Journal of microbiology and biotechnology最新文献_第3页

Understanding Metabolic Pathway Rewiring by Oncogenic Gamma Herpesvirus. 了解致癌γ-疱疹病毒的代谢途径重配。

IF 2.5 4区生物学

Journal of microbiology and biotechnology Pub Date : 2024-11-28 Epub Date: 2024-08-30 DOI: 10.4014/jmb.2407.07039

Un Yung Choi, Seung Hyun Lee

引用次数: 0

Distributions of Fecal Indicators at Aquaculture Areas in a Bay of Republic of Korea. 大韩民国海湾水产养殖区的粪便指标分布。

IF 2.5 4区生物学

Journal of microbiology and biotechnology Pub Date : 2024-11-28 Epub Date: 2024-10-16 DOI: 10.4014/jmb.2406.06001

SungJun Park, Cheonghoon Lee, Sung Jae Jang, Kyuseon Cho, Jin Hwi Kim, Woon-Ki Kim, Joo-Hyon Kang, Kwon-Sam Park, GwangPyo Ko

{"title":"Distributions of Fecal Indicators at Aquaculture Areas in a Bay of Republic of Korea.","authors":"SungJun Park, Cheonghoon Lee, Sung Jae Jang, Kyuseon Cho, Jin Hwi Kim, Woon-Ki Kim, Joo-Hyon Kang, Kwon-Sam Park, GwangPyo Ko","doi":"10.4014/jmb.2406.06001","DOIUrl":"10.4014/jmb.2406.06001","url":null,"abstract":"Aquaculture products, such as clams, scallops, and oysters, are major vectors of fecal-derived pathogens. Male-specific and somatic coliphages are strongly correlated with human noroviruses, the major enteric viruses worldwide. Geographic information system with local land-use patterns can also provide valuable information for tracking sources of fecal-derived pathogens. We examined distributions of four fecal indicator microorganisms, i.e., male-specific and somatic coliphage, total coliform, and Escherichia coli (E. coli) in three river and seawater sampling sites located on the coast of Gomso Bay in the Republic of Korea during the sampling period (from March 2015 to January 2016). Geospatial analyses of fecal indicators and correlations between environmental parameters and fecal indicators or among fecal indicators were also performed. Overall, river water samples showed highest concentrations of both types of coliphage in summer (July 2015). High concentrations of both total coliform and E. coli were detected in river water during the period from July to September 2015. High concentrations of all fecal indicators were found at site GL02, located in the innermost part of Gomso Bay, which has high-density agriculture and residential areas. Environmental factors related to precipitation-cumulative precipitation on and from 3 days before the sampling day (Prep-0 and Prep-3, respectively)-and salinity were strongly correlated with the concentrations of all fecal indicators. The present results suggest that investigations of multiple fecal indicators with systemic geospatial information are necessary for precisely tracking fecal contaminations of aquaculture products.","PeriodicalId":16481,"journal":{"name":"Journal of microbiology and biotechnology","volume":"34 12","pages":"2223-2230"},"PeriodicalIF":2.5,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142522114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of Plasmid Curing Efficiency across Five Lactic Acid Bacterial Species. 五种乳酸菌质粒固化效率的比较

IF 2.5 4区生物学

Journal of microbiology and biotechnology Pub Date : 2024-11-28 Epub Date: 2024-09-11 DOI: 10.4014/jmb.2406.06003

Chan-Hyeok Park, Haneol Yang, Seunghyun Kim, Chan-Seok Yun, Byung-Chun Jang, Yeong-Jin Hong, Doo-Sang Park

