Psychiatric Comorbidities in Fibromyalgia: A Comparison With Chronic Conditions and Healthy Controls.

IF 1.3 4区医学 Q3 CLINICAL NEUROLOGY

Journal of Nervous and Mental Disease Pub Date : 2025-08-01 Epub Date: 2025-07-16 DOI:10.1097/NMD.0000000000001836

Chen Avni, Maya Morr, Dana Sinai, Paz Toren

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Abstract

Introduction: Fibromyalgia is characterized by chronic widespread pain and psychiatric comorbidities, but robust comparative data remain limited.

Methods: This retrospective cohort study compared psychiatric diagnoses and medication use among matched groups with fibromyalgia, chronic pain, chronic fatigue syndrome, rheumatoid arthritis, and healthy controls (total N=5,040), using data from a large national health care provider.

Results: Psychiatric disorders were most prevalent in fibromyalgia, followed by chronic pain, chronic fatigue syndrome, rheumatoid arthritis, and healthy controls. In fibromyalgia patients, anxiety (55.1%) and depression (48.7%) were predominant, accompanied by extensive medication use. Notably, fibromyalgia showed exceptionally high relative risks for Cluster B personality disorders (RR=34), personality disorders overall (RR=24), and PTSD (RR=22.75).

Conclusions: Fibromyalgia patients experience significantly elevated psychiatric comorbidities compared with other chronic conditions. Comprehensive and integrated multidisciplinary care strategies are necessary to address the distinct psychiatric burden associated with fibromyalgia. This study extends prior work by directly comparing fibromyalgia to other chronic conditions and identifying distinct psychiatric risk patterns in a culturally diverse national cohort.

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纤维肌痛的精神合并症：与慢性疾病和健康对照的比较

纤维肌痛的特点是慢性广泛疼痛和精神合并症，但可靠的比较数据仍然有限。方法：这项回顾性队列研究比较了纤维肌痛、慢性疼痛、慢性疲劳综合征、类风湿关节炎和健康对照患者的精神病诊断和药物使用情况（总N= 5040），数据来自一家大型国家卫生保健机构。结果：精神疾病在纤维肌痛患者中最为普遍，其次是慢性疼痛、慢性疲劳综合征、类风湿关节炎和健康对照组。纤维肌痛患者以焦虑（55.1%）和抑郁（48.7%）为主，并伴有广泛的药物使用。值得注意的是，纤维肌痛显示出B类人格障碍（RR=34）、整体人格障碍（RR=24）和创伤后应激障碍（RR=22.75）的异常高的相对风险。结论：与其他慢性疾病相比，纤维肌痛患者的精神合并症明显升高。全面和综合的多学科护理策略是必要的，以解决与纤维肌痛相关的独特精神负担。本研究通过直接比较纤维肌痛与其他慢性疾病，并在文化多样化的国家队列中确定不同的精神风险模式，扩展了先前的工作。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Nervous and Mental Disease 医学-精神病学

CiteScore

2.90

自引率

5.30%

发文量

233

审稿时长

3-8 weeks

期刊介绍： The Journal of Nervous and Mental Disease publishes peer-reviewed articles containing new data or ways of reorganizing established knowledge relevant to understanding and modifying human behavior, especially that defined as impaired or diseased, and the context, applications and effects of that knowledge. Our policy is summarized by the slogan, "Behavioral science for clinical practice." We consider articles that include at least one behavioral variable, clear definition of study populations, and replicable research designs. Authors should use the active voice and first person whenever possible.