Journal of Nanobiotechnology最新文献

{"title":"Correction: A dual-targeting bio-liposomes nanodrug repair endothelial cell dysfunction and restore macrophage cholesterol flow homeostasis to treat early atherosclerosis.","authors":"Qi Zhang, Shengchao Ma, Xue Kang, Yi Liu, Fei Ma, Feifei Yu, Xiaolan Luo, Guizhong Li, Yinju Hao, Huiping Zhang, Bin Liu, Yideng Jiang","doi":"10.1186/s12951-026-04941-x","DOIUrl":"10.1186/s12951-026-04941-x","url":null,"abstract":"","PeriodicalId":16383,"journal":{"name":"Journal of Nanobiotechnology","volume":"24 1","pages":""},"PeriodicalIF":15.0,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13536623/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reprogramming pulmonary B cells by ANXA1 silencing halts lung metastatic niche formation in breast cancer.","authors":"Xiaoke Gao, Meng Zhang, Xiaohan Yao, Jing Wang, Xueying Wang, Xiaohan Lou, Jiajia Wan, Xixi Duan, Lijing Zhang, Ningjing Lei, Hefei Huang, Siyuan Huang, Linlin Yan, Bo Qin, Jinkun Zhang, Zhihai Qin, Fazhan Wang","doi":"10.1186/s12951-026-04995-x","DOIUrl":"10.1186/s12951-026-04995-x","url":null,"abstract":"<p><p>Lung metastasis remains a determinant of poor prognosis and survival in breast cancer and is understood to depend on a permissive pulmonary immune niche rather than tumor cell traits alone. Here, we developed a host-directed RNA interference strategy to modulate this niche by reprogramming pulmonary B cells for breast cancer lung metastasis treatment. IF7C peptide-decorated cationic liposomes were constructed, which preferentially accumulated in the lung, and were internalized by pulmonary B cells, enabling selective silencing of annexin A1 (ANXA1). In tumor-conditioned primary B cells, ANXA1 knockdown reshaped the transcriptional landscape and shifted cytokine output away from an immunosuppressive profile characterized by IL-10, TGF-β, and IL-35. Functionally, ANXA1-silenced B cells lost their capacity to drive CD4⁺ T cells toward Foxp3⁺ regulatory differentiation and instead promoted Th1 features, while concurrently relieving suppression of CD8⁺ T-cell proliferation. In two postoperative syngeneic breast cancer models, perioperative administration achieved ANXA1 silencing in pulmonary B cells, reduced lung Treg accumulation, enhanced CD8⁺ T-cell infiltration and effector activity, and suppressed metastatic outgrowth with favorable systemic safety. These findings identify pulmonary B cells as an actionable regulator of the lung metastatic niche and establish perioperative, B-cell-focused ANXA1 silencing as a practical approach to prevent postoperative lung metastatic recurrence.</p>","PeriodicalId":16383,"journal":{"name":"Journal of Nanobiotechnology","volume":"24 1","pages":""},"PeriodicalIF":15.0,"publicationDate":"2026-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13527983/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148865155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: MXene-based nanosheet for enhanced glioma therapy via photonic hyperthermia to boost the abscopal effect of radioimmunotherapy.","authors":"Huan Zhu, Zhaoyuan Zhang, Rong Jiang, Liangfu Xu, Xiangdi Yang, Jie Chen, Zhenning Wang, Xiao Xu, Zhigang Liu","doi":"10.1186/s12951-026-04927-9","DOIUrl":"10.1186/s12951-026-04927-9","url":null,"abstract":"","PeriodicalId":16383,"journal":{"name":"Journal of Nanobiotechnology","volume":"24 1","pages":""},"PeriodicalIF":15.0,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13501604/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148813344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: ZnO colludes with C. acnes in healing delay and Scar hyperplasia by barrier destruction.","authors":"Fenglan Zhang, Tianyi Wang, Wenqiao Wang, Yaqian Lv, Yingshan Qu, Danping Liu, Xiaoyue Sun, Xiaoying Kong, Changyuan Wang, Jinsheng Shi","doi":"10.1186/s12951-026-04928-8","DOIUrl":"10.1186/s12951-026-04928-8","url":null,"abstract":"","PeriodicalId":16383,"journal":{"name":"Journal of Nanobiotechnology","volume":"24 1","pages":""},"PeriodicalIF":15.0,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13501674/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148813361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: A NIR-Ⅱ-Immunostimulatory nanoplatform rewires immunometabolism to unleash STING-driven antitumor immunity.","authors":"Xun Yang, Xuefeng Chen, Minhao Chen, Simei Yang, Ya Wu, Hongye Liao, Tong Xia, Gaoyang Shen, Changzhen Sun, Li Liu","doi":"10.1186/s12951-026-04904-2","DOIUrl":"10.1186/s12951-026-04904-2","url":null,"abstract":"","PeriodicalId":16383,"journal":{"name":"Journal of Nanobiotechnology","volume":"24 1","pages":""},"PeriodicalIF":15.0,"publicationDate":"2026-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13499304/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148794308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Multi-functional self-assembly nanoparticles originating from small molecule natural product for oral insulin delivery