{"title":"Comparison of Plasmid Curing Efficiency across Five Lactic Acid Bacterial Species.","authors":"Chan-Hyeok Park, Haneol Yang, Seunghyun Kim, Chan-Seok Yun, Byung-Chun Jang, Yeong-Jin Hong, Doo-Sang Park","doi":"10.4014/jmb.2406.06003","DOIUrl":"10.4014/jmb.2406.06003","url":null,"abstract":"With the recent stringent criteria for antibiotic susceptibility in probiotics, the presence of antibiotic resistance genes and plasmids associated with their transfer has become a limiting factor in the approval of probiotics. The need to remove genes related to antibiotic resistance and virulence through plasmid curing for the authorization of probiotics is increasing. In this study, we investigated the curing efficiency of ethidium bromide, acridine orange, and novobiocin at different concentrations and durations in five strains of plasmid-bearing lactic acid bacteria and examined the curing characteristics in each strain. Limosibacillus reuteri and Lacticaseibacillus paracasei exhibited curing efficiencies ranging from 5% to 44% following treatment with ethidium bromide (10-50 μg/ml) for 24-72 h, while Lactobacillus gasseri showed the highest efficiency at 14% following treatment with 10 μg/ml novobiocin for 24 h. Lactiplantibacillus plantarum, which harbors two or more plasmids, demonstrated curing efficiencies ranging from 1% to 8% after an additional 72-h treatment of partially cured strains with 10 μg/ml novobiocin. Plasmid curing in strains with larger plasmids exhibited lower efficiencies and required longer durations. In strains harboring two or more plasmids, a relatively low curing efficiency with a single treatment and a high frequency of false positives, wherein recovery occurred after curing, were observed. Although certain strains exhibited altered susceptibilities to specific antibiotics after curing, these outcomes could not be attributed to the loss of antibiotic resistance genes. Furthermore, the genomic data from the cured strains revealed minimal changes throughout the genome that did not lead to gene mutations.","PeriodicalId":16481,"journal":{"name":"Journal of microbiology and biotechnology","volume":"34 11","pages":"2385-2395"},"PeriodicalIF":2.5,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142467896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel gnd_v2 Fusion Tag and Engineered TEV Protease Enable Efficient Production of Brazzein. 新型 gnd_v2 融合标记和工程化 TEV 蛋白酶可高效生产 Brazzein。

IF 2.5 4区生物学

Journal of microbiology and biotechnology Pub Date : 2024-11-28 Epub Date: 2024-09-09 DOI: 10.4014/jmb.2407.07047

Yu Wang, Jiayao Zheng, Fan Wen, Bowen Tu, Lun Cui

{"title":"Novel gnd_v2 Fusion Tag and Engineered TEV Protease Enable Efficient Production of Brazzein.","authors":"Yu Wang, Jiayao Zheng, Fan Wen, Bowen Tu, Lun Cui","doi":"10.4014/jmb.2407.07047","DOIUrl":"10.4014/jmb.2407.07047","url":null,"abstract":"Protein solubility and purification challenges often hinder the large-scale production of valuable proteins like brazzein, a potent sweet protein with significant health benefits and commercial potential. This study introduces two novel tools to overcome protein expression and purification bottlenecks: a gnd_v2 fusion tag and an engineered Tobacco Etch Virus (TEV) protease. The gnd_v2 tag, derived from 6-phosphogluconate dehydrogenase, was engineered to improve the soluble expression of brazzein. This tag increased brazzein's solubility by four times compared to the wild-type gnd tag, marking a significant advancement in efficient brazzein production. To address the challenge of cleaving the fusion tag, we engineered a TEV protease variant with high efficiency, particularly at the glutamine residue at brazzein's P1' site - a known difficulty for wild-type TEV proteases. We achieved streamlined production of pure, functional brazzein by integrating this tailored protease cleavage with an ultrafiltration-based purification protocol. Notably, the purified brazzein demonstrated a sweetness potency approximately 2500 times that of sucrose, highlighting its potential as a high-intensity natural sweetener. While this study focused on brazzein, the gnd_v2 tag shows promise for enhancing the solubility of other challenging proteins. More broadly, this work presents a versatile toolset for the scalable production of diverse functional proteins, with significant implications for industrial applications in food and pharmaceutical domains.","PeriodicalId":16481,"journal":{"name":"Journal of microbiology and biotechnology","volume":"34 11","pages":"2310-2320"},"PeriodicalIF":2.5,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142289455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Mitophagy-Related Genes on the Diagnosis and Development of Esophageal Squamous Cell Carcinoma via Single-Cell RNA-seq Analysis and Machine Learning Algorithms. 通过单细胞RNA-seq分析和机器学习算法研究有丝分裂相关基因对食管鳞状细胞癌诊断和发展的影响

IF 2.5 4区生物学

Journal of microbiology and biotechnology Pub Date : 2024-11-28 Epub Date: 2024-09-23 DOI: 10.4014/jmb.2407.07052

