Ophthalmologica Indonesiana最新文献_第8页

THE EFFECT OF ORAL VITAMIN D ON TUMOR NECROSIS FACTOR-? EXPRESSION IN TRABECULAR MESHWORK OF WISTAR GLAUCOMA MODEL 口服维生素 d 对小梁网膜中肿瘤坏死因子表达的影响表达的影响

Ophthalmologica Indonesiana Pub Date : 2024-02-12 DOI: 10.35749/vrszrr85

Rikha Erina, Andrini Ariesti, Hendriati

{"title":"THE EFFECT OF ORAL VITAMIN D ON TUMOR NECROSIS FACTOR-? EXPRESSION IN TRABECULAR MESHWORK OF WISTAR GLAUCOMA MODEL","authors":"Rikha Erina, Andrini Ariesti, Hendriati","doi":"10.35749/vrszrr85","DOIUrl":"https://doi.org/10.35749/vrszrr85","url":null,"abstract":"Introduction & ObjectivesElevated intraocular pressure (IOP) is a risk factor for the development and progression of glaucomathat can induces inflammation in the trabecular meshwork through the production of proinflammatorycytokines such as TNF-?. Inflammation induce mechanical stress and changes in theextracellular matrix in the trabecular meshwork, resulting in hypertonicity and resistance toaqueous humor outflow. Vitamin D can modulate cytokine production by suppressing TH1 cellexpression and inducing TH2 cell expression. The production of pro-inflammatory cytokines can besuppressed by the presence of vitamin D. \u0000MethodsAn experimental study of 30 wistar glaucoma model were divided into 3 groups, non treatmentgroup ( A and B) and the oral vitamin D (1200 IU/kg/day) group (C) for 14 days. TNF-? expressionsin trabecular meshwork were measured by immunohistochemical staining. Group A was measuredon day 3, while group B and C were measured on day 14. The differences between the three groupswere analyzed statistically using one way ANOVA test. Significantly different if the p<0.05. \u0000ResultsThe mean expression of TNF- ? in the trabecular meshwork of wistar glaucoma model in group A, B,and C was 22,2 ± 2,51%, 39,1 ± 3.98%, 34.2 ± 3,19 % respectively. There was significantlydifference in TNF-? expressions between the three groups (p<0.001). \u0000ConclusionVitamin D per oral can decrease TNF-? expression in the trabecular meshwork of wistar glaucomamodel on day 14 . Studies in wistar and humans are still needed to assess the effect of vitamin D onothers pro-inflammatory cytokines in glaucoma.","PeriodicalId":165753,"journal":{"name":"Ophthalmologica Indonesiana","volume":"35 19","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139782525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Challenges in Diagnosing Functional Visual Loss and Malingering: a Case Report 诊断功能性视力丧失和误诊的挑战：病例报告

Ophthalmologica Indonesiana Pub Date : 2024-02-12 DOI: 10.35749/01gvwf45

Rona Ali Badjrai, Sarah Shabrina, Subandono Bambang Indrasto, Arlin Chyntia Dewi

{"title":"Challenges in Diagnosing Functional Visual Loss and Malingering: a Case Report","authors":"Rona Ali Badjrai, Sarah Shabrina, Subandono Bambang Indrasto, Arlin Chyntia Dewi","doi":"10.35749/01gvwf45","DOIUrl":"https://doi.org/10.35749/01gvwf45","url":null,"abstract":"Abstract \u0000Introduction : Functional Visual Loss (FVL) is decreased visual acuity and/or altered visual fields without any associated organic pathology and is considered within the spectrum of malingering. It manifests as either simulating an ophthalmic disease or denying ophthalmic disease. Thorough history-taking and careful examination of the patient are essential in reaching the diagnosis. \u0000Case Illustration : A 17-year-old female came with complaints of a spinning headache, sudden and painless blurry vision in both eyes, double vision, and a history of syncope for the last two days. Ophthalmology examination revealed UCVA was 0.5/60 for both eyes with inconsistent answers from the patient. The confrontation test, light reflex, funduscopy, Humphrey visual test, OCT, and MRI were normal. Malingering was suspected and a psychiatric consultation was made. The patient was found to be a victim of bullying and had a history of visual hallucinations. The patient was then diagnosed with severe depression with psychotic signs. \u0000Discussion : \u0000Conclusion : FVL can be suspected when there is inconsistency in the results of some clinical basic tests. Despite the association between FVL and psychological problems like depression is complicated, this condition may occur in a bidirectional relationship in which depression leads to disability or contrarily. In conclusion, diagnosing visual problems in malingering patients can be challenging. Subjective and objective tests are needed to help practitioners confirm the malingering state of the patient. Practitioners also should be aware of the underlying risk of psychological problems among persons reporting visual function loss.","PeriodicalId":165753,"journal":{"name":"Ophthalmologica Indonesiana","volume":"33 15","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139782591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Relationship between Characteristics and Underlying Eye Disorders with Optical Aid Selection and Visual Acuity Status Differences in Children with Low Vision Before and After Optical Aid Selection 选择助视器前后低视力儿童的特征和潜在眼疾与助视器选择和视力状况差异之间的关系

