Journal of Nervous and Mental Disease最新文献

When Kinnier Wilson Brought Sherrington's Decerebration Experiments to the Bedside. 当金尼尔-威尔逊将谢林顿的 "脱盲实验 "带到病床前时。

IF 1.3 4区医学

Journal of Nervous and Mental Disease Pub Date : 2026-04-01 Epub Date: 2022-10-26 DOI: 10.1007/s12028-022-01619-8

Eelco F M Wijdicks

引用次数: 0

Activation Syndrome in Patients Diagnosed With Major Depressive Disorder for the First Time: The Role of Past Hypomania Symptoms and Atypical Depression as Risk Factors. 首次诊断为重度抑郁障碍患者的激活综合征：既往轻躁症状和非典型抑郁作为危险因素的作用

IF 1.3 4区医学

Journal of Nervous and Mental Disease Pub Date : 2026-03-09 DOI: 10.1097/NMD.0000000000001871

Onur Gökçen, Kader Semra Karataş, Merve Akkuş, Feyza Dönmez, Mete Arslan Konak

{"title":"Activation Syndrome in Patients Diagnosed With Major Depressive Disorder for the First Time: The Role of Past Hypomania Symptoms and Atypical Depression as Risk Factors.","authors":"Onur Gökçen, Kader Semra Karataş, Merve Akkuş, Feyza Dönmez, Mete Arslan Konak","doi":"10.1097/NMD.0000000000001871","DOIUrl":"https://doi.org/10.1097/NMD.0000000000001871","url":null,"abstract":"Aim: Activation syndrome, a possible consequence of antidepressant treatment, has been linked to suicidal ideation, yet its definition remains debated. This study investigated the frequency and risk factors of activation syndrome in patients with first-episode major depressive disorder.Methods: Two hundred six patients were assessed at baseline, week 2, and week 4. Baseline measures included the Hypomania-Checklist-32, the Temperament Evaluation of Memphis, Pisa, Paris, and San Diego-autoquestionnaire, and evaluations of anxious distress, mixed features, and atypical depression. Follow-up interviews assessed activation syndrome.Results: Activation Syndrome occurred in 33% (n = 68). It was associated with younger age, atypical depression, higher Hypomania-Checklist-32 scores, anxious distress, cyclothymic/irritable temperaments, and suicidal ideation. Logistic regression showed past hypomania and atypical depression as significant predictors. Associations remained after excluding mania/hypomania cases.Conclusions: In first-episode major depressive disorder, past hypomania symptoms and atypical depression increase activation syndrome risk, highlighting the need for close monitoring given implications for bipolarity and suicidality.","PeriodicalId":16480,"journal":{"name":"Journal of Nervous and Mental Disease","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147377936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metacognitive Interpersonal Group Therapy for Adolescents With Personality Disorders: Results From the METAMIND-A Pilot Randomized Controlled Trial. 青少年人格障碍的元认知人际团体治疗：meta - a随机对照试验的结果。

IF 1.3 4区医学

Journal of Nervous and Mental Disease Pub Date : 2026-03-09 DOI: 10.1097/NMD.0000000000001869

Felix Inchausti, Nancy V García-Poveda, Alejandro Ballesteros-Prados, Eduardo Fonseca-Pedrero, Angus MacBeth, Raffaele Popolo, Giancarlo Dimaggio

{"title":"Metacognitive Interpersonal Group Therapy for Adolescents With Personality Disorders: Results From the METAMIND-A Pilot Randomized Controlled Trial.","authors":"Felix Inchausti, Nancy V García-Poveda, Alejandro Ballesteros-Prados, Eduardo Fonseca-Pedrero, Angus MacBeth, Raffaele Popolo, Giancarlo Dimaggio","doi":"10.1097/NMD.0000000000001869","DOIUrl":"https://doi.org/10.1097/NMD.0000000000001869","url":null,"abstract":"Aim: This pilot RCT evaluated the feasibility, acceptability, and preliminary effects of Metacognitive Interpersonal Group Therapy for Adolescents (MIT-GA) compared with waiting list plus treatment-as-usual (WL+TAU).Methods: One hundred adolescents (14-18 years) meeting DSM-IV criteria for PDs (excluding antisocial PD) were randomized to MIT-GA or WL+TAU for 4 months. Primary outcomes included treatment acceptability, psychosocial functioning (CGAS, IIP-64), and symptom severity (SCL-90-R GSI). Secondary outcomes were depression (Y-BDI), caregiver stress (PSS), and parental self-efficacy (BPSES). Mechanisms of change included metacognition (MAS-A), alexithymia (TAS-20), and impulsivity (BIS-11).Results: MIT-GA participants showed greater improvements in psychosocial functioning (d = 0.80) and parental stress (d = 0.65) versus WL+TAU. No significant between-group differences were found in overall symptom severity. MIT-GA also improved metacognition, alexithymia, and attentional impulsivity. No adverse events were reported.Conclusions: These findings support the feasibility and potential utility of MIT-GA for adolescents with PDs.","PeriodicalId":16480,"journal":{"name":"Journal of Nervous and Mental Disease","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147377908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predicting Social Motivation and Interactions in Schizophrenia: An Ecological Momentary Assessment Study. 预测精神分裂症的社会动机和相互作用：一项生态瞬时评估研究。

