Journal of neurophysiology最新文献

{"title":"Targeting intracranial electrical stimulation to network regions defined within individuals causes network-level effects.","authors":"Christopher Cyr, Ania M Holubecki, Lingxiao Shi, Maya Lakshman, Joseph J Salvo, Nathan L Anderson, James E Kragel, Sarah M Lurie, Joel Voss, Vasileios Kokkinos, Joshua Rosenow, Stephan U Schuele, Elizabeth L Johnson, Christina Zelano, Rodrigo M Braga","doi":"10.1152/jn.00589.2025","DOIUrl":"10.1152/jn.00589.2025","url":null,"abstract":"<p><p>Intracranial electrical stimulation (ES) is routinely used therapeutically, diagnostically, and to provide causal evidence in neuroscience studies. However, our understanding of the brain network-level effects of ES remains limited. We applied precision functional mapping (PFM), based on functional magnetic resonance imaging (fMRI), to define large-scale networks within individual patients with epilepsy. We show that single-pulse electrical stimulation (SPES) and high-frequency electrical stimulation (HFES) are more likely to evoke within-network responses and elicit network-related behavioral effects, respectively, when applied near a PFM-defined network region. Network-level effects were more likely when stimulating sites in white matter, in close proximity to the targeted network, and within a region predominantly occupied by the targeted network. Furthermore, network-specific modulation may be achievable by applying lower current intensities at these sites. Our findings support that modulation of specific networks is achievable by targeting ES to a functional anatomic \"sweet spot\" that can be identified using PFM.<b>NEW & NOTEWORTHY</b> Precision functional magnetic resonance imaging (fMRI) allows within-individual network definition in patients with epilepsy. Intracranial stimulation effects are aligned with individual-level network topography. Current intensity and proximity to white matter were also critical for effects. Precision fMRI can be used to target stimulation to modulate specific networks.</p>","PeriodicalId":16563,"journal":{"name":"Journal of neurophysiology","volume":" ","pages":"601-624"},"PeriodicalIF":2.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13427260/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148345638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction for Matsuda et al., volume 135, p. 1611-1620.","authors":"","doi":"10.1152/jn.00109.2026_COR","DOIUrl":"https://doi.org/10.1152/jn.00109.2026_COR","url":null,"abstract":"","PeriodicalId":16563,"journal":{"name":"Journal of neurophysiology","volume":"136 2","pages":"745"},"PeriodicalIF":2.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148706789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sigmoidal decoding from distinct M1 spiking populations and LFP band power for locomotion speed in mice.","authors":"Ghazaal Tahmasebi, Sophia Vargas, Christian Fofie Kuete, Pegah Haghighi, Elysandra Solis, Ajaree Massaquoi, Joseph J Pancrazio","doi":"10.1152/jn.00112.2026","DOIUrl":"10.1152/jn.00112.2026","url":null,"abstract":"<p><p>The extent to which the primary motor cortex (M1) encodes locomotion speed is relatively unexplored, with some studies suggesting linear or gain-modulated tuning. Here, we show that there are neurons in the mouse M1 where spiking relates to locomotion speed in a manner consistent with a sigmoidal state-transition model implemented by two functionally distinct neural populations. In addition, sigmoidal framework extends to local field potential (LFP) band power, enabling a direct within-animal comparison of spiking and LFP-based speed encoding. We recorded extracellular activity (5,889 single units, 384 channels) using chronic 32-channel laminar arrays in eight mice locomoting on a motorized treadmill over 8 wk, with actual speed tracked via DeepLabCut. Unsupervised clustering of temporal firing rate profiles identified two groups: speed-positively related (70.8%) and speed-inversely related (29.2%) units. Sigmoidal models of speed-positively related rate tuning significantly outperformed linear and quadratic alternatives for both populations, and the two clusters shared a common speed threshold (∼2.3 m/min) consistent with a shared subcortical locomotor gate. When exploring decoding, the minority speed-inversely related population demonstrated significantly higher decoding accuracy via inverse-sigmoid transformation compared with the larger speed-positively related population or all units combined, an advantage that generalized across animals via leave-one-animal-out cross-validation. LFP band power also exhibited sigmoidal tuning relative to locomotion speed, but decoded speed with lower fidelity. These findings suggest a push-pull sigmoidal architecture for spiking-based speed representation in M1 and demonstrate that LFP provides a complementary and stable signal for coarser speed estimation.