Ophthalmologica Indonesiana最新文献_第9页

EFFECT OF MEMANTINE AS N-METHYL D-ASPARTATE RECEPTOR ANTAGONIST ON CASPASE-9 LEVEL OF RETINAL GANGLION CELL IN METHANOL TOXIC OPTIC NEUROPATHY RAT MODEL 美金刚作为 n-甲基 d-天冬氨酸受体拮抗剂对甲醇毒性视神经病变大鼠模型视网膜神经节细胞 Caspase-9 水平的影响

Ophthalmologica Indonesiana Pub Date : 2024-02-12 DOI: 10.35749/w4yryv09

Antonia Kartika, Rusti Hanindyasari, Dianita Veulina Ginting, Pretyllayolamada

{"title":"EFFECT OF MEMANTINE AS N-METHYL D-ASPARTATE RECEPTOR ANTAGONIST ON CASPASE-9 LEVEL OF RETINAL GANGLION CELL IN METHANOL TOXIC OPTIC NEUROPATHY RAT MODEL","authors":"Antonia Kartika, Rusti Hanindyasari, Dianita Veulina Ginting, Pretyllayolamada","doi":"10.35749/w4yryv09","DOIUrl":"https://doi.org/10.35749/w4yryv09","url":null,"abstract":"Abstract \u0000Introduction & Objectives : Methanol toxic optic neuropathy (MTON) remains as a health issue in developing countries and there are no current definitive treatments. Accumulation of formic acid as metabolite of methanol causes mitochondrial dysfunction that can reduce ATP synthesis rate, disrupt axoplasmic transport, and elevate the reactive oxygen species (ROS). All of these mechanisms lead to the death of retinal ganglion cell (RGC) and optic nerve. RGC destruction in MTON has similar patterns with those that have been observed in glaucoma, ischemia, and trauma cases, that is through excessive activation of glutamate neurotransmitter via N-Methyl D-Aspartate receptors (NMDAR). Memantine is a NMDAR antagonist that inhibit the ion channel of NMDAR. This inhibitory effect of NMDAR by memantine is expected to reduce intracellular calcium level, prevent apoptosis of RGC, and prevent further mitochondrial dysfunction. Caspase-9 is essential to eliminate cells by executing apoptotic Objective: To observe the effect of Memantine on Caspase-9 level of RGC in Methanol-Intoxicated Rats. \u0000Methods : This experimental study was performed on 28 Methanol-Intoxicated Rats that are assigned into four treatment groups: K1 (MTON;enucleated day-3), K2 (MTON+Memantine; enucleated day-3), K3 (MTON; enucleated day-7), and K4 (MTON+Memantine; enucleated day-7). During the experiment, all groups were exposed to N2O:O2 gas and were given methanol orally. Caspase-9 level of RGC were measured immediately after enucleation. \u0000Results : The average of Caspase-9 level (ng/ml): K1=197,88±33,98; K2=205,64±63,66; K3=243,15±40,13; K4=150,08±119,60. The Caspase-9 level was significantly lower in K4 compared to K3 (p value =0.038). \u0000Conclusion : Memantine decrease the level of Caspase-9 of RGC in Methanol Toxic Optic Neuropathy rat model.","PeriodicalId":165753,"journal":{"name":"Ophthalmologica Indonesiana","volume":"50 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139783932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DIFFERENT CONJUNCTIVAL AUTOGRAFT TECHNIQUES FOR PTERYGIUM SURGICAL EXCISION, A CASE SERIES 不同结膜自体移植技术用于翼状胬肉手术切除的病例系列

Ophthalmologica Indonesiana Pub Date : 2024-02-12 DOI: 10.35749/9gevkg97

ANNISAK FITRIYANA, Angga Fajriansyah, Arief Akhdestira Mustaram, Patriotika Muslima, Elfa Ali Idrus

