Journal of Nanobiotechnology最新文献_第3页

CXCL12-targeting siRNA nanoparticles alleviate immunosuppression and inhibit tumor progression in esophageal squamous cell carcinoma. 靶向cxcl12的siRNA纳米颗粒减轻食管鳞状细胞癌的免疫抑制并抑制肿瘤进展。

IF 10.6 1区生物学

Journal of Nanobiotechnology Pub Date : 2025-07-16 DOI: 10.1186/s12951-025-03476-x

Shuyao Zhang, Hong Jiang, Chengkuan Zhao, Yanli Lei, Shaojie Liu, Chengcheng Xu, Xiaoshan Chen, Danling Zheng, Xiaolong Wu, Xinyue Lin, Wang Chen, Yun Chen, Jianxiang Huang, XiaoLong Wei, Yihui Huang, Chaoxian Lin

{"title":"CXCL12-targeting siRNA nanoparticles alleviate immunosuppression and inhibit tumor progression in esophageal squamous cell carcinoma.","authors":"Shuyao Zhang, Hong Jiang, Chengkuan Zhao, Yanli Lei, Shaojie Liu, Chengcheng Xu, Xiaoshan Chen, Danling Zheng, Xiaolong Wu, Xinyue Lin, Wang Chen, Yun Chen, Jianxiang Huang, XiaoLong Wei, Yihui Huang, Chaoxian Lin","doi":"10.1186/s12951-025-03476-x","DOIUrl":"10.1186/s12951-025-03476-x","url":null,"abstract":"Esophageal squamous cell carcinoma (ESCC) is associated with a highly immunosuppressive tumor microenvironment (TME), driven in part by cancer-associated fibroblasts (CAFs) that promote immune evasion through the secretion of CXCL12. CXCL12 interacts with the CXCR4 receptor on immune cells, disrupting CD8+ T cell migration and anti-tumor function. To address this, we developed an innovative siRNA-based therapeutic approach targeting CXCL12 in CAFs. Using lipid nanocarriers (LNCs) as delivery vehicles, we engineered LNCs@si-CXCL12 nanoparticles to specifically silence CXCL12 expression in CAFs. In vitro studies demonstrated that LNCs@si-CXCL12 restored CD8+ T cell migration and inhibited ESCC cell proliferation and migration. In vivo experiments in a spontaneous ESCC mouse model showed that CXCL12 silencing through nanoparticle delivery significantly reduced tumor growth, enhanced CD8+ T cell-mediated tumoricidal activity, and improved overall survival. These findings highlight the potential of siRNA-loaded nanoparticles targeting CXCL12 as a novel therapeutic strategy to reprogram the immunosuppressive TME and enhance immune responses in ESCC. This approach provides a promising avenue for improving treatment outcomes and overcoming immune evasion in ESCC.","PeriodicalId":16383,"journal":{"name":"Journal of Nanobiotechnology","volume":"23 1","pages":"519"},"PeriodicalIF":10.6,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12269133/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144649705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lyophilized apoptotic vesicles restore DNA damage and mitochondria dysfunction to ameliorate radiation enteritis. 冻干细胞凋亡囊泡修复DNA损伤和线粒体功能障碍，改善放射性肠炎。

IF 10.6 1区生物学

Journal of Nanobiotechnology Pub Date : 2025-07-16 DOI: 10.1186/s12951-025-03592-8

Bo Yang, Huigen Luo, Xutong Yan, Lingzhi Li, Zhiqing Huang, Yexiang Jiang, Xueli Mao, Songtao Shi, Lan Ma

引用次数: 0

Efficacy and safety of Fe-curcumin coordination polymer nanodots to prevent corneal neovascularization in alkali burn models. 铁-姜黄素配位聚合物纳米点防止碱烧伤模型角膜新生血管的有效性和安全性。

IF 10.6 1区生物学

Journal of Nanobiotechnology Pub Date : 2025-07-16 DOI: 10.1186/s12951-025-03555-z

