Journal of neurophysiology最新文献

{"title":"Did the mechanisms for orientation selectivity evolve along the same lines in eutherians and metatherians?","authors":"Kerstin Erika Schmidt, Amanda Domingues Fonseca, Friedrich Schwarz, Sergio Neuenschwander","doi":"10.1152/jn.00192.2025","DOIUrl":"10.1152/jn.00192.2025","url":null,"abstract":"","PeriodicalId":16563,"journal":{"name":"Journal of neurophysiology","volume":" ","pages":"1916-1918"},"PeriodicalIF":2.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144009397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How shape information is coded by V4 cortical response of macaque monkey.","authors":"Meilan Liu, Shanshan Chang, Meixuan Chen, Peichao Li, Anna Wang Roe, Jia Ming Hu","doi":"10.1152/jn.00520.2024","DOIUrl":"10.1152/jn.00520.2024","url":null,"abstract":"<p><p>Previous neural recording studies have shown that monkey V4 can process shape information across populations of neurons. The responses recorded from each single neuron make it possible to retrieve shape information. However, these studies did not fully characterize the spatial distribution of activity in the cortex. There are multiple types of functional columns (orientation, curvature) in V4; how do these structures respond to different shapes? Here, with intrinsic optical imaging, we explored the cortical responses of V4 to contours (straight and curved) and shapes (circle and square). We found that in V4 the response of neurons to different shapes is highly dependent on the compositional features contained in the shape. A specific local network would have a higher response magnitude to its corresponding shape than other shapes. Meanwhile, the cortical response of V4 exhibits a tolerance to the shift of stimulus location. Our results suggest that two essential cortical response features in V4 are the specificity of the activated response pattern in the cortex and tolerance to the stimulus location variance. These features can help decode shape information from imaging results.<b>NEW & NOTEWORTHY</b> At the cortical response level, the V4 area of the macaque monkey employs two critical principles of shape coding: specificity of the activated response pattern to shape components within the stimuli and tolerance to variations in stimulus location.</p>","PeriodicalId":16563,"journal":{"name":"Journal of neurophysiology","volume":" ","pages":"2016-2028"},"PeriodicalIF":2.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144021724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frontal and temporo-parietal changes in delta and alpha power accompany stress-induced vasoconstriction and blood pressure response.","authors":"Joe Braun, Mariya Patel, Will Woods, Charlotte Keatch, Tatiana Kameneva, Elisabeth Lambert","doi":"10.1152/jn.00618.2024","DOIUrl":"10.1152/jn.00618.2024","url":null,"abstract":"<p><p>Exaggerated blood pressure and vasoconstriction responses during acute mental stress are prospectively associated with an increased risk of hypertension, arrhythmia, and vascular dysfunction. This study assessed electrophysiological brain power and cardiovascular response to acute psychological stress during concurrent recordings of magnetoencephalography, muscle sympathetic nerve activity, and blood pressure in 29 healthy participants. Brain power was filtered through delta (1-4 Hz), theta (4-8 Hz), alpha (8-13 Hz), beta (13-30 Hz), low gamma (30-80 Hz), and high gamma (80-120 Hz) bands. Stress induced significant increases in systolic blood pressure (SBP), 5.2 ± 5.6 mmHg, heart rate, 4.1 ± 4.8 beats/min, and sympathetic nerve activity, 4.0 ± 8.0 bursts per minute (means ± SD, <i>P</i> < 5). Whole head and region of interest analyses showed stress induced significant increases in delta power in the right medial frontal cortex, anterior cingulate, and amygdala. Alternatively, there were significant decreases in alpha power in the left and right precuneus, posterior cingulate, hippocampus, and in the right thalamus and insula. Correlation analyses revealed that reduced alpha power in the right insula was correlated with SBP (<i>r</i> = 0.446). Moreover, reduced alpha power in the left amygdala was correlated with SBP (<i>r</i> = 0.392), anxiety, and depression inventory scores, <i>P</i> < 0.01. The reduced alpha power in the insula and amygdala was pronounced in participants displaying heightened sympathetic nerve reactivity to stress. Similarly, participants who displayed higher mean SBP reactivity (of 19 mmHg) to stress showed reduced alpha power in the precuneus, hippocampus, and amygdala. Our results suggest that regionalized and frequency-specific brain power is involved in neurogenic blood pressure regulation in normotensive individuals.