Journal of Nervous and Mental Disease最新文献_第2页

Tobacco Use Disorder and Co-Occurring Mental Health Conditions: Considerations for Future DSM. 烟草使用障碍和共同发生的精神健康状况：对未来DSM的考虑。

IF 1.5 4区医学

Journal of Nervous and Mental Disease Pub Date : 2026-09-01 Epub Date: 2026-09-29 DOI: 10.1097/NMD.0000000000001877

Megan M Kelly, Maria Karekla, Jaimee L Heffner

引用次数: 0

Emotional and Early Maladaptive Schemas in Adolescents Diagnosed With Major Depressive Disorder. 青少年重度抑郁障碍的情绪和早期适应不良图式。

IF 1.5 4区医学

Journal of Nervous and Mental Disease Pub Date : 2026-08-25 DOI: 10.1097/NMD.0000000000001886

Mesut Sari, Yasemin İmrek, Güler Göl Özcan, Yusuf Öztürk, Gonca Özyurt, Kadir Özdel, Ali Evren Tufan

{"title":"Emotional and Early Maladaptive Schemas in Adolescents Diagnosed With Major Depressive Disorder.","authors":"Mesut Sari, Yasemin İmrek, Güler Göl Özcan, Yusuf Öztürk, Gonca Özyurt, Kadir Özdel, Ali Evren Tufan","doi":"10.1097/NMD.0000000000001886","DOIUrl":"https://doi.org/10.1097/NMD.0000000000001886","url":null,"abstract":"Aim: Early maladaptive schemas and dysfunctional emotional schema beliefs are implicated in adolescent major depressive disorder; however, their relationship with comorbid anxiety disorders remains unclear.Methods: In this cross-sectional controlled cohort study, 87 adolescents diagnosed with major depressive disorder according to Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition criteria and 100 healthy controls completed the Young Schema Questionnaire-Short Form 3, the Leahy Emotional Schema Scale, the Beck Depression Inventory, and the Screen for Child Anxiety Related Emotional Disorders. Hierarchical regression analyses examined predictors of depressive symptom severity.Results: Adolescents with major depressive disorder demonstrated significantly higher early maladaptive schema and emotional schema scores than controls. Comorbid anxiety disorders were associated with greater schema pathology. In hierarchical regression analyses, LESS-II total score emerged as the strongest independent correlate of depressive symptom severity.Conclusions: Schema-related dysfunction is prominent in adolescent depression, particularly when anxiety is present.","PeriodicalId":16480,"journal":{"name":"Journal of Nervous and Mental Disease","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148818354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Traumatic Experiences and Obsessive-Compulsive Symptoms the Mediating Role of Dissociation: Erratum. 创伤经历与强迫症状：分离的中介作用：勘误。

IF 1.5 4区医学

Journal of Nervous and Mental Disease Pub Date : 2026-07-16 DOI: 10.1097/NMD.0000000000001878

Gianluca Santoro, Lucia Sideli, Fanny Guglielmucci, Grazia Terrone, Adriano Schimmenti

引用次数: 0

Response to the Correspondence on "Risk of Schizophrenia After a Diagnosis of Epilepsy". 对“癫痫诊断后精神分裂症风险”函件的回应。

IF 1.5 4区医学

Journal of Nervous and Mental Disease Pub Date : 2026-07-01 Epub Date: 2026-07-29 DOI: 10.1097/NMD.0000000000001879

Seung Won Lee, Hohyun Jung, Youngoh Bae

引用次数: 0

Metacognitive Interpersonal Group Therapy for Adolescents With Personality Disorders: Results From the METAMIND-A Pilot Randomized Controlled Trial. 青少年人格障碍的元认知人际团体治疗：meta - a随机对照试验的结果。

IF 1.5 4区医学

Journal of Nervous and Mental Disease Pub Date : 2026-07-01 Epub Date: 2026-07-20 DOI: 10.1097/NMD.0000000000001869

Felix Inchausti, Nancy V García-Poveda, Alejandro Ballesteros-Prados, Eduardo Fonseca-Pedrero, Angus MacBeth, Raffaele Popolo, Giancarlo Dimaggio

