Alcohol Dependence and Quality of Life: Role of Gender and Psychiatric Comorbidities.

IF 1.6 4区医学 Q3 CLINICAL NEUROLOGY

Journal of Nervous and Mental Disease Pub Date : 2025-06-01 Epub Date: 2025-05-05 DOI:10.1097/NMD.0000000000001830

Zrnka Kovačić Petrović, Tina Peraica, Mirta Blažev, Dragica Kozarić-Kovačić

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引用次数: 0

Abstract

Abstract: To address the lack of studies on the impact of gender and psychiatric comorbidities on alcohol dependence (AD) and quality of life (QoL), we conducted a cross-sectional study. We compared QoL between 328 men and 86 women with AD, and 215 healthy men and 120 women. Additionally, we examined the association of alcohol-related variables and psychiatric comorbidity with the QoL of men and women with AD while controlling for sociodemographic variables. A structured clinical interview for sociodemographic and alcohol-related variables, Mini International Neuropsychiatric Interview (M.I.N.I.), and World Health Organization QoL (WHOQoL)-BREF scale, was applied. QoL was poorer for AD subjects compared to healthy controls, with no gender differences. Regression analysis showed that the number of hospitalizations and AD with personality disorder predicted poorer QoL for men, whereas AD with depression predicted poorer social relationships for women. These findings suggest the need for gender-differentiated treatment.

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酒精依赖和生活质量：性别和精神合并症的作用

摘要：为了解决性别和精神合并症对酒精依赖（AD）和生活质量（QoL）影响的研究缺乏的问题，我们进行了一项横断面研究。我们比较了328名患有AD的男性和86名女性、215名健康男性和120名女性的生活质量。此外，在控制社会人口变量的情况下，我们检查了酒精相关变量和精神共病与AD男性和女性患者生活质量的关系。采用社会人口学和酒精相关变量的结构化临床访谈，Mini国际神经精神病学访谈（M.I.N.I.）和世界卫生组织生活质量(WHOQoL)-BREF量表。与健康对照组相比，AD受试者的生活质量较差，没有性别差异。回归分析显示，住院次数和阿尔茨海默病合并人格障碍预测男性较差的生活质量，而阿尔茨海默病合并抑郁症预测女性较差的社会关系。这些发现表明有必要进行性别区分治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Nervous and Mental Disease 医学-精神病学

CiteScore

2.90

自引率

5.30%

发文量

233

审稿时长

3-8 weeks

期刊介绍： The Journal of Nervous and Mental Disease publishes peer-reviewed articles containing new data or ways of reorganizing established knowledge relevant to understanding and modifying human behavior, especially that defined as impaired or diseased, and the context, applications and effects of that knowledge. Our policy is summarized by the slogan, "Behavioral science for clinical practice." We consider articles that include at least one behavioral variable, clear definition of study populations, and replicable research designs. Authors should use the active voice and first person whenever possible.