Journal of Neural Transmission最新文献

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Stress in lockdown: exploring the interplay and effects of cortisol and psychological distress in parent-child dyads. 封锁中的压力:探索亲子双体中皮质醇和心理困扰的相互作用和影响。
IF 4 4区 医学
Journal of Neural Transmission Pub Date : 2025-09-01 Epub Date: 2025-03-10 DOI: 10.1007/s00702-025-02898-z
Alexe Bilodeau-Houle, Félix Duplessis-Marcotte, Catherine Raymond, Rachel Primiani, Marie-France Marin
{"title":"Stress in lockdown: exploring the interplay and effects of cortisol and psychological distress in parent-child dyads.","authors":"Alexe Bilodeau-Houle, Félix Duplessis-Marcotte, Catherine Raymond, Rachel Primiani, Marie-France Marin","doi":"10.1007/s00702-025-02898-z","DOIUrl":"10.1007/s00702-025-02898-z","url":null,"abstract":"<p><p>During the COVID-19 pandemic, some children experienced psychological distress. Moreover, pandemic-related stressors were associated with changes in hair cortisol concentrations (HCC) in youth. Research has shown that parental distress influenced children's well-being during the pandemic, but it remains unclear whether parental distress is associated with children's HCC during the pandemic. Furthermore, as some preliminary evidence suggests that children's HCC may predict their emotional response to the pandemic, it is essential to assess whether children's HCC provides insight into their susceptibility to developing symptoms associated with stress-related psychopathologies. The present study aimed to (1) examine the association between parental pandemic-related distress and children's HCC; (2) investigate the moderating role of parental distress on the association between parent and child HCC; and (3) explore the association between children's HCC and their distress longitudinally. In June 2020, 71 parent-child (8-15 y/o) dyads provided a hair sample to assess pre-pandemic HCC (December 2019-March 2020) and pandemic HCC (March-June 2020) in Quebec, Canada. Post-traumatic stress, anxiety, depression, and stress symptoms were also assessed in dyads every three months from June 2020 to March 2021. Results showed that parental stress symptoms and HCC were positively associated with children's HCC during the pandemic. Moreover, children's pre-pandemic and pandemic HCC were independently negatively associated with children's anxiety symptoms during the pandemic. These results provide evidence of an association between parental physiological and psychological stress and their children's HCC during the pandemic and suggest that HCC may help identify youth at risk of developing anxiety symptoms during chronic stressful events.</p>","PeriodicalId":16579,"journal":{"name":"Journal of Neural Transmission","volume":" ","pages":"1235-1254"},"PeriodicalIF":4.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Psychological, neuroendocrine and inflammatory stress responses in women after miscarriage or stillbirth: investigating early psychobiological adaptations to potential traumatic events. 流产或死产后妇女的心理、神经内分泌和炎症应激反应:调查对潜在创伤事件的早期心理生物学适应
IF 4 4区 医学
Journal of Neural Transmission Pub Date : 2025-09-01 Epub Date: 2025-04-29 DOI: 10.1007/s00702-025-02927-x
Luis Gerber, Markus M Müller, Alexandra Oender, Sophia Urbanczyk, Peter Radermacher, Cosima Brucker, Barbara Stein, Christiane Waller, Nicolas Rohleder
{"title":"Psychological, neuroendocrine and inflammatory stress responses in women after miscarriage or stillbirth: investigating early psychobiological adaptations to potential traumatic events.","authors":"Luis Gerber, Markus M Müller, Alexandra Oender, Sophia Urbanczyk, Peter Radermacher, Cosima Brucker, Barbara Stein, Christiane Waller, Nicolas Rohleder","doi":"10.1007/s00702-025-02927-x","DOIUrl":"10.1007/s00702-025-02927-x","url":null,"abstract":"<p><strong>Background: </strong>Miscarriage (MC) and stillbirth (SB) can be considered as potentially traumatic events (PTE) and affect approximately 10-20% of all pregnancies. PTEs can lead to the development of post-traumatic stress disorder (PTSD). While the psychobiology of PTSD is well-understood, our knowledge on psychobiological adaptations shortly after a PTE is limited. This study aimed to shed light on early psychobiological changes associated with MC and SB.