Journal of Medicine and Life最新文献_第8页

The impact of arachnoid structures on skull-base meningioma surgical management: a radiological analysis and narrative review. 蛛网膜结构对颅底脑膜瘤手术治疗的影响：放射学分析和综述。

Journal of Medicine and Life Pub Date : 2024-07-01 DOI: 10.25122/jml-2024-0349

Gheorghe Ungureanu, Alexandru Florian, Stefan Ioan Florian

{"title":"The impact of arachnoid structures on skull-base meningioma surgical management: a radiological analysis and narrative review.","authors":"Gheorghe Ungureanu, Alexandru Florian, Stefan Ioan Florian","doi":"10.25122/jml-2024-0349","DOIUrl":"https://doi.org/10.25122/jml-2024-0349","url":null,"abstract":"The presence of intact arachnoid membranes between skull base meningiomas and critical neurovascular structures is crucial for predicting surgical outcomes, understanding tumor development and growth, and planning the feasibility of tumor resection or the need for adjuvant treatments. While neurosurgeons often utilize the subarachnoid cisterns to enhance access to these tumors and facilitate their removal, a comprehensive review aimed at health professionals involved in the diagnosis and treatment of this complex pathology, including radiologists, neurologists, oncologists, ophthalmologists, and neurosurgeons is still lacking. This study aims to summarize the interaction between skull base meningiomas, subarachnoid cisterns, and arachnoid membranes, emphasizing their significance in both the diagnosis and treatment of this pathology. By conducting a thorough radiological assessment of skull base meningiomas, correlating these findings with intraoperative observations, and reviewing relevant literature, we summarize the critical relationship between skull base meningiomas and the surrounding subarachnoid spaces. We concisely describe how arachnoid structures influence tumor growth and interaction with neurovascular elements. We advocate for the inclusion of tumor-arachnoid relationships in the medical literature concerning the treatment of these tumors. A better understanding and description of the interaction between tumors and neurovascular structures will aid in planning and attempting safer treatments, minimizing surgical risks, predicting potential tumor progression, and the need for adjuvant treatments.","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"17 7","pages":"682-689"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11493166/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142502176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pediatric respiratory infectious emergencies: clinical profiles and outcomes. 小儿呼吸道传染急症：临床概况和结果。

Journal of Medicine and Life Pub Date : 2024-07-01 DOI: 10.25122/jml-2024-0044

Imad Mohammed Khojah, Noura Wagih Alazhary, Anas Saeed Alyazidi, Mohammed Abdullah Alsubaie, Maha Khider Alghamdi, Abdulkarim Abbas Jawhari

{"title":"Pediatric respiratory infectious emergencies: clinical profiles and outcomes.","authors":"Imad Mohammed Khojah, Noura Wagih Alazhary, Anas Saeed Alyazidi, Mohammed Abdullah Alsubaie, Maha Khider Alghamdi, Abdulkarim Abbas Jawhari","doi":"10.25122/jml-2024-0044","DOIUrl":"https://doi.org/10.25122/jml-2024-0044","url":null,"abstract":"Infectious diseases are among the most frequent causes of hospital admission and a substantial contributor to morbidity and mortality. These diseases pose a persistent concern, particularly within the pediatric population, where delays or inappropriate management can result in serious harm. Additionally, infectious diseases contribute to overcrowding in pediatric emergency departments (EDs). This study aimed to explore the epidemiology, clinical presentation, diagnostics, outcome, and social and behavioral impacts of infectious diseases on child health. We conducted a retrospective, single-hospital study at a tertiary care center that is publicly funded and owned to serve the entire community. Pediatric patients with at least one or more chief complaints related to the respiratory system or infectious etiology were included. Data analysis was performed using SPSS to assess relationships between variables. A total of 15,106 patients were included, with a mean age of 3.80 years. The largest age group was toddlers (42.8%). Most cases (71.9%) were classified as urgent (Priority 3). Regarding patient outcomes, 76.1% were discharged after receiving appropriate treatment in the ED, and 22.9% required admission for further management. Nearly 38% of patients presented with a single complaint. Fever was the most frequent complaint across all groups. In summary, this study provides insights into the presentation of pediatric respiratory infectious diseases in the emergency room. The study revealed that toddlers were the most affected age group, with fever and cough being the common symptoms.","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"17 7","pages":"716-721"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11493157/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142502268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cost-effective optimized method to process 3D tumoral spheroids in microwell arrays for immunohistochemistry analysis. 在微孔阵列中处理三维肿瘤球体以进行免疫组化分析的经济高效的优化方法。