Ophthalmologica Indonesiana Pub Date : 2024-02-12 DOI: 10.35749/6mad5m93

Andityo Sidohutomo, Ria Sandy Deneska, R. Loebis

{"title":"The Relationship between Characteristics and Underlying Eye Disorders with Optical Aid Selection and Visual Acuity Status Differences in Children with Low Vision Before and After Optical Aid Selection","authors":"Andityo Sidohutomo, Ria Sandy Deneska, R. Loebis","doi":"10.35749/6mad5m93","DOIUrl":"https://doi.org/10.35749/6mad5m93","url":null,"abstract":"Background: Low vision is a vision disorder that can have a significant impact on a person's independence, especially in children. According to WHO data from 2019, 246 million people suffer from low vision. Ophthalmologists must prioritize low-vision services such as refractive correction and low-vision assessment. This study aims to learn more about the relationship between characteristics and underlying eye disorders with optical aid selection, as well as differences in visual acuity status in children with low vision before and after optical aid selection. \u0000Methods: This study was an analytic observational retrospective cohort using medical records of children with low vision in RSUD Dr. Soetomo Surabaya. This study analyzed the relationship between characteristics (gender, age, education level, intervention history) and underlying eye disorders with optical aid selection using the Chi-Square test, while visual acuity status differences before and after optical aid selection were analyzed using the Wilcoxon test. \u0000Results: There were no relationships between characteristics (gender, age, education level, intervention history) and underlying eye disorders with optical aid selection (p > 0.05). There were differences in visual acuity status before and after optical aid selection (p < 0.05) with a minimum decrease of 0.1 logMAR which means an increase in visual acuity in all 72 samples of children with low vision after optical aid selection. \u0000Conclusion: These data provide new evidence of essential links between visual acuity status before and after optical aid selection. However, characteristics (gender, age, education level, intervention history) and underlying eye disorders were not associated with optical aid selection.","PeriodicalId":165753,"journal":{"name":"Ophthalmologica Indonesiana","volume":"34 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139782616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

COENZYME Q10 EFFECT ON NMDA RECEPTOR EXPRESSION AND RETINAL GANGLION CELL DENSITY (Experimental Study in Traumatic Optic Neuropathy Model of Wistar Rat) 辅酶 Q10 对 NMDA 受体表达和视网膜神经胶质细胞密度的影响（创伤性视神经病变 Wistar 大鼠模型的实验研究）

Ophthalmologica Indonesiana Pub Date : 2024-02-12 DOI: 10.35749/1s6kza05

FRANSISKA BANJARNAHOR, Riski Prihatningtias, Trilaksana Nugroho, Hermawan Istiadi