Xuzhi Mo, Feng Ji, Jianguang Chen, Chengcheng Yi, Fang Wang

{"title":"Impact of Mitophagy-Related Genes on the Diagnosis and Development of Esophageal Squamous Cell Carcinoma via Single-Cell RNA-seq Analysis and Machine Learning Algorithms.","authors":"Xuzhi Mo, Feng Ji, Jianguang Chen, Chengcheng Yi, Fang Wang","doi":"10.4014/jmb.2407.07052","DOIUrl":"10.4014/jmb.2407.07052","url":null,"abstract":"As a treatment for esophageal squamous cell carcinoma (ESCC), which is common and fatal, mitophagy is a conserved cellular mechanism that selectively removes damaged mitochondria and is crucial for cellular homeostasis. While tumor development and resistance to anticancer therapies are related to ESCC, their role in ESCC remains unclear. Here, we investigated the relationship between mitophagy-related genes (MRGs) and ESCC to provide novel insights into the role of mitophagy in ESCC prognosis and diagnosis prediction. First, we identified MRGs from the GeneCards database and examined them at both the single-cell and transcriptome levels. Key genes were selected and a prognostic model was constructed using least absolute shrinkage and selection operator analysis. External validation was performed using the GSE53624 dataset and Kaplan-Meier survival analysis was performed to identify PYCARD as a gene significantly associated with survival in ESCC. We then examined the effect of PYCARD on ESCC cell proliferation and migration and identified 169 MRGs at the single-cell and transcriptome levels, as well as the high-risk groups associated with cancer-related pathways. Thirteen key genes were selected for model construction via multiple machine learning algorithms. PYCARD, which is upregulated in patients with ESCC, was negatively correlated with prognosis and its knockdown inhibited ESCC cell proliferation and migration. Our ESCC prediction model based on mitophagy-related genes demonstrated promising results and provides more options for the management and clinical treatment of ESCC patients. Moreover, targeting or regulating PYCARD levels might offer new therapeutic strategies for ESCC patients in clinical settings.","PeriodicalId":16481,"journal":{"name":"Journal of microbiology and biotechnology","volume":"34 11","pages":"2362-2375"},"PeriodicalIF":2.5,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142348416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antimelanogenic and Antioxidant Effects of Postbioics of Lactobacillus Strains in α-MSH-Induced B16F10 Melanoma Cells via CREB/MITF and MAPKs Signaling Pathway. 通过 CREB/MITF 和 MAPKs 信号通路，乳酸杆菌菌株后生物制剂在 α-MSH 诱导的 B16F10 黑色素瘤细胞中的抗黑色素生成和抗氧化作用

IF 2.5 4区生物学

Journal of microbiology and biotechnology Pub Date : 2024-11-28 Epub Date: 2024-09-30 DOI: 10.4014/jmb.2408.08015

Hye-Won Lee, Yu-Rim Lee, Kyung-Min Park, Na-Kyoung Lee, Hyun-Dong Paik

{"title":"Antimelanogenic and Antioxidant Effects of Postbioics of Lactobacillus Strains in α-MSH-Induced B16F10 Melanoma Cells via CREB/MITF and MAPKs Signaling Pathway.","authors":"Hye-Won Lee, Yu-Rim Lee, Kyung-Min Park, Na-Kyoung Lee, Hyun-Dong Paik","doi":"10.4014/jmb.2408.08015","DOIUrl":"10.4014/jmb.2408.08015","url":null,"abstract":"Abnormal melanin synthesis can lead to severe skin problems. This study investigated the anti-melanogenic effects on α-melanocyte stimulating hormone (α-MSH)-induced B16F10 cells using cell-free supernatants of Lactiplantibacillus plantarum WB326 and Levilactobacillus brevis WB2810. Samples were prepared using 1 mg/ml freeze-dried culture supernatant. Cell viability was assessed using B16F10 cells and MTT assay. Tyrosinase inhibition and melanin content decreased in the samples compared to those treated with α-MSH. This effect was also observed when L-DOPA staining was used under a microscope. Moreover, the mRNA expression levels of microphthalmia-associated transcription factor (MITF), tyrosinase, tyrosinase-related protein (TRP)-1, and TRP-2 decreased in the sample-treated group. Protein expression of the CREB/MITF/MAPK signaling pathway was also reduced. Using HPLC analysis, lactic and acetic acids were detected in the culture supernatants. Finally, the antioxidant effects of the samples were confirmed by comparison with those of Trolox and arbutin. According to the experimental results, their utilization is possible in the fields of functional materials and cosmetic ingredients.","PeriodicalId":16481,"journal":{"name":"Journal of microbiology and biotechnology","volume":"34 11","pages":"2279-2289"},"PeriodicalIF":2.5,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142522095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular Characterization and Interaction between Human VEGF-D and VEGFR-3. 人血管内皮生长因子-D 和血管内皮生长因子受体-3 之间的分子特征和相互作用。

