Journal of Neural Transmission最新文献_第10页

Clinicians' viewpoints on current paradigms of care and research in Parkinson's disease. 临床医生对当前帕金森病护理和研究模式的看法。

IF 3.2 4区医学

Journal of Neural Transmission Pub Date : 2024-12-01 Epub Date: 2024-08-19 DOI: 10.1007/s00702-024-02822-x

Thomas Müller, Carsten Buhmann, Martin Delf, Fabian Klostermann, Andreas Kupsch, Axel Lipp, Martina Müngersdorf, Wolfram von Pannwitz, Martin Südmeyer

{"title":"Clinicians' viewpoints on current paradigms of care and research in Parkinson's disease.","authors":"Thomas Müller, Carsten Buhmann, Martin Delf, Fabian Klostermann, Andreas Kupsch, Axel Lipp, Martina Müngersdorf, Wolfram von Pannwitz, Martin Südmeyer","doi":"10.1007/s00702-024-02822-x","DOIUrl":"10.1007/s00702-024-02822-x","url":null,"abstract":"Aim of this review is to discuss the value of current ongoing research initiatives in Parkinson's disease from the clinicians' point of view. The repeat, recent failures on progress slowing reflect the drifting apart between initially promising experimental and then disappointing clinical outcomes in the translational trials with well selected Parkinson's disease patients. A similar development concerns the emerging gap between novel developed drugs with improved pharmacokinetic behaviour and their limited use in the clinical practice following approval. Restricted regional different worldwide availability and direct, respectively indirect budget limitations for neurologists in private practice are essential hurdles. They prevent the widespread prescription of these compounds. As a result return of investment for the pharmaceutical industry becomes more and more uncertain. The interest for research on novel treatment approaches for the amelioration of motor and non motor symptoms declines. Clinicians crucially scrutinize the claim for an optimum patient care by payers and regulators.","PeriodicalId":16579,"journal":{"name":"Journal of Neural Transmission","volume":" ","pages":"1455-1462"},"PeriodicalIF":3.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142004431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The pathobiology of depression in Huntington's disease: an unresolved puzzle. 亨廷顿抑郁症的病理生物学：一个未解之谜。

IF 3.2 4区医学

Journal of Neural Transmission Pub Date : 2024-12-01 Epub Date: 2024-02-13 DOI: 10.1007/s00702-024-02750-w

Kurt A Jellinger

{"title":"The pathobiology of depression in Huntington's disease: an unresolved puzzle.","authors":"Kurt A Jellinger","doi":"10.1007/s00702-024-02750-w","DOIUrl":"10.1007/s00702-024-02750-w","url":null,"abstract":"Huntington's disease (HD) is an autosomal-dominant progressive neurodegenerative disease that manifests with a triad of symptoms including motor dysfunctions, cognitive deficits, and prominent neuropsychiatric symptoms, the most common of which is depression, with a prevalence between 30 and 70%. Depressive symptoms occur in all stages of HD, beginning in presymptomatic HD gene carriers, and are strongly associated with suicidal ideation and suicidality, but their relationship with other clinical dimensions in HD is controversial and the underlying pathophysiology is poorly understood. Analysis of the available literature until November 2023 concerned the prevalence, clinical manifestations, neuroimaging, transgenic models, and treatment options of HD depression. While it was believed that depression in HD is due to psychosomatic factors in view of the fatal disease, studies in transgenic models of HD demonstrated molecular changes including neurotrophic and serotonergic dysregulation and disorders of the hypothalamic-pituitary-adrenal axis inducing depression-like changes. While relevant neuropathological data are missing, recent neuroimaging studies revealed correlations between depressive symptoms and dysfunctional connectivities in the default mode network, basal ganglia and prefrontal cortex, and changes in limbic and paralimbic structures related to the basic neurodegenerative process. The impact of response to antidepressants in HD patients is controversial; selective serotonin reuptake inhibitors are superior to serotonin-norepinephrine reuptake inhibitors, while electroconvulsive therapy may be effective for pharmacotherapy resistant cases. Since compared to major depressive disorder and depression in other neurodegenerative diseases, our knowledge of the molecular basis in HD depression is limited, further studies to elucidate the heterogeneous pathogenesis in this fatal disorder are warranted.","PeriodicalId":16579,"journal":{"name":"Journal of Neural Transmission","volume":" ","pages":"1511-1522"},"PeriodicalIF":3.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139723029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In situ stoichiometry amounts of p62 and poly-ubiquitin exceed the increase of alpha-synuclein during degeneration of catecholamine cells induced by autophagy inhibition in vitro. 在体外自噬抑制诱导的儿茶酚胺细胞变性过程中，p62和多泛素的原位定量超过了α-突触核蛋白的增加量。