Journal of Medicine and Life Pub Date : 2024-06-01 DOI: 10.25122/jml-2024-0267

Mircea Bogdan Matei, Carmen Letitia Marinescu, Christien Oktaviani Matei, Alex-Sebastian Pînzariu, Leon Zăgrean, Mihaela Georgeta Moisescu

{"title":"Cost-effective optimized method to process 3D tumoral spheroids in microwell arrays for immunohistochemistry analysis.","authors":"Mircea Bogdan Matei, Carmen Letitia Marinescu, Christien Oktaviani Matei, Alex-Sebastian Pînzariu, Leon Zăgrean, Mihaela Georgeta Moisescu","doi":"10.25122/jml-2024-0267","DOIUrl":"https://doi.org/10.25122/jml-2024-0267","url":null,"abstract":"This study presents an improved method for obtaining spheroids microwell arrays for histological processing and analysis, focusing on glioblastoma (U87 MG) and breast adenocarcinoma (MCF-7) tumor models. By transitioning from traditional 2D cell cultures to 3D systems, this approach overcomes the limitations of 2D cultures by more accurately replicating the tumor microenvironment. The method consists of producing homotypic and heterotypic spheroids using low-adherence agarose-coated wells, embedding these spheroids in agarose microwell arrays, and conducting immunohistochemistry (IHC) to analyze cellular and molecular profiles. Morphological analyses were performed using OrganoSeg software, and IHC staining confirmed marker expressions consistent with respective tumor types. The study details the workflow from 2D cell culture to IHC analysis, including agarose well coating, spheroid embedding, and IHC staining for markers such as EMA, p53, Ki-67, ER, PR, and HER2. Results demonstrated compact, round U87 MG spheroids and fibroblast-stabilized MCF-7 spheroids, with both types exhibiting specific marker expressions. This innovative approach significantly enhances the efficiency of producing and analyzing large volumes of spheroids, making it both quick and cost-effective. It offers a robust drug screening and cancer research platform, maintaining spheroid traceability even in bulk workflow conditions. Furthermore, this methodology supports advances in personalized medicine by providing a more physiologically relevant model than 2D cultures, which is crucial for investigating tumor behavior and therapeutic responses through IHC.","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"17 6","pages":"601-609"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11407497/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142289312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic approaches in Hirschsprung's disease: clinical cases. 赫氏胃肠病的治疗方法：临床病例。

Journal of Medicine and Life Pub Date : 2024-06-01 DOI: 10.25122/jml-2024-0307

Viorel Țandea, Ionuț Daniel Răducan, Oana Neagu, Silviu Constantinoiu

{"title":"Therapeutic approaches in Hirschsprung's disease: clinical cases.","authors":"Viorel Țandea, Ionuț Daniel Răducan, Oana Neagu, Silviu Constantinoiu","doi":"10.25122/jml-2024-0307","DOIUrl":"10.25122/jml-2024-0307","url":null,"abstract":"Hirschsprung's disease is a congenital disorder characterized by the absence of ganglion cells in the myenteric and submucosal plexuses of the colon, resulting in impaired peristalsis and functional intestinal obstruction. This condition affects approximately 1 in 5,000 newborns, with a higher prevalence in boys. Although first identified in the 17th century, its connection to chronic constipation was clearly established by Harald Hirschsprung in 1886. Contemporary treatment strategies emphasize early diagnosis, surgical excision of the aganglionic segment, and specialized postoperative care to restore normal colonic function and improve the quality of life for affected individuals. This article reviews current therapeutic strategies, highlighting advanced surgical techniques, diagnostic methods, and postoperative management. Two clinical cases illustrate the impact and treatment of the disease. The first case involves a 5-month-old male with severe malnutrition, dehydration, and acute enterocolitis, who underwent a right-side colostomy and later a Duhamel-type extramucosal sphincter-rectal-myotomy, showing favorable progress. The second case is a 1.5-year-old patient with a history of colostomy and ileostomy, requiring further surgery. Histopathological examinations in both cases revealed the absence of ganglion cells, confirming the diagnosis of Hirschsprung's disease.","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"17 6","pages":"644-648"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11407488/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142289332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Decoding visual evoked potential latency: revealing neurological connections in Parkinson's disease. 解码视觉诱发电位潜伏期：揭示帕金森病的神经联系。