Yan Huo, Lele Song, Zhihui Han, Yihan Yang, Tianyao Wang, Zhao Chen, Qi Yang, Yongkang Qiu, Wenpeng Huang, Ran Tao, Liang Cheng, Lei Kang

{"title":"Efficacy and safety of Fe-curcumin coordination polymer nanodots to prevent corneal neovascularization in alkali burn models.","authors":"Yan Huo, Lele Song, Zhihui Han, Yihan Yang, Tianyao Wang, Zhao Chen, Qi Yang, Yongkang Qiu, Wenpeng Huang, Ran Tao, Liang Cheng, Lei Kang","doi":"10.1186/s12951-025-03555-z","DOIUrl":"10.1186/s12951-025-03555-z","url":null,"abstract":"Alkali burns pose a significant risk of corneal injury, leading to potential blindness. During the progression of alkali burns, heightened oxidation levels can induce corneal damage, resulting in diminished clarity and vision loss. In this study, we chose metallic iron in conjunction with a small molecule, curcumin, to synthesize a curcumin-iron coordinated nanocomposite aimed at enhancing the bioaccessibility and targeting capabilities of curcumin. It could be found that Fe-curcumin coordination polymer nanodots (Fe-Cur CPNs) were comparably effective in suppressing corneal neovascularization, and they exhibited notable advantages in promoting corneal epithelial repair with minimal adverse effects. Additionally, Fe-Cur CPNs inhibited the activation of the nuclear factor-κ-gene binding (NF-κB) signaling pathway by scavenging reactive oxygen species (ROS), thus mitigating corneal neovascularization, which might represent a potential mechanism underlying the therapeutic effect of the Fe-Cur CPNs in alkali burn treatment. Moreover, treatment with the Fe-Cur CPNs did not result in any signs of cytotoxicity, hematological toxicity, or internal organ damage, further confirming the safety profile of this therapeutic agent. In conclusion, Fe-Cur CPNs present a novel, safe, and efficacious approach for addressing corneal alkali burns.","PeriodicalId":16383,"journal":{"name":"Journal of Nanobiotechnology","volume":"23 1","pages":"518"},"PeriodicalIF":10.6,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12265349/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144649706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

N-doped carbon dots for dual-modality NIR fluorescence imaging and photothermal therapy. n掺杂碳点用于双模态近红外荧光成像和光热治疗。

IF 10.6 1区生物学

Journal of Nanobiotechnology Pub Date : 2025-07-15 DOI: 10.1186/s12951-025-03497-6

Hui-Xian Shi, Xuan Qu, Tong-Tong Zhao, Zhong-Fu An, Chuan-Yi Zhang, Hong-Liang Wang

引用次数: 0

Unveiling new therapeutic targets for esophageal cancer treatment through single-cell transcriptomics: pH-responsive nanobubbles enhance the efficacy of 125I radiotherapy. 通过单细胞转录组学揭示食管癌治疗的新靶点：ph响应纳米泡增强125I放疗的疗效。

IF 10.6 1区生物学

Journal of Nanobiotechnology Pub Date : 2025-07-15 DOI: 10.1186/s12951-025-03552-2

Yiliang Wang, BangHua Zhong, Xiaoyu Chen, Yue Zhao, Dasheng Cai, Letian Qu, Tao Bai

引用次数: 0

Correction: Multi-enzymatic biomimetic cerium-based MOFs mediated precision chemodynamic synergistic antibacteria and tissue repair for MRSA-infected wounds. 更正：多酶仿生铈基mof介导mrsa感染伤口的精确化学动力学协同抗菌和组织修复。

IF 10.6 1区生物学

Journal of Nanobiotechnology Pub Date : 2025-07-15 DOI: 10.1186/s12951-025-03547-z