IF 3.2 4区医学

Journal of Neural Transmission Pub Date : 2024-12-01 Epub Date: 2024-06-18 DOI: 10.1007/s00702-024-02795-x

Paola Lenzi, Gloria Lazzeri, Michela Ferrucci, Carla Letizia Busceti, Stefano Puglisi-Allegra, Francesco Fornai

{"title":"In situ stoichiometry amounts of p62 and poly-ubiquitin exceed the increase of alpha-synuclein during degeneration of catecholamine cells induced by autophagy inhibition in vitro.","authors":"Paola Lenzi, Gloria Lazzeri, Michela Ferrucci, Carla Letizia Busceti, Stefano Puglisi-Allegra, Francesco Fornai","doi":"10.1007/s00702-024-02795-x","DOIUrl":"10.1007/s00702-024-02795-x","url":null,"abstract":"Neurodegenerative disorders are typically featured by the occurrence of neuronal inclusions. In the case of Parkinson's disease (PD) these correspond to Lewy bodies (LBs), which are routinely defined as proteinaceous inclusions composed of alpha-synuclein (alpha-syn). In turn, alpha-syn is considered to be the key protein in producing PD and fostering its progression. Recent studies challenged such a concept and emphasized the occurrence of other proteins such as p62 and poly-ubiquitin (Poly-ub) in the composition of LBs, which are also composed of large amounts of tubulo-vesicular structures. All these components, which accumulate within the cytosol of affected neurons in PD, may be the consequence of a dysfunction of major clearing pathways. In fact, autophagy-related systems are constantly impaired in inherited PD and genetic models of PD. The present study was designed to validate whether a pharmacological inhibition of autophagy within catecholamine cells produces cell damage and accumulation of specific proteins and tubulo-vesicular structures. The stoichiometry counts of single proteins, which accumulate within catecholamine neurons was carried out along with the area of tubulo-vesicular structures. In these experimental conditions p62 and Poly-ub accumulation exceeded at large the amounts of alpha-syn. In those areas where Poly-ub and p62 were highly expressed, tubulo-vesicular structures were highly represented compared with surrounding cytosol. The present study confirms new vistas about LBs composition and lends substance to the scenario that autophagy inhibition rather than a single protein dysfunction as key determinant of PD.","PeriodicalId":16579,"journal":{"name":"Journal of Neural Transmission","volume":" ","pages":"1397-1414"},"PeriodicalIF":3.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11608283/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141419590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Revolutionizing our understanding of Parkinson's disease: Dr. Heinz Reichmann's pioneering research and future research direction. 彻底改变我们对帕金森病的认识：Heinz Reichmann 博士的开创性研究和未来研究方向。

IF 3.2 4区医学

Journal of Neural Transmission Pub Date : 2024-12-01 Epub Date: 2024-08-07 DOI: 10.1007/s00702-024-02812-z

Masaru Tanaka, László Vécsei

{"title":"Revolutionizing our understanding of Parkinson's disease: Dr. Heinz Reichmann's pioneering research and future research direction.","authors":"Masaru Tanaka, László Vécsei","doi":"10.1007/s00702-024-02812-z","DOIUrl":"10.1007/s00702-024-02812-z","url":null,"abstract":"Millions of individuals around the world are afflicted with Parkinson's disease (PD), a prevalent and incapacitating neurodegenerative disorder. Dr. Reichmann, a distinguished professor and neurologist, has made substantial advancements in the domain of PD research, encompassing both fundamental scientific investigations and practical applications. His research has illuminated the etiology and treatment of PD, as well as the function of energy metabolism and premotor symptoms. As a precursor to a number of neurotransmitters and neuromodulators that are implicated in the pathophysiology of PD, he has also investigated the application of tryptophan (Trp) derivatives in the disease. His principal findings and insights are summarized and synthesized in this narrative review article, which also emphasizes the challenges and implications for future PD research. This narrative review aims to identify and analyze the key contributions of Reichmann to the field of PD research, with the ultimate goal of informing future research directions in the domain. By examining Reichmann's work, the study seeks to provide a comprehensive understanding of his major contributions and how they can be applied to advance the diagnosis and treatment of PD. This paper also explores the potential intersection of Reichmann's findings with emerging avenues, such as the investigation of Trp and its metabolites, particularly kynurenines, which could lead to new insights and potential therapeutic strategies for managing neurodegenerative disorders like PD.","PeriodicalId":16579,"journal":{"name":"Journal of Neural Transmission","volume":" ","pages":"1367-1387"},"PeriodicalIF":3.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11608389/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141897587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impaired dual-task gait in Parkinson's disease is associated with brain morphology changes. 帕金森病患者双任务步态受损与大脑形态变化有关。