through modulating tight junctions.","authors":"Xiaohui Jia, Zhihua Yuan, Yuqin Yang, Xuemei Huang, Nana Han, Xiaojing Liu, Xiaoyu Lin, Tao Ma, Bing Xu, Penglong Wang, Haimin Lei","doi":"10.1186/s12951-026-04926-w","DOIUrl":"10.1186/s12951-026-04926-w","url":null,"abstract":"","PeriodicalId":16383,"journal":{"name":"Journal of Nanobiotechnology","volume":"24 1","pages":""},"PeriodicalIF":15.0,"publicationDate":"2026-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13499319/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148794305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AI-guided design of plectin-1-targeted ⁶⁸Ga-radiotracers reveals EP300-mediated membrane relocalization of plectin-1 in pancreatic ductal adenocarcinoma.","authors":"Chunjuan Jiang, Fengsheng Zhang, Simin He, Xuan Huang, Jiamin Zhu, Panli Li, Jindian Li, Xiangwei Wang, Shaoli Song","doi":"10.1186/s12951-026-04938-6","DOIUrl":"10.1186/s12951-026-04938-6","url":null,"abstract":"<p><strong>Background: </strong>Plectin-1 (PLEC) is a membrane-associated biomarker implicated in the progression of pancreatic ductal adenocarcinoma (PDAC) and is an attractive target for molecular imaging. However, peptide-based radiotracers targeting PLEC remain limited, and the mechanisms linking plectin-1 relocalization to aggressive biology have yet to be fully elucidated.</p><p><strong>Methods: </strong>In the present study, we performed stepwise in silico screening to identify membrane-associated metastatic drivers in PDAC. Then, we performed convolutional neural network-assisted docking to guide the design of ⁶⁸Ga-labeled NOTA-conjugated plectin-1-targeted monomeric (FZPN) and dimeric (FZPN-dimer) radiotracers. Radiochemical characterization, surface plasmon resonance, cellular uptake, blocking, pharmacokinetic, microPET/CT, biodistribution, and preliminary toxicity studies were then undertaken in PANC-1 models. Mechanistic studies assessed the subcellular localization of PLEC, its interaction with EP300, acetylation, and the functional role of lysine 1310 (K1310).</p><p><strong>Results: </strong>PLEC emerged as the top membrane-enriched, metastasis-linked, and prognostically adverse candidate for PDAC. Analysis demonstrated that the [⁶⁸Ga]Ga-NOTA-FZPN-dimer exhibited high affinity for PLEC, favorable hydrophilicity and stability, and significantly higher cellular uptake and tumor accumulation than the monomeric tracer, with receptor-specific blockade in vitro and in vivo. In PANC-1 xenografts, tumor uptake of the dimer reached 3.8 ± 0.5%ID/g at 30 min after injection and remained higher than that of the monomer at all imaging time points. Mechanistically, PDAC tissues exhibited membrane-enriched PLEC; EP300 interacted with PLEC, acetylation was increased in PDAC cells, and the deacetylation-mimetic PLEC-K1310R mutant redirected plectin-1 away from the plasma membrane and reduced cell migration.</p><p><strong>Conclusions: </strong>Collectively, our findings show that [⁶⁸Ga]Ga-NOTA-FZPN-dimer represents a promising PLEC-targeted PET radiotracer for molecular imaging in PDAC. EP300-mediated acetylation at K1310 appears to drive the membrane relocalization of PLEC and promote the migration of tumor cells, providing biological support for PLEC-targeted imaging and a rationale for further translational development.</p>","PeriodicalId":16383,"journal":{"name":"Journal of Nanobiotechnology","volume":"24 1","pages":""},"PeriodicalIF":15.0,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13531995/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148864927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Probiotic-based sequential delivery system for gut-brain co-therapy against inflammatory bowel disease-associated anxiety/depression","authors":"Xinxin Liu, Luo Zhao, Liulu Wu, Yangyang Zhang, Yange Du, Ziqing Wang, Mengya Niu, Cuixia Zheng, Hongmin Liu, Lei Wang","doi":"10.1186/s12951-026-04850-z","DOIUrl":"https://doi.org/10.1186/s12951-026-04850-z","url":null,"abstract":"With the emergence of the gut-brain axis, inflammatory bowel disease (IBD) is no longer simply regarded as a localized intestinal disease but as a systemic disorder intimately associated with psychiatric comorbidities, including anxiety and depression. However, conventional therapeutic strategies predominantly target localized colonic inflammation, which often yields suboptimal outcomes. This highlights a critical need for gut-brain co-therapy to achieve comprehensive IBD management. Based on our observation that indole-3-acetic acid (IAA) possesses the potential to attenuate hippocampal neuroinflammation and subsequently modulate intestinal inflammation via the acetylcholine pathway, we engineered a gut-brain co-therapy delivery platform (CB-ASA/IAA/L). This system comprises Clostridium butyricum (CB) loaded with 5-aminosalicylic acid (5-ASA), encapsulated by a pH-responsive Eudragit L100-55 layer incorporating IAA. This microecological preparation is based on effective protection