Journal of Medicine and Life最新文献_第9页

Impact of Vojta therapy combined with standard care on psychometric and functional parameters in patients with chronic lower back pain: a randomized controlled trial. Vojta 疗法与标准护理相结合对慢性下背痛患者心理测量和功能参数的影响：随机对照试验。

Journal of Medicine and Life Pub Date : 2024-05-01 DOI: 10.25122/jml-2024-0024

Monica Elena Iosub, Sebastian Tirla, Liviu Lazar

{"title":"Impact of Vojta therapy combined with standard care on psychometric and functional parameters in patients with chronic lower back pain: a randomized controlled trial.","authors":"Monica Elena Iosub, Sebastian Tirla, Liviu Lazar","doi":"10.25122/jml-2024-0024","DOIUrl":"10.25122/jml-2024-0024","url":null,"abstract":"Chronic low back pain (LBP) is very common, resulting in functional deficits and significant socio-economic burden. Non-pharmacological treatments, such as physical-psychological therapy, are frequently utilized. Vojta therapy (VT) is a type of physical therapy that effectively enhances the automatic control of body posture. This study aimed to evaluate the effects of combining VT with the usual standard of care (USC) therapy on psychometric and functional parameters in patients with chronic LBP. A total of 148 patients diagnosed with chronic LBP were recruited and randomized into two groups: LBP-VT (n = 82) and LBP-USC (n = 66). Patients were assessed for demographic characteristics, comorbid conditions, clinical findings, health status, pain symptom scales, psychometric, and functional parameters. The LBP-VT group received VT in addition to USC and electrotherapy, while the LBP-USC group received only USC. Initial Hamilton Depression Scale assessments indicated moderate depression, which improved to mild depression post-treatment. The effect of the treatment on self-esteem was significant for the LBP-VT group and moderate for the LBP-USC group. Functional parameters improved in both groups, with the LBP-VT group having significantly better results. Combining VT with standard care, electrotherapy, and massage significantly improved posture, reduced depression associated with functional deficits, and enhanced self-esteem in patients with chronic LBP.","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"17 5","pages":"478-485"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11320620/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141982528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Knowledge, attitudes, and practices of adults in the Kingdom of Saudi Arabia regarding Helicobacter pylori-induced gastric ulcers, cancers, and treatment. 沙特阿拉伯王国成年人对幽门螺杆菌引起的胃溃疡、癌症和治疗的认识、态度和做法。

Journal of Medicine and Life Pub Date : 2024-05-01 DOI: 10.25122/jml-2023-0536

Mohammed Attieh Alzahrani, Saeed Jarallah AlQahtani, Meshari Saad Alqahtani, Hatem Mostafa Asiri, Abdulaziz Mohammed Abudasir, Khalid Talab Alshahrani, Ahmed Saad Al Zomia

{"title":"Knowledge, attitudes, and practices of adults in the Kingdom of Saudi Arabia regarding Helicobacter pylori-induced gastric ulcers, cancers, and treatment.","authors":"Mohammed Attieh Alzahrani, Saeed Jarallah AlQahtani, Meshari Saad Alqahtani, Hatem Mostafa Asiri, Abdulaziz Mohammed Abudasir, Khalid Talab Alshahrani, Ahmed Saad Al Zomia","doi":"10.25122/jml-2023-0536","DOIUrl":"10.25122/jml-2023-0536","url":null,"abstract":"Helicobacter pylori (HP) infection presents a significant threat to global health with serious associated morbidities. This study aimed to assess awareness, attitudes, and practices related to HP in the Kingdom of Saudi Arabia (KSA) through a survey-based cross-sectional study involving 2,541 respondents. We used a structured online questionnaire to gather data on personal and sociodemographic characteristics, as well as HP-related knowledge, attitudes, and practices. The survey was distributed through various social media platforms. The results revealed that 59.4% of respondents demonstrated good knowledge about HP, with a mean knowledge score of 3.7 ± 1.0 out of 5. Knowledge gaps were particularly evident regarding the contagiousness and transmission modes of HP. The mean attitude score was 12.2 ± 2.2 out of a maximum score of 15. In total, 37.6% of respondents reported ever being tested for HP, with 54.2% testing positive. Among those treated for HP, only 79% received antibiotic therapy and 37.8% received acid-reducing medications. Knowledge levels were significantly higher among younger and highly educated respondents (P < 0.001), and respondents with higher knowledge scores also had higher attitude scores than those with lower knowledge scores (12.6 ± 2.0 vs. 11.6 ± 2.0, P < 0.001). Individuals who had undergone HP testing had significantly higher knowledge levels than those who did not (62.3 vs. 57.8, P = 0.024). These findings underscore the urgent need for raising the population's awareness regarding the risks, prevention, and management of HP infection through targeted educational strategies.","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"17 5","pages":"523-529"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11320613/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141982529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The 20^th century: the dawn of modern neurotrauma treatment. 20 世纪：现代神经创伤治疗的曙光。