IF 3.2 4区医学

Journal of Neural Transmission Pub Date : 2024-12-01 Epub Date: 2024-02-28 DOI: 10.1007/s00702-024-02758-2

Radim Krupička, Christiane Malá, Slávka Neťuková, Tereza Hubená, Filip Havlík, Ondrej Bezdicek, Petr Dušek, Evžen Růžička

{"title":"Impaired dual-task gait in Parkinson's disease is associated with brain morphology changes.","authors":"Radim Krupička, Christiane Malá, Slávka Neťuková, Tereza Hubená, Filip Havlík, Ondrej Bezdicek, Petr Dušek, Evžen Růžička","doi":"10.1007/s00702-024-02758-2","DOIUrl":"10.1007/s00702-024-02758-2","url":null,"abstract":"In Parkinson's disease (PD), impaired gait and cognition affect daily activities, particularly in the more advanced stages of the disease. This study investigated the relationship between gait parameters, cognitive performance, and brain morphology in patients with early untreated PD. 64 drug-naive PD patients and 47 healthy controls (HC) participated in the study. Single- and dual-task gait (counting task) were examined using an expanded Timed Up & Go Test measured on a GaitRite walkway. Measurements included gait speed, stride length, and cadence. A brain morphometry analysis was performed on T1-weighted magnetic resonance (MR) images. In PD patients compared to HC, gait analysis revealed reduced speed (p < 0.001) and stride length (p < 0.001) in single-task gait, as well as greater dual-task cost (DTC) for speed (p = 0.007), stride length (p = 0.014) and cadence (p = 0.029). Based on the DTC measures in HC, PD patients were further divided into two subgroups with normal DTC (PD-nDTC) and abnormally increased DTC (PD-iDTC). For PD-nDTC, voxel-based morphometric correlation analysis revealed a positive correlation between a cluster in the left primary motor cortex and stride-length DTC (r = 0.57, p = 0.027). For PD-iDTC, a negative correlation was found between a cluster in the right lingual gyrus and the DTC for gait cadence (r=-0.35, pFWE = 0.018). No significant correlations were found in HC. The associations found between brain morphometry and gait performance with a concurrent cognitive task may represent the substrate for gait and cognitive impairment occurring since the early stages of PD.","PeriodicalId":16579,"journal":{"name":"Journal of Neural Transmission","volume":" ","pages":"1389-1395"},"PeriodicalIF":3.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11608385/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139983132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Facets of movement disorders- a tribute to Heinz Reichmann. 运动障碍的方方面面--向海因茨-莱克曼致敬。

IF 3.2 4区医学

Journal of Neural Transmission Pub Date : 2024-12-01 Epub Date: 2024-11-05 DOI: 10.1007/s00702-024-02857-0

Peter Riederer, Etienne C Hirsch

引用次数: 0

An orthogonal approach for analysis of underivatized steroid hormones using ultrahigh performance supercritical fluid chromatography-mass spectrometry (UHPSFC-MS). 利用超高效超临界流体色谱-质谱（UHPSFC-MS）分析未充分活化的类固醇激素的正交方法。

IF 3.2 4区医学

Journal of Neural Transmission Pub Date : 2024-11-15 DOI: 10.1007/s00702-024-02862-3

Perry Devo, Victoria Cretu, Harsha Radhakrishnan, Darren Hamilton-Pink, Stergios Boussios, Saak V Ovsepian

{"title":"An orthogonal approach for analysis of underivatized steroid hormones using ultrahigh performance supercritical fluid chromatography-mass spectrometry (UHPSFC-MS).","authors":"Perry Devo, Victoria Cretu, Harsha Radhakrishnan, Darren Hamilton-Pink, Stergios Boussios, Saak V Ovsepian","doi":"10.1007/s00702-024-02862-3","DOIUrl":"https://doi.org/10.1007/s00702-024-02862-3","url":null,"abstract":"The crucial role of steroid hormones in health and diseases merits their high-throughput, accurate and affordable measurements in biological specimens. Despite advances in analytical methods, sensing and quantifying steroid hormones remains challenging. Immunoassays offer excellent sensitivity but are inherently labour-intensive, costly, and prone to false positives. Mass spectrometry (MS) has been increasingly utilised, with the main hurdle being the isobaric tendencies of similar analytes, which complicates their separation and accurate quantification. This study compares ultrahigh-performance supercritical fluid chromatography separation (UHPSFC) and ultra-high-performance liquid chromatography (UHPLC) for MS detection. It optimises the column chemistry, temperature, and pressure to provide an operational protocol for the resolution and quantification of analytes. It presents the systematic characterisation of UHPSFC-MS performance by investigating spiked blood samples using Solid-Phase Extraction (SPE) and describes the matrix effects associated with MS measurements. Although both separation methods showed adequate resolution, specificity, and retention time, UHPSFC-MS was superior for five out of seven columns tested. With added high-throughput capacities, UHPSFC-MS, thus, offers an optimal solution for the analysis of steroid hormones for research, medical chemistry, and clinical diagnostics.","PeriodicalId":16579,"journal":{"name":"Journal of Neural Transmission","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142639058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Grasping the big picture: impact analysis of screening tools for timely referral for device-aided therapies. 把握全局：筛查工具对及时转诊接受器械辅助疗法的影响分析。

