Alexandru Cosmin Pantazi, Wassan Nori, Mustafa Ali Kassim Kassim, Adriana Luminita Balasa, Cristina Maria Mihai, Tatiana Chisnoiu, Larisia Mihai, Adina Ungureanu, Corina Elena Frecus, Sergiu Ioachim Chirila, Simona Claudia Cambrea
{"title":"生命第一年肠道微生物群与特应性皮炎的关系。","authors":"Alexandru Cosmin Pantazi, Wassan Nori, Mustafa Ali Kassim Kassim, Adriana Luminita Balasa, Cristina Maria Mihai, Tatiana Chisnoiu, Larisia Mihai, Adina Ungureanu, Corina Elena Frecus, Sergiu Ioachim Chirila, Simona Claudia Cambrea","doi":"10.25122/jml-2024-0287","DOIUrl":null,"url":null,"abstract":"<p><p>The connection between the immune response and the composition of gut microbiota has been associated with an increased prevalence of atopic dermatitis in the first year of life. The study aimed to investigate gut microbiota characteristics in infants with atopic dermatitis compared to healthy infants to better understand the link between early-life microbiota composition and the development of atopic dermatitis. The study analyzed the intestinal microbiota of 121 infants with clinical signs of atopic dermatitis, divided into Group I (infants with atopic dermatitis) and Group II (healthy controls). The study showed that infants with atopic dermatitis presented increased values of proteolytic bacteria mainly represented by <i>Enterobacter</i> species (<i>P</i> = 0.041), <i>Klebsiella</i> species (<i>P</i> = 0.038), and <i>Escherichia coli</i> (<i>P</i> = 0.013), with significantly decreased levels of acidifying bacteria represented by <i>Enterococcus</i> species, <i>Lactobacillus</i> and <i>Bifidobacterium</i> (<i>P</i> < 0.05) and normal levels of <i>Clostridium</i> species, <i>Candida albicans, Mould fungi</i> and <i>Geotrichum</i> species. This study highlights distinct differences in the gut microbiota of infants with atopic dermatitis, providing insights into the dynamic intestinal ecosystem during early life for future personalized therapeutic strategies.</p>","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"17 10","pages":"948-952"},"PeriodicalIF":0.0000,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11665751/pdf/","citationCount":"0","resultStr":"{\"title\":\"Gut microbiota profile and atopic dermatitis in the first year of life.\",\"authors\":\"Alexandru Cosmin Pantazi, Wassan Nori, Mustafa Ali Kassim Kassim, Adriana Luminita Balasa, Cristina Maria Mihai, Tatiana Chisnoiu, Larisia Mihai, Adina Ungureanu, Corina Elena Frecus, Sergiu Ioachim Chirila, Simona Claudia Cambrea\",\"doi\":\"10.25122/jml-2024-0287\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The connection between the immune response and the composition of gut microbiota has been associated with an increased prevalence of atopic dermatitis in the first year of life. The study aimed to investigate gut microbiota characteristics in infants with atopic dermatitis compared to healthy infants to better understand the link between early-life microbiota composition and the development of atopic dermatitis. The study analyzed the intestinal microbiota of 121 infants with clinical signs of atopic dermatitis, divided into Group I (infants with atopic dermatitis) and Group II (healthy controls). The study showed that infants with atopic dermatitis presented increased values of proteolytic bacteria mainly represented by <i>Enterobacter</i> species (<i>P</i> = 0.041), <i>Klebsiella</i> species (<i>P</i> = 0.038), and <i>Escherichia coli</i> (<i>P</i> = 0.013), with significantly decreased levels of acidifying bacteria represented by <i>Enterococcus</i> species, <i>Lactobacillus</i> and <i>Bifidobacterium</i> (<i>P</i> < 0.05) and normal levels of <i>Clostridium</i> species, <i>Candida albicans, Mould fungi</i> and <i>Geotrichum</i> species. This study highlights distinct differences in the gut microbiota of infants with atopic dermatitis, providing insights into the dynamic intestinal ecosystem during early life for future personalized therapeutic strategies.</p>\",\"PeriodicalId\":16386,\"journal\":{\"name\":\"Journal of Medicine and Life\",\"volume\":\"17 10\",\"pages\":\"948-952\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11665751/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Medicine and Life\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.25122/jml-2024-0287\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Medicine and Life","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.25122/jml-2024-0287","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
Gut microbiota profile and atopic dermatitis in the first year of life.
The connection between the immune response and the composition of gut microbiota has been associated with an increased prevalence of atopic dermatitis in the first year of life. The study aimed to investigate gut microbiota characteristics in infants with atopic dermatitis compared to healthy infants to better understand the link between early-life microbiota composition and the development of atopic dermatitis. The study analyzed the intestinal microbiota of 121 infants with clinical signs of atopic dermatitis, divided into Group I (infants with atopic dermatitis) and Group II (healthy controls). The study showed that infants with atopic dermatitis presented increased values of proteolytic bacteria mainly represented by Enterobacter species (P = 0.041), Klebsiella species (P = 0.038), and Escherichia coli (P = 0.013), with significantly decreased levels of acidifying bacteria represented by Enterococcus species, Lactobacillus and Bifidobacterium (P < 0.05) and normal levels of Clostridium species, Candida albicans, Mould fungi and Geotrichum species. This study highlights distinct differences in the gut microbiota of infants with atopic dermatitis, providing insights into the dynamic intestinal ecosystem during early life for future personalized therapeutic strategies.
期刊介绍：
The Journal of Medicine and Life publishes peer-reviewed articles from various fields of medicine and life sciences, including original research, systematic reviews, special reports, case presentations, major medical breakthroughs and letters to the editor. The Journal focuses on current matters that lie at the intersection of biomedical science and clinical practice and strives to present this information to inform health care delivery and improve patient outcomes. Papers addressing topics such as neuroprotection, neurorehabilitation, neuroplasticity, and neuroregeneration are particularly encouraged, as part of the Journal''s continuous interest in neuroscience research. The Editorial Board of the Journal of Medicine and Life is open to consider manuscripts from all levels of research and areas of biological sciences, including fundamental, experimental or clinical research and matters of public health. As part of our pledge to promote an educational and community-building environment, our issues feature sections designated to informing our readers regarding exciting international congresses, teaching courses and relevant institutional-level events.
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