Journal of Neural Transmission最新文献_第4页

Differential patterns of executive dysfunction across depressive phenotype in schizophrenia and major depressive disorder. 精神分裂症和重度抑郁症患者抑郁表型中执行功能障碍的差异模式。

IF 3.2 4区医学

Journal of Neural Transmission Pub Date : 2025-04-27 DOI: 10.1007/s00702-025-02929-9

Yunxuan Ping, Nannan Liu, Tongxin Li, Chenghao Lu, Min Zeng, Xiao Zhang, Linxuan Wang, Jingxuan Liu, Shen Li, Jie Li

{"title":"Differential patterns of executive dysfunction across depressive phenotype in schizophrenia and major depressive disorder.","authors":"Yunxuan Ping, Nannan Liu, Tongxin Li, Chenghao Lu, Min Zeng, Xiao Zhang, Linxuan Wang, Jingxuan Liu, Shen Li, Jie Li","doi":"10.1007/s00702-025-02929-9","DOIUrl":"https://doi.org/10.1007/s00702-025-02929-9","url":null,"abstract":"Executive functioning (EF) deficits are common in both schizophrenia (SZ) and major depressive disorder (MDD). However, it remains unclear whether specific EF subdomains are differently affected in SZ and MDD, particularly in relation to depressive symptoms. This study aims to investigate EF subdomains in MDD, SZ with depressive symptoms (SZ-D), SZ without depressive symptoms (SZ-ND) and healthy controls (HC), and to explore the relationships between psychopathological symptoms and EF performance. A total of 213 participants were recruited, including 76 MDD, 81 SZ patients and 56 HC. EF was assessed using the n-back, Stroop color-word and more-odd shifting tasks. The 17-item Hamilton Depression Scale, Hamilton Anxiety Scale and Positive and Negative Syndrome Scale were used to assess depression, anxiety and psychopathological symptoms. In the 2-back task, SZ-D patients had longer response time (RT) (p < 0.01), while SZ-ND patients had lower accuracy rates (AR) (p < 0.01) compared to MDD patients and HC. In more-odd shifting task, SZ-D patients showed longer RT for shift cost (p < 0.01), and SZ-ND patients had lower AR for shift cost (p < 0.01) compared to MDD and HC. Multiple regression analysis revealed that negative symptoms were associated with AR in the 2-back condition in SZ-D, while in SZ-ND, negative symptoms was related to AR in the 1-back condition. SZ patients showed more severe EF dysfunction, with depressive symptoms in SZ primarily affecting response speed rather than accuracy. Negative symptoms were associated with EF dysfunction in both MDD and SZ patients.","PeriodicalId":16579,"journal":{"name":"Journal of Neural Transmission","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143988781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ventral STN stimulation is associated with improved axial motor outcomes in Parkinson's disease. 腹侧STN刺激与帕金森病轴向运动结果的改善有关。

IF 3.2 4区医学

Journal of Neural Transmission Pub Date : 2025-04-24 DOI: 10.1007/s00702-025-02931-1

Madison Butler, Asra Askari, Brandon Zhu, Kara Wyant, Daniel Leventhal, Parag G Patil, Kelvin L Chou

{"title":"Ventral STN stimulation is associated with improved axial motor outcomes in Parkinson's disease.","authors":"Madison Butler, Asra Askari, Brandon Zhu, Kara Wyant, Daniel Leventhal, Parag G Patil, Kelvin L Chou","doi":"10.1007/s00702-025-02931-1","DOIUrl":"https://doi.org/10.1007/s00702-025-02931-1","url":null,"abstract":"Subthalamic nucleus (STN) deep brain stimulation (DBS) is well-established for improving appendicular motor signs but its effect on axial motor signs is less clear. Additionally, the location of active electrode contact within the STN has been shown to differentially affect motor outcomes. We investigate the effect of STN DBS and the role of active electrode contact location on axial motor outcomes. Axial scores were assessed in 70 patients with advanced PD between 6 and 12 months after bilateral STN DBS. Repeated measures one-way ANOVA was performed to compare the mean axial motor scores between different medication and stimulation treatment conditions. Multiple linear regression was performed to determine the association between electrode contact location and axial motor score. The mean duration of follow-up was 7.37 ± 2.49 months. The mean total axial score was improved with STN DBS compared to the OFF MED-OFF STIM condition (6.36 ± 4.50 vs. 8.91 ± 5.49, p < 0.0001). A more dorsal electrode contact location on the right was associated with increased (worsened) total axial score (slope = 0.407, p = 0.0047). Total axial score was also lower (improved) in the anterior ventral STN region but not the posterior ventral STN region on the right. STN DBS improves total axial score and several axial subscores in patients with PD 6-12 months postoperatively. A more ventral electrode contact location on the right was associated with improved axial score. Additional research is warranted to determine if this is the optimal stimulation location to improve axial signs in other DBS cohorts.","PeriodicalId":16579,"journal":{"name":"Journal of Neural Transmission","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144025900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vital nutrition: enhancing health in advanced Parkinson's disease with device-aided therapies. 重要营养：用设备辅助疗法增强晚期帕金森病的健康。