<b>NEW & NOTEWORTHY</b> This study reveals that locomotion speed is encoded in mouse primary motor cortex through a sigmoidal state-transition mechanism carried by two functionally distinct spiking populations with a shared speed threshold. Using high-density laminar recordings and markerless motion tracking, we show that this framework extends to local field potentials and enables accurate, generalizable decoding. These findings establish a push-pull sigmoidal architecture and highlight implications for stable, calibration-light brain-machine interface design.</p>","PeriodicalId":16563,"journal":{"name":"Journal of neurophysiology","volume":" ","pages":"807-823"},"PeriodicalIF":2.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148549577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cold stimulation applied concurrently with high-frequency electrical stimulation does not attenuate the development of secondary pinprick hypersensitivity in humans.","authors":"Emanuel N van den Broeke, Elise Ercken, Linde Maes, José Biurrun Manresa, Diana M Torta","doi":"10.1152/jn.00075.2026","DOIUrl":"10.1152/jn.00075.2026","url":null,"abstract":"<p><p>Diffuse noxious inhibitory controls (DNIC) reduce spinal nociceptive processing in animal models, and the human analogue, conditioned pain modulation (CPM), is thought to engage descending inhibitory pathways. A recent translational study reported that neither cuff-induced DNIC in animals nor cuff-induced CPM in humans interferes with high-frequency electrical stimulation (HFS)-induced spinal sensitization in animals or secondary pinprick hypersensitivity in humans. In contrast, another human study, using cold-water immersion to induce CPM, observed a substantial reduction in low-frequency stimulation (LFS)-induced secondary pinprick hypersensitivity. Here, we tested whether cold-water immersion applied concurrently with HFS reduces HFS-evoked pain and attenuates the subsequent development of secondary pinprick hypersensitivity. In a preregistered crossover study, healthy participants (<i>n</i> = 30) received HFS on the forearm during immersion of the contralateral hand in either 4°C water (experimental condition) or room-temperature water (control condition). Pressure pain thresholds (PPTs), HFS-evoked pain ratings, and the magnitude and spatial extent of secondary pinprick hypersensitivity were assessed. Cold-water immersion, but not room-temperature water, significantly increased PPTs, confirming the CPM effect. However, neither HFS-evoked pain nor the intensity or spatial extent of HFS-induced secondary pinprick hypersensitivity differed between conditions. Under the present experimental conditions, recruitment of pain-inhibitory mechanisms by cold-water immersion was insufficient to meaningfully alter the development of HFS-induced secondary pinprick hypersensitivity.<b>NEW & NOTEWORTHY</b> We introduce a novel paradigm combining high-frequency stimulation (HFS) with concurrent cold-water immersion to induce conditioned pain modulation. No evidence was found for an interaction between conditioned pain modulation and the development of high-frequency stimulation-induced pinprick hypersensitivity.</p>","PeriodicalId":16563,"journal":{"name":"Journal of neurophysiology","volume":" ","pages":"509-517"},"PeriodicalIF":2.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148436869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sensory gating and auditory steady-state response analysis of eye contact deficit marmosets using a noninvasive scalp EEG system.","authors":"Kimihiro Kimura, Masataka Yamaguchi, Tomokazu Nakako, Yoshihiro Iwamura, Naho Konoike, Katsuki Nakamura, Yohei Kobayashi, Kazuhito Ikeda","doi":"10.1152/jn.00582.2025","DOIUrl":"10.1152/jn.00582.2025","url":null,"abstract":"<p><p>An electroencephalogram (EEG) is a record of electrical signals generated by brain cells that is expected to be used as biomarkers in central nervous system (CNS) diseases. Recently, a noninvasive method of scalp EEG in marmosets has been developed. This method holds promise for evaluating the drug responsiveness of event-related potentials (ERPs) in disease model marmosets, yet such applications remain unexplored. Here, we used