Journal of Medicine and Life Pub Date : 2024-05-01 DOI: 10.25122/jml-2024-1008

Stefana-Andrada Dobran, Dafin Fior Muresanu

引用次数: 0

Trigeminal neuralgia caused by venous compression: a comprehensive literature review. 静脉压迫引起的三叉神经痛：文献综述。

Journal of Medicine and Life Pub Date : 2024-05-01 DOI: 10.25122/jml-2024-0040

Abdallah Alzeeralhouseini, Galina Moisak, Ekaterina Labzina, Jamil Rzaev

引用次数: 0

Empagliflozin alone and in combination with metformin mitigates diabetes-associated renal complications. Empagliflozin 单独或与二甲双胍联用可减轻糖尿病相关肾脏并发症。

Journal of Medicine and Life Pub Date : 2024-05-01 DOI: 10.25122/jml-2023-0301

Zena Madhag, Zahraa Al-Isawi

{"title":"Empagliflozin alone and in combination with metformin mitigates diabetes-associated renal complications.","authors":"Zena Madhag, Zahraa Al-Isawi","doi":"10.25122/jml-2023-0301","DOIUrl":"10.25122/jml-2023-0301","url":null,"abstract":"Diabetes mellitus is a major public health concern, often leading to undiagnosed micro- and macrovascular complications, even in patients with controlled blood glucose levels. Recent evidence suggests that empagliflozin and metformin have renoprotective effects in addition to their hypoglycemic action. This study investigated the potential protective effect of empagliflozin and metformin on diabetic renal complications. Forty-two adult male Sprague Dawley rats were randomized into six groups: normal control, diabetic control, metformin (250 mg/kg), empagliflozin (10 mg/kg), and combination therapy groups. Type 2 diabetes was induced in rats by a single intraperitoneal injection of streptozotocin (40 mg/kg) following two weeks of 10% fructose solution in their drinking water. Blood glucose, creatinine, urea nitrogen, inflammatory markers (IL-6, TNF-α), and renal tissue caspase-3 were assessed after eight weeks. Blood glucose, urea, creatinine, serum IL-6, TNF-α, and tissue caspase-3 were significantly decreased in the treatment groups compared to the diabetic group. The histopathological findings revealed that treatment with empagliflozin and/or metformin improved the damage in the renal tissue caused by diabetes-induced nephropathy. Moreover, co-administration of empagliflozin and metformin resulted in even better outcomes. Our data revealed that empagliflozin and metformin could improve renal function and decrease inflammation and apoptosis in diabetic animals, delaying the progression of diabetic nephropathy. Combined treatment with metformin and empagliflozin proved to have an additive protective action on renal tissue.","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"17 5","pages":"530-535"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11320611/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141982527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of maternal ABO blood type with lesion level and birthweight of children with spina bifida: a descriptive study. 母亲 ABO 血型与脊柱裂患儿病变程度和出生体重的关系：一项描述性研究。

Journal of Medicine and Life Pub Date : 2024-05-01 DOI: 10.25122/jml-2024-0072

Thomas Lee Farley

{"title":"Association of maternal ABO blood type with lesion level and birthweight of children with spina bifida: a descriptive study.","authors":"Thomas Lee Farley","doi":"10.25122/jml-2024-0072","DOIUrl":"10.25122/jml-2024-0072","url":null,"abstract":"The etiology of spina bifida, a neural tube birth defect, is largely unknown, but a majority of cases are thought to be genetic in origin. Although maternal blood type was found not to be associated with the occurrence of spina bifida, the analysis was never extended to other aspects of the disorder. The purpose of this descriptive study was to determine if maternal blood type was related to characteristics of children with spina bifida. The blood type of 221 mothers of children with spina bifida enrolled on the Arkansas Spinal Cord Disability Registry from 1995 to 2008 was obtained by mailed questionnaire. All children were community-dwelling and from singleton pregnancies. As expected, analysis of mother-child data showed that the distribution of mothers' blood type was not statistically different from the general population (chi-squared, P = 0.9203). However, the blood type of these mothers was associated with their child's lesion level (chi-squared, P = 0.011). Mothers with blood type A more frequently had children with thoracic lesions; mothers with non-A blood types more frequently had children with lumbar and sacral lesions. In addition, mean birthweight differed by mothers' blood type (analysis of variance, P = 0.025). Children of mothers with blood type A had the highest mean birthweight, while those of mothers with blood type AB had the lowest. Also, hydrocephalus was present more frequently in children with thoracic lesions compared to those with lumbar and sacral lesions (chi-squared, P = 0.001). Interestingly, these results were significant for female children but not for male children. In conclusion, maternal blood type was associated with lesion level and birthweight of children with spina bifida.","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"17 5","pages":"492-499"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11320617/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141982497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The possible cardioprotective effect of ghrelin during experimental endotoxemia in mice. 在小鼠实验性内毒素血症期间，胃泌素可能具有保护心脏的作用。