</p><p><strong>Methods: </strong>We included 25 women who had experienced a MC/SB within the previous three months and compared them with 28 healthy control women. All participants were asked to attend a study appointment, during which they participated in a socially evaluated cold-pressor test (SECPT) to induce psychosocial stress. Saliva and blood samples were collected at rest, immediately and at 20, 45 and 90 min after the SECPT. We determined salivary cortisol levels and α-amylase (sAA) activity, and plasma interleukin-6 (IL-6) concentrations. We assessed symptoms of PTSD, anxiety and depression using self-report questionnaires.</p><p><strong>Results: </strong>Women who had experienced MC or SB reported significantly more symptoms of PTSD (p < 0.001) and anxiety (p < 0.001), when compared to the control group. Despite elevated psychological distress in the MC/SB group, there were no significant differences of salivary cortisol, sAA and IL-6 levels between the two groups at rest or after SECPT induced stress.</p><p><strong>Conclusions: </strong>Despite the high psychological strain on women after MC/SB, the stress is not yet reflected at a biological level. These results highlight the complex relationship between early trauma, PTSD symptoms, and biological responses. Further research is needed to understand the long-term effects of trauma related to MC/SB, and the development of PTSD, as well as the underlying mechanisms contributing to the observed psychological and biological changes.</p>","PeriodicalId":16579,"journal":{"name":"Journal of Neural Transmission","volume":" ","pages":"1263-1274"},"PeriodicalIF":4.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143967888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Deep brain stimulation in progressive supranuclear palsy: a dead-end story? A narrative review. 深部脑刺激治疗进行性核上性麻痹:一个没有出路的故事?叙述性评论
IF 4 4区 医学
Journal of Neural Transmission Pub Date : 2025-08-01 Epub Date: 2025-03-24 DOI: 10.1007/s00702-025-02904-4
Gabriele Bellini, Giulia Di Rauso, Lorenzo Fontanelli, Elena Benevento, Lucrezia Becattini, Daniela Frosini, Roberto Ceravolo, Eleonora Del Prete
{"title":"Deep brain stimulation in progressive supranuclear palsy: a dead-end story? A narrative review.","authors":"Gabriele Bellini, Giulia Di Rauso, Lorenzo Fontanelli, Elena Benevento, Lucrezia Becattini, Daniela Frosini, Roberto Ceravolo, Eleonora Del Prete","doi":"10.1007/s00702-025-02904-4","DOIUrl":"10.1007/s00702-025-02904-4","url":null,"abstract":"<p><p>Progressive supranuclear palsy (PSP) is a rare, debilitating neurodegenerative disorder that significantly impairs both motor and cognitive functions. Current pharmacological treatments offer only transient symptomatic relief, driving interest in the past in alternative therapeutic strategies such as deep brain stimulation. Deep brain stimulation (DBS), known for its success in treating motor symptoms of Parkinson's disease, has been explored as a possible symptomatic treatment for PSP, considering the pedunculopontine nucleus (PPN), involved in motor control and postural stability, as a promising target for deep brain stimulation in PSP. However, its complex anatomy and the clinical variability of PSP complicate the prediction and generalization of the effectiveness of DBS. The present review examines the existing studies in the literature about DBS in PSP patients. Some studies highlighted modest benefits in motor symptoms, while others reported variable outcomes and inherent risks of the procedure. Generally, patients with a parkinsonism predominant phenotype have shown some subjective or clinical improvements in gait and balance when subjected to low-frequency stimulation. While DBS of the PPN holds promise for ameliorating gait and balance of PSP, current evidence does not yet establish clear criteria for ideal candidates, nor does it provide overwhelmingly supportive results in favor of PPN-DBS in PSP patients. Without any further systematic study is not possible to define accurate candidate selection parameters and understand long-term outcomes and safety profiles.</p>","PeriodicalId":16579,"journal":{"name":"Journal of Neural Transmission","volume":" ","pages":"1095-1111"},"PeriodicalIF":4.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gut microbiota and the tryptophan-kynurenine pathway in anxiety: new insights and treatment strategies. 肠道菌群和焦虑中的色氨酸-犬尿氨酸途径:新的见解和治疗策略。