{"title":"DIFFERENT CONJUNCTIVAL AUTOGRAFT TECHNIQUES FOR PTERYGIUM SURGICAL EXCISION, A CASE SERIES","authors":"ANNISAK FITRIYANA, Angga Fajriansyah, Arief Akhdestira Mustaram, Patriotika Muslima, Elfa Ali Idrus","doi":"10.35749/9gevkg97","DOIUrl":"https://doi.org/10.35749/9gevkg97","url":null,"abstract":"Abstract \u0000Introduction : Pterygium is a wing shaped fibrovascular growth that extends from the conjunctiva onto the cornea. There are many techniques available for pterygium removal, from simple excision to excision and repair of the defect with modified techniques. \u0000Case Illustration : 1. A 50-year-old woman presented with a grade II pterygium in both of her eyes. She was undergone sliding flap pterygium excision for her right eye. Case 2. A 32-year-old man presented with a grade II pterygium in his left eye. He was then undergone rotational flap pterygium excision for his left eye. Case 3 A-55-year-old woman presented with a grade II-III double head pterygium. She was later undergone modified conjunctival autograft double head pterygium excision for his left eye. \u0000Discussion : Surgical management is the gold standard for pterygium treatment. Indications for pterygium excision include decreased visual acuity due to astigmatism, obstruction of visual axis, repeated irritation and cosmetics. Surgical techniques for excision of the pterygium include bare sclera excision, tissue grafting using conjunctival graft, membrane transplantation amnion and limbal- conjunctival autograft. There are several choices of conjunctival graft techniques after pterygium excision, such as conjunctival sliding flap, conjunctival rotational flap, and modified conjunctival autograft. Modified conjunctival autograft technique was performed for double head pterygium management. The technique consisting of horizontally modified conjunctival autograft and vertically modified conjunctival autograft. \u0000Conclusion : The choices of surgical excision techniques for pterygium depends on the grades of the pterygium and operator’s preference.","PeriodicalId":165753,"journal":{"name":"Ophthalmologica Indonesiana","volume":"43 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139783970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Did the metal object hit the cornea? A case report of penetrating ocular injury with embedded foreign body 金属物体是否击中了角膜？一例嵌入异物的穿透性眼外伤报告

Ophthalmologica Indonesiana Pub Date : 2024-02-12 DOI: 10.35749/7fy1ce37

Agung Nugroho, Dearaini, Annisa Windyani, D. Susantono, Rishka Pangestika, Yulinda Arty Laksmita, Syska Widyawati, G. Adriono

{"title":"Did the metal object hit the cornea? A case report of penetrating ocular injury with embedded foreign body","authors":"Agung Nugroho, Dearaini, Annisa Windyani, D. Susantono, Rishka Pangestika, Yulinda Arty Laksmita, Syska Widyawati, G. Adriono","doi":"10.35749/7fy1ce37","DOIUrl":"https://doi.org/10.35749/7fy1ce37","url":null,"abstract":"Introduction : Penetrating ocular injury with IOFBs may cause severe ocular damage. We demonstrate the diagnostic and treatment approach in a case of scleral laceration with a large IOFB. \u0000Case Illustration : A-24-year-old male presented with a rusty segment of fence wire, sized 15x11 mm, embedded near the nasal corneal margin of the right eye. Upon initial examination the vision was 6/9 with normal IOP. The object obstructed the view of the entry site, therefore corneal wound was suspected. CT scan showed penetrating metal object without posterior segment involvement. Anti-tetanus injection, topical and oral levofloxacin were given. He underwent exploration, foreign body removal and repair surgery. During surgery, the wound was revealed as a scleral laceration, 4 mm from nasal limbus. One day post-operative, vision was 6/20. A 0.1 mm hypopyon was found, along with fibrin at nasal vitreous. Oral and topical corticosteroids were given, and hypopyon disappeared the next day. One week after surgery, vision improved to 6/7.5, with clear vitreous and normal retina. \u0000Discussion : Ocular injuries with large IOFBs can hinder clinical examination. Corneal entry wound should be ruled out, due to potential permanent damage to visual axis. CT scan was helpful in assessing the depth of object penetration. The object was removed successfully, with no damage to the cornea and retina. Anti-tetanus, antibiotics and corticosteroids were able to control infection and inflammation. \u0000Conclusion : Large IOFBs which do not affect the visual axis, can be managed with successful outcome, by prompt removal and repair of the entry wound, and control of infection and inflammation.","PeriodicalId":165753,"journal":{"name":"Ophthalmologica Indonesiana","volume":"43 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139783972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ocular Penetration Trauma due to Bamboo Resulting in Evisceration: A Case Report 竹子造成的眼球穿透性创伤导致眼球撕裂：病例报告