Journal of Medicine and Life Pub Date : 2024-05-01 DOI: 10.25122/jml-2023-0228

Zinah Majid, Bashaer Muhammad-Baqir, Dhirgam Falih Al-Shimerty, Najah Rayish Hadi

{"title":"The possible cardioprotective effect of ghrelin during experimental endotoxemia in mice.","authors":"Zinah Majid, Bashaer Muhammad-Baqir, Dhirgam Falih Al-Shimerty, Najah Rayish Hadi","doi":"10.25122/jml-2023-0228","DOIUrl":"10.25122/jml-2023-0228","url":null,"abstract":"This study aimed to evaluate the cardioprotective effects of ghrelin in septic mice, focusing on its anti-inflammatory and antioxidant properties. Thirty-five male Swiss mice (8-12 weeks old, 23-33g) were randomly assigned to five groups (n = 7 each): (1) Normal, fed usual diets, (2) Sham, subjected to anesthesia and laparotomy, (3) Sepsis, subjected to cecal ligation and puncture, (4) Vehicle, given an equivalent volume of intraperitoneal saline injections immediately after cecal ligation and puncture, and (5) Ghrelin-treated, administered 80 µg/kg ghrelin intraperitoneal injections immediately following cecal ligation and puncture. Serum levels of tumor necrosis factor-alpha (TNF-α), macrophage migration inhibitory factor (MIF), toll-like receptor 4 (TLR4), and 8-epi-prostaglandin F2 alpha (8-epi-PGF2α) were measured. The extent of cardiac damage was also evaluated histologically. The mean serum levels of TNF-α, MIF, TLR4, and 8-epi-PGF2α levels were significantly higher in the sepsis and vehicle groups than in the normal and sham groups. The levels were significantly lower in the ghrelin-treated group than in the vehicle and sepsis groups. Histological analysis revealed normal myocardial architecture in the normal and sham groups, whereas the sepsis and vehicle groups had severe myocardial injury. The ghrelin-treated group displayed histological features similar to the sham group, indicating reduced myocardial damage. Ghrelin ameliorated sepsis-induced cardiotoxicity in mice by exhibiting strong anti-inflammatory and antioxidant effects. These findings suggest that ghrelin may be a promising therapeutic candidate for the prevention of sepsis-induced cardiotoxicity.","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"17 5","pages":"486-491"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11320619/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141982532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of different intracanal irrigants on the push-out bond strength of dentin in damaged anterior primary teeth. 不同的根管内冲洗剂对受损前牙基牙牙本质推出粘接强度的影响

Journal of Medicine and Life Pub Date : 2024-05-01 DOI: 10.25122/jml-2024-0164

Leila Bassir, Shirin Taravati, Farzad Nouri, Saeide Rahimi

{"title":"The effect of different intracanal irrigants on the push-out bond strength of dentin in damaged anterior primary teeth.","authors":"Leila Bassir, Shirin Taravati, Farzad Nouri, Saeide Rahimi","doi":"10.25122/jml-2024-0164","DOIUrl":"10.25122/jml-2024-0164","url":null,"abstract":"This experimental study investigated the effect of different intracanal irrigants on the push-out bond strength of dentin in damaged anterior primary teeth. The crowns of 90 anterior primary teeth were sectioned horizontally, 1 mm above the cementoenamel junction (CEJ). Following canal preparation with K-files, all groups except the negative control received normal saline irrigation. Canals were then irrigated with either 3% or 5.25% sodium hypochlorite (NaOCl), 2% or 0.2% chlorhexidine (CHX) solution (except negative and positive controls). The roots were filled with Metapex material and covered with a calcium hydroxide liner. In root canals, the bond was applied by self-etching and then light-cured for 20 seconds before canals were restored incrementally with composite. Stereomicroscopes were used to assess failure patterns. Push-out bond strengths (MPa ± SD) were: 3% NaOCl (16.92 ± 5.78), 5.25% NaOCl (8.96 ± 3.55), 2% CHX (14.76 ± 5.56), and 0.2% CHX (7.76 ± 2.93). Significant differences were seen across the irrigants regarding the push-out bond strength of dentin sections (P <0.001). The most frequent failures were adhesive and cohesive. NaOCl and CHX irrigants increased the push-out bond strength compared to controls. Compared to controls, both 3% NaOCl and 2% CHX irrigants significantly increased the push-out bond strength of dentin in non-vital anterior primary teeth.","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"17 5","pages":"536-542"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11320612/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141982531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The financial burden of SARS-CoV-2 pregnancies in a tertiary exclusive COVID-19 maternity. 在一家 COVID-19 专科三级医院中，SARS-CoV-2 孕妇所造成的经济负担。