this EEG method to record ERPs such as sensory gating and auditory steady-state response (ASSR) in marmosets exhibiting eye contact deficit (ECD), a common characteristic of autism spectrum disorder, and evaluated the phenotypes and drug responsiveness. EEG data were recorded from nine ECD marmosets and nine normal marmosets during auditory stimulus. In the sensory gating assessment, the P1 and N1 amplitudes evoked by the first (click 1) and second auditory click (click 2) were evaluated. Compared with normal marmosets, the P1-N1 amplitude against click 1 (S1 amplitude) was decreased in the ECD marmosets, and diazepam administration restored it. Moreover, in the ASSR assessment, phase-locking factor (PLF) and evoked power during 30 or 40 Hz clicks were evaluated. Diazepam administration increased the PLF and evoked power only in the ECD group. In conclusion, we demonstrated that the phenotypes and drug responsiveness differences between normal and ECD marmosets can be evaluated using ERPs measured by the noninvasive scalp EEG method. These results suggest that ERPs recorded by this method can serve as translational biomarkers for elucidating the disease pathology and for drug development.<b>NEW & NOTEWORTHY</b> This study investigated the practicality of the noninvasive scalp EEG method in assessing the phenotypes and drug responsiveness of marmosets with behavioral abnormalities. This study showed that the method can detect the reduction of S1 amplitude in eye contact deficit (ECD) marmosets and differences in drug responsiveness in sensory gating and auditory steady-state response (ASSR) between normal and ECD marmosets. These results suggest that event-related potentials (ERPs) recorded by this method may serve as translational biomarkers.</p>","PeriodicalId":16563,"journal":{"name":"Journal of neurophysiology","volume":" ","pages":"679-688"},"PeriodicalIF":2.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148239464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction for Lebrun et al., volume 134, 2025, p. 1897-1911.","authors":"","doi":"10.1152/jn.00278.2025_COR","DOIUrl":"https://doi.org/10.1152/jn.00278.2025_COR","url":null,"abstract":"","PeriodicalId":16563,"journal":{"name":"Journal of neurophysiology","volume":"136 2","pages":"633"},"PeriodicalIF":2.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148648133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sympathetic long-term facilitation following acute intermittent hypoxia is similar in the diurnal rest versus active phase in vagal-intact rats.","authors":"Alec L E Butenas, Gordon S Mitchell","doi":"10.1152/jn.00218.2026","DOIUrl":"10.1152/jn.00218.2026","url":null,"abstract":"<p><p>Acute intermittent hypoxia (AIH) elicits long-lasting increases in phrenic and sympathetic nerve activity, effects known as phrenic (pLTF) and sympathetic long-term facilitation (sympLTF), respectively. In anesthetized, paralyzed, vagotomized, and ventilated rats, pLTF magnitude following AIH consisting of 15, 1-min isocapnic hypoxic episodes (i.e., 15x1) is greater during the mid-rest versus mid-active phase of the diurnal cycle. However, it is unknown if sympLTF exhibits similar diurnal regulation. In urethane-anesthetized, mechanically ventilated, male Sprague-Dawley rats, we hypothesized that sympLTF elicited by 15x1 AIH ([Formula: see text] 40-55 mmHg) is greater in the mid-rest than in mid-active diurnal phase. We report renal sympathetic nerve activity (RSNA) remained elevated 90 min post-AIH, with similar responses in mid-rest (<i>n</i> = 20) versus mid-active phase rats (<i>n</i> = 17). No significant increase was observed in time control rats in either mid-rest (<i>n</i> = 10) or mid-active phase (<i>n</i> = 9). Mean ΔRSNA (%) was 142 ± 184 during mid-rest AIH and 101 ± 124 during mid-active AIH, versus 34 ± 28 and 28 ± 52 in corresponding mid-rest and mid-active time controls. There was a significant main effect of AIH on ΔRSNA (%) (<i>P</i> = 0.020), with no effect of time of day (<i>P</i> = 0.544) and no interaction (<i>P</i> = 0.644). Increases in RSNA following AIH were driven primarily by increases in burst amplitude and duration, with minimal changes in burst frequency. Furthermore, mean arterial pressure did not change from baseline in any group (all <i>P</i> > 0.05). These findings demonstrate that AIH elicits modest increases in RSNA that are not accompanied by increases in arterial pressure and are not modulated by time of day, contrasting with the diurnal regulation of pLTF.