IF 3.2 4区 医学
Journal of Neural Transmission Pub Date : 2025-07-01 Epub Date: 2025-05-14 DOI: 10.1007/s00702-025-02938-8
Garry Hunjan, Shiv Shankar Shah, Sourabh Kosey, Khadga Raj Aran
{"title":"Gut microbiota and the tryptophan-kynurenine pathway in anxiety: new insights and treatment strategies.","authors":"Garry Hunjan, Shiv Shankar Shah, Sourabh Kosey, Khadga Raj Aran","doi":"10.1007/s00702-025-02938-8","DOIUrl":"10.1007/s00702-025-02938-8","url":null,"abstract":"<p><p>Anxiety disorders are mental health disorders characterized by long-lasting fear, worry, nervousness, and alterations in gut microbiota (GM). The GM is a vital modulator of brain function through the gut-brain axis, which acts as the neural pathway between the central and peripheral nervous systems. Dysbiosis of GM plays an essential role in anxiety development because of alterations in the vagus nerve, increased intestinal permeability, and altered breakdown of tryptophan (TRP). The Kynurenine (KYN) pathway plays a crucial role in the pathogenesis of anxiety disorders, primarily through its neuroprotective (KYNA) and neurotoxic (QUIN) metabolites. Higher ratios of KYNA/QUIN result in neuroprotection, whereas higher KYN/TRP ratios indicate increased QUIN production causing neuroinflammation. Studies on germ-free models exhibit higher plasma TRP levels, which interrupt the metabolic balance of TRP-derived compounds, thus causing brain impairment. A key issue in anxiety disorders is the dysregulation of GM, which disrupts TRP metabolism and neuroinflammatory pathways, however, remains poorly understood. Hence, the proper understanding of these mechanisms is crucial for future therapeutic advancements. Here, we highlight the significance of the TRP-KYN pathway and the potential of modulating KYN pathway enzymes, such as kynurenine aminotransferases (KATs), to adjust KYNA levels and restore neurotransmitter balance. It further discusses new therapeutic methods with a particular focus on probiotics that may restore GM and modulate TRP metabolism. Advancing our understanding of the intricate relationship between GM and anxiety disorders may facilitate novel, microbiota-targeted interventions. This ultimately contributes to precision medicine approaches in mental health care, thereby enhancing treatment efficacy and patient outcomes.</p>","PeriodicalId":16579,"journal":{"name":"Journal of Neural Transmission","volume":" ","pages":"943-977"},"PeriodicalIF":3.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neural autoantibodies in psychiatric disorders are associated with antibodies against viral pathogens: a retrospective study of 619 patients. 精神疾病患者的神经自身抗体与病毒性病原体抗体相关:一项619例患者的回顾性研究。
IF 3.2 4区 医学
Journal of Neural Transmission Pub Date : 2025-07-01 Epub Date: 2025-05-17 DOI: 10.1007/s00702-025-02943-x
Niels Hansen, Vincent Buschatzky, Anne Katharina Bastin, Kristin Rentzsch, Bianca Teegen, Daniel Luedecke, Thomas Skripuletz, Hannah Benedictine Maier, Stefan Bleich, Jürgen Gallinat, Hermann Esselmann, Ildiko Rita Dunay, Inga Zerr, Dirk Fitzner, Jens Wilftang, Alexandra Neyazi, Björn Hendrik Schott, Berend Malchow