IF 3.2 4区医学

Journal of Neural Transmission Pub Date : 2025-04-24 DOI: 10.1007/s00702-025-02935-x

Onanong Phokaewvarangkul, Ioanna Markaki, Harmen R Moes, Igor Petrovic, Anette Schrag, Roongroj Bhidayasiri

引用次数: 0

Alcohol-induced accumbal dopamine- and taurine release in female and male Wistar rats, an in vivo microdialysis study. 酒精诱导雌性和雄性Wistar大鼠伏隔多巴胺和牛磺酸释放，一项体内微透析研究。

IF 3.2 4区医学

Journal of Neural Transmission Pub Date : 2025-04-18 DOI: 10.1007/s00702-025-02928-w

Anna Loftén, Karin Ademar, Klara Danielsson, Bo Söderpalm, Louise Adermark, Mia Ericson

{"title":"Alcohol-induced accumbal dopamine- and taurine release in female and male Wistar rats, an in vivo microdialysis study.","authors":"Anna Loftén, Karin Ademar, Klara Danielsson, Bo Söderpalm, Louise Adermark, Mia Ericson","doi":"10.1007/s00702-025-02928-w","DOIUrl":"https://doi.org/10.1007/s00702-025-02928-w","url":null,"abstract":"Alcohol use disorder (AUD) is a relapsing brain disorder involving major neurobiological changes. Upon alcohol exposure, dopamine (DA) levels increase in the nucleus accumbens (nAc), a key region of the mesolimbic DA system involved in reward and reinforcement. A concomitant increase in extracellular taurine within the nAc has been shown to be important for the alcohol-induced DA increase. Sex differences in alcohol consumption and in the development of AUD have previously been shown. However, knowledge regarding sex differences in alcohol-induced DA and concomitant taurine release is limited. The aim of this study was to examine potential sex differences in alcohol-induced increases of extracellular levels of DA and taurine within the nAc, following local and systemic alcohol administration. To this end, in vivo microdialysis was performed using male and female Wistar rats. Following systemic alcohol administration, both male and female rats displayed a significant increase of both DA and taurine within the nAc, with no observed sex differences. In contrast, males displayed a significant increase in both DA and taurine following alcohol administration locally into the nAc whilst female rats displayed a blunted DA response and an attenuated taurine increase. Basal levels of DA or taurine did not differ significantly between males and females. The results presented here suggest that local accumbal mechanisms contribute to a greater extent to the alcohol-induced DA increase in male compared to female rats, whilst the response to systemic alcohol administration is similar between sexes.","PeriodicalId":16579,"journal":{"name":"Journal of Neural Transmission","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of DAGLB variants in Japanese early-onset Parkinson's disease. 日本早发性帕金森病DAGLB变异的鉴定

IF 3.2 4区医学

Journal of Neural Transmission Pub Date : 2025-04-17 DOI: 10.1007/s00702-025-02926-y

Yue Luo, Manabu Funayama, Taku Hatano, Yuanzhe Li, Hiroyo Yoshino, Satoshi Yamashita, Akira Mori, Ryoichi Nakamura, Yoshio Hashizume, Mari Yoshida, Yuichi Riku, Naomi Kanzato, Nobutaka Hattori

