Gut microbiota profile and atopic dermatitis in the first year of life.

Q3 Medicine

Journal of Medicine and Life Pub Date : 2024-10-01 DOI:10.25122/jml-2024-0287

Alexandru Cosmin Pantazi, Wassan Nori, Mustafa Ali Kassim Kassim, Adriana Luminita Balasa, Cristina Maria Mihai, Tatiana Chisnoiu, Larisia Mihai, Adina Ungureanu, Corina Elena Frecus, Sergiu Ioachim Chirila, Simona Claudia Cambrea

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引用次数: 0

Abstract

The connection between the immune response and the composition of gut microbiota has been associated with an increased prevalence of atopic dermatitis in the first year of life. The study aimed to investigate gut microbiota characteristics in infants with atopic dermatitis compared to healthy infants to better understand the link between early-life microbiota composition and the development of atopic dermatitis. The study analyzed the intestinal microbiota of 121 infants with clinical signs of atopic dermatitis, divided into Group I (infants with atopic dermatitis) and Group II (healthy controls). The study showed that infants with atopic dermatitis presented increased values of proteolytic bacteria mainly represented by Enterobacter species (P = 0.041), Klebsiella species (P = 0.038), and Escherichia coli (P = 0.013), with significantly decreased levels of acidifying bacteria represented by Enterococcus species, Lactobacillus and Bifidobacterium (P < 0.05) and normal levels of Clostridium species, Candida albicans, Mould fungi and Geotrichum species. This study highlights distinct differences in the gut microbiota of infants with atopic dermatitis, providing insights into the dynamic intestinal ecosystem during early life for future personalized therapeutic strategies.

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生命第一年肠道微生物群与特应性皮炎的关系。

免疫反应和肠道微生物群组成之间的联系与出生后第一年特应性皮炎患病率的增加有关。该研究旨在调查特应性皮炎婴儿与健康婴儿的肠道微生物群特征，以更好地了解生命早期微生物群组成与特应性皮炎发展之间的联系。本研究对121例有特应性皮炎临床症状的婴儿进行肠道菌群分析，分为ⅰ组（特应性皮炎婴儿）和ⅱ组（健康对照）。研究表明，特应性皮炎患儿以肠杆菌、克雷伯氏菌、大肠杆菌为主要代表的蛋白水解菌（P = 0.041）、克雷伯氏菌（P = 0.038）、大肠杆菌（P = 0.013）含量升高，以肠球菌、乳杆菌、双歧杆菌为主要代表的酸化菌含量显著降低（P < 0.05），梭状芽孢杆菌、白色念珠菌、霉菌和土曲菌含量正常。这项研究强调了特应性皮炎婴儿肠道微生物群的明显差异，为未来个性化治疗策略提供了早期生命动态肠道生态系统的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Medicine and Life Medicine-Medicine (all)

CiteScore

1.90

自引率

0.00%

发文量

202

期刊介绍： The Journal of Medicine and Life publishes peer-reviewed articles from various fields of medicine and life sciences, including original research, systematic reviews, special reports, case presentations, major medical breakthroughs and letters to the editor. The Journal focuses on current matters that lie at the intersection of biomedical science and clinical practice and strives to present this information to inform health care delivery and improve patient outcomes. Papers addressing topics such as neuroprotection, neurorehabilitation, neuroplasticity, and neuroregeneration are particularly encouraged, as part of the Journal''s continuous interest in neuroscience research. The Editorial Board of the Journal of Medicine and Life is open to consider manuscripts from all levels of research and areas of biological sciences, including fundamental, experimental or clinical research and matters of public health. As part of our pledge to promote an educational and community-building environment, our issues feature sections designated to informing our readers regarding exciting international congresses, teaching courses and relevant institutional-level events.