{"title":"COENZYME Q10 EFFECT ON NMDA RECEPTOR EXPRESSION AND RETINAL GANGLION CELL DENSITY (Experimental Study in Traumatic Optic Neuropathy Model of Wistar Rat)","authors":"FRANSISKA BANJARNAHOR, Riski Prihatningtias, Trilaksana Nugroho, Hermawan Istiadi","doi":"10.35749/1s6kza05","DOIUrl":"https://doi.org/10.35749/1s6kza05","url":null,"abstract":"Abstract \u0000Introduction & Objectives : Traumatic optic neuropathy is a visual disturbance condition after acute injury to optic nerve. This injury results in retinal ganglion cells ischemic leading to excitotoxicity and apoptosis. Coenzyme Q10 (CoQ10) is an antioxidant and cofactor in electron transport within mitochondria that inhibits glutamate excitotoxicity and thereby preventing retinal ganglion cell apoptosis. This research aims to prove the effect of coenzyme Q10 on NMDA receptor expression and retinal ganglion cell density in rat model of traumatic optic neuropathy. \u0000Methods : This study use post-test only randomized controlled groups design. Traumatic optic neuropathy wistar rats model was made by optic nerve crushed method, then given oral CoQ10 100mg/kgBW after 1 hour for 14 days in treatment group. Retinal histopathological specimen was made with immunohistochemistry and Haematoxyllin-eosin staining and examined under microscope with 400x magnification. Data was verified and statistically analyzed. \u0000Results : The NMDA receptor expression in the treatment group was significantly lower than control (p=0.009). The retinal ganglion cell density in the treatment group was significantly higher than control (p=0.009). There was a significant correlation between NMDA receptor expression and retinal ganglion cell density in the treatment group (p = 0.012) with a strong negative correlation direction (r = - 0.652). \u0000Conclusion : Administration of CoQ10 in traumatic optic neuropathy model rats affects NMDA receptor expression and retinal ganglion cell density. NMDA receptor expression was lower with higher retinal ganglion cell density in the treatment group. NMDA receptor expression was inversely proportional to retinal ganglion cell density in the treatment group.","PeriodicalId":165753,"journal":{"name":"Ophthalmologica Indonesiana","volume":"1 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139782874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A GOOD RESULT IN COMBINATION OF LARGE SUPERIOR RECTUS RECESSION AND PRISMATIC GLASSES IN UNILATERAL DISSOCIATION VERTICAL DEVIATION: A CASE REPORT 在单侧分离性垂直偏斜中结合大直上肌后退和棱镜眼镜的良好效果：病例报告

Ophthalmologica Indonesiana Pub Date : 2024-02-12 DOI: 10.35749/wgjfj090

Nur Fitriana Corprianti Marchilia, Reni Prastyani

{"title":"A GOOD RESULT IN COMBINATION OF LARGE SUPERIOR RECTUS RECESSION AND PRISMATIC GLASSES IN UNILATERAL DISSOCIATION VERTICAL DEVIATION: A CASE REPORT","authors":"Nur Fitriana Corprianti Marchilia, Reni Prastyani","doi":"10.35749/wgjfj090","DOIUrl":"https://doi.org/10.35749/wgjfj090","url":null,"abstract":"Introduction : Severe DVD is one of the indications for surgery. There are guidelines recommended for management based on grading of severity and the surgeon’s preference. Large recession of superior rectus muscle and prismatic glasses yield good result in unilateral DVD reported in this paper. \u0000Case Illustration : A 21 year-old student stated difficulty in working with his microscope since 2 years ago. He had a history of double vision since childhood. The visual acuity in both eyes were 5/5. Qualitative strabismus examination resulted in hypertropia RE and intermittent exotropia. When the occluder was removed from RE, a non fixating eye would appear elevated and did not correspond with the contralateral eye hypotropia. Krimsky test revealed RE hypertropia 30? PD, exotropia 10? PD. Sensory evaluation using WFDT was normal in near and crossed diplopia in distance. Patient diagnosed with unilateral DVD then underwent superior rectus recession in 10 mm. The following month, patient was still experiencing vertical diplopia. The patient was given 3 PD prismatic glasses. Consequently, diplopia was absent and stereoacuity test using TNO was 480 seconds of arch \u0000Discussion : DVD can’t be fully corrected by surgery due to central cortical innervational problem. The residual symptom can be corrected by conservative management. Large SR recession in combination with prismatic glasses was found to improve vertical deviation and reduce diplopia. \u0000Conclusion : While large superior rectus recession can significantly improve vertical deviation, it can not completely remove binocular symptom","PeriodicalId":165753,"journal":{"name":"Ophthalmologica Indonesiana","volume":"15 17","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139783016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effects of Bevacizumab in Augmenting Trabeculectomy for Glaucoma : Systematic Review and Meta-Analysis 贝伐单抗对青光眼小梁切除术的增效作用：系统综述与元分析