Shiqi Chen, Yifan Li, Qiang Ma, Jiayi Liang, Zhiyue Feng, Sihan Wang, Shuai Zhang, Ke Han, Boyan Sun, Hongping Wang, Haiyang Jiang

引用次数: 0

Reprogramming tumor-associated macrophages and blocking PD-L1 via engineered outer membrane vesicles to enhance T cell infiltration and cytotoxic functions. 重编程肿瘤相关巨噬细胞并通过工程外膜囊阻断PD-L1以增强T细胞浸润和细胞毒性功能。

IF 10.6 1区生物学

Journal of Nanobiotechnology Pub Date : 2025-07-15 DOI: 10.1186/s12951-025-03507-7

Zhiqiang Chen, Bo Wang, Jianwei Zheng, Chao Liu, Peijun Xu, Qianqian Zhou, Jiayong Li, Zijian Shi, Zhenduo Wang, Xuyan Wang, Shunjin Xia, Fangquan Xu, Xiaofeng Yao, Yu Wang, Xinwei Wang, Xiao Zhao, Nana Ma, Yu Ren, Keman Cheng, Xuan Zhou

{"title":"Reprogramming tumor-associated macrophages and blocking PD-L1 via engineered outer membrane vesicles to enhance T cell infiltration and cytotoxic functions.","authors":"Zhiqiang Chen, Bo Wang, Jianwei Zheng, Chao Liu, Peijun Xu, Qianqian Zhou, Jiayong Li, Zijian Shi, Zhenduo Wang, Xuyan Wang, Shunjin Xia, Fangquan Xu, Xiaofeng Yao, Yu Wang, Xinwei Wang, Xiao Zhao, Nana Ma, Yu Ren, Keman Cheng, Xuan Zhou","doi":"10.1186/s12951-025-03507-7","DOIUrl":"10.1186/s12951-025-03507-7","url":null,"abstract":"The immunosuppressive tumor microenvironment (TME) critically undermines the efficacy of T cell-based tumor immunotherapy by impeding CD8+ T cell infiltration and cytotoxic function, primarily through tumor-associated macrophages (TAMs) and immune checkpoint molecules such as programmed death ligand 1 (PD-L1). Here, we present a multifunctional nanoplatform, IN@OMV-PDL1nb, designed to simultaneously inhibit TAM-derived immunosuppressive metabolite itaconic acid (ITA) by targeting immune-responsive gene 1 (IRG1) and block PD-L1 within the TME. Engineered outer membrane vesicles (OMVs) serve as precision delivery vehicles for the IRG1 inhibitor IRG1-IN-1 (IN) and as carriers for PD-L1 nanobody release, activated by matrix metalloproteinase-2 (MMP-2). IN@OMV-PDL1nb effectively inhibits IRG1 expression in TAMs, thus reducing the accumulation of ITA, restoring chemokines (CXCL9 and CXCL10) secretion, and enhancing CD8+ T cells infiltration within tumors. The released PD-L1 nanobody protects CD8+ T cells, preserving their tumoricidal activity. In murine tumor models, IN@OMV-PDL1nb significantly inhibited tumor growth, increased survival, and enhanced antigen presentation and T cell recruitment. Additionally, IN@OMV-PDL1nb induced robust adaptive immunity, facilitating antigen-specific immune memory that prevented tumor recurrence and metastasis. This dual-targeting approach offers a promising strategy to overcome TME-driven immunosuppression in tumor immunotherapy.","PeriodicalId":16383,"journal":{"name":"Journal of Nanobiotechnology","volume":"23 1","pages":"514"},"PeriodicalIF":10.6,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12261675/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: A green, versatile, and facile strategy for anti-biofouling surface with ultra-high graft density polyethylene glycol. 更正：使用超高接枝密度聚乙二醇，是一种绿色、通用、简便的抗生物污染表面策略。

IF 10.6 1区生物学

Journal of Nanobiotechnology Pub Date : 2025-07-14 DOI: 10.1186/s12951-025-03586-6