{"title":"Identification of DAGLB variants in Japanese early-onset Parkinson's disease.","authors":"Yue Luo, Manabu Funayama, Taku Hatano, Yuanzhe Li, Hiroyo Yoshino, Satoshi Yamashita, Akira Mori, Ryoichi Nakamura, Yoshio Hashizume, Mari Yoshida, Yuichi Riku, Naomi Kanzato, Nobutaka Hattori","doi":"10.1007/s00702-025-02926-y","DOIUrl":"https://doi.org/10.1007/s00702-025-02926-y","url":null,"abstract":"Hereditary factors play a significant role in the development of Parkinson's disease and the identification of causative genes is ongoing. Biallelic variants in Diacylglycerol lipase β (DAGLB) are related to early-onset Parkinson's disease (EOPD) in the Chinese population, and have also been identified in an Algerian case. To date, no EOPD cases with DAGLB variants have been reported among Japanese patients. This study was conducted to clarify the occurrence of DAGLB variants among Japanese EOPD patients. We screened 270 patients with sporadic EOPD (male: female ratio, 1.37:1; mean age at onset ± standard deviation, 37.32 ± 7.91 years), and 276 patients with suspected autosomal recessive Parkinson's disease (ARPD, male: female ratio, 0.75:1; mean age at onset ± standard deviation, 58.86 ± 14.67 years). Genetic screening of all coding exons and flanking splicing regions was performed by Sanger sequencing. We identified two rare biallelic variants in two patients, both from consanguineous families. One variant was a homozygous frameshift variant (c.1770_1771del, p.Tyr591ProfsTer26), which was predicted to be pathogenic. The other was a missense variant (c.1444T > C, p.Tyr482His) and was predicted to be benign, with co-segregation ruled out for this variant. We identified a pathogenic variant in the DAGLB gene. Together with previous reports, these findings provide further evidence that loss-of-function variants in DAGLB are involved in EOPD in the Japanese population.","PeriodicalId":16579,"journal":{"name":"Journal of Neural Transmission","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144012250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sphingolipidoses: expanding the spectrum of α-synucleinopathies. 鞘脂病：扩大α-突触核蛋白病的范围。

IF 3.2 4区医学

Journal of Neural Transmission Pub Date : 2025-04-17 DOI: 10.1007/s00702-025-02925-z

Daniel Erskine, Agnieszka K Bronowska, Tiago F Outeiro, Johannes Attems

{"title":"Sphingolipidoses: expanding the spectrum of α-synucleinopathies.","authors":"Daniel Erskine, Agnieszka K Bronowska, Tiago F Outeiro, Johannes Attems","doi":"10.1007/s00702-025-02925-z","DOIUrl":"https://doi.org/10.1007/s00702-025-02925-z","url":null,"abstract":"Although α-synuclein pathology is typically associated with Lewy body diseases and multiple systems atrophy, increasing evidence indicates that it also occurs in a group of lysosomal storage disorders termed sphingolipidoses caused by the incomplete degradation, and subsequent accumulation, of a class of lipids termed sphingolipids. Notably, a number of genes that cause sphingolipidoses are also risk genes for Lewy body diseases, suggesting aetiological links between these distinct disorders. In the present review, we discuss the sphingolipidoses in which α-synuclein pathology has been reported: Gaucher disease, Krabbe disease, metachromatic leukodystrophy, Tay-Sachs disease and Anderson-Fabry disease, and describe the characteristic clinical and pathological features of these disorders, in addition to the evidence suggesting α-synuclein pathology occurs in these disorders. Finally, we evaluate the pathological mechanisms that underlie these rare disorders, with particular attention to how the enzymatic deficiency, substrate accumulation, or both, could contribute to the genesis of α-synuclein pathology and the implications of this for Lewy body diseases.","PeriodicalId":16579,"journal":{"name":"Journal of Neural Transmission","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143968155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optical coherence tomography reveals retinal structural abnormalities in α-synucleinopathies: insights from the Padua-CESNE cohort. 光学相干断层扫描显示α-突触核蛋白病的视网膜结构异常：来自Padua-CESNE队列的见解。

IF 3.2 4区医学

Journal of Neural Transmission Pub Date : 2025-04-15 DOI: 10.1007/s00702-025-02918-y

M Campagnolo, M Puthenparampil, A Emmi, L Weis, E Basili, V Mauceri, A Miscioscia, M Carecchio, A Guerra, V Misenti, C Fogliano, P Gallo, A Antonini