IF 1.3 4区医学

Journal of Nervous and Mental Disease Pub Date : 2026-02-27 DOI: 10.1097/NMD.0000000000001872

Danielle B Abel, Daniel Fulford, Joanna M Fiszdon

{"title":"Predicting Social Motivation and Interactions in Schizophrenia: An Ecological Momentary Assessment Study.","authors":"Danielle B Abel, Daniel Fulford, Joanna M Fiszdon","doi":"10.1097/NMD.0000000000001872","DOIUrl":"https://doi.org/10.1097/NMD.0000000000001872","url":null,"abstract":"Aim: Researchers have studied mechanisms underlying social motivation in schizophrenia, including reward learning, hostile attribution bias, and defeatist performance beliefs. Yet, existing work is limited by the use of laboratory paradigms and/or trait-level measures.Methods: This study used ecological momentary assessment (EMA) to determine factors that influence daily social motivation. Eighty-two Veterans with psychosis completed four electronic surveys per day for one week. Social activity, including appraisals of interactions, experienced enjoyment, and desire for future socialization, was collected.Results: Increases in social rewards and performance appraisals predicted desire for social interactions, but did not predict the number of subsequent interactions. Hostile attributions were not associated with desire nor subsequent interactions.Conclusions: Results support the value of EMA to measure state-level changes in motivation and suggest positive experiences and performance appraisals are important, malleable determinants of social motivation. Yet, these factors may not entirely determine future social behavior. Other influences should be considered.","PeriodicalId":16480,"journal":{"name":"Journal of Nervous and Mental Disease","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147307051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trends of Mental Illnesses Across Developing Countries in Africa and Asia: A Comparative Analysis. 非洲和亚洲发展中国家的精神疾病趋势：比较分析。

IF 1.3 4区医学

Journal of Nervous and Mental Disease Pub Date : 2026-02-01 Epub Date: 2026-01-26 DOI: 10.1097/NMD.0000000000001865

Dhikrullah Mudathir, Uche Nwatu, Md Sarafat Hossain

{"title":"Trends of Mental Illnesses Across Developing Countries in Africa and Asia: A Comparative Analysis.","authors":"Dhikrullah Mudathir, Uche Nwatu, Md Sarafat Hossain","doi":"10.1097/NMD.0000000000001865","DOIUrl":"10.1097/NMD.0000000000001865","url":null,"abstract":"Aim: Mental illness significantly influences national development by reflecting a nation's socioeconomic well-being. This study compares mental illness trends in developing countries in Asia and Africa.Methods: Secondary data from the mental health depression disorder data set (2000-2017) were analyzed for Bangladesh, India, Nigeria, and Ghana. Key disorders examined include depression, schizophrenia, anxiety, substance use disorder, and bipolar disorder.Results: Schizophrenia, anxiety, and bipolar disorder remained relatively stable across countries. Schizophrenia was highest in Bangladesh, while bipolar disorder was more prevalent in Nigeria and India. Depression declined in Bangladesh and India but increased steadily in Nigeria and Ghana. Anxiety correlated strongly with depression in Bangladesh and Nigeria. In Ghana, anxiety and bipolar disorder together increased depression. In India, all mental illnesses except bipolar disorder were linked to increased depression.Conclusions: Understanding mental illness in a global context is vital for developing targeted mental health interventions and restructuring the systems in developing countries.","PeriodicalId":16480,"journal":{"name":"Journal of Nervous and Mental Disease","volume":" ","pages":"27-33"},"PeriodicalIF":1.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146052476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mental Illness Attributions and Their Association With Psychotherapy Change Process Expectations. 心理疾病归因及其与心理治疗改变过程期望的关系。