{"title":"Neural autoantibodies in psychiatric disorders are associated with antibodies against viral pathogens: a retrospective study of 619 patients.","authors":"Niels Hansen, Vincent Buschatzky, Anne Katharina Bastin, Kristin Rentzsch, Bianca Teegen, Daniel Luedecke, Thomas Skripuletz, Hannah Benedictine Maier, Stefan Bleich, Jürgen Gallinat, Hermann Esselmann, Ildiko Rita Dunay, Inga Zerr, Dirk Fitzner, Jens Wilftang, Alexandra Neyazi, Björn Hendrik Schott, Berend Malchow","doi":"10.1007/s00702-025-02943-x","DOIUrl":"10.1007/s00702-025-02943-x","url":null,"abstract":"<p><p>A history of viral infection has been associated with a higher risk for psychiatric disorders. One potential underlying mechanism is that antiviral immunological responses could trigger cross-reactivity between viral and neural antigens, which would raise the co-occurrence of antiviral antibodies and anti-neural autoantibodies. We studied 619 patients' psychiatric diagnoses from the Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Germany. Anti-neural autoantibodies and antiviral antibody specific indices were measured in serum and/or cerebrospinal fluid (CSF) from all patients. Among these 619 patients, 115 tested positive for serum and/or CSF neural autoantibodies (18.6%), with the most often identified autoantibodies being anti-GAD65 in serum (2.2%) and CSF (1.6%), and anti-NMDA in serum (0.6%) and CSF (1.3%). The three main diagnostic groups presenting neural autoantibodies were patients with organic psychiatric disorders including dementia (81 of 377; 21.7%), those with psychotic disorders (9 of 66; 13.6%), and patients with affective disorders (19 of 138; 13.9%). Logistic regression analysis revealed a significant association between the varicella zoster virus (VZV) antibody-specific index and autoantibody positivity in patients with all diagnoses (F00-F79) (p < 0.005). Furthermore, the rubella antibody-specific index proved to be significantly associated with neural autoantibody positivity (p < 0.001) across all patients (F00-F79), and in those with affective disorders (p < 0.01). Our results show that VZV and rubella antiviral antibodies are associated with a higher propensity to develop anti-neural autoantibodies, suggesting that the known association between viral infection and later developing psychiatric disorders may be partly attributable to the development of anti-neural autoimmunity.</p>","PeriodicalId":16579,"journal":{"name":"Journal of Neural Transmission","volume":" ","pages":"1063-1074"},"PeriodicalIF":3.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12208994/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Therapeutic potential of COX-2 inhibitors in neuropsychiatric disorders. COX-2抑制剂在神经精神疾病中的治疗潜力。
IF 3.2 4区 医学
Journal of Neural Transmission Pub Date : 2025-07-01 Epub Date: 2025-05-05 DOI: 10.1007/s00702-025-02932-0
Veerta Sharma, Prateek Sharma, Thakur Gurjeet Singh
{"title":"Therapeutic potential of COX-2 inhibitors in neuropsychiatric disorders.","authors":"Veerta Sharma, Prateek Sharma, Thakur Gurjeet Singh","doi":"10.1007/s00702-025-02932-0","DOIUrl":"10.1007/s00702-025-02932-0","url":null,"abstract":"<p><p>Neuropsychiatric disorders such as bipolar disorder, migraine, major depressive disorder, epilepsy, attention-deficit/hyperactivity disorder, autism spectrum disorder and schizophrenia, are a huge burden on global health, impacting millions of individuals worldwide and posing significant barriers to effective treatment. Despite advancements in medication and psychotherapy, many patients continue to suffer from severe symptoms and receive little alleviation. All of these conditions are quite frequent, yet they affect people in a way that is exceedingly detrimental. The increasing evidence suggests the connection between these disorders and inflammation. Therefore, the use of anti-inflammatory agents, namely cyclooxygenase-2 (COX-2) inhibitors, offers a new approach to prevent and treat neuropsychiatric disorders. This review discusses about the COX pathway and the role of COX-2 in the neuroinflammation. Furthermore, this review highlights the COX-2 inhibitors as a promising therapeutic agent in these neuropsychiatric disorders, however, further studies are required to assess appropriate illness stage-related indication.</p>","PeriodicalId":16579,"journal":{"name":"Journal of Neural Transmission","volume":" ","pages":"999-1011"},"PeriodicalIF":3.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144012602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Optical coherence tomography reveals retinal structural abnormalities in α-synucleinopathies: insights from the Padua-CESNE cohort. 光学相干断层扫描显示α-突触核蛋白病的视网膜结构异常:来自Padua-CESNE队列的见解。