Journal of Medicine and Life Pub Date : 2024-06-01 DOI: 10.25122/jml-2024-0319

Diana Sipos-Lascu, Ştefan Cristian Vesa, Nicu-Catalin Draghici, Livia Livint Popa, Lacramioara Perju-Dumbrava

{"title":"Decoding visual evoked potential latency: revealing neurological connections in Parkinson's disease.","authors":"Diana Sipos-Lascu, Ştefan Cristian Vesa, Nicu-Catalin Draghici, Livia Livint Popa, Lacramioara Perju-Dumbrava","doi":"10.25122/jml-2024-0319","DOIUrl":"10.25122/jml-2024-0319","url":null,"abstract":"Parkinson's disease (PD) is a complex neurodegenerative disorder characterized by diverse motor and non-motor symptoms. Visual evoked potentials (VEPs) provide valuable insights into the neurological changes in PD. This study examines VEP latency to explore potential connections between visual processing and PD progression, focusing on whether inter-eye latency differences are influenced by disease severity and symptomatology. A cross-sectional observational study was conducted with 59 PD patients at the Neurology I Clinic, Cluj-Napoca County Emergency Clinical Hospital, from October 2019 to October 2021. Patients underwent neurological and psychological evaluations, including VEP testing with a reversal pattern technique. P100 wave latency was assessed for both eyes, and associations with clinical indicators like Hoehn and Yahr stages, UPDRS scores, and non-motor symptoms were analyzed. VEP latencies for the right and left eyes were 108.7 ± 10.6 ms and 108.4 ± 9.7 ms, respectively, with no significant inter-eye differences (P = 0.8). UPDRS item 4 scores correlated significantly with both latencies (P = 0.003 for the left eye and P <0.001 for the right). Latency differences between eyes were shorter in patients with symmetrical parkinsonism compared to those with unilateral predominance. Age correlated weakly with P100 latency, and a weak correlation was found between anhedonia scores and right-eye latency. VEP latency is sensitive to PD motor severity, with shorter inter-eye latency differences in symmetrical parkinsonism, suggesting balanced dopaminergic dysfunction. VEP latency differences offer insights into neurophysiological changes in PD, reflecting dopaminergic dysfunction and its impact on visual processing. These findings support the potential of VEPs as diagnostic and prognostic tools in PD assessment.","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"17 6","pages":"639-643"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11407499/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142289313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Somatic and germline mutations in endometrial cancer. 子宫内膜癌中的体细胞和种系突变。

Journal of Medicine and Life Pub Date : 2024-06-01 DOI: 10.25122/jml-2024-0313

Robert Botea, Madalina Piron-Dumitrascu, Tiberiu Augustin Georgescu, Camil Laurentiu Bohiltea, Silviu Cristian Voinea, Valentin Nicolae Varlas, Simona Raluca Iacoban, Nicolae Suciu