Journal of Medicine and Life Pub Date : 2024-05-01 DOI: 10.25122/jml-2024-0128

Tina-Ioana Bobei, Romina-Marina Sima, Gabriel-Petre Gorecki, Mihaela Amza, Anca Bobircă, Mihai Popescu, Bashar Haj Hamoud, Liana Pleș

{"title":"The financial burden of SARS-CoV-2 pregnancies in a tertiary exclusive COVID-19 maternity.","authors":"Tina-Ioana Bobei, Romina-Marina Sima, Gabriel-Petre Gorecki, Mihaela Amza, Anca Bobircă, Mihai Popescu, Bashar Haj Hamoud, Liana Pleș","doi":"10.25122/jml-2024-0128","DOIUrl":"10.25122/jml-2024-0128","url":null,"abstract":"The COVID-19 pandemic had a major impact on health systems worldwide, and Romania was no exception. The impact on healthcare expenses for pregnant women was considerable, especially in COVID-19-only tertiary centers. This study aimed to analyze the impact of the COVID-19 pandemic on healthcare costs in a designated COVID-19 maternity ward. We conducted an observational study comparing pregnant women with SARS-CoV-2 (study group) to those without the infection (control group). Patients were recruited at Bucur Maternity Hospital from March 2020 to March 2022. We evaluated expenses for the entire period of hospitalization, treatment, medical supplies, and medical investigations. The study included 600 pregnant women, divided equally into two groups of 300 each. Significant cost differences were observed between the COVID-19 and non-COVID-19 groups: medication costs (664.56 EUR vs. 39.49 EUR), administrative costs (191.79 EUR vs. 30.28 EUR), and medical investigation costs (191.15 EUR vs. 29.42 EUR). The costs for a severe case of COVID-19 were about two times higher than a mild case and 70 times higher than a non-COVID-19 case (P <0.001). We identified a significant cost increase due to SARS-CoV-2 infection in our unit. The expenses were augmented by the time of hospitalization, medication, and medical investigations. COVID-19 had a significant impact on healthcare costs, mostly among pregnant women with severe disease. The strategy of operating exclusively as a COVID-19 unit proved to be inefficient and highly costly to our hospital.","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"17 5","pages":"471-477"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11320610/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141984289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The outcome of the retrosigmoid approach in the decompression of vestibular schwannomas - a retrospective cohort study of 60 consecutive cases. 前庭分裂瘤减压术中的回旋蛛网膜方法的疗效--对 60 例连续病例的回顾性队列研究。

Journal of Medicine and Life Pub Date : 2024-04-01 DOI: 10.25122/jml-2024-0055

Hassan Kadri, Mohamad Shehadeh Agha, Raed Abouharb, Rostom Mackieh, Thea Kadri

{"title":"The outcome of the retrosigmoid approach in the decompression of vestibular schwannomas - a retrospective cohort study of 60 consecutive cases.","authors":"Hassan Kadri, Mohamad Shehadeh Agha, Raed Abouharb, Rostom Mackieh, Thea Kadri","doi":"10.25122/jml-2024-0055","DOIUrl":"10.25122/jml-2024-0055","url":null,"abstract":"This multicenter retrospective cohort study aimed to evaluate the effectiveness of the retrosigmoid surgical approach in decompressing vestibular schwannomas, focusing on tumor decompression, neurological function preservation, and postoperative complications. A cohort of 60 patients, operated between 2016 and 2019, was analyzed for age, sex, symptoms, tumor size, surgery duration, complications, mortality, and facial/auditory functions using established criteria. Hearing loss was observed in 80% of patients, mainly progressive, with tumor size emerging as a critical prognostic factor. Facial weakness affected 10% of patients preoperatively; postoperatively, 35% of patients had affected facial nerve function, with 10% exhibiting poor or no facial nerve function, linked to resection extent rather than tumor size. Tinnitus was more prevalent with larger tumors, whereas headaches were common irrespective of size. Balance disorders improved after surgery, especially in case of larger tumors. Functional recovery varied, with 41.67% of patients returning to their previous activity within 4 months, 25% within 4-12 months, and 33.33% remaining inactive. The mortality rate was low at 3.3 %, with two deaths out of 60 patients after surgery. This analysis highlights surgery risks for vestibular schwannomas (e.g., facial nerve decline, tinnitus, headaches), but also emphasizes benefits like improved balance and low mortality. Many patients regain professional activity, stressing the importance of informed treatment decisions for this condition.","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"17 4","pages":"426-431"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11282897/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141788365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0