Ophthalmologica Indonesiana Pub Date : 2024-02-12 DOI: 10.35749/byaet056

Richardo Rusli, Franky Kasih

{"title":"The Effects of Bevacizumab in Augmenting Trabeculectomy for Glaucoma : Systematic Review and Meta-Analysis","authors":"Richardo Rusli, Franky Kasih","doi":"10.35749/byaet056","DOIUrl":"https://doi.org/10.35749/byaet056","url":null,"abstract":"Introduction & Objectives : Anti-vascular endothelial growth factor (VEGF) agents have been used to slow the healing response and postoperative scar tissue formation. To determine the effectiveness of adding Anti VEGF bevacizumab to the results of trabeculectomy in glaucoma. \u0000Methods : Searches were conducted in a structured way using keywords across several data sources, including Pubmed, Proquest and Cochrane library. The keywords used for searching were “Bevacizumab”, “Trabeculectomy” and “Glaucoma”. The reviewed articles are Randomized Control Trial in english, conducted on humans in the last 15 years. The review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. \u0000Results : From a total of 353 articles, there were 6 studies with 362 eyes of 352 patients been evaluated for the effectiveness of bevacizumab addition to trabeculectomy. The primary outcome of all articles was the assessment of Intra Ocular Pressure (IOP). No significant difference in IOP was found between the subconjunctival bevacizumab + Mytomycin-c group and mytomycin-c alone group (MD 0.11 ; 95% CI -0.10 to 0.33), as well as subconjunctival comparison with mytomycin-c (MD 0.11 ; 95% CI -0.29 to 0.50). Similar results were also found in the intracameral and placebo groups (MD 0.08 ; -0.22 to 0.38). However, 3 articles reported significant differences in peripheral vascularity of the bleb both by the Moorfields Bleb Grading System and by the Indiana Bleb Appearance System. \u0000Conclusion : The addition of bevacizumab to trabeculectomy did not show any benefit in reducing IOP when compared with MMC. But it gives better peripheral vascularity of the bleb.","PeriodicalId":165753,"journal":{"name":"Ophthalmologica Indonesiana","volume":"21 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139783112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Correlation of CD4 Count and Dry Eye Disease (DED) Severity Among HIV Patients: A Case Study in Voluntary Counseling and Testing Clinic Prof Ngoerah General Hospital, Bali 艾滋病患者 CD4 细胞计数与干眼症 (DED) 严重程度的临床相关性：巴厘岛 Ngoerah 综合医院教授自愿咨询和检测诊所的案例研究

Ophthalmologica Indonesiana Pub Date : 2024-02-12 DOI: 10.35749/889m8k12

Putu Ayu Wulansari

{"title":"Clinical Correlation of CD4 Count and Dry Eye Disease (DED) Severity Among HIV Patients: A Case Study in Voluntary Counseling and Testing Clinic Prof Ngoerah General Hospital, Bali","authors":"Putu Ayu Wulansari","doi":"10.35749/889m8k12","DOIUrl":"https://doi.org/10.35749/889m8k12","url":null,"abstract":"Abstract \u0000Introduction & Objectives : Dry Eye Disease is a multi-factorial ocular surface and tear film instability disease. It has been reported as one of the most frequent anterior segment ocular manifestations in HIV patients, occurring late in the disease. The study aimed to investigate clinical correlation of CD4 count and severity of the disease. \u0000Methods : This study was a hospital based cross-sectional study where 75 HIV patients (150 eyes) aged 18-50 years old were referred to ophthalmology clinic in VCT for ocular surface related complaints and were included in the study. \u0000Results : The study showed significant moderate positive correlation between CD4 count with Tear Break Up Time (TBUT) (r-value=0.509;p-value=0.05) and negatively correlated with Ocular Surface Disease Index (OSDI) score (r-value=-0.252, p-value=0.035). There were a significant difference in CD4 count between mild and moderate dry eyes (p-value=0.005) and between mild and severe dry eyes (p-value=0.005), however no significant difference was observed between moderate and severe dry eyes (p value=0.435). The severity of dry eye in HIV patients also tends to differ in-between clinical stage of the disease (p value=0.513) and with the presence of co-infection (p value=0.228), although the result was not statistically significant. \u0000Conclusion : There is a correlation between CD4 Count and Dry Eye Disease severity among HIV patients. The lower the CD4, the higher the risk for HIV patients to get severe dry eye disease. This shows the importance of CD4 control and monitoring to prevent various ocular disease and manifestations related to HIV.","PeriodicalId":165753,"journal":{"name":"Ophthalmologica Indonesiana","volume":"36 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139783428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