<b>NEW & NOTEWORTHY</b> This study illustrates a correlation between electrophysiological brain power, sympathetic nerve activity, and blood pressure in response to stress. Notable mental stress-induced changes were observed, including an increase in delta power in the frontal regions and a decrease in alpha power in the temporal and parietal regions. The diminished alpha power in the insula, amygdala, precuneus, and hippocampus was particularly significant among individuals exhibiting greater vasoconstrictor activity and a higher increase in systolic blood pressure.</p>","PeriodicalId":16563,"journal":{"name":"Journal of neurophysiology","volume":" ","pages":"1815-1827"},"PeriodicalIF":2.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144009400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gait speed-related changes in electrocortical activity in younger and older adults.","authors":"Jacob Salminen, Chang Liu, Erika M Pliner, Madison Tenerowicz, Arkaprava Roy, Natalie Richer, Jungyun Hwang, Chris J Hass, David J Clark, Rachael D Seidler, Todd M Manini, Yenisel Cruz-Almeida, Daniel P Ferris","doi":"10.1152/jn.00544.2024","DOIUrl":"10.1152/jn.00544.2024","url":null,"abstract":"<p><p>Preferred and maximum walking speeds decline as we age, and the decline has been associated with worsening health. Slowing of gait in older individuals is correlated with biomechanical and neural factors, but historically it has been difficult to measure whole brain activity during walking. Recent advances in mobile brain imaging with high-density electroencephalography (EEG) allow for separation and localization of electrical brain activity during walking. We studied younger (<i>N</i> = 31) and older (<i>N</i> = 59) adults walking on a treadmill at different speeds (0.25-1.0 m/s) while we recorded electrocortical dynamics with EEG. We hypothesized that faster walking speeds would result in greater sensorimotor and posterior parietal theta-band (4-7 Hz) spectral power and lower beta-band (13-30 Hz) spectral power compared to slower walking speeds for older adults, consistent with previous studies on younger adults. Additionally, we used a standardized test of physical function to group older adults into high-functioning [Short Physical Performance Battery (SPPB) ≥ 10] and low-functioning (SPPB < 10) groups for comparison. In agreement with our hypotheses, sensorimotor and posterior parietal theta power increased and beta power decreased at faster walking speeds. We also found that left posterior parietal, mid cingulate, and cuneus exhibited differences in theta power at faster speeds between younger and older adults. The results suggest that older and younger adults activate cortical areas throughout the brain while walking at different speeds and older adults, particularly those with lower mobility, recruit greater cognitive resources in parietal cortex compared to younger adults. These results could inform stimulation protocols targeting parietal cortex.<b>NEW & NOTEWORTHY</b> Older and younger adults show widespread EEG beta power decreases at faster walking speeds compared to slower walking speeds. Older adults differentially alter EEG theta power while walking compared to younger adults. Prior studies with functional near-infrared spectroscopy (fNIRS) have documented differences in prefrontal activation in older adults walking compared to younger adults, but our results show cortical changes within speed and age outside of the prefrontal cortex.</p>","PeriodicalId":16563,"journal":{"name":"Journal of neurophysiology","volume":" ","pages":"1761-1794"},"PeriodicalIF":2.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144009404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distinct and complementary roles of corticospinal and corticoreticulospinal pathways in motor behaviors post stroke.","authors":"Christopher M Patrick","doi":"10.1152/jn.00068.2025","DOIUrl":"10.1152/jn.00068.2025","url":null,"abstract":"<p><p>Taga et al. (<i>J Neurophysiol</i> 132: 1917-1936, 2024) investigates the distinct roles of the corticospinal tract (CST) and corticoreticulospinal tract (CReST) in chronic motor behaviors post stroke. Their findings indicate that CST projection strength is associated with motor control and muscle individuation, whereas CReST projection strength is associated with strength. These results provide evidence that the CST and CReST pathways serve unique but complementary functions in regulating human movement.