<b>NEW & NOTEWORTHY</b> Acute intermittent hypoxia (AIH) is widely reported to elicit plasticity in sympathetic nerve activity in anesthetized, vagotomized rats. Here, we demonstrate that, in vagal-intact rats, only modest renal sympathetic nerve plasticity occurs (without change in mean arterial pressure) in response to AIH delivery in the diurnal rest or active phase. Similarity in AIH-induced renal sympathetic nerve plasticity versus time-dependent drift in sham rats highlights the need for careful experimental controls in studies of sympathetic plasticity.</p>","PeriodicalId":16563,"journal":{"name":"Journal of neurophysiology","volume":" ","pages":"746-753"},"PeriodicalIF":2.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13584407/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148648060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simultaneous neuron evidence for much higher covariation with saccadic reaction time of superior colliculus than primary visual cortex visual responses.","authors":"Yue Yu, Ziad M Hafed","doi":"10.1152/jn.00226.2026","DOIUrl":"10.1152/jn.00226.2026","url":null,"abstract":"<p><p>Visual response strength in the primate superior colliculus (SC) has recently been shown to inversely correlate with trial-by-trial saccadic reaction time in a much stronger way than visual response strength in the primary visual cortex (V1). However, for any given visual stimulus onset, populations of neurons in each brain area are concurrently activated, leaving open the question of how V1 visual response strength can predict trial-by-trial saccadic reaction time when multiple simultaneously recorded neurons are taken into account. Using a classic visually guided saccade task, here we assessed the quality of predicting trial-by-trial saccadic reaction time from the visual response strengths of 1 to 10 simultaneously recorded neurons in each brain area. For each session, we modeled saccadic reaction time as a weighted linear combination of the visual response strengths of <i>N</i> simultaneously recorded neurons. Consistent with the prior work, the visual response strength of a single SC neuron was better than that of a single V1 neuron at predicting reaction time. By adding more simultaneously recorded neurons, the prediction got much better in the SC, but not in V1. Only for 100% contrast dark stimuli (darker in luminance than the surrounding gray background) did V1 show an increase in prediction quality with more simultaneously recorded neurons. This increase, which was still substantially weaker than in the SC, could reflect the ecological relevance of dark contrasts in scenes. These results suggest that despite qualitative similarities between SC and V1 visual responses, SC visual responses are functionally reformatted from their V1 counterparts.<b>NEW & NOTEWORTHY</b> The superior colliculus (SC) is an important sensory-motor structure for controlling eye movements, and it receives a significant portion of its inputs directly from the primary visual cortex (V1). Despite this, SC visual responses are much better correlated with trial-by-trial variability in saccadic eye movement timing than V1 visual responses, and this effect is strongly amplified when considering simultaneously recorded neurons. Thus, SC and V1 visual responses serve fundamentally different functions from a motor perspective.</p>","PeriodicalId":16563,"journal":{"name":"Journal of neurophysiology","volume":" ","pages":"534-545"},"PeriodicalIF":2.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148396829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intranasal poly(I:C)-induced inflammation alters olfactory bulb-entorhinal cortex circuit and its coupling to breathing.","authors":"César Alexander Zaa, Ricardo Jair Ramírez-Carreto, Benito Ordaz-Sánchez, Anahí Chavarría, Fernando Peña-Ortega","doi":"10.1152/jn.00129.2026","DOIUrl":"10.1152/jn.00129.2026","url":null,"abstract":"<p><p>The olfactory bulb (OB)-entorhinal cortex (EC) circuit is involved in odor information processing and contextualization, as well as other cognitive processes that require the proper generation of neuronal network activity patterns often synchronized with breathing and affected during rhinitis. Although both the OB and the EC frequently show clear signs of neuroinflammation and neuronal stress in response to a variety of peripheral and central proinflammatory stimuli, the functional state of the OB-EC circuit during experimental rhinitis has not been explored. To fill this gap, we explored the impact of nasal inflammation, induced by the viral mimetic