Journal of Medical Virology最新文献

{"title":"Community and Hospital-Based Laboratory Surveillance for Influenza, Respiratory Syncytial Virus, and SARS-CoV-2 During the 2023–2024 Season, Lyon, France","authors":"Cécile Chauvel,&nbsp;Jean-Sébastien Casalegno,&nbsp;Benoit Visseaux,&nbsp;Vincent Vieillefond,&nbsp;Stéphanie Haim-Boukozba,&nbsp;Vincent Enouf,&nbsp;Emmanuel Chanard,&nbsp;Margaux Fabre,&nbsp;Marie-Anne Rameix-Welti,&nbsp;Antoine Oblette,&nbsp;Jean-Marc Giannoli,&nbsp;Juliette Paireau,&nbsp;Laurence Josset,&nbsp;Bruno Lina,&nbsp;Alexandre Gaymard,&nbsp;Simon Cauchemez,&nbsp;Florence Morfin,&nbsp;Marta C. Nunes,&nbsp;Antonin Bal","doi":"10.1002/jmv.70549","DOIUrl":"https://doi.org/10.1002/jmv.70549","url":null,"abstract":"<p>Influenza, respiratory syncytial virus (RSV) and SARS-CoV-2 are among the main respiratory viruses circulating in the population, with a significant burden on public health. While individuals at higher risk are more likely to develop severe symptoms leading to hospitalization, viral circulation in the community remains less extensively monitored. This study compared viral circulation between RELAB, a recently established community-based laboratory surveillance network (<i>n</i> = 22 843 tested patients) and hospital surveillance at the Hospices Civils de Lyon, France (<i>n</i> = 23 046 tested patients), for the season 2023–2024. For influenza and SARS-CoV-2, similar trends were observed in at-risk populations (children under 5 years and adults over 65 years) in both settings. Circulation of these two viruses was first detected in the community and insights from the young adult population (19–64 years) were only captured in the community network. Circulation of RSV was more intense in terms of number of cases and started in the pediatric population, and consequently was more represented in the hospital setting. In conclusion, this study highlighted the complementarity between community and hospital surveillance, as different populations and periods of viral circulation were observed.</p>","PeriodicalId":16354,"journal":{"name":"Journal of Medical Virology","volume":"97 9","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jmv.70549","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144915210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"South-to-Southeast Expansion of HIV-1 Subtype C in Brazil","authors":"Daniel Polita,&nbsp;Laise de Moraes,&nbsp;Marta Giovanetti,&nbsp;Filipe Ferreira de Almeida Rego,&nbsp;Gabriel Carvalho,&nbsp;Luciane Amorim Santos,&nbsp;Ricardo Khouri,&nbsp;Dennis Maletich Junqueira","doi":"10.1002/jmv.70580","DOIUrl":"https://doi.org/10.1002/jmv.70580","url":null,"abstract":"<p>HIV-1 group M subtype C (HIV-1C) is the predominant genetic variant in southern Brazil but has been sparsely detected in other regions of the country. Our study aimed to identify HIV-1C transmission links across Brazil using phylogenetic reconstruction and to infer trends in geographical patterns and dissemination beyond the southern region. We retrieved 3693 HIV-1C (partial <i>pol</i>) sequences from NCBI and LANL databases and applied maximum likelihood phylogenetic reconstruction to infer transmission clusters, using clade confidence (SH-aLRT) and intracluster genetic distance as critical parameters. Our results suggest that the Southern states of Brazil have played a key role in fueling the HIV-1C epidemic in São Paulo, particularly through transmissions from Paraná and Santa Catarina. In contrast, despite having one of the highest HIV-1C prevalence rates of Brazil, Rio Grande do Sul exhibited a highly concentrated epidemic with limited epidemiological linkages to other states. São Paulo seems to be a crucial hub for HIV-1C dissemination, connecting the epidemic in the southern states with other regions. Central states may act as secondary hubs, facilitating connections between the southeastern and northeastern regions. This study enhances the understanding of the geographical dynamics and expansion patterns of HIV-1C in Brazil, emphasizing the significance of regional epidemiological connections.