</p>","PeriodicalId":16563,"journal":{"name":"Journal of neurophysiology","volume":" ","pages":"1967-1970"},"PeriodicalIF":2.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reverse correlation of natural statistics for ecologically relevant characterization of human perceptual templates.","authors":"Lorenzo Landolfi, Peter Neri","doi":"10.1152/jn.00059.2024","DOIUrl":"10.1152/jn.00059.2024","url":null,"abstract":"<p><p>Psychophysical reverse correlation is an established technique for characterizing perceptual templates. Its application is best suited to a scenario in which <i>1</i>) the human observer operates as a template matcher, and <i>2</i>) the perceptual system is probed using radially symmetric noise, such as Gaussian white noise. When both conditions apply, the resulting estimate of the perceptual template directly reflects the actual template engaged by observers. However, when either condition fails, template estimates can be highly distorted to the point of becoming uninterpretable. This limitation is particularly pertinent when ecological relevance is under consideration because natural signals are clearly nothing like white noise. Template distortions associated with natural statistics may be corrected using a number of methods, many of which have been tested in single neurons, but none of which has been tested in human observers. We studied the applicability (or lack thereof) of five such methods to multiple experimental conditions under which the human visual system approaches a template matcher to different degrees of approximation. We find that methods based on minimizing/maximizing loss/information, such as logistic regression and maximally informative dimensions, outperform other approaches under the conditions of our experiments, and therefore represent promising tools for the characterization of human perceptual templates under ecologically relevant conditions. However, we also identify plausible scenarios under which those same approaches produce misleading outcomes, urging caution when interpreting results from those and related methods.<b>NEW & NOTEWORTHY</b> Reverse correlation is the method of choice for estimating neuronal/perceptual receptive fields, however, its applicability to natural behavior is hampered by the highly structured statistics of natural scenes. Although contemporary techniques for incorporating natural statistics have proven successful in neuronal settings, their applicability to psychophysical settings is unknown. We demonstrate that those techniques are indeed applicable to human observers, but with some important caveats that, if ignored, may lead to gross misinterpretations of the perceptual process.</p>","PeriodicalId":16563,"journal":{"name":"Journal of neurophysiology","volume":" ","pages":"1717-1739"},"PeriodicalIF":2.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144004459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-altitude-induced cerebral edema in mice is alleviated by bestatin-mediated blood-brain barrier protection.","authors":"Hao Wang, Qi Zhang, Ping Ma, Ning Huang, Yi Chen, Yuan Cheng, Jin Chen","doi":"10.1152/jn.00381.2024","DOIUrl":"10.1152/jn.00381.2024","url":null,"abstract":"<p><p>High-altitude cerebral edema (HACE), arising from exposure to acute hypobaric hypoxia (HH), is a severe and potentially life-threatening evolution of acute mountain sickness (AMS) in high-altitude areas. CD13 is reported to facilitate angiogenesis by degrading extracellular matrix, including tight junctions (TJs). As an effective CD13 inhibitor, bestatin has demonstrated benefits in antiangiogenic therapies for various tumors. However, the impact of bestatin on HACE remains to be elucidated. The present study aims to explore the effects of bestatin in a HACE mouse model. HACE was established by placing 8-wk-old male C57BL/6 mice in a HH environment with a simulated altitude of 7,000 m above sea level for 48 h. Bestatin (1 mg/kg) was administrated intraperitoneally. The effects of bestatin were evaluated with brain water content (BWC) measurements, blood-brain barrier (BBB) integrity detection, and neurological impairment assessments. Increased brain CD13 levels were observed in mice after acute HH exposure. Bestatin significantly lowered BWC and mitigated BBB disruption and naturally improved neurological deficits. Additionally, bestatin curbed HH-induced microglial activation and the loss of astrocytes and neurons. Mechanistically, bestatin suppressed the activation of Hif-1α/NF-κB signaling pathway and reduced Matrix metalloproteinase 9 (MMP-9) expression and activity in the hippocampus of HACE mice. Acute HH-induced upregulation of CD13 primarily damages the BBB by enhancing MMP-9 expression and microglial activation, leading to vasogenic edema, and bestatin, by inhibiting CD13, has the ability to reduce cerebral edema and neurological deficits, showing potential as a future HACE prevention and treatment strategy.