Ophthalmologica Indonesiana Pub Date : 2024-02-12 DOI: 10.35749/py0xmj02

Indah Latifah, Dr. Lailus Sofatul Layyin, Sp.M

{"title":"Ocular Penetration Trauma due to Bamboo Resulting in Evisceration: A Case Report","authors":"Indah Latifah, Dr. Lailus Sofatul Layyin, Sp.M","doi":"10.35749/py0xmj02","DOIUrl":"https://doi.org/10.35749/py0xmj02","url":null,"abstract":"Introduction : Penetrating ocular trauma includes open-eye trauma, which leads to the time and a precision of eye- penetrating trauma’s management determine the advanced vision prognosis. In this case a male experience penetration trauma of the right eye due to exposure to the bamboo, delaying and inadequate management resulted in evisceration of the right eye. A 42-year-old male came to ER RSUD Prof. Soekandar mojokerto with bloody right eye and pain from getting a piece of bamboo from two days before entering the hospital. The patient also complained that the right eye is swollen so that it is unable to open the eyes. vision examination revealed LP (-) in the right eye, visual acuity in the left eye was 6/6, soft palpation in the right eye, normal palpation in the left eye, examination of the right anterior segment of the eye revealed that part of the eyeball content had prolapsed and for the left eye within the normal range. During laboratory tests, 15.280 white blood cells were found, which confirmed the infection of the right eye. \u0000Case Illustration : Descriptive Study \u0000Discussion : The observations on these patients include covered the right eye, antibiotic, steroids, and analgesic by intravenous injection. Based on the condition of the patient's right eye, it is advisable to do evisceration of the right eyeball under general anesthesia. \u0000Conclusion : Penetrating ocular trauma resulting in extensive intra ocular tissue damage and poor vision prognosis, considered for evisceration, in order to prevent the development of the sympatetic ophthalmia.","PeriodicalId":165753,"journal":{"name":"Ophthalmologica Indonesiana","volume":"28 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139784150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ACETAZOLAMIDE INDUCED SECONDARY ANGLE CLOSURE GLAUCOMA: A RARE CASE REPORT 乙酰唑胺诱发继发性闭角型青光眼：罕见病例报告

Ophthalmologica Indonesiana Pub Date : 2024-02-12 DOI: 10.35749/5mw96e77

Siti Mutia Atisundara, R. M. Rifada, Sonie Umbara, Elsa Gustianty, Andhika Prahasta

{"title":"ACETAZOLAMIDE INDUCED SECONDARY ANGLE CLOSURE GLAUCOMA: A RARE CASE REPORT","authors":"Siti Mutia Atisundara, R. M. Rifada, Sonie Umbara, Elsa Gustianty, Andhika Prahasta","doi":"10.35749/5mw96e77","DOIUrl":"https://doi.org/10.35749/5mw96e77","url":null,"abstract":"Introduction : Drugs such as topiramate, acetazolamide, methazolamide, buproprion, and trimethoprim- sulfamethoxazole potentially cause an elevation of IOP. Drug-induced glaucoma may be an ophthalmic emergency if not treated promptly and can results in permanent visual loss. \u0000Case Illustration : A 36-years-old female came to Glaucoma Unit at Cicendo National Eye Hospital with progressive blurred vision since 1 year ago, worsening in the past six months. Accompanying symptoms included pain, headache, halo, and conjunctival hyperemia. She had been diagnosed with glaucoma and received timolol maleate, acetazolamide, and glycerin. Seven days later, her visual acuity worsened to 3/60 ph 0.15 RE and 2/60 ph 0.15 LE, with high IOP in both eyes, with the higher IOP being >30 mmHg. The cup-to-disc ratio was 0.3 RE and 0,8 LE. The anterior segment showed shallow anterior chamber, mid-dilated pupil, and conjunctival injection (Figure 1.). Gonioscopy examination showed Schwalbe line of both eyes (Figure 2.). Acetazolamide was stopped, and one week later the condition resolved (Figure 3.). \u0000Discussion : Secondary angle closure glaucoma caused by acetazolamide is important to consider because most people tolerate acetazolamide well. The mechanism of closed-angle glaucoma can be pupillary block and non-pupillary block. Non-pupillary block is caused by thickening, forward movement the iris-lens diaphragm, rotation of the ciliary body, and choroidal effusion. This process is an idiosyncratic reaction to certain systemic drugs. \u0000Conclusion : Few cases were reported about secondary bilateral angle closure glaucoma due to acetazolamide. Treatment of angle closure glaucoma involves stopping acetazolamide","PeriodicalId":165753,"journal":{"name":"Ophthalmologica Indonesiana","volume":"98 47","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139784195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Topical Treatment for Dry Eye Disease Related to Sjögren's Syndrome: A Systematic Review 与斯约格伦综合征相关的干眼症的局部治疗：系统回顾