IF 1.3 4区医学

Journal of Nervous and Mental Disease Pub Date : 2026-02-01 Epub Date: 2026-01-30 DOI: 10.1097/NMD.0000000000001868

Dana Elberg, Pragya Sharma, Javier Fernández Alvarez, Kehan Shen, Dana Tzur Bitan

{"title":"Mental Illness Attributions and Their Association With Psychotherapy Change Process Expectations.","authors":"Dana Elberg, Pragya Sharma, Javier Fernández Alvarez, Kehan Shen, Dana Tzur Bitan","doi":"10.1097/NMD.0000000000001868","DOIUrl":"10.1097/NMD.0000000000001868","url":null,"abstract":"Introduction: Although researchers have extensively studied expectations, we know little about their associations with individuals' perceptions of illness. In this study, we explored whether individuals' expectations of psychotherapy were associated with their mental illness attributions.Methods: Participants ( N =291) completed the Mental Illness Attribution Questionnaire (MIAQ) and the Expectations of Active Processes in Psychotherapy Scale (EAPPS). We utilized linear regressions to evaluate their associations while adjusting for potential confounders.Results: The belief that mental illness originated in biology was associated with most change process expectations ( p <0.007, .16< b <.27). Social/stress attributions were associated with the expectation that psychotherapy would foster resilience and sharing sensitive contents openly and securely ( b =.31, p =0.000; b =.34, p =0.000). Supernatural attributions were associated with the expectation that psychotherapy would focus on exploring therapist-patient relations ( b =.28, p =0.003).Conclusions: Results suggest that individuals' perceptions about the origins of mental illness are related to their psychotherapy change process expectations.","PeriodicalId":16480,"journal":{"name":"Journal of Nervous and Mental Disease","volume":" ","pages":"34-41"},"PeriodicalIF":1.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146093248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Use of EQUATOR Network Templates in JNMD: The STROBE Guideline for Observational Studies. 在JNMD中使用EQUATOR网络模板：观察性研究的STROBE指南。

IF 1.3 4区医学

Journal of Nervous and Mental Disease Pub Date : 2026-02-01 Epub Date: 2026-02-11 DOI: 10.1097/NMD.0000000000001866

Kimberly A Yonkers

引用次数: 0

Associations Between Mental Disorders and Risk of Mild Cognitive Impairment: A Nationwide Cohort Study. 精神障碍与轻度认知障碍风险之间的关联：一项全国性队列研究。

IF 1.3 4区医学

Journal of Nervous and Mental Disease Pub Date : 2026-01-01 Epub Date: 2025-12-29 DOI: 10.1097/NMD.0000000000001863

Yejin Lee, Hyewon Kim, Jin-Hyung Jung, Kyungdo Han, Hong Jin Jeon

{"title":"Associations Between Mental Disorders and Risk of Mild Cognitive Impairment: A Nationwide Cohort Study.","authors":"Yejin Lee, Hyewon Kim, Jin-Hyung Jung, Kyungdo Han, Hong Jin Jeon","doi":"10.1097/NMD.0000000000001863","DOIUrl":"https://doi.org/10.1097/NMD.0000000000001863","url":null,"abstract":"Aim: The role of mental disorders as risk factors for mild cognitive impairment (MCI) remains underexplored. Previous studies often focused narrowly on mental disorders, overlooking comorbidities among psychiatric patients.Methods: Utilizing a nationwide cohort from 2009 to 2020, this study analyzed 2,717,131 individuals aged 40 years and above. Cox proportional hazards regression analysis was used to determine associations of mental disorders (depressive disorders, bipolar and related disorders, schizophrenia, anxiety disorders, insomnia) and the risk of MCI.Results: Any mental disorder was associated with a 50% increased risk of MCI (HR: 1.50; 95% CI: 1.48-1.51), except for schizophrenia, which did not significantly alter the MCI risk (HR: 1.08; 95% CI 0.92-1.25). Individuals with a single diagnosis exhibited heightened MCI risk even when participants with multiple diagnoses were excluded (HR: 1.43; 95% CI: 1.41-1.45).Conclusions: Our findings advocate for a comprehensive approach addressing both disorder types and further cognitive deterioration.","PeriodicalId":16480,"journal":{"name":"Journal of Nervous and Mental Disease","volume":"214 1","pages":"1-12"},"PeriodicalIF":1.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145850428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Cross-Sectional Study of Social Exclusion in Schizophrenia: Emotional Blunting and Autonomic Arousal in Response to Cyberball. 精神分裂症患者社会排斥的横断面研究：情绪钝化和对赛博球反应的自主神经觉醒。