</p>","PeriodicalId":16354,"journal":{"name":"Journal of Medical Virology","volume":"97 9","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jmv.70580","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144914864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibody and B-Cell Responses to PHH-1V81 XBB.1.16-Adapted SARS-CoV-2 Booster Vaccination Are Associated With Variant Neutralization","authors":"Cèlia Torres,&nbsp;Alfons Jiménez,&nbsp;Meritxell Deulofeu,&nbsp;Antoni Prenafeta,&nbsp;Carlota Dobaño,&nbsp;Gemma Moncunill,&nbsp;Laura Ferrer,&nbsp;Luis M. Molinos-Albert","doi":"10.1002/jmv.70583","DOIUrl":"https://doi.org/10.1002/jmv.70583","url":null,"abstract":"<p>Immune escape by SARS-CoV-2 emerging variants jeopardizes vaccine effectiveness, necessitating new immunization strategies. Here, we assessed the antibody B-cell response in 40 individuals receiving either the PHH-1V81 XBB.1.16- or BNT162b2 XBB.1.5-adapted vaccine boosters. Both immunizations significantly increased ancestral-reactive B cells cross-recognizing the vaccine variant. Notably, XBB.1.16 cross-reactive B cells were associated with neutralizing responses, reinforcing the potential of PHH-1V81 as a strong boosting candidate against emerging variants.</p>","PeriodicalId":16354,"journal":{"name":"Journal of Medical Virology","volume":"97 9","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jmv.70583","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144915212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Symptoms and Risk Factors for Long COVID: A Cross-Sectional Study in Primary Care","authors":"Assel Muratovna Shigayeva Ferreira,&nbsp;Flávia Emília Leite de Lima Ferreira,&nbsp;Caio César Ferreira Alverga,&nbsp;João Agnaldo do Nascimento,&nbsp;André Luís Bonifácio de Carvalho,&nbsp;Gabriel Rodrigues Martins de Freitas,&nbsp;João Aurílio Cardoso de Moraes,&nbsp;Izabele da Silva Rocha,&nbsp;Lucas Tomaz da Silva,&nbsp;Beatriz Carolinny Pereira da Silva Alves,&nbsp;Cleidilaine Ramos de Oliveira,&nbsp;José Ricardo Araujo Cardoso,&nbsp;Ruth Maria Mendonça Anacleto,&nbsp;Leandro Pernambuco","doi":"10.1002/jmv.70579","DOIUrl":"https://doi.org/10.1002/jmv.70579","url":null,"abstract":"<p>This study aimed to determine the occurrence and risk factors for persistent symptoms after mild to moderate severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in patients who presented in primary care during the 2021 pandemic. A retrospective cross-sectional survey was conducted in six public family health care units in Joao Pessoa, Brazil. A questionnaire with a set of 18 validated clinical outcomes was used to assess prolonged symptoms beyond 3 months of duration in 226 adults who had confirmed SARS-CoV-2 infection. Binary logistic regression models were used to estimate adjusted odds ratios (aOR) and risk factors for Long COVID. A total of 16 outcomes were significantly associated with Long COVID. The largest aOR were estimated for short-term memory loss, anxiety, and loss of attention. The risk factors for Long COVID included ≥ 5 symptoms (15.82, 7.33–34.15, <i>p</i> &lt; 0.0001), female sex (aOR: 1.91, 95% CI: 1.03–3.53, <i>p</i> = 0.032), age 40–49 years (3.45, 1.14–10.51, <i>p</i> = 0.029), and age 70+ years (4.0, 1.01–15.51, <i>p</i> = 0.045). Findings highlight a high frequency of persistent symptoms in adults who initially had non-severe SARS-CoV-2 infection, who are predominantly of working age, and who did not present multiple comorbidities. This study supports the need for assessing clinical outcomes and risk factors on Long COVID in primary care using routinely recorded clinical outcomes.</p>","PeriodicalId":16354,"journal":{"name":"Journal of Medical Virology","volume":"97 9","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jmv.70579","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144915211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric and Adult Inborn Errors of Immunity and COVID-19: A Comparative Study","authors":"Cansu Özdemiral,&nbsp;Saliha Esenboga,&nbsp;Ayşegul Akarsu,&nbsp;Nadira Nabiyeva Cevik,&nbsp;Arzu Topeli,&nbsp;Yasemin Ozsurekci,&nbsp;Ilhan Tezcan,&nbsp;Deniz Cagdas","doi":"10.1002/jmv.70550","DOIUrl":"https://doi.org/10.1002/jmv.70550","url":null,"abstract":"<div>\u0000 \u0000 <p>COVID-19 has worse clinical outcomes in inborn errors of immunity (IEI) patients. We aimed to determine COVID-19-related hospitalization/ICU admission/mortality risk in patients with IEI. We included 62 COVID-19 (29 children and 33 adults) in a referral center. F/M ratio was 0.94 with median age, 19 (8 months-64 years) years. 