{"title":"Metacognitive Interpersonal Group Therapy for Adolescents With Personality Disorders: Results From the METAMIND-A Pilot Randomized Controlled Trial.","authors":"Felix Inchausti, Nancy V García-Poveda, Alejandro Ballesteros-Prados, Eduardo Fonseca-Pedrero, Angus MacBeth, Raffaele Popolo, Giancarlo Dimaggio","doi":"10.1097/NMD.0000000000001869","DOIUrl":"10.1097/NMD.0000000000001869","url":null,"abstract":"Aim: This pilot RCT evaluated the feasibility, acceptability, and preliminary effects of Metacognitive Interpersonal Group Therapy for Adolescents (MIT-GA) compared with waiting list plus treatment-as-usual (WL+TAU).Methods: One hundred adolescents (14-18 years) meeting DSM-IV criteria for PDs (excluding antisocial PD) were randomized to MIT-GA or WL+TAU for 4 months. Primary outcomes included treatment acceptability, psychosocial functioning (CGAS, IIP-64), and symptom severity (SCL-90-R GSI). Secondary outcomes were depression (Y-BDI), caregiver stress (PSS), and parental self-efficacy (BPSES). Mechanisms of change included metacognition (MAS-A), alexithymia (TAS-20), and impulsivity (BIS-11).Results: MIT-GA participants showed greater improvements in psychosocial functioning ( d = 0.80) and parental stress ( d = 0.65) versus WL+TAU. No significant between-group differences were found in overall symptom severity. MIT-GA also improved metacognition, alexithymia, and attentional impulsivity. No adverse events were reported.Conclusions: These findings support the feasibility and potential utility of MIT-GA for adolescents with PDs.","PeriodicalId":16480,"journal":{"name":"Journal of Nervous and Mental Disease","volume":" ","pages":"74-80"},"PeriodicalIF":1.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147377908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reconsidering the Association Between Epilepsy and Schizophrenia: Diagnostic Misclassification of Epilepsy-related Psychoses. 重新考虑癫痫与精神分裂症之间的关系：癫痫相关精神病的诊断分类错误。

IF 1.5 4区医学

Journal of Nervous and Mental Disease Pub Date : 2026-07-01 Epub Date: 2026-07-29 DOI: 10.1097/NMD.0000000000001875

Karim Abdel Aziz, Inês d'Almeida, Martin M Schumacher, Josef Finsterer, João Gama-Marques

引用次数: 0

Efficacy and Safety of Aripiprazole in Children and Adolescents With Autism Spectrum Disorder: A Meta-Analysis. 阿立哌唑治疗儿童和青少年自闭症谱系障碍的有效性和安全性：一项荟萃分析。

IF 1.5 4区医学

Journal of Nervous and Mental Disease Pub Date : 2026-07-01 Epub Date: 2026-05-20 DOI: 10.1097/NMD.0000000000001874

Şenay Kılınçel, Furkan Bulut, Oğuzhan Kılınçel

{"title":"Efficacy and Safety of Aripiprazole in Children and Adolescents With Autism Spectrum Disorder: A Meta-Analysis.","authors":"Şenay Kılınçel, Furkan Bulut, Oğuzhan Kılınçel","doi":"10.1097/NMD.0000000000001874","DOIUrl":"10.1097/NMD.0000000000001874","url":null,"abstract":"Aim: Aripiprazole is one of the few pharmacological agents approved for managing irritability in children and adolescents with autism spectrum disorder (ASD).Methods: Randomized controlled trials comparing oral aripiprazole with placebo or active drugs in participants under 18 years were systematically searched in major databases through September 2025 (last search: September 15, 2025). The primary outcome was change in Aberrant Behavior Checklist-Irritability (ABC-I) scores; data were synthesized using random-effects models.Results: Eleven trials ( N = 1,135) were included. Aripiprazole significantly reduced irritability (mean difference = -5.18; 95% CI = -6.72 to -3.64; I 2 = 0%) and improved global ratings versus placebo. Common adverse effects were weight gain, sedation, and extrapyramidal symptoms, though discontinuation rates were comparable to placebo.Conclusions: Aripiprazole effectively and safely reduces irritability in pediatric ASD. Although adverse effects are frequent, they are generally manageable, supporting individualized dosing and long-term monitoring.","PeriodicalId":16480,"journal":{"name":"Journal of Nervous and Mental Disease","volume":" ","pages":"81-88"},"PeriodicalIF":1.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13405634/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147972954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Activation Syndrome in Patients Diagnosed With Major Depressive Disorder for the First Time: The Role of Past Hypomania Symptoms and Atypical Depression as Risk Factors. 首次诊断为重度抑郁障碍患者的激活综合征：既往轻躁症状和非典型抑郁作为危险因素的作用