IF 1.3 4区医学

Journal of Nervous and Mental Disease Pub Date : 2026-01-01 Epub Date: 2025-12-12 DOI: 10.1097/NMD.0000000000001864

Maria Lidia Gerra, Martina Ardizzi, Paolo Ossola, Silvia Martorana, Veronica Leoni, Paolo Riva, Emanuele Preti, Carlo Marchesi, Chiara De Panfilis, Vittorio Gallese

{"title":"A Cross-Sectional Study of Social Exclusion in Schizophrenia: Emotional Blunting and Autonomic Arousal in Response to Cyberball.","authors":"Maria Lidia Gerra, Martina Ardizzi, Paolo Ossola, Silvia Martorana, Veronica Leoni, Paolo Riva, Emanuele Preti, Carlo Marchesi, Chiara De Panfilis, Vittorio Gallese","doi":"10.1097/NMD.0000000000001864","DOIUrl":"10.1097/NMD.0000000000001864","url":null,"abstract":"Introduction: Social exclusion affects patients with schizophrenia (SCZ) both because of a fundamental disposition to introversion and through social discrimination. Here, we explore the emotional and cardiac autonomic responses to ostracism using a ball-tossing experiment.Methods: Through a cross-sectional design, 30 patients with SCZ and 30 healthy controls (HC) performed the Cyberball task. We measured respiratory sinus arrhythmia (RSA) at baseline, immediately after each gameplay (inclusion and ostracism) and after 10 minutes (reflective stage), as well as self-reported ratings of threats toward one's fundamental need to belong.Results: Participants with SCZ showed reduced RSA at baseline, which remained low for the task's entire duration, regardless of the experimental condition. When excluded, they self-reported a lower sense of threat to fundamental needs, as compared with HC.Conclusions: Patients with SCZ showed a persistent defensive autonomic state and displayed a blunted emotional response to experimental ostracism, suggesting difficulties in activating social engagement strategies.","PeriodicalId":16480,"journal":{"name":"Journal of Nervous and Mental Disease","volume":" ","pages":"18-24"},"PeriodicalIF":1.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145743126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Violence Trajectories on Treatment Outcomes in Schizophrenia Spectrum Disorders. 暴力轨迹对精神分裂症谱系障碍治疗结果的影响。

IF 1.3 4区医学

Journal of Nervous and Mental Disease Pub Date : 2026-01-01 Epub Date: 2025-12-29 DOI: 10.1097/NMD.0000000000001862

George Nader, Matisse Ducharme, Philip Gerretsen, Corinne Fischer, Ariel Graff, Vincenzo De Luca, Alexander I F Simpson

{"title":"Effects of Violence Trajectories on Treatment Outcomes in Schizophrenia Spectrum Disorders.","authors":"George Nader, Matisse Ducharme, Philip Gerretsen, Corinne Fischer, Ariel Graff, Vincenzo De Luca, Alexander I F Simpson","doi":"10.1097/NMD.0000000000001862","DOIUrl":"https://doi.org/10.1097/NMD.0000000000001862","url":null,"abstract":"Introduction: The relationship between violence and schizophrenia spectrum disorders (SSDs) is complex and poorly understood. Moreover, violence takes different trajectories, depending on its onset relative to that of the illness. However, the effect of such trajectories on the illness is not fully understood in nonforensic populations.Methods: Two hundred twenty-three participants with SSD were recruited and divided into different violence subgroups using the Brown-Goodwin scale. Psychotic, affective, cognitive, and functional outcomes were measured.Results: Subgroups only significantly differed in psychotic outcomes, such as paranoia (p=.044), measured by the Symptoms Checklist Scores (SCL-90). Pair-wise analysis revealed that those with childhood and adulthood violence displayed significantly higher paranoia, compared with the nonviolent group (p=.015). However, this was not significant after correcting for multiple comparisons.Conclusions: Different violence trajectories are associated with different symptomatic outcomes in SSD. This suggests an interplay between violence and psychosis, which is important for comprehensive treatment approaches.","PeriodicalId":16480,"journal":{"name":"Journal of Nervous and Mental Disease","volume":"214 1","pages":"13-17"},"PeriodicalIF":1.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145850439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0