IF 3.2 4区 医学
Journal of Neural Transmission Pub Date : 2025-07-01 Epub Date: 2025-04-15 DOI: 10.1007/s00702-025-02918-y
M Campagnolo, M Puthenparampil, A Emmi, L Weis, E Basili, V Mauceri, A Miscioscia, M Carecchio, A Guerra, V Misenti, C Fogliano, P Gallo, A Antonini
{"title":"Optical coherence tomography reveals retinal structural abnormalities in α-synucleinopathies: insights from the Padua-CESNE cohort.","authors":"M Campagnolo, M Puthenparampil, A Emmi, L Weis, E Basili, V Mauceri, A Miscioscia, M Carecchio, A Guerra, V Misenti, C Fogliano, P Gallo, A Antonini","doi":"10.1007/s00702-025-02918-y","DOIUrl":"10.1007/s00702-025-02918-y","url":null,"abstract":"<p><p>The complexity of α-synucleinopathies, namely Parkinson's disease (PD) and multiple system atrophy (MSA), calls for the adoption a multimodal approach integrating biological, morphological, and functional data. Phosphorylated α-synuclein (α-syn) detection in bodily fluids and tissues such as the skin helps provide biological characterization of the disease, but specific and accessible biomarkers are not available yet. The aim of this study was to define the role of Optical Coherence Tomography (OCT, a minimally invasive retinal imaging technique) patterns as possible biomarkers in the early stages of α-synucleinopathies, also supporting the differential diagnosis. Thirty-five (23 PD, 12 MSA), clinically, biologically and genetically characterized patients included in the PADUA-CESNE (Centro Studi per la Neurodegenerazione) cohort underwent OCT. A significant atrophy in the inferior, superior and temporal regions of the Retinal Nerve Fiber Layer (RNFL) and in the inner nuclear layer (INL) were observed in PD compared to controls, differently from MSA. Hyperreflective foci (HRF) counts were elevated across all retinal layers in all patients with PD exhibiting significantly higher numbers, suggesting microglial activation and greater retinal damage. Further research regarding OCT patterns in PD and MSA may consolidate the role of specific features, such as INL abnormalities and different HRF counts, in supporting the diagnosis and differential diagnosis in α-synucleinopathies. In light of the availability of potentially disease-modifying therapies, studies should focus on newly diagnosed patients, also undergoing thorough clinical, biological and genetic characterization.</p>","PeriodicalId":16579,"journal":{"name":"Journal of Neural Transmission","volume":" ","pages":"1013-1022"},"PeriodicalIF":3.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12208970/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143967437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification of DAGLB variants in Japanese early-onset Parkinson's disease. 日本早发性帕金森病DAGLB变异的鉴定
IF 3.2 4区 医学
Journal of Neural Transmission Pub Date : 2025-07-01 Epub Date: 2025-04-17 DOI: 10.1007/s00702-025-02926-y
Yue Luo, Manabu Funayama, Taku Hatano, Yuanzhe Li, Hiroyo Yoshino, Satoshi Yamashita, Akira Mori, Ryoichi Nakamura, Yoshio Hashizume, Mari Yoshida, Yuichi Riku, Naomi Kanzato, Nobutaka Hattori