and delivery of CB, achieving the delivery of IAA to the brain and 5-ASA to the colon simultaneously. This sequential-release delivery system achieved intestinal barrier repair, promoted macrophage polarization toward the M2 phenotype, and restored Th17/Treg balance to recover intestinal homeostasis, while simultaneously alleviating anxiety- and depression-like behaviors in colitis mice. Importantly, the system demonstrated a robust ability to prevent inflammatory recurrence, a major clinical challenge in IBD treatment. This research offers a new avenue for the effective treatment of IBD-associated anxiety/depression by coordinating neuroimmune modulation with local intestinal repair. Schematic illustration of the synthesis, site-specific gastrointestinal delivery, and gut–brain axis-mediated therapeutic mechanisms of CB-ASA/IAA/L against inflammatory bowel disease and associated anxiety/depression.","PeriodicalId":16383,"journal":{"name":"Journal of Nanobiotechnology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148861235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FeDx-SF@βE assembly for AML treatment via GATA1/SLC40A1 pathway-mediated iron homeostasis disorder","authors":"Xuexue Liu, Chenxi Li, Wei Ge, Di Zhou, Yushuo Hao, Li Yi, Xiaolong Ma, Lihua Shao, Yuxiang Sun, Peipei Xu, Xiao Du, Siliang Wang","doi":"10.1186/s12951-026-04910-4","DOIUrl":"https://doi.org/10.1186/s12951-026-04910-4","url":null,"abstract":"Acute myeloid leukemia (AML) is an aggressive hematologic malignancy characterized by rapid progression, therapeutic resistance, and poor prognosis. Inducing ferroptosis in AML cells represents a promising therapeutic strategy. In this study, transcriptomic analyses first revealed that ferroptosis-associated transcriptional states were closely associated with prognosis and ex vivo drug-response heterogeneity in AML, providing a rationale for ferroptosis-oriented therapeutic design. Based on these findings, and further supported by a transcriptome-based target-scoring strategy, β-elemene (βE), a clinically used natural compound derived from traditional Chinese medicine, was selected as a candidate ferroptosis-related agent. We subsequently developed a nanodelivery system, designated FeDx-SF@βE, based on alcohol-induced silk fibroin (SF) folding to co-deliver ferric dextran (FeDx) and βE. The resulting nanoparticles exhibited a uniform particle size of 182.3 nm, favorable colloidal stability, and sustained drug release behavior. In vitro studies demonstrated efficient cellular uptake of FeDx-SF@βE by AML cells, leading to significantly inhibited cell viability. Pharmacological cell-death inhibitor rescue experiments showed that ferrostatin-1 produced the most pronounced protective effect, indicating that FeDx-SF@βE-induced AML cell death was predominantly ferroptosis-dependent. Mechanistically, βE-containing treatment suppressed the nuclear translocation of the transcription factor GATA1 and downregulated the iron efflux channel SLC40A1. GATA1/SLC40A1 gain- and loss-of-function analyses further demonstrated that activation of this axis attenuated FeDx-SF@βE-induced iron overload and ferroptotic injury, whereas suppression of this axis promoted intracellular iron retention, oxidative stress, lipid peroxidation, and mitochondrial damage. In combination with FeDx-derived iron supply, βE-mediated inhibition of the GATA1/SLC40A1 iron-export axis resulted in intracellular iron overload, glutathione depletion, ROS accumulation, extensive lipid peroxidation, and ferroptosis. Bulk transcriptomic and virtual-cell analyses further supported the involvement of the GATA1/SLC40A1 axis in ferroptosis-associated AML states and linked βE-related transcriptional programs to this regulatory mechanism. In a disseminated AML xenograft model, FeDx-SF@βE exhibited enhanced antileukemic efficacy and favorable biosafety. Collectively, this work provides a combined ferroptosis-oriented nanotherapeutic strategy for AML treatment and highlights the GATA1/SLC40A1 iron-homeostasis axis as a functionally relevant mechanism for ferroptosis-targeted nanomedicine design.","PeriodicalId":16383,"journal":{"name":"Journal of Nanobiotechnology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148861234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Reversing the immunosuppressive microenvironment with reduced redox level by microwave-chemo-immunostimulant Ce-Mn MOF for improved immunotherapy.","authors":"Zhiheng Zeng, Changhui Fu, Xiaohan Sun, Meng Niu, Xiangling Ren, Longfei Tan, Qiong Wu, Zhongbing Huang, Xianwei Meng","doi":"10.1186/s12951-026-04925-x","DOIUrl":"https://doi.org/10.1186/s12951-026-04925-x","url":null,"abstract":"","PeriodicalId":16383,"journal":{"name":"Journal of Nanobiotechnology","volume":"24 1","pages":""},"PeriodicalIF":15.0,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13488196/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148794282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}