{"title":"Optical coherence tomography reveals retinal structural abnormalities in α-synucleinopathies: insights from the Padua-CESNE cohort.","authors":"M Campagnolo, M Puthenparampil, A Emmi, L Weis, E Basili, V Mauceri, A Miscioscia, M Carecchio, A Guerra, V Misenti, C Fogliano, P Gallo, A Antonini","doi":"10.1007/s00702-025-02918-y","DOIUrl":"https://doi.org/10.1007/s00702-025-02918-y","url":null,"abstract":"The complexity of α-synucleinopathies, namely Parkinson's disease (PD) and multiple system atrophy (MSA), calls for the adoption a multimodal approach integrating biological, morphological, and functional data. Phosphorylated α-synuclein (α-syn) detection in bodily fluids and tissues such as the skin helps provide biological characterization of the disease, but specific and accessible biomarkers are not available yet. The aim of this study was to define the role of Optical Coherence Tomography (OCT, a minimally invasive retinal imaging technique) patterns as possible biomarkers in the early stages of α-synucleinopathies, also supporting the differential diagnosis. Thirty-five (23 PD, 12 MSA), clinically, biologically and genetically characterized patients included in the PADUA-CESNE (Centro Studi per la Neurodegenerazione) cohort underwent OCT. A significant atrophy in the inferior, superior and temporal regions of the Retinal Nerve Fiber Layer (RNFL) and in the inner nuclear layer (INL) were observed in PD compared to controls, differently from MSA. Hyperreflective foci (HRF) counts were elevated across all retinal layers in all patients with PD exhibiting significantly higher numbers, suggesting microglial activation and greater retinal damage. Further research regarding OCT patterns in PD and MSA may consolidate the role of specific features, such as INL abnormalities and different HRF counts, in supporting the diagnosis and differential diagnosis in α-synucleinopathies. In light of the availability of potentially disease-modifying therapies, studies should focus on newly diagnosed patients, also undergoing thorough clinical, biological and genetic characterization.","PeriodicalId":16579,"journal":{"name":"Journal of Neural Transmission","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143967437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Co-occurrence of parkinson disease and multiple sclerosis - a critical note. 帕金森氏症和多发性硬化症的共存——一个关键的注意事项。

IF 3.2 4区医学

Journal of Neural Transmission Pub Date : 2025-04-11 DOI: 10.1007/s00702-025-02922-2

Kurt A Jellinger

{"title":"Co-occurrence of parkinson disease and multiple sclerosis - a critical note.","authors":"Kurt A Jellinger","doi":"10.1007/s00702-025-02922-2","DOIUrl":"https://doi.org/10.1007/s00702-025-02922-2","url":null,"abstract":"While multiple sclerosis (MS) is associated with various movement disorders, in particular tremor and ataxia, its combination with parkinsonism is rare and co-occurrence of MS and Parkinson disease (PD) has been reported in only few definite cases. Theories about this co-occurrence range from coincidental to causal, but the true prevalence, basic features and causal relations between the two entities have not been systemically evaluated. Although there are cases of causal relationship between parkinsonism and MS related to demyelinating lesions affecting the dopaminergic nigrostriatal pathway, in a limited number of cases, PD (some gene-mediated) and MS may coexist as two separate diseases in the same patients. The prevalence of MS in LRRK2 PD, while rare, supports an important role for immune function in both disorders, while the role of PD-related PINK is still open. Furthermore, several common genes such as BACE2, CD69, CLC, CPA3 and DEFAs may play important roles in MS and PD, while MS and PD share iron accumulation in substantia nigra, which may be due to protein-protein interaction networks related to metal homeostasis. In view of the various pathogenic possibilities, the causal relationship of concurring MS and PD deserves critical consideration.","PeriodicalId":16579,"journal":{"name":"Journal of Neural Transmission","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143970586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuroimaging in multiple system atrophy: clinical implications and novel developments. 多系统萎缩的神经影像学：临床意义和新进展。

IF 3.2 4区医学

Journal of Neural Transmission Pub Date : 2025-04-11 DOI: 10.1007/s00702-025-02921-3

Wolfgang H Jost, Alexander Rau, Joachim Brumberg, Horst Urbach, Philipp T Meyer, Nils Schröter