IF 1.5 4区医学

Journal of Nervous and Mental Disease Pub Date : 2026-05-01 Epub Date: 2026-03-09 DOI: 10.1097/NMD.0000000000001871

Onur Gökçen, Kader Semra Karataş, Merve Akkuş, Feyza Dönmez, Mete Arslan Konak

{"title":"Activation Syndrome in Patients Diagnosed With Major Depressive Disorder for the First Time: The Role of Past Hypomania Symptoms and Atypical Depression as Risk Factors.","authors":"Onur Gökçen, Kader Semra Karataş, Merve Akkuş, Feyza Dönmez, Mete Arslan Konak","doi":"10.1097/NMD.0000000000001871","DOIUrl":"10.1097/NMD.0000000000001871","url":null,"abstract":"Aim: Activation syndrome, a possible consequence of antidepressant treatment, has been linked to suicidal ideation, yet its definition remains debated. This study investigated the frequency and risk factors of activation syndrome in patients with first-episode major depressive disorder.Methods: Two hundred six patients were assessed at baseline, week 2, and week 4. Baseline measures included the Hypomania-Checklist-32, the Temperament Evaluation of Memphis, Pisa, Paris, and San Diego-autoquestionnaire, and evaluations of anxious distress, mixed features, and atypical depression. Follow-up interviews assessed activation syndrome.Results: Activation Syndrome occurred in 33% ( n = 68). It was associated with younger age, atypical depression, higher Hypomania-Checklist-32 scores, anxious distress, cyclothymic/irritable temperaments, and suicidal ideation. Logistic regression showed past hypomania and atypical depression as significant predictors. Associations remained after excluding mania/hypomania cases.Conclusions: In first-episode major depressive disorder, past hypomania symptoms and atypical depression increase activation syndrome risk, highlighting the need for close monitoring given implications for bipolarity and suicidality.","PeriodicalId":16480,"journal":{"name":"Journal of Nervous and Mental Disease","volume":" ","pages":"59-67"},"PeriodicalIF":1.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147377936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Separation, Trauma, and Developmental Cost: The Mental Health Effects of Immigration Enforcement on Children. 分离、创伤和发展成本：移民执法对儿童心理健康的影响。

IF 1.5 4区医学

Journal of Nervous and Mental Disease Pub Date : 2026-05-01 Epub Date: 2026-05-28 DOI: 10.1097/NMD.0000000000001873

Yael Dvir

引用次数: 0

Should We Adjust for Baseline Covariates in Randomized Clinical Trials? 我们应该在随机临床试验中调整基线协变量吗？

IF 1.5 4区医学

Journal of Nervous and Mental Disease Pub Date : 2026-05-01 Epub Date: 2026-05-28 DOI: 10.1097/NMD.0000000000001876

Ralitza Gueorguieva

{"title":"Should We Adjust for Baseline Covariates in Randomized Clinical Trials?","authors":"Ralitza Gueorguieva","doi":"10.1097/NMD.0000000000001876","DOIUrl":"10.1097/NMD.0000000000001876","url":null,"abstract":"Introduction: The primary goal in randomized clinical trials (RCTs) is to estimate the causal effects of interventions. Since prognostic factors can also affect outcomes, RCTs often employ covariate-adjusted analyses. It is important to review reasons for adjustment, advantages and disadvantages of adjustments, and reiterate best practices.Methods: We reviewed guidelines and recommendations for covariate adjustment from authoritative sources, including the European Medicines Agency and the US Food and Drug Administration, as well as recent studies and meta-analyses.Results: While post hoc adjustments for baseline covariates may lead to bias, unadjusted analyses and prespecified adjusted analyses are valid approaches for RCTs. Adjustment for highly prognostic variables can enhance precision and power. Direct adjustment methods and more complex methods, such as inverse probability of treatment weighting, can be applied.Conclusions: Covariate adjustments should be prespecified, theoretically justified, and transparently reported. This approach aligns with the CONSORT 2025 guidelines, emphasizing methodological rigor and transparency.","PeriodicalId":16480,"journal":{"name":"Journal of Nervous and Mental Disease","volume":"214 3","pages":"43-44"},"PeriodicalIF":1.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148471143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0