Wenjie Liu, Suqin He, Hao Liu, Zeyu Shou, Kaiyuan Huo, Hongping Xiang, Aihan Feng, Wei Lu, Na Li

引用次数: 0

Engineered Panax notoginseng polysaccharide micelles inhibit macrophage polarization and delay the progression of rheumatoid arthritis via JAK2-STAT3 signaling pathway. 工程三七多糖胶束通过JAK2-STAT3信号通路抑制巨噬细胞极化，延缓类风湿关节炎的进展。

IF 10.6 1区生物学

Journal of Nanobiotechnology Pub Date : 2025-07-14 DOI: 10.1186/s12951-025-03576-8

Yang Yu, Liang Kong, Rui-Bo Guo, Ya-Ni Zhang, Shu-Tong Li, Feng-Yuan Zhang, Xin Wang, Yang Liu, Xiu-Ying Li, Xue-Tao Li

{"title":"Engineered Panax notoginseng polysaccharide micelles inhibit macrophage polarization and delay the progression of rheumatoid arthritis via JAK2-STAT3 signaling pathway.","authors":"Yang Yu, Liang Kong, Rui-Bo Guo, Ya-Ni Zhang, Shu-Tong Li, Feng-Yuan Zhang, Xin Wang, Yang Liu, Xiu-Ying Li, Xue-Tao Li","doi":"10.1186/s12951-025-03576-8","DOIUrl":"10.1186/s12951-025-03576-8","url":null,"abstract":"Background: The imbalance of macrophage polarization plays a pivotal role in the progression of rheumatoid arthritis (RA). Reprogramming macrophages from the pro-inflammatory M1 phenotype to the anti-inflammatory M2 phenotype is considered a promising therapeutic strategy.Methods: To address this challenge, Panax notoginseng polysaccharides (PNP) with varying molecular weights were chemically conjugated with deoxycholic acid (DC) to obtain amphiphilic conjugates (PNP-DC), which self-assembled into micelles (PNP-Ms). After screening for optimal molecular weight, folic acid (FA) was introduced onto the micelle surface, and Polyphyllin I (PPI) was encapsulated to form FA-modified, PPI-loaded micelles (FA-PPI-Ms) with macrophage-targeting capability.Results: FA-PPI-Ms showed enhanced cellular uptake via FA receptor-mediated endocytosis and effectively eliminated reactive oxygen species (ROS), reduced inflammatory cytokine production, and exhibited good biosafety. In vivo, FA-PPI-Ms significantly alleviated joint swelling and inflammation in RA rat models. Mechanistic studies based on RNA sequencing and experimental validation revealed that FA-PPI-Ms suppressed the JAK2/STAT3 signaling pathway, thereby promoting M2 macrophage polarization and restoring the M1/M2 balance.Conclusion: This study presents a novel FA-PPI-Ms delivery system for targeted macrophages. By modulating polarization through inhibition of JAK2/STAT3 signaling, the system offers a promising therapeutic strategy for RA and potentially other inflammatory diseases.","PeriodicalId":16383,"journal":{"name":"Journal of Nanobiotechnology","volume":"23 1","pages":"509"},"PeriodicalIF":10.6,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12261558/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: Biomimetic nanocomplexes loading with evolocumab and curcumin for synergistic anti-atherosclerosis therapy in ApoE^-/- mice. 修正：载evolocumab和姜黄素的仿生纳米复合物用于ApoE-/-小鼠的协同抗动脉粥样硬化治疗。

IF 10.6 1区生物学

Journal of Nanobiotechnology Pub Date : 2025-07-14 DOI: 10.1186/s12951-025-03566-w

Yi Liu, Shengchao Ma, Feng Li, Hanshuang Ding, Qi Zhang, Feifei Yu, Huiping Zhang, Yinju Hao, Bin Liu, Yideng Jiang

引用次数: 0