Comparison of Changes in Quality of Life Based on Changes in Disease Severity in Graves Ophthalmopathy Patients Following Intraorbital Triamcinolone Acetonide Injection

Ophthalmologica Indonesiana Pub Date : 2024-02-12 DOI:10.35749/r46k6b08

LADY PRANODIA SUKMAWIDOWATI

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Abstract

Abstract Introduction & Objectives : Graves ophthalmopathy (GO) is associated with visual impairment and appearance changes, affecting the quality of life. Intraorbital injection of triamcinolone acetonide (TCA) in GO resulted in clinical improvement, but its effect on the quality of life is unknown. The objective of this study was to compare the changes in quality of life after intraorbital injection of TCA between different groups based on changes in disease severity. Methods : Intraorbital injection of TCA was performed on 30 subjects with GO. Disease severity was assessed according to the European Group of Graves Ophthalmopathy (EUGOGO) criteria. Quality of life was measured using the Indonesian version of Graves Ophthalmopathy Quality of Life (GO-QOL) questionnaire. Changes in disease severity and GO-QOL scores were recorded before intraorbital injection of TCA and 1 month after. Subjects were divided into groups based on changes in disease severity: decreased, remained constant, and increased. Changes in quality of life between the groups were compared statistically. Results : Changes in GO-QOL appearance scores in patients with decreased disease severity were significantly higher (p= 0.016) than those in patients whose disease severity remained constant. Changes in GO-QOL visual function scores in patients with decreased disease severity were higher but not statistically significant (p> 0.05) compared to those in patients whose disease severity remained constant. Conclusion : Changes in the appearance aspect of quality of life after intraorbital injection of TCA in patients with decreased disease severity are better than that in patients whose disease severity remained constant, whereas changes in the visual function aspect are not significantly different.

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根据疾病严重程度的变化比较巴塞杜氏眼病患者眶内注射曲安奈德后生活质量的变化

摘要引言和目的：巴塞杜氏眼病（Graves ophthalmopathy，GO）与视力损伤和外观改变有关，影响生活质量。眶内注射曲安奈德（TCA）可改善巴塞杜氏眼病的临床症状，但其对生活质量的影响尚不清楚。本研究的目的是根据疾病严重程度的变化，比较不同组别在眶内注射曲安奈德后生活质量的变化。方法：对 30 名 GO 患者进行眶内注射 TCA。根据欧洲巴塞杜氏眼病组织（EUGOGO）的标准评估疾病严重程度。生活质量采用印度尼西亚版的巴塞杜氏眼病生活质量（GO-QOL）问卷进行测量。在眶内注射三氯乙酸前和注射后一个月，记录疾病严重程度和GO-QOL评分的变化。根据疾病严重程度的变化将受试者分为三组：病情减轻组、病情不变组和病情加重组。对各组间生活质量的变化进行统计比较。结果：疾病严重程度减轻患者的 GO-QOL 外观评分变化（p= 0.016）明显高于疾病严重程度保持不变的患者。与病情严重程度保持不变的患者相比，病情严重程度减轻的患者的 GO-QOL 视觉功能评分变化更高，但无统计学意义（p> 0.05）。结论：眶内注射三氯乙酸后，病情严重程度降低的患者在生活质量外观方面的变化优于病情严重程度保持不变的患者，而在视觉功能方面的变化则无明显差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Ophthalmologica Indonesiana

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