VISUAL OUTCOME BETWEEN EARLY AND DELAYED VITRECTOMY IN ENDOPHTHALMITIS PATIENTS OPERATED IN KARIADI GENERAL HOSPITAL, SEMARANG : TWO YEARS DESCRIPTIVE STUDY 在塞马良 Kariadi 综合医院接受手术的眼底病患者早期和延迟玻璃体切除术之间的视觉效果：为期两年的描述性研究

Ophthalmologica Indonesiana Pub Date : 2024-02-12 DOI: 10.35749/9apdah80

Suci Rahmayanti, Satya Hutama Pragnanda

{"title":"VISUAL OUTCOME BETWEEN EARLY AND DELAYED VITRECTOMY IN ENDOPHTHALMITIS PATIENTS OPERATED IN KARIADI GENERAL HOSPITAL, SEMARANG : TWO YEARS DESCRIPTIVE STUDY","authors":"Suci Rahmayanti, Satya Hutama Pragnanda","doi":"10.35749/9apdah80","DOIUrl":"https://doi.org/10.35749/9apdah80","url":null,"abstract":"Introduction & ObjectivesEndophthalmitis is a medical emergency caused by infection of tissue or fluids inside the eyeball.Vitrectomy for endophthalmitis is one of the treatment choice and leads to VA gains in some cases.Timing of surgery and visual outcome after surgery are vital to acknowledge. This study aims toanalyze the difference of visual outcome between early and delayed vitrectomy in endophthalmitispatients operated in Dr. Kariadi General Hospital \u0000MethodsA Retrospective study held from medical record of patients with endophthalmitis underwentvitrectomy surgery from January 2021 – January 2023 in Dr. Kariadi General Hospital, Semarang.Endophthalmitis patients caused by trauma were excluded. All of the patients had immediatevitrectomy, and based on duration of symptoms, the patients were divided into two groups, earlyvitrectomy (duration of symptoms ? 7 days) and delayed vitrectomy (duration of symptoms > 7days). Independent t- test method was used to analyze the data (significant if p<0.05) \u0000ResultsTotally 30 endophthalmitis patients (30 eyes) were obtained. There were 18 patients (60%) had earlyvitrectomy and 12 patients (40%) had delayed vitrectomy. Postoperative examination showed 13(72%) patients with early vitrectomy had improved VA, and 5 (28%) had constant VA. On the otherhand, patients with delayed vitrectomy showed 5 (42%) had improved VA, 6 (50%) had constant VA,and 1 (8%) had decreased VA. The difference between two groups was significant (p=0.014) \u0000ConclusionThis study found endophthalmitis patients with early vitrectomy had significant better visualoutcome than delayed vitrectomy","PeriodicalId":165753,"journal":{"name":"Ophthalmologica Indonesiana","volume":"31 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139783483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of Changes in Quality of Life Based on Changes in Disease Severity in Graves Ophthalmopathy Patients Following Intraorbital Triamcinolone Acetonide Injection 根据疾病严重程度的变化比较巴塞杜氏眼病患者眶内注射曲安奈德后生活质量的变化

