{"title":"2,3-脱氢水飞蓟宾对神经胶质细胞和氯喹处理小鼠的止痒作用。","authors":"Bo-Mi Kim, Byoung Ok Cho, Seon Il Jang","doi":"10.4014/jmb.2502.02015","DOIUrl":null,"url":null,"abstract":"<p><p>Pruritus is an inflammatory skin disorder that reduces the patient's quality of life. Meanwhile, 2,3-dehydrosilybin (DHS) belongs to a class of flavonolignans derived from milk thistle seeds, and is known to have anticancer, hepatoprotective, antioxidant, and angiogenic effects. In the current study, the inhibitory effect of DHS on pruritus was investigated in lipopolysaccharide (LPS)-stimulated microglia, IL-31- and IL-6-treated astrocytes, and chloroquine-treated mice. DHS was shown to suppress pruritus-related cytokines IL-31 and IL-6 in LPS-treated microglia. Moreover, DHS inhibited activation of MAPKs (p38, ERK, and JNK) in LPS-stimulated microglia. Furthermore, DHS prevented activation of STAT3 and LCN-2 production in IL-31- and IL-6-treated astrocytes. In addition, DHS inhibited scratching and GFAP expression in chloroquine-treated mice. These results suggest that DHS may prevent and/or treat pruritus.</p>","PeriodicalId":16481,"journal":{"name":"Journal of microbiology and biotechnology","volume":"35 ","pages":"e2502015"},"PeriodicalIF":2.5000,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12149399/pdf/","citationCount":"0","resultStr":"{\"title\":\"Antipruritic Effect of 2,3-Dehydrosilybin in Glial Cells and Chloroquine-Treated Mice.\",\"authors\":\"Bo-Mi Kim, Byoung Ok Cho, Seon Il Jang\",\"doi\":\"10.4014/jmb.2502.02015\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Pruritus is an inflammatory skin disorder that reduces the patient's quality of life. Meanwhile, 2,3-dehydrosilybin (DHS) belongs to a class of flavonolignans derived from milk thistle seeds, and is known to have anticancer, hepatoprotective, antioxidant, and angiogenic effects. In the current study, the inhibitory effect of DHS on pruritus was investigated in lipopolysaccharide (LPS)-stimulated microglia, IL-31- and IL-6-treated astrocytes, and chloroquine-treated mice. DHS was shown to suppress pruritus-related cytokines IL-31 and IL-6 in LPS-treated microglia. Moreover, DHS inhibited activation of MAPKs (p38, ERK, and JNK) in LPS-stimulated microglia. Furthermore, DHS prevented activation of STAT3 and LCN-2 production in IL-31- and IL-6-treated astrocytes. In addition, DHS inhibited scratching and GFAP expression in chloroquine-treated mice. These results suggest that DHS may prevent and/or treat pruritus.</p>\",\"PeriodicalId\":16481,\"journal\":{\"name\":\"Journal of microbiology and biotechnology\",\"volume\":\"35 \",\"pages\":\"e2502015\"},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2025-05-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12149399/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of microbiology and biotechnology\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://doi.org/10.4014/jmb.2502.02015\",\"RegionNum\":4,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"BIOTECHNOLOGY & APPLIED MICROBIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of microbiology and biotechnology","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.4014/jmb.2502.02015","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"BIOTECHNOLOGY & APPLIED MICROBIOLOGY","Score":null,"Total":0}
Antipruritic Effect of 2,3-Dehydrosilybin in Glial Cells and Chloroquine-Treated Mice.
Pruritus is an inflammatory skin disorder that reduces the patient's quality of life. Meanwhile, 2,3-dehydrosilybin (DHS) belongs to a class of flavonolignans derived from milk thistle seeds, and is known to have anticancer, hepatoprotective, antioxidant, and angiogenic effects. In the current study, the inhibitory effect of DHS on pruritus was investigated in lipopolysaccharide (LPS)-stimulated microglia, IL-31- and IL-6-treated astrocytes, and chloroquine-treated mice. DHS was shown to suppress pruritus-related cytokines IL-31 and IL-6 in LPS-treated microglia. Moreover, DHS inhibited activation of MAPKs (p38, ERK, and JNK) in LPS-stimulated microglia. Furthermore, DHS prevented activation of STAT3 and LCN-2 production in IL-31- and IL-6-treated astrocytes. In addition, DHS inhibited scratching and GFAP expression in chloroquine-treated mice. These results suggest that DHS may prevent and/or treat pruritus.
期刊介绍：
The Journal of Microbiology and Biotechnology (JMB) is a monthly international journal devoted to the advancement and dissemination of scientific knowledge pertaining to microbiology, biotechnology, and related academic disciplines. It covers various scientific and technological aspects of Molecular and Cellular Microbiology, Environmental Microbiology and Biotechnology, Food Biotechnology, and Biotechnology and Bioengineering (subcategories are listed below). Launched in March 1991, the JMB is published by the Korean Society for Microbiology and Biotechnology (KMB) and distributed worldwide.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