<b>NEW & NOTEWORTHY</b> Our findings indicate that acute hypobaric hypoxia exposure can induce a series of changes in cerebral vascular permeability through upregulation of CD13, leading to cerebral edema and neurological deficits. Bestatin, as a specific CD13 inhibitor, can effectively alleviate brain damage caused by acute hypobaric hypoxia exposure and is a potential high-altitude cerebral edema (HACE) therapeutic drug.</p>","PeriodicalId":16563,"journal":{"name":"Journal of neurophysiology","volume":" ","pages":"1902-1915"},"PeriodicalIF":2.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143968274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interneurons exhibit attenuated ectopic action potential firing in a severe neurodevelopmental disorder.","authors":"Sophie F Hill, Sophie R Liebergall, Eric R Wengert, Ethan M Goldberg, Brian B Theyel","doi":"10.1152/jn.00133.2025","DOIUrl":"10.1152/jn.00133.2025","url":null,"abstract":"<p><p>Dravet syndrome (DS) is a severe neurodevelopmental disorder associated with treatment-resistant epilepsy and features of autism spectrum disorder due to loss of the voltage-gated sodium channel subunit Nav1.1. Recent work suggests that a pathogenic mechanism of DS is impaired action potential propagation along axons of cerebral cortex parvalbumin-positive fast-spiking GABAergic interneurons (PVINs). Here, we investigated another aspect of axonal physiology: action potentials generated in the distal axon, known as \"ectopic\" action potentials (EAPs). We hypothesized that EAP frequency could be a proxy for the excitability of the distal axon and that EAPs would be attenuated in neocortical layer 2/3 PVINs from DS mice due to axonal dysfunction. We identified reduced EAP generation in DS PVINs at both <i>postnatal day</i> (P)18-21 and P35-56 and a complete absence of barrage (repetitive EAP) firing. This is the first evidence of impaired EAP firing in a disease model.<b>NEW & NOTEWORTHY</b> Dravet syndrome (DS) is a severe form of epilepsy primarily caused by reduced excitability of inhibitory neurons. Our research identifies a new abnormality in DS mice: reduced ectopic action potentials (EAPs). We have previously shown that EAPs are engaged after increased excitability, manifesting in most parvalbumin-expressing interneurons (PVINs) as a high-frequency train of persistent action potentials. Our work represents the first evidence linking a deficiency in EAP generation-an underexplored intrinsic property-with any neuropathology.</p>","PeriodicalId":16563,"journal":{"name":"Journal of neurophysiology","volume":" ","pages":"1692-1698"},"PeriodicalIF":2.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12151314/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143972269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neural and psychoacoustic insights into amplitude modulation processing and its link with speech perception in noise.","authors":"Clémence Basire, Irene Lorenzini, Laurianne Cabrera","doi":"10.1152/jn.00007.2025","DOIUrl":"10.1152/jn.00007.2025","url":null,"abstract":"<p><p>Temporal modulations, especially amplitude modulations (AMs), play a fundamental role in speech perception in noisy environments, as highlighted by psychoacoustic research. However, the mechanisms underlying AM processing and its contribution to speech perception in noise remain unclear. The present study combined both behavioral psychophysics and electroencephalography (EEG) measures to investigate AM processing and its relationship to the perception of consonants in noise for young adults with normal hearing. Participants completed psychoacoustic measures of AM sensitivity, i.e., detection thresholds for AM fluctuations at 8 Hz, and susceptibility to AM masking (the effect on AM detection thresholds of interfering AM fluctuations carried by a masker) at 8 Hz. In addition, participants underwent an EEG recording measuring the neural AM following response (AMFR, or envelope following response) for AM tones modulated at 8 or 40 Hz presented without masking. Finally, they completed a consonant identification task in a stationary speech-shaped noise. Results showed a significant positive correlation between the signal-to-noise ratio of the AMFR recorded at 8 Hz and AM masking effects measured at the same rate. This finding is discussed in terms of both reduced selectivity of AM filters and elevated internal noise. Finally, no relationship between AM measures and consonant-in-noise perception was observed, suggesting that the mechanisms involved in AM processing may not fully capture the ability of adults with normal hearing to identify consonants in noisy backgrounds.