53.2% had primary antibody deficiency. Hospitalization rate was 11/29 in children, 21/33 in adults and 7/11 in patients with combined immunodeficiency diseases. Myalgia was more common in adults compared to children (<i>p</i> = 0.013). Inpatients have more cough compared to outpatients (<i>p</i> = 0.002). D-dimer and ferritin levels were higher in inpatients (<i>p</i> = 0.033 and <i>p</i> = 0.046, respectively). Cough (OR: 6.05; [95% CI: 1.76–20.74], <i>p</i> = 0.004) and immunoglobulin replacement therapy use in IEI (OR: 5.15; [95% CI: 1.46–18.11], <i>p</i> = 0.010) were related to hospitalization risk. Inpatients with intensive care unit (ICU) admission had higher ferritin levels (<i>p</i> = 0.02). 77.4% had at least one comorbidity like pulmonary (45.2%), autoimmune (38.7%), and gastrointestinal diseases (32.3%). ICU admission was high in agammaglobulinemia (40%) and immune dyseregulation (ID) (16.6%). An LRBA deficiency patient experienced MIS-C (Multisystem Inflammatory Syndrome in Children) and another died. Eight patients, four in the present center, received convalescent plasma (X-linked agammaglobulinemia [XLA] [<i>n</i> = 3], autosomal recessive agammaglobulinemia [<i>n</i> = 1], LRBA deficiency [<i>n</i> = 1], and CTLA4 deficiency [<i>n</i> = 1], CVID [<i>n</i> = 1], and STAT1 deficiency [<i>n</i> = 1]). Overall mortality was 6.5%, high in ID (16.6%), none in children. Higher D-dimer and ferritin levels is associated with a higher hospitalization ratio- twice in adults compared to children. Overall mortality (6.5%) was about six times the general population with no mortality in children. A high ICU ratio in agammaglobulinemia, suggesting the importance of mucosal IgA in COVID-19 defense. Convalescent plasma helps shorten hospitalization period in agammaglobulinemia.</p>\u0000 </div>","PeriodicalId":16354,"journal":{"name":"Journal of Medical Virology","volume":"97 9","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144905593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatitis B Viral Rebound in People With HIV Under HBV-Active Antiretroviral Therapy","authors":"Costanza Bertoni,&nbsp;Sara Diotallevi,&nbsp;Riccardo Lolatto,&nbsp;Girolamo Piromalli,&nbsp;Hamid Hasson,&nbsp;Alessia Siribelli,&nbsp;Sabrina Bagaglio,&nbsp;Caterina Uberti Foppa,&nbsp;Antonella Castagna,&nbsp;Giulia Morsica","doi":"10.1002/jmv.70573","DOIUrl":"https://doi.org/10.1002/jmv.70573","url":null,"abstract":"<div>\u0000 \u0000 <p>We investigated factors associated with HBV-rebound in people with HIV (PWH) with chronic HBV (CHBV) under HBV-active antiretroviral therapy (ART): emtricitabine (FTC)+tenofovir alafenamide (TAF) or 3TC/FTC+ tenofovir disoproxil fumarate (TDF) regimen. The present study included PWH/CHBV followed as outpatients from October 2008 to August 2023 at San Raffaele Hospital, Milan, Italy. The baseline evaluation was the date of first negative HBV-DNA (&lt; 10 IU/mL) after the first positive result before HBV active ART. Last evaluation (LE) was the first HBV-rebound (≥ 10 IU/mL) or last HBV undetectable in persistently HBV-DNA negative PWH. Odds ratio (and corresponding 95% confidence interval) of HBV-rebound, adjusted for nadir CD4 cells, ALT levels, and ART active on both viruses was estimated by multivariable logistic regression. Of 153 PWH/CHBV under ART active on both viruses, 25 (16.3%) had at least one HBV-rebound. Multivariate analysis at LE, showed that PWH on 3TC/FTC had a higher probability of HBV-rebound [adjusted odds ratio, aOR=4.88 (95%confidence interval, CI = 1.28, 20.10), <i>p</i> = 0.02], while PWH on FTC + TAF had lower probability of HBV-rebound [aOR = 0.05 (95%CI = 0.002, 0.27), <i>p</i> = 0.005], both compared to those on 3TC/FCT + TDF. Hepatitis B-rebound was associated with higher ALT levels [aOR=1.03 (95% CI = 1.01, 1.05) per 1-U/L higher, <i>p</i> = 0.001]. FTC + TAF based ART seemed to be related to a better control of HBV-DNA than 3TC/FTC + TDF and 3TC/FTC alone. Hepatitis B-rebound may exert an effect on liver inflammation, as suggested by the increase of transaminases levels.