{"title":"Somatic and germline mutations in endometrial cancer.","authors":"Robert Botea, Madalina Piron-Dumitrascu, Tiberiu Augustin Georgescu, Camil Laurentiu Bohiltea, Silviu Cristian Voinea, Valentin Nicolae Varlas, Simona Raluca Iacoban, Nicolae Suciu","doi":"10.25122/jml-2024-0313","DOIUrl":"https://doi.org/10.25122/jml-2024-0313","url":null,"abstract":"Endometrial cancer is a complex disease influenced by both somatic and germline mutations. While individual mutations in genes such as PTEN, PIK3CA, and members of the DNA mismatch repair (MMR) system have been extensively studied, comprehensive analyses comparing somatic and germline mutations within the same cohort are limited. This study compares these mutations using whole exome sequencing (WES) data from tumor and blood samples in patients with endometrial cancer. Thirteen female patients with histologically confirmed endometrial cancer were selected. Tumor tissues and matched blood samples were collected and subjected to WES at the CeGaT laboratory, followed by bioinformatics analysis and annotation using the Geneyx platform. WES revealed significant somatic and germline DNA mutations, with key pathogenic variants identified in genes such as PTEN, PIK3CA, TP53, MLH1, and MSH2. Comparative analysis showed distinct and overlapping mutation profiles, highlighting the importance of integrating somatic and germline data in endometrial cancer research.","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"17 6","pages":"564-573"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11407495/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142289318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Axial length and keratometry characteristics of patients undergoing cataract surgery in Saudi Arabia. 沙特阿拉伯白内障手术患者的轴向长度和角膜测量特征。

Journal of Medicine and Life Pub Date : 2024-06-01 DOI: 10.25122/jml-2024-0122

Ghada Aljuhani, Mona Alharbi, Rami Alsaidi, Abeer Alharbi

{"title":"Axial length and keratometry characteristics of patients undergoing cataract surgery in Saudi Arabia.","authors":"Ghada Aljuhani, Mona Alharbi, Rami Alsaidi, Abeer Alharbi","doi":"10.25122/jml-2024-0122","DOIUrl":"https://doi.org/10.25122/jml-2024-0122","url":null,"abstract":"Cataract surgery is one of the most successful surgical procedures, mainly due to the recent developments in surgical instruments and intraocular lens (IOL) measurements. Understanding the nature of axial length (AL) and keratometry readings (K) in patients with cataracts has significant implications for accurate postoperative IOL size selection. This study aimed to measure AL and K in patients undergoing cataract surgery in Saudi Arabia. This retrospective study included patients who underwent cataract surgery in Madinah, Saudi Arabia. The medical records of adult patients between May 2022 and May 2023 were reviewed, and those with a history of retinal detachment, refractive surgery, or trauma were excluded. The AL and K readings were obtained from the patient's IOL master results. A total of 691 eyes from 451 patients were included in the analysis. The mean age was 64.54 years old. Most of the patients were women (55%). The mean AL, K1, and K2 values were 23.27, 43.42, and 44.69, respectively. Linear regression analysis was used to measure the relationship between AL and K, revealing an inverse relationship in our findings. As AL increased by one unit, the mean K was estimated to decrease by 0.548, with a 95% confidence interval. Our results demonstrated an inverse relationship between AL and K, implying that when AL increases, K decreases, or the corneal curvature becomes flat. Further studies are needed to investigate the biomechanical mechanisms underlying this relationship.","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"17 6","pages":"620-624"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11407489/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142289395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The 13^th World Congress for Neurorehabilitation, 22 - 25 May, Vancouver, Canada - Advancing Neurorehabilitation across Time(s) and Continents. 第 13 届世界神经康复大会，5 月 22-25 日，加拿大温哥华--跨越时间和大陆推进神经康复。

Journal of Medicine and Life Pub Date : 2024-06-01 DOI: 10.25122/jml-2024-1009

Alexandra Gherman, Dafin Fior Muresanu

引用次数: 0

Personality interferences in the pathology of breast cancer: a cross-sectional single-center study. 乳腺癌病理学中的人格干扰因素：一项横断面单中心研究。

Journal of Medicine and Life Pub Date : 2024-06-01 DOI: 10.25122/jml-2024-0302

Andra Oltean, Andrei Manea, Aurel Nireştean, Raluca Niculescu, Mircea Gîrbovan, Elena Gabriela Strete