Ophthalmologica Indonesiana Pub Date : 2024-02-12 DOI: 10.35749/r46k6b08

LADY PRANODIA SUKMAWIDOWATI

{"title":"Comparison of Changes in Quality of Life Based on Changes in Disease Severity in Graves Ophthalmopathy Patients Following Intraorbital Triamcinolone Acetonide Injection","authors":"LADY PRANODIA SUKMAWIDOWATI","doi":"10.35749/r46k6b08","DOIUrl":"https://doi.org/10.35749/r46k6b08","url":null,"abstract":"Abstract \u0000Introduction & Objectives : Graves ophthalmopathy (GO) is associated with visual impairment and appearance changes, affecting the quality of life. Intraorbital injection of triamcinolone acetonide (TCA) in GO resulted in clinical improvement, but its effect on the quality of life is unknown. The objective of this study was to compare the changes in quality of life after intraorbital injection of TCA between different groups based on changes in disease severity. \u0000Methods : Intraorbital injection of TCA was performed on 30 subjects with GO. Disease severity was assessed according to the European Group of Graves Ophthalmopathy (EUGOGO) criteria. Quality of life was measured using the Indonesian version of Graves Ophthalmopathy Quality of Life (GO-QOL) questionnaire. Changes in disease severity and GO-QOL scores were recorded before intraorbital injection of TCA and 1 month after. Subjects were divided into groups based on changes in disease severity: decreased, remained constant, and increased. Changes in quality of life between the groups were compared statistically. \u0000Results : Changes in GO-QOL appearance scores in patients with decreased disease severity were significantly higher (p= 0.016) than those in patients whose disease severity remained constant. Changes in GO-QOL visual function scores in patients with decreased disease severity were higher but not statistically significant (p> 0.05) compared to those in patients whose disease severity remained constant. \u0000Conclusion : Changes in the appearance aspect of quality of life after intraorbital injection of TCA in patients with decreased disease severity are better than that in patients whose disease severity remained constant, whereas changes in the visual function aspect are not significantly different.","PeriodicalId":165753,"journal":{"name":"Ophthalmologica Indonesiana","volume":"81 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139783673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intravitreous aflibercept or vitrectomy for initial treatment of diabetic vitreous hemorrhage? A Systematic Review of Current Evidence 玻璃体内阿弗利百普或玻璃体切割术用于糖尿病玻璃体出血的初始治疗？当前证据的系统回顾

Ophthalmologica Indonesiana Pub Date : 2024-02-12 DOI: 10.35749/zjwqv392

Indra Utami Mutiara Ningrum, Marchia Primarhyani

{"title":"Intravitreous aflibercept or vitrectomy for initial treatment of diabetic vitreous hemorrhage? A Systematic Review of Current Evidence","authors":"Indra Utami Mutiara Ningrum, Marchia Primarhyani","doi":"10.35749/zjwqv392","DOIUrl":"https://doi.org/10.35749/zjwqv392","url":null,"abstract":"Introduction & Objectives : To assess the efficacy and safety of intravitreous aflibercept versus vitrectomy in patients with diabetic vitreous hemorrhage (VH) \u0000Methods : Cochrane Central Register of Controlled Trials, MEDLINE, and EMBASE database were searched. No constraints based on language or publication date were applied. Only randomized controlled trials (RCTs) comparing intravitreal aflibercept injection with vitrectomy procedure were included. Search results were screened independently by two authors. Data extraction and synthesis were performed according to The Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. The primary outcome measures were best-corrected visual acuity obtained at least 6 months following interventions, rate of recurrent hemorrhage, and periprocedural ocular adverse events. The quality of evidence was assessed using the GRADE tools. \u0000Results : Two clinical trials that randomized 239 eyes were included in this review. There was no evidence ofa difference in primary outcome of mean visual acuity at six months between randomized groups. However, patients receiving intravitreous aflibercept were more likely to experience recurrent VH than those undergoing vitrectomy (RR 3.12 95% CI 1.95 - 4.99, absolute effect of 32 more people with recurrent VH per 100 people treated with aflibercept). Rates of periprocedural ocular complications were similar in both groups. \u0000Conclusion : Intravitreous aflibercept safety and efficacy appear to be non-inferior compared to vitrectomy for initial management of diabetic VH. Further well-designed studies are needed to investigate the long- term effects of treatments.","PeriodicalId":165753,"journal":{"name":"Ophthalmologica Indonesiana","volume":"62 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139783743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0