</p>\u0000 </div>","PeriodicalId":16354,"journal":{"name":"Journal of Medical Virology","volume":"97 9","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144897739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pexophagy Triggered by Enterovirus 71 Modulates the Production of Pro-Inflammatory Cytokines Through Cholesterol Accumulation in Lysosomes","authors":"Tai Yang,&nbsp;Guowei He,&nbsp;Lingbing Chen,&nbsp;Lili Deng,&nbsp;Meimei Ren,&nbsp;Qing Zhao,&nbsp;Yuan Xiong,&nbsp;Bo Wang","doi":"10.1002/jmv.70578","DOIUrl":"https://doi.org/10.1002/jmv.70578","url":null,"abstract":"<div>\u0000 \u0000 <p>Mounting evidence indicates that pexophagy plays a pivotal role in various physiological and pathological processes. However, the crosstalk between pexophagy and enterovirus 71 (EV71) replication remains to be illustrated. The study aims to explore the molecular mechanisms and pathogenesis underlying the role of pexophagy in EV71 infection. In this study, our findings confirm and extend previous observations that autophagy facilitates EV71 replication. Next, we present strong novel evidence that EV71 replication can trigger excessive hydrogen peroxide in peroxisomes by mislocalization of peroxisomal catalase, leading to pexophagy. Moreover, our data indicate that dysfunctional peroxisomes elicit cholesterol accumulation in lysosomes, contributing to upregulated level of production of pro-inflammatory cytokines. Collectively, our study demonstrates that pexophagy may act as a new candidate player involved in the pathogenesis of EV71 infection via regulating oxidative stress status and inflammation, which provides a solid basis for the development of novel antivirus treatment.</p>\u0000 </div>","PeriodicalId":16354,"journal":{"name":"Journal of Medical Virology","volume":"97 9","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144897740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular Detection of Non-Polio Enteroviruses and Emergence of Novel Enterovirus D111 in Stool Samples From Children Reported With Acute Flaccid Paralysis Symptoms During 2021 in Pakistan","authors":"Muhammad Naveed Adil,&nbsp;Muhammad Athar Abbas,&nbsp;Muhammad Masroor Alam,&nbsp;Muhammad Suleman Rana,&nbsp;Muhammad Salman,&nbsp;Massab Umair,&nbsp;Adnan Khurshid,&nbsp;Nayab Mahmood,&nbsp;Yasir Arshad,&nbsp;Muzzamil Ahmed,&nbsp;Hamza Ahmed Mirza,&nbsp;Ghulam Mujtaba,&nbsp;Muhammad Qaisar Ali,&nbsp;Muhammad Moaaz Anwar,&nbsp;Muhammad Anas","doi":"10.1002/jmv.70566","DOIUrl":"https://doi.org/10.1002/jmv.70566","url":null,"abstract":"<div>\u0000 \u0000 <p>This study explores the molecular detection and genetic diversity of non-polio enteroviruses (NPEVs) reported with symptoms of acute flaccid paralysis (AFP) cases (referring to individual patients) in Pakistan during 2021. A total of 2337 stool samples were analyzed through WHO-recommended intratypic differentiation (ITD) using real-time PCR. Among these, 134 samples detected positive for NPEVs, corresponding to 66 individuals AFP cases. From these, 21 representative samples—selected based on sample quality and geographical distribution across Punjab, Sindh, and Khyber Pakhtunkhwa province—underwent partial VP1 gene sequencing. Thirteen distinct enterovirus serotypes were identified, with Enterovirus B (EV-B) being predominant (95.24%). Echovirus 13 (14.29%) was most frequent, followed by E-7, CV-B2, E-11, E-12, E-20, and EV-B75 (each 9.52%). Punjab contributed the highest proportion (52.38%) of sequenced cases. Most affected children were under 5 years old, with the highest proportion (42.8%) between 13 and 24 months. A significant finding was the first detection of novel Enterovirus D111 (EV-D111) in Pakistan and Asia, identified in the stool sample of a 72-month-old child reported with the symptoms of acute flaccid paralysis. However, due to limited clinical data and the absence of confirmatory neurological evaluationsno definitive causal relationship could be set up between EV-D111 and the observed AFP symptoms. Confirmation was achieved via Sanger sequencing. Phylogenetic analysis indicated that the EV-D111 strain clustered closely with strains from Central Africa and retained conserved capsid motifs. These findings highlight the substantial genetic diversity of NPEVs in Pakistani AFP cases and amphasize the importance of enhanced molecular surveillance to detect emerging and rare strains like EV-D111, which are critical for strengthening AFP monitoring and public health preparedness in the region.