Ophthalmologica Indonesiana Pub Date : 2024-02-12 DOI: 10.35749/txm3jz57

Priscilla Jessica, Syafa Sadida Zahra

{"title":"Topical Treatment for Dry Eye Disease Related to Sjögren's Syndrome: A Systematic Review","authors":"Priscilla Jessica, Syafa Sadida Zahra","doi":"10.35749/txm3jz57","DOIUrl":"https://doi.org/10.35749/txm3jz57","url":null,"abstract":"Abstract \u0000Introduction & Objectives : Sjögren’s syndrome (SS) is a systemic autoimmune disorder characterized by dry eyes and dry mouth caused by inflammation in exocrine glands. Dry eye with SS is often more severe than non-SS dry eye and can greatly affect patients’ quality of life, thus treatment modalities must be selected carefully. This study aims to evaluate the recent studies on topical treatment for dry eye disease related to SS and provide evidence based recommendation for clinical practice. \u0000Methods : Electronic literature search was performed through the PubMed and Cochrane database from the last 10 years. We only included studies with prospective clinical trial design, a follow-up period of at least 4 weeks, and had outcome parameters among the following: Ocular Surface Disease Index, Schirmer test, tear break up time, tear meniscus height, and corneal fluorescein staining. \u0000Results : Fifteen studies were selected from 125 articles retrieved. We identified clinical trials using tacrolimus, cyclosporine, cortisol phosphate, diquafosol, rebamipide, fluorometholone, hydrocortisone, clobetasone butyrate, autologous serum, autologous platelet lysate, artificial tear, and various type of vehicles including hyaluronic acid, sodium hyaluronate, almond oil, ceftazidime,or saline solution. \u0000Conclusion : Cyclosporine has comparably equal efficacy to corticosteroid eye drops in improving signs and symptoms of dry eye in SS, but with a better safety for long-term use. Autologous serum is also an effective therapy with the best concentration being 100% serum (no dilution). Diquafosol is a promising therapy but more research is needed to confirm its efficacy and safety.","PeriodicalId":165753,"journal":{"name":"Ophthalmologica Indonesiana","volume":"97 30","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139784366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Binocular Diplopia in Miller Fisher Syndrome Pediatric Patient: A Rare Case Report 米勒-费雪综合征儿科患者的双眼复视：罕见病例报告