IF 3.2 4区医学

Journal of Neural Transmission Pub Date : 2024-11-01 Epub Date: 2024-07-15 DOI: 10.1007/s00702-024-02783-1

H R Moes, H S Dafsari, W H Jost, N Kovacs, Z Pirtošek, T Henriksen, C Falup-Pecurariu, M Minár, E Buskens, T van Laar

{"title":"Grasping the big picture: impact analysis of screening tools for timely referral for device-aided therapies.","authors":"H R Moes, H S Dafsari, W H Jost, N Kovacs, Z Pirtošek, T Henriksen, C Falup-Pecurariu, M Minár, E Buskens, T van Laar","doi":"10.1007/s00702-024-02783-1","DOIUrl":"10.1007/s00702-024-02783-1","url":null,"abstract":"Several screening tools are available to assist general neurologists in the timely identification of patients with advanced Parkinson's disease (PD) who may be eligible for referral for a device-aided therapy (DAT). However, it should be noted that not all of these clinical decision rules have been developed and validated in a thorough and consistent manner. Furthermore, only a limited number of head-to-head comparisons have been performed. Available studies suggest that D-DATS has a higher positive predictive value and higher specificity than the 5-2-1 criteria, while the sensitivity of both screening tools is similar. However, unanswered questions remain regarding the validity of the decision rules, such as whether the diagnostic performance measures from validation studies are generalizable to other populations. Ultimately, the question is whether a screening tool will effectively and efficiently improve the quality of life of patients with PD. To address this key question, an impact analysis should be performed. The authors intend to set up a multinational cluster randomised controlled trial to compare the D-DATS and 5-2-1 criteria on the downstream consequences of implementing these screening tools, with a particular focus on the impact on disability and quality of life.","PeriodicalId":16579,"journal":{"name":"Journal of Neural Transmission","volume":" ","pages":"1295-1305"},"PeriodicalIF":3.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11502603/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141616636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuroplasticity in Parkinson's disease. 帕金森病的神经可塑性。

IF 3.2 4区医学

Journal of Neural Transmission Pub Date : 2024-11-01 Epub Date: 2024-08-05 DOI: 10.1007/s00702-024-02813-y

Bogdan Ovidiu Popescu, Lucia Batzu, Pedro J Garcia Ruiz, Delia Tulbă, Elena Moro, Patrick Santens

引用次数: 0

Monotherapy with infusion therapies - useful or not? 输液疗法的单一疗法--有用还是没用？

IF 3.2 4区医学

Journal of Neural Transmission Pub Date : 2024-11-01 Epub Date: 2024-07-05 DOI: 10.1007/s00702-024-02801-2

Petra Bago Rožanković, Anders Johansson, Klivényi Péter, Ivan Milanov, Per Odin

{"title":"Monotherapy with infusion therapies - useful or not?","authors":"Petra Bago Rožanković, Anders Johansson, Klivényi Péter, Ivan Milanov, Per Odin","doi":"10.1007/s00702-024-02801-2","DOIUrl":"10.1007/s00702-024-02801-2","url":null,"abstract":"Infusion pump-based therapies are an effective treatment option for patients with advanced Parkinson´s disease. Achieving monotherapy with infusion-based therapies could simplify the treatment regimen, provide better medication adherence, reduce adverse events and drug interactions. This review presents the literature data on the efficacy, safety, and achievability of monotherapy with all available infusion-based therapies, including apomorphine, levodopa-carbidopa-intestinal gel (LCIG), levodopa-entacapone-carbidopa intestinal gel (LECIG), and foslevodopa-foscarbidopa (LDp/CDp). In summary, monotherapy is achievable and effective in most patients on intestinal levodopa infusion therapy and in some patients on apomorphine infusion. There is a need for further investigation of monotherapy compared to polytherapy, especially in new pump treatment options (LECIG and LDp/CDp). Future research should reveal which patients on infusion-based therapies could benefit from monotherapy, including identification of potential baseline predictors of achieving monotherapy in patients treated with specific infusion-based therapies.","PeriodicalId":16579,"journal":{"name":"Journal of Neural Transmission","volume":" ","pages":"1341-1348"},"PeriodicalIF":3.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141534576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0