</p>\u0000 </div>","PeriodicalId":16354,"journal":{"name":"Journal of Medical Virology","volume":"97 9","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144897738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful Treatment With Tocilizumab for Refractory RS-Virus-Induced Hemophagocytic Lymphohistiocytosis in Multiple Myeloma","authors":"Henk-Jan Boiten,&nbsp;Robert F. Hoedemaeker,&nbsp;Ward (EJ) Libourel","doi":"10.1002/jmv.70577","DOIUrl":"https://doi.org/10.1002/jmv.70577","url":null,"abstract":"<div>\u0000 \u0000 <p>Hemophagocytic lymphohistiocytosis (HLH) may be triggered by infections (mostly viral infections). HLH triggered by the evolving respiratory syncytial virus (RSV) is rare. HLH is characterized by excessive immune activation and is life-threatening with high mortality. We show that tocilizumab led to a rapid clinical improvement in a multirefractory RSV-induced HLH patient. Tocilizumab appears to be a promising therapeutic option and is well-tolerated.</p>\u0000 </div>","PeriodicalId":16354,"journal":{"name":"Journal of Medical Virology","volume":"97 8","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144891630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stability of the Crimean-Congo Hemorrhagic Fever Virus on Inanimate Surfaces and Implications for Infection Control","authors":"Abdou Allayeh,&nbsp;Fusun Can,&nbsp;Önder Ergönül","doi":"10.1002/jmv.70575","DOIUrl":"https://doi.org/10.1002/jmv.70575","url":null,"abstract":"<div>\u0000 \u0000 <p>The Crimean-Congo Hemorrhagic Fever Virus (CCHFV) presents a serious public health challenge, with a case fatality rate reaching 40% among hospitalized patients and an estimated three billion people at risk globally. Recognized as the first virus on the World Health Organization's (WHO) Blueprint priority diseases list, CCHFV demands urgent and focused intervention. Despite extensive research on various viral agents, there remain significant gaps in understanding how long CCHFV can survive on different surfaces. This study aims to fill that gap by investigating the viability of CCHFV on commonly encountered materials: plastic, stainless steel, latex gloves, and aluminum foil. The virus's viability was tested under three temperature conditions (37°C, 20°C, and 5°C) over a 10-day period. Log-linear regression was employed to analyze the decay rates of the virus on each surface. The findings reveal that CCHFV can remain viable for prolonged periods. Specifically, the virus can survive up to 9 days on stainless steel at 5°C, 8 days on plastic, 6 days on latex gloves, and 5 days on aluminum foil. Importantly, the study highlighted that CCHFV's survival decreases at higher temperatures, with detectable levels persisting only until Day 9 at lower temperatures. This pioneering investigation into the surface viability of CCHFV provides critical data that can inform future research and public health interventions aimed at reducing the risks associated with CCHFV. By understanding the conditions that affect the virus's persistence, health authorities can better devise strategies to minimize transmission and protect public health. Overall, the study underscores the importance of continued research into the environmental stability of CCHFV, which is vital for managing outbreaks and enhancing preparedness against this significant viral threat.</p>\u0000 </div>","PeriodicalId":16354,"journal":{"name":"Journal of Medical Virology","volume":"97 8","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144885356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}