Therapeutic potential of COX-2 inhibitors in neuropsychiatric disorders.

IF 3.2 4区医学 Q2 CLINICAL NEUROLOGY

Journal of Neural Transmission Pub Date : 2025-07-01 Epub Date: 2025-05-05 DOI:10.1007/s00702-025-02932-0

Veerta Sharma, Prateek Sharma, Thakur Gurjeet Singh

{"title":"Therapeutic potential of COX-2 inhibitors in neuropsychiatric disorders.","authors":"Veerta Sharma, Prateek Sharma, Thakur Gurjeet Singh","doi":"10.1007/s00702-025-02932-0","DOIUrl":null,"url":null,"abstract":"<p><p>Neuropsychiatric disorders such as bipolar disorder, migraine, major depressive disorder, epilepsy, attention-deficit/hyperactivity disorder, autism spectrum disorder and schizophrenia, are a huge burden on global health, impacting millions of individuals worldwide and posing significant barriers to effective treatment. Despite advancements in medication and psychotherapy, many patients continue to suffer from severe symptoms and receive little alleviation. All of these conditions are quite frequent, yet they affect people in a way that is exceedingly detrimental. The increasing evidence suggests the connection between these disorders and inflammation. Therefore, the use of anti-inflammatory agents, namely cyclooxygenase-2 (COX-2) inhibitors, offers a new approach to prevent and treat neuropsychiatric disorders. This review discusses about the COX pathway and the role of COX-2 in the neuroinflammation. Furthermore, this review highlights the COX-2 inhibitors as a promising therapeutic agent in these neuropsychiatric disorders, however, further studies are required to assess appropriate illness stage-related indication.</p>","PeriodicalId":16579,"journal":{"name":"Journal of Neural Transmission","volume":" ","pages":"999-1011"},"PeriodicalIF":3.2000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Neural Transmission","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00702-025-02932-0","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/5/5 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Neuropsychiatric disorders such as bipolar disorder, migraine, major depressive disorder, epilepsy, attention-deficit/hyperactivity disorder, autism spectrum disorder and schizophrenia, are a huge burden on global health, impacting millions of individuals worldwide and posing significant barriers to effective treatment. Despite advancements in medication and psychotherapy, many patients continue to suffer from severe symptoms and receive little alleviation. All of these conditions are quite frequent, yet they affect people in a way that is exceedingly detrimental. The increasing evidence suggests the connection between these disorders and inflammation. Therefore, the use of anti-inflammatory agents, namely cyclooxygenase-2 (COX-2) inhibitors, offers a new approach to prevent and treat neuropsychiatric disorders. This review discusses about the COX pathway and the role of COX-2 in the neuroinflammation. Furthermore, this review highlights the COX-2 inhibitors as a promising therapeutic agent in these neuropsychiatric disorders, however, further studies are required to assess appropriate illness stage-related indication.

查看原文本刊更多论文

COX-2抑制剂在神经精神疾病中的治疗潜力。

双相情感障碍、偏头痛、重度抑郁症、癫痫、注意力缺陷/多动障碍、自闭症谱系障碍和精神分裂症等神经精神疾病是全球健康的巨大负担，影响到全世界数百万人，并对有效治疗构成重大障碍。尽管药物和心理治疗取得了进步，但许多患者仍然患有严重的症状，而且几乎没有得到缓解。所有这些情况都很常见，但它们对人们的影响却是极其有害的。越来越多的证据表明，这些疾病与炎症之间存在联系。因此，使用抗炎药物，即环氧化酶-2 （COX-2）抑制剂，为预防和治疗神经精神疾病提供了一种新的途径。本文就COX通路及COX-2在神经炎症中的作用作一综述。此外，这篇综述强调了COX-2抑制剂作为一种有前景的治疗这些神经精神疾病的药物，然而，需要进一步的研究来评估适当的疾病阶段相关适应症。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Neural Transmission 医学-临床神经学

CiteScore

7.20

自引率

3.00%

发文量

112

审稿时长

2 months

期刊介绍： The investigation of basic mechanisms involved in the pathogenesis of neurological and psychiatric disorders has undoubtedly deepened our knowledge of these types of disorders. The impact of basic neurosciences on the understanding of the pathophysiology of the brain will further increase due to important developments such as the emergence of more specific psychoactive compounds and new technologies. The Journal of Neural Transmission aims to establish an interface between basic sciences and clinical neurology and psychiatry. It intends to put a special emphasis on translational publications of the newest developments in the field from all disciplines of the neural sciences that relate to a better understanding and treatment of neurological and psychiatric disorders.