{"title":"Personality interferences in the pathology of breast cancer: a cross-sectional single-center study.","authors":"Andra Oltean, Andrei Manea, Aurel Nireştean, Raluca Niculescu, Mircea Gîrbovan, Elena Gabriela Strete","doi":"10.25122/jml-2024-0302","DOIUrl":"https://doi.org/10.25122/jml-2024-0302","url":null,"abstract":"Individual personality refers to the Ego and the interpersonal sector. The Ego corresponds to consciousness and self-esteem, including the capacities for emotional self-regulation, self-control, self-evaluation, and self-direction in relation to personal goals. When neoplastic and psychiatric diseases coexist, a patient's quality of life is significantly impacted. While there are somatic differences in disease progression, how the illness is perceived and mainly experienced depends on personality traits. In this study, we administered the DECAS Personality Inventory (a Romanian-validated instrument based on the Five-Factor model of personality) to a group of 121 patients diagnosed with breast cancer to explore the relationships among their personality traits. Descriptive statistics revealed that the mean T scores for openness, extroversion, and emotional stability were low, while the scores for conscientiousness and agreeableness were at an average level. Our findings suggest that, in the studied group, low levels of emotional stability, extroversion, and openness were unfavorable personality dimensions that should be a primary focus of therapeutic strategies, as they significantly affect the quality of life in patients with breast cancer.","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"17 6","pages":"588-592"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11407491/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142289317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optical microscopy evaluation of root canal filling removal by beginner operators in posterior teeth. 光学显微镜评估初学者对后牙根管充填物的清除。

Journal of Medicine and Life Pub Date : 2024-06-01 DOI: 10.25122/jml-2024-0283

Bogdan Dimitriu, Ioana Suciu, Oana Elena Amza, Mihai Ciocârdel, Dana Bodnar, Ana Maria Cristina Țâncu, Mihaela Tanase, Maria Sabina Branescu, Mihaela Chirilă

{"title":"Optical microscopy evaluation of root canal filling removal by beginner operators in posterior teeth.","authors":"Bogdan Dimitriu, Ioana Suciu, Oana Elena Amza, Mihai Ciocârdel, Dana Bodnar, Ana Maria Cristina Țâncu, Mihaela Tanase, Maria Sabina Branescu, Mihaela Chirilă","doi":"10.25122/jml-2024-0283","DOIUrl":"https://doi.org/10.25122/jml-2024-0283","url":null,"abstract":"This study analyzed the effectiveness of root canal filling removal in lower molars performed by beginner operators using optical microscopy. A total of 55 mandibular first and second molars with mesial roots exhibiting an average curvature of 10-20° were selected based on preoperative radiographs. Instrumentation was done with ProTaper Gold (Dentsply Sirona) up to F2 (25/.08), using 2ml of 2.5% NaOCl irrigation solution after each file. Root canal obturation was performed using gutta-percha points with cold lateral condensation and Sealapex (Kerr Dental). Coronal fillings were made with composite resin and stored in distilled water for two years. Removal of the root canal fillings was performed with AF Retreatment Rotary (AFRR) and AF Blue R3 (AFBR3) (Fanta Dental Materials) under reciprocating motion with 2.5% NaOCl irrigation. Cross-sections of the coronal, middle, and apical thirds were analyzed at 40x magnification using a STEINDORFF POL microscope with a digital camera. Image analysis was conducted using Image J software, version 1.54, to determine the efficiency of root canal filling removal by percentage. Statistical analysis via one-way ANOVA revealed significant differences between distal and mesial roots (P < 0.05). Specifically, for mesial roots, the removal efficiency was 70.65% in the coronal third, 54.66% in the middle third, and 21.32% in the apical third. Significant difficulties were noted due to fractured files, calcifications, and debris accumulation in the isthmuses. The study concluded that the protocol using Fanta files demonstrated significant differences in removal efficiency correlated with root curvature, compounded by the inexperience of beginner operators. The findings highlight the challenges faced by novice practitioners in achieving effective root canal filling removal.","PeriodicalId":16386,"journal":{"name":"Journal of Medicine and Life","volume":"17 6","pages":"555-563"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11407485/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142289316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0