IF 2.5 4区生物学

Journal of microbiology and biotechnology Pub Date : 2024-11-20 DOI: 10.4014/jmb.2409.09060

Chae Eun Seo, Han Na Lee, Mi Suk Jeong, Se Bok Jang

{"title":"Molecular Characterization and Interaction between Human VEGF-D and VEGFR-3.","authors":"Chae Eun Seo, Han Na Lee, Mi Suk Jeong, Se Bok Jang","doi":"10.4014/jmb.2409.09060","DOIUrl":"https://doi.org/10.4014/jmb.2409.09060","url":null,"abstract":"Angiogenesis and lymphangiogenesis are some of the routes that cause metastasis. Vascular Endothelial Growth Factors (VEGFs) stimulate angiogenesis and lymphangiogenesis through VEGF receptors. Especially, VEGF-D and its receptor, VEGFR-3, play a pivotal role in regulating cellular processes such as survival, proliferation, and migration, thereby influencing lymphangiogenesis. The aim of this research is to clarify the molecular characteristics of VEGF-D and VEGFR-3 proteins and identify the key residues that are essential for the interaction between VEGF-D and VEGFR-3. Experiments, including size exclusion chromatography and GST pull-down assay analysis, reveal that specific residues, particularly D103 and Q110, are essential for VEGF-D/VEGFR-3 binding. Mutations in these residues induce structural alterations, resulting in reduced binding affinity and impaired activation of VEGFR-3. Moreover, this study suggests that a synthesized peptide, designed based on key residues of VEGF-D involved in binding to VEGFR-3, may act as a metastasis suppressor by competitively inhibiting the interaction between VEGF-D and VEGFR-3. Understanding these molecular interactions is expected to have significant potential to develop therapeutic peptides that can inhibit cancer cell-induced lymphangiogenesis and resolve metastasis via lymphangiogenesis across various cancer types.","PeriodicalId":16481,"journal":{"name":"Journal of microbiology and biotechnology","volume":"34 12","pages":"1-10"},"PeriodicalIF":2.5,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142739790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Comprehensive Review of Naringenin, a Promising Phytochemical with Therapeutic Potential. 柚皮苷--一种具有治疗潜力的植物化学物质--综述。

IF 2.5 4区生物学

Journal of microbiology and biotechnology Pub Date : 2024-11-20 DOI: 10.4014/jmb.2410.10006

Jun Hong Shin, Seung Ho Shin

引用次数: 0

Green Tea Attenuates the Particulate Matter (PM)_2.5-Exposed Gut-Brain Axis Dysfunction through Regulation of Intestinal Microenvironment and Hormonal Changes. 绿茶通过调节肠道微环境和激素变化减轻颗粒物（PM）2.5暴露的肠脑轴功能障碍

IF 2.5 4区生物学

Journal of microbiology and biotechnology Pub Date : 2024-10-31 DOI: 10.4014/jmb.2409.09035