<b>NEW & NOTEWORTHY</b> Results showed a significant correlation between the amplitude modulation (AM) following response (AMFR) and AM masking effect. Participants who are more susceptible to AM masking exhibit higher neural tracking of AM at the same fluctuation rate (8 Hz). This result might be explained both in terms of reduced selectivity of AM filters and elevated internal noise. Our results also showed no relationship between AM measures and consonant-in-noise perception, indicating that AM sensitivity mechanisms do not fully explain speech-in-noise perception skills in young normal-hearing adults.</p>","PeriodicalId":16563,"journal":{"name":"Journal of neurophysiology","volume":" ","pages":"1828-1835"},"PeriodicalIF":2.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144025311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute effects of orofacial, neck, and shoulder relaxation exercises and chewing on soleus H-reflex and motor unit discharge patterns.","authors":"Marša Magdič, Aleš Holobar, Matej Kramberger, Matjaž Vogrin, Nina Murks, Anita Fekonja, Miloš Kalc","doi":"10.1152/jn.00461.2024","DOIUrl":"10.1152/jn.00461.2024","url":null,"abstract":"<p><p>The interconnected nature of orofacial, neck musculature, and the neural system suggests that localized activities, such as teeth clenching, can influence remote spinal excitability. Although stretching exercises are known to have both local and remote effects, the specific impact of orofacial muscle stretching remains underexplored. This study investigates the effects of two interventions: 25 guided orofacial and neck stretching and mobility exercises (exercises), and chewing six chewing gums for six minutes (chewing), on the soleus H-reflex and D1 presynaptic inhibition. Ten volunteers (mean age: 28.75 ± 9 yr) participated, with H-reflex measurements collected using high-density electromyography (HDsEMG) before and after each intervention. Latency (H_LAT), duration (H_DUR), peak-to-peak (H_P2P, D1_P2P), and positive peak (H_POS) amplitudes were extracted from unconditioned and conditioned H-reflexes. The ratio (D1_P2P/H_P2P) between conditioned (D1_P2P) and unconditioned (H_P2P) H-reflex was calculated to study the D1 presynaptic inhibition mechanisms. In addition, 8,400 firings from 376 distinct motor units (MUs), categorized by firing threshold were analyzed for latency, firing ratio, and inhibition probability (D1_PROB). H_P2P, H_POS decreased and H_DUR was significantly increased after the exercise intervention, whereas the chewing intervention had no effect on these parameters. The D1_P2P/H_P2P ratio and D1_PROB remained unchanged, suggesting that the observed drop in H_P2P is not mediated by presynaptic inhibition mechanisms. Single MU analysis confirmed the H-reflex findings. The results of this study suggest that stretching and mobility exercises targeting the neck and orofacial region can reduce neuromuscular excitability, offering potential for nonpharmacological management of conditions associated with motoneuron hyperexcitability and general whole body relaxation.<b>NEW & NOTEWORTHY</b> This study provides the first evidence that orofacial and neck mobility exercises can acutely reduce spinal excitability in remote lower-limb muscles. By combining high-density surface EMG with both global and single motor unit H-reflex analyses, we demonstrate a decrease in soleus H-reflex amplitude independent of presynaptic inhibition. These findings suggest potential nonpharmacological applications for managing motoneuron hyperexcitability and promoting whole body relaxation in individuals with cervical and orofacial constraints.</p>","PeriodicalId":16563,"journal":{"name":"Journal of neurophysiology","volume":" ","pages":"1886-1901"},"PeriodicalIF":2.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144007563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}