Ophthalmologica Indonesiana Pub Date : 2024-02-12 DOI: 10.35749/36zz6w74

Dinda Zhafira, Reni Prastyani, P. Gunawan, Riza Noviandi, Sunny Mariana Samosir

{"title":"Binocular Diplopia in Miller Fisher Syndrome Pediatric Patient: A Rare Case Report","authors":"Dinda Zhafira, Reni Prastyani, P. Gunawan, Riza Noviandi, Sunny Mariana Samosir","doi":"10.35749/36zz6w74","DOIUrl":"https://doi.org/10.35749/36zz6w74","url":null,"abstract":"Introduction : Miller Fisher Syndrome (MFS) is a rare variant of Guillain-Barré syndrome that usually presents with ataxia, areflexia and ophthalmoplegia. It is more common among patients in their 40s and number of cases in pediatric patients is significantly smaller. Our objective is to report a rare case of diplopia in Miller Fisher. \u0000Case Illustration : An 11 years old boy came with complaint of double vision and history of gaze restriction. Patient had history of inpatient admission due to acute progressive generalized limb weakness and walking difficulty followed by respiratory failure. Patient also had history of chewing and swallowing difficulty. Inpatient treatment included intravenous immunoglobulin (IVIG) for 5 days which resultedin clinical improvement. Electromyography examination done while hospitalization showed normal results. Orthoptic examination revealed 15 degrees exotropia of left eye with 30 prism dioptres (PD) at near and far distance. Worth four dot test resulted in cross diplopia with no abnormality in head CT scan. After 2 months follow-up with push-up pencil exercise, patient showed improvement of symptoms. \u0000Discussion : MFS is a clinical diagnosis that can be assessed by clinical triad of ataxia, areflexia and ophthalmoplegia. Diagnosis can be supported by ancillary test such as cerebrospinal fluid analysis, electrophysiologic studies or antibody anti-GQ1b . Treatment of MFS are mainly for supportive care with respiratory support and immunotherapy if needed in severe cases. \u0000Conclusion : The outcome of MFS is usually good with a complete recovery. The improvements generally begin within two to four weeks after the onset of neurological symptoms and complete within six months.","PeriodicalId":165753,"journal":{"name":"Ophthalmologica Indonesiana","volume":"96 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139784387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mean Platelet Volume As Retinopathy Diabetic Predictive Factor in Peripheral Hospital: Could it be? 平均血小板体积是周边医院糖尿病视网膜病变的预测因素：可能吗？

Ophthalmologica Indonesiana Pub Date : 2024-02-12 DOI: 10.35749/6fwsdw68

Denny Indra Maulana, Masniah

{"title":"Mean Platelet Volume As Retinopathy Diabetic Predictive Factor in Peripheral Hospital: Could it be?","authors":"Denny Indra Maulana, Masniah","doi":"10.35749/6fwsdw68","DOIUrl":"https://doi.org/10.35749/6fwsdw68","url":null,"abstract":"Introduction & ObjectivesSeveral studies conducted that diabetic retinopathy (DR) pathogenesis may be linked tomicrocirculation disorders and microvascular damage. Platelets have a significant role inmicrocirculation changes that lead to microvascular injury. Mean Platelet Volume (MPV) is used as amarker to indicate the platelet’s average size and activity. The association between MPV and DR in apatient’s blood sample has been established. Aim of this study is to evaluate the association of MPVwith DR in our population. \u0000MethodsThis was a cross-sectional study in Brigjend H. Hasan Hospital within 183 patients which classifiedinto three groups including: I. DM without DR (n=61), II. DM with Non-proliferative DR (n=61), andIII. DM with proliferative DR (n=61). Data about gender, age and laboratory markers (MVP, HbA1C,fasting blood glucose) were collected, then analyzed using SPSS. \u0000ResultsMPV value was significantly higher in group II and III compared to group I (p<0.001). The MPVvalue was also significantly higher in PDR Group compared to NPDR Group (adj. OR 7.91, 95% CI:3.79-16.5). The FBG value also significantly higher in group II and III compared to group I(p=0.012). On the other hand, HbA1C value mean was higher in group II and III but not statisticallysignificant (p=0.052). \u0000ConclusionThis study demonstrated relationship between higher MPV with DR and its severity. Consideringthat MPV can be easily measured and suitable as parameter reflective platelet function, DR and itsprogressivity can be clinically monitored using this method.","PeriodicalId":165753,"journal":{"name":"Ophthalmologica Indonesiana","volume":"84 16","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139784428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

THE RELATIONSHIP OF INTERLEUKIN-6 LEVELS AND THE DEGREE OF MYOPIA IN YOUNG ADULTS IN NORTH SUMATRA UNIVERSITY HOSPITAL 北苏门答腊大学医院青壮年白细胞介素-6 水平与近视程度的关系