Jong Min Kim, Hyo Lim Lee, Min Ji Go, Hyun-Jin Kim, Mi Jeong Sung, Ho Jin Heo

{"title":"Green Tea Attenuates the Particulate Matter (PM)2.5-Exposed Gut-Brain Axis Dysfunction through Regulation of Intestinal Microenvironment and Hormonal Changes.","authors":"Jong Min Kim, Hyo Lim Lee, Min Ji Go, Hyun-Jin Kim, Mi Jeong Sung, Ho Jin Heo","doi":"10.4014/jmb.2409.09035","DOIUrl":"https://doi.org/10.4014/jmb.2409.09035","url":null,"abstract":"Chronic exposure to particulate matter (PM)2.5 causes brain damage through intestinal imbalance. This study was estimated to confirm the regulatory activity of green tea against chronic PM2.5 exposure-induced abnormal gut-brain axis (GBA) in BALB/c mice. The green tea, as an aqueous extract of matcha (EM), ameliorated the colon length, short chain fatty acid contents, antioxidant biomarkers, myeloperoxidase (MPO) activity, and serum inflammatory cytokines. EM regulated the gut microbiota related to tryptophan intake and hormone metabolism. EM showed regulatory effect of intestinal tight junction (TJ) protein, inflammatory response, and apoptotic biomarkers. In addition, EM improved PM2.5-induced tryptophan-related hormonal metabolic dysfunction in intestinal tissue and serum. Through the ameliorating effect on GBA function, the consumption of EM presented the protective effect against inflammatory effect, apoptosis, synaptic damage, and hormonal activity in cerebral tissue, and suppressed abnormal change of brain lipid metabolites. In particular, EM intake showed relatively excellent improvement effects on indicators including Bacteroides, Ruminococcus, Murinobaculaceae, Allopreyotella, cyclooxygenase-2 (COX-2), acetylcholinesterase (AChE), 11,12 dihydroxyeicosatrienoic acid (DHET), and intestinal acetate from the PM group. These findings indicate that the dietary intake of EM might provide a regulatory effect against PM2.5-exposed GBA dysfunction via the intestinal microbiota and hormonal changes.","PeriodicalId":16481,"journal":{"name":"Journal of microbiology and biotechnology","volume":"34 12","pages":"1-14"},"PeriodicalIF":2.5,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142687054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-Inflammatory Activity of Biotransformed Platycodon grandiflorum Root Extracts Containing 3-O-β-D-Glucopyranosyl Platycosides in LPS-Stimulated Alveolar Macrophages, NR8383 Cells. 含 3-O-β-D-Glucopyranosyl Platycosides 的生物转化桔梗根提取物在 LPS 刺激的肺泡巨噬细胞 NR8383 细胞中的抗炎活性

IF 2.5 4区生物学

Journal of microbiology and biotechnology Pub Date : 2024-10-31 DOI: 10.4014/jmb.2408.08005

Jeong Won Choi, Hyeok Jin Choi, Chae Sun Na, Hwan Lee, Byung Joo Lee, Kyung-Chul Shin, Jin Boo Jeong

{"title":"Anti-Inflammatory Activity of Biotransformed Platycodon grandiflorum Root Extracts Containing 3-O-β-D-Glucopyranosyl Platycosides in LPS-Stimulated Alveolar Macrophages, NR8383 Cells.","authors":"Jeong Won Choi, Hyeok Jin Choi, Chae Sun Na, Hwan Lee, Byung Joo Lee, Kyung-Chul Shin, Jin Boo Jeong","doi":"10.4014/jmb.2408.08005","DOIUrl":"https://doi.org/10.4014/jmb.2408.08005","url":null,"abstract":"Acute lung injury (ALI) is a severe inflammatory condition characterized by excessive immune responses and oxidative stress, leading to significant tissue damage. Given the need for novel therapeutic agents, this study aimed to explore the anti-inflammatory activity and mechanisms of biotransformed Platycodon grandiflorum root extracts (BT-PGR), which were enzymatically processed using rapidsase PL Classic from Aspergillus niger. The goal was to assess the potential of BT-PGR as a natural treatment for ALI. BT-PGR effectively inhibited the production of NO, iNOS, IL-1β, IL-6, and TNF-α induced by LPS in NR8383 cells. BT-PGR inhibited the phosphorylation of ERK1/2, p38, JNK and p65 in LPS-stimulated NR8383 cells. In addition, BT-PGR suppressed LPS-mediated activation of NFκB luciferase activity. BT-PGR increased the levels of HO-1 and the inhibition of HO-1 by ZnPP attenuated BT-PGR-mediated inhibition of NO production. In addition, the inhibition of PI3K by LY294002 blocked the BT-PGR-mediated increase of HO-1 level. BT-PGR increased nuclear Nrf2 level and the knockdown of Nrf2 by siRNA inhibited BT-PGR-mediated increase of HO-1 level. In addition, inhibition of PI3K by LY294002 suppressed the increase of nuclear Nrf2 level. Based on these results, it can be inferred that BT-PGR exhibits anti-inflammatory activity in rat alveolar macrophages, suggesting its potential as a natural candidate for the improvement of ALI.","PeriodicalId":16481,"journal":{"name":"Journal of microbiology and biotechnology","volume":"34 12","pages":"1"},"PeriodicalIF":2.5,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142546002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0