{"title":"Identification of DAGLB variants in Japanese early-onset Parkinson's disease.","authors":"Yue Luo, Manabu Funayama, Taku Hatano, Yuanzhe Li, Hiroyo Yoshino, Satoshi Yamashita, Akira Mori, Ryoichi Nakamura, Yoshio Hashizume, Mari Yoshida, Yuichi Riku, Naomi Kanzato, Nobutaka Hattori","doi":"10.1007/s00702-025-02926-y","DOIUrl":"10.1007/s00702-025-02926-y","url":null,"abstract":"<p><p>Hereditary factors play a significant role in the development of Parkinson's disease and the identification of causative genes is ongoing. Biallelic variants in Diacylglycerol lipase β (DAGLB) are related to early-onset Parkinson's disease (EOPD) in the Chinese population, and have also been identified in an Algerian case. To date, no EOPD cases with DAGLB variants have been reported among Japanese patients. This study was conducted to clarify the occurrence of DAGLB variants among Japanese EOPD patients. We screened 270 patients with sporadic EOPD (male: female ratio, 1.37:1; mean age at onset ± standard deviation, 37.32 ± 7.91 years), and 276 patients with suspected autosomal recessive Parkinson's disease (ARPD, male: female ratio, 0.75:1; mean age at onset ± standard deviation, 58.86 ± 14.67 years). Genetic screening of all coding exons and flanking splicing regions was performed by Sanger sequencing. We identified two rare biallelic variants in two patients, both from consanguineous families. One variant was a homozygous frameshift variant (c.1770_1771del, p.Tyr591ProfsTer26), which was predicted to be pathogenic. The other was a missense variant (c.1444T > C, p.Tyr482His) and was predicted to be benign, with co-segregation ruled out for this variant. We identified a pathogenic variant in the DAGLB gene. Together with previous reports, these findings provide further evidence that loss-of-function variants in DAGLB are involved in EOPD in the Japanese population.</p>","PeriodicalId":16579,"journal":{"name":"Journal of Neural Transmission","volume":" ","pages":"1023-1030"},"PeriodicalIF":3.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144012250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ferroptosis: a new target for depression prevention and treatment. 上睑下垂:抑郁症防治的新靶点。
IF 3.2 4区 医学
Journal of Neural Transmission Pub Date : 2025-07-01 Epub Date: 2025-05-03 DOI: 10.1007/s00702-025-02912-4
Wenxuan Liang, Haowei Guo, Luyao Li, Wupeng Tan, Jianfeng Liu, Xiaoli Hu, Yuchu Wang, Shouhong Zhou
{"title":"Ferroptosis: a new target for depression prevention and treatment.","authors":"Wenxuan Liang, Haowei Guo, Luyao Li, Wupeng Tan, Jianfeng Liu, Xiaoli Hu, Yuchu Wang, Shouhong Zhou","doi":"10.1007/s00702-025-02912-4","DOIUrl":"10.1007/s00702-025-02912-4","url":null,"abstract":"<p><p>Depression, a significant mental health issue, is one of the diseases with the highest disability rates worldwide. The exact etiology of depression remains undetermined, complicating the development of treatment strategies targeting specific mechanisms, and there is currently no effective cure. In this context, ferroptosis may represent a breakthrough in the understanding of depression. Ferroptosis is primarily associated with iron accumulation and lipid peroxidation, and recent studies have revealed its potential association with depression. Clinical evidence suggests that ferroptosis may influence the development and function of the hippocampus through interactions with neuroinflammation. Activated microglia, astrocytes, and neurons are involved in ferroptosis. This review summarizes recent findings on how ferroptosis contributes to depression, including glutathione peroxidase 4 (GPX4), nuclear factor-erythroid 2-related factor 2 (Nrf2), phase separation, and neuroinflammatory pathways, allowing the proposal of some new hypotheses. We hope that exploring the role of ferroptosis in the mechanism of depression will offer a new perspective on the complex biological basis of depression and provide theoretical support for the development of new therapeutic methods.</p>","PeriodicalId":16579,"journal":{"name":"Journal of Neural Transmission","volume":" ","pages":"979-997"},"PeriodicalIF":3.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143997617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ventral STN stimulation is associated with improved axial motor outcomes in Parkinson's disease. 腹侧STN刺激与帕金森病轴向运动结果的改善有关。
IF 3.2 4区 医学
Journal of Neural Transmission Pub Date : 2025-07-01 Epub Date: 2025-04-24 DOI: 10.1007/s00702-025-02931-1
Madison Butler, Asra Askari, Brandon Zhu, Kara Wyant, Daniel Leventhal, Parag G Patil, Kelvin L Chou
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