{"title":"Neuroimaging in multiple system atrophy: clinical implications and novel developments.","authors":"Wolfgang H Jost, Alexander Rau, Joachim Brumberg, Horst Urbach, Philipp T Meyer, Nils Schröter","doi":"10.1007/s00702-025-02921-3","DOIUrl":"https://doi.org/10.1007/s00702-025-02921-3","url":null,"abstract":"Multiple system atrophy (MSA) is a neurodegenerative disorder characterized by cerebellar dysfunction, a Parkinsonian syndrome with poor response to levodopa and autonomic failure. The diagnosis of MSA is particularly challenging in its early stages due to symptom overlap with other neurodegenerative Parkinson syndromes. Recent advances in neuroimaging have greatly improved the accuracy of the diagnosis in clinical routine and provided valuable insights into the pathophysiology and progression of MSA. Macrostructural MRI shows atrophy in regions such as the putamen and pontocerebellar regions, distinguishing MSA from other Parkinson syndromes. Advanced imaging techniques, including diffusion tensor imaging (DTI), free water imaging and quantitative susceptibility mapping, add further value in assessing disease progression. While dopamine transporter (DAT) imaging is the mainstay for confirmation of nigrostriatal degeneration in suspected neurodegenerative Parkinson syndromes and may enable to identify prodromal cases, cardiac sympathetic imaging with [123I]MIBG scintigraphy may be used for delineation of MSA from Parkinson's disease (PD). Positron emission tomography (PET) with the glucose analogue [18F]FDG depicts disease-specific metabolic patterns in MSA and various neurodegenerative diseases, which do not only enable a highly accurate differential diagnosis of MSA (e.g., from PD and other atypical Parkinson syndromes) but also carry important prognostic and pathophysiological information. Various other PET radiopharmaceuticals currently under investigation in MSA provide novel insights into neurotransmitter system changes, glial pathology and, most recently, α-synuclein pathology. These imaging modalities considerably expand the diagnostic and prognostic capabilities in MSA and may provide important biomarkers for tracking disease development, progression and treatment.","PeriodicalId":16579,"journal":{"name":"Journal of Neural Transmission","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pathomechanisms of neuropsychiatric disturbances in atypical parkinsonian disorders: a current view. 非典型帕金森病中神经精神障碍的病理机制：当前观点。

IF 3.2 4区医学

Journal of Neural Transmission Pub Date : 2025-04-01 Epub Date: 2025-02-15 DOI: 10.1007/s00702-025-02890-7

Kurt A Jellinger

{"title":"Pathomechanisms of neuropsychiatric disturbances in atypical parkinsonian disorders: a current view.","authors":"Kurt A Jellinger","doi":"10.1007/s00702-025-02890-7","DOIUrl":"10.1007/s00702-025-02890-7","url":null,"abstract":"Multiple system atrophy (MSA), corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP) are the most common atypical parkinsonisms. These adult-onset and lethal neurodegenerative disorders of unknown etiology are clinically characterized by varying combinations of autonomic, levodopa-poorly responsive parkinsonsm, motor, non-motor, cerebellar syndromes, behavioral, cognitive and other neuropsychiatric disorders. Although their pathological hallmarks are different-MSA α-synucleinopathy, CBD and PSP 4-repeat (4R) tauopathies-their neuropsychiatric disturbances include anxiety, depression, agitations, attention-executive dysfunctions, less often compulsive and REM sleep behavior disorders (RBD), which may contribute to disease progression and reduced quality of life (QoL) of patients and caregivers. The present paper reviews the prevalence and type of neuropsychiatric profile in these atypical parkinsonian syndromes, their neuroimaging, and pathogenic backgrounds based on extensive literature research. MSA patients show anxiety, apathy (depression), initial RBD, attentional and executive dysfunction; PSP patients present with apathy, depression, disinhibition, and to a lesser extent, anxiety and agitation; CBD patients are featured by executive and visuospatial dysfunctions, irritability, alien limb phenomena, sleep and language disorders. Neuropsychiatric disorders in these syndromes are often similar, due to disruption of prefronto-subcortical (limbic) and striato-thalamo-cortical circuitries or default mode and attention network disorder. This supports the concept that they are brain network disorders due to complex pathogenic mechanisms related to the basic proteinopathies that are still poorly understood. Psychotic symptoms, hallucinations and delusions are rare. Neuropsychiatric changes in these disorders are often premature and anticipate motor dysfunctions; their assessment and further elucidation of their pathogenesis are warranted as a basis for early diagnosis and adequate treatment of these debilitating comorbidities.","PeriodicalId":16579,"journal":{"name":"Journal of Neural Transmission","volume":" ","pages":"495-518"},"PeriodicalIF":3.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0