Ophthalmologica Indonesiana Pub Date : 2024-02-12 DOI: 10.35749/jqnkkw14

Salman Saisar Hidayat, A. A. Amra, R. R. Lubis

{"title":"THE RELATIONSHIP OF INTERLEUKIN-6 LEVELS AND THE DEGREE OF MYOPIA IN YOUNG ADULTS IN NORTH SUMATRA UNIVERSITY HOSPITAL","authors":"Salman Saisar Hidayat, A. A. Amra, R. R. Lubis","doi":"10.35749/jqnkkw14","DOIUrl":"https://doi.org/10.35749/jqnkkw14","url":null,"abstract":"Background. \u0000Myopia is one of the refractive errors where parallel light from infinity is focused in front of the retina without accommodation. Various cytokines have been implicated in the development of myopia, including interleukin-6 (IL6) and matrix metalloproteinase-2 (MMP-2). IL-6 is one of the pro-inflammatory cytokines that play a role in ocular disease pathology. Chronic subclinical inflammation may play a role in elongation of the eyeball, inflammation promotes the breakdown of the scleral extracellular matrix and results in axial elongation. \u0000Objective. \u0000To determine the relationship of interleukin-6 levels and the degree of myopia in young adults in North Sumatra University Hospital. \u0000Methods. \u0000This research is an analytic observational study with a case control design, held from February 2022. Primary and secondary data are collected from interviews and direct observation. Bivariate analysis of differences in interleukin-6 levels in myopia and emmetropia uses T-independent test, if the data are normally distributed. If the data are not normally distributed, then the Mann Whitney test is used. Bivariate analysis to analyze differences in interleukin-6 levels based on the degree of myopia uses the Kruskal Wallis test, followed by a post hoc test using the Mann Whitney test and t-independent. \u0000Results. \u0000A total sample consists of 30 patients who suffer from myopia and 30 control samples. The mean age in the myopia group was 28.87 years with the youngest age being 25 years and oldest age 34 years. Most of them are moderate myopia with 15 people (50%). There was no significant difference in interleukin-6 levels between myopia and control groups (p = 0.147). There was a difference in the mean level of interleukin-6 based on the degree of myopia (p = 0.005). \u0000Conclusions. \u0000There is an association between interleukin-6 levels and the degree of myopia in young adult patients. No differences in interleukin-6 levels were found significant between myopia and control groups.","PeriodicalId":165753,"journal":{"name":"Ophthalmologica Indonesiana","volume":"97 47","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139784441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CHOPPING METHODS IN APPROACHING HARD CATARACT: OPTIONS AND RECOMMENDATION 处理硬性白内障的切削方法：选择和建议

Ophthalmologica Indonesiana Pub Date : 2024-02-12 DOI: 10.35749/m8tx2q11

MUHAMMAD IQBAL, Haikal Hamas Putra Iqra

{"title":"CHOPPING METHODS IN APPROACHING HARD CATARACT: OPTIONS AND RECOMMENDATION","authors":"MUHAMMAD IQBAL, Haikal Hamas Putra Iqra","doi":"10.35749/m8tx2q11","DOIUrl":"https://doi.org/10.35749/m8tx2q11","url":null,"abstract":"Abstract \u0000Introduction & Objectives : Mature cataracts with hard-nuclear and soft-nuclear cataracts were different in their anatomical features and their management approach. Degeneration of zonules, loss of capsule and cortical liquefaction are often found in hard cataracts. Therefore, different approaches are required in this condition. Chopping methods have several advantages in managing the nucleus which plays a major part in cataract surgery. It lessened phaco power which minimized endothelial damage. The risk of intraoperative zonular dehiscence may also be lowered with chopping methods. Several chopping methods are widely accepted in approaching hard cataracts such as vertical chop, horizontal chop, crater and chop, drill and chop, stop and chop, and multilevel chop. Burst mode which requires high vacuum and power to chop and flow rates must be adequately comprehended by the surgeon in achieving the optimal result. This review discussed chopping methods in cataract surgery. \u0000Methods : Several chopping methods are widely accepted in approaching hard cataracts such as vertical chop, horizontal chop, crater and chop, drill and chop, stop and chop, and multilevel chop. \u0000Results : Burst mode which requires high vacuum and power to chop and flow rates must be adequately comprehended by the surgeon in achieving the optimal result. \u0000Conclusion : This review discussed chopping methods in cataract surgery.","PeriodicalId":165753,"journal":{"name":"Ophthalmologica Indonesiana","volume":"83 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139784593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0