polyinosinic:polycytidylic acid [poly(I:C)], on the circuit composed of the OB and EC by measuring their individual neural network activities and quantifying their functional connectivity in the absence and presence of odors. We also measured the presence of proinflammatory markers in both structures and the animals' olfaction. We found that three daily intranasal poly(I:C) administrations are enough to increase proinflammatory cytokine levels in the OB and EC and to reduce olfactory detection in a novel context. Intranasal poly(I:C)-induced inflammation leads to a reduction in the power of OB and EC neural network activity and diminishes their response to odors. Moreover, poly(I:C)-induced inflammation reduces coupling between the OB and the EC at various frequencies, including those close to the respiratory rhythm. It also reduces the coupling between the EC and breathing, which is not observed in the OB. Taken together, our findings indicate that intranasal viral infection leads to neuroinflammation in the OB-EC circuit, affecting its function and connectivity, as well as its coupling to breathing, which could contribute to the olfactory and cognitive deficits observed in rhinitis.<b>NEW & NOTEWORTHY</b> To understand the olfactory and cognitive deficits observed in viral rhinitis, we described the impact of nasal inflammation, induced by the viral mimetic poly(I:C), on the circuit composed of the olfactory bulb and entorhinal cortex by measuring their individual neural network activities and their functional connectivity in the absence and presence of odors. We also evaluated signs of neuroinflammation in both structures and the animals' olfaction, revealing pathological mechanisms behind neurological manifestations associated with rhinitis.</p>","PeriodicalId":16563,"journal":{"name":"Journal of neurophysiology","volume":" ","pages":"643-652"},"PeriodicalIF":2.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148471417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gaze-centered spatial coding of touch on a hand-held tool.","authors":"Lefteris Zografos Themelis, W Pieter Medendorp, Luke E Miller","doi":"10.1152/jn.00165.2025","DOIUrl":"10.1152/jn.00165.2025","url":null,"abstract":"<p><p>Humans possess the remarkable ability to project tactile sensations outside their body and onto a hand-held tool that they are using. Despite nearly a century of research, the computations underlying this projection have not been adequately addressed. In the present study, we used model-driven psychophysics to fill this gap. We hypothesized that tool-based sensory projection involves the remapping of touch from sensory feedback in the hand into an egocentric coordinate system. We first formalized the computational steps underlying tactile remapping. We designed a novel tool-sensing experiment that allowed us to rigorously test this model. In this task, participants contacted an object with a hand-held rod and then judged whether the object was above or below where they were currently looking. This comparison would only be possible if the touch on the tool was projected outside the hand. Crucially, both object location and gaze position varied independently, allowing us to characterize the hand-to-space-to-gaze remapping process. Model-based curve fitting provided strong evidence that all participants in our task projected touch outside their body and into gaze-centered coordinates. Crucially, the resolution of this projection was similar to what has been found for touch on the body. These findings provide the first step toward characterizing the computations underlying the spatial projection of touch on external objects, highlighting the incredible versatility of the sensorimotor system.<b>NEW & NOTEWORTHY</b> Humans possess the remarkable ability to project tactile sensations outside their body and onto a hand-held tool. Despite nearly a century of research, the computations underlying this projection have not been adequately addressed. We combined computational modeling and psychophysics to demonstrate that egocentric tactile remapping underlies tool-based sensory projection. These findings provide the first characterization of the computations underlying the spatial projection of touch on external objects, highlighting the incredible versatility of the sensorimotor system.</p>","PeriodicalId":16563,"journal":{"name":"Journal of neurophysiology","volume":" ","pages":"468-473"},"PeriodicalIF":2.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147987482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}