托珠单抗成功治疗难治性rs病毒诱导的多发性骨髓瘤的噬血细胞淋巴组织细胞增多症

IF 4.6 3区医学 Q1 VIROLOGY

Journal of Medical Virology Pub Date : 2025-08-23 DOI:10.1002/jmv.70577

Henk-Jan Boiten, Robert F. Hoedemaeker, Ward (EJ) Libourel

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引用次数: 0

摘要

噬血细胞性淋巴组织细胞增多症（HLH）可能由感染（主要是病毒感染）引起。由进化的呼吸道合胞病毒（RSV）引发的HLH是罕见的。HLH的特点是免疫过度激活，死亡率高，危及生命。我们显示tocilizumab导致了多难治性rsv诱导的HLH患者的快速临床改善。Tocilizumab似乎是一种有希望的治疗选择，并且耐受性良好。

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Successful Treatment With Tocilizumab for Refractory RS-Virus-Induced Hemophagocytic Lymphohistiocytosis in Multiple Myeloma

Hemophagocytic lymphohistiocytosis (HLH) may be triggered by infections (mostly viral infections). HLH triggered by the evolving respiratory syncytial virus (RSV) is rare. HLH is characterized by excessive immune activation and is life-threatening with high mortality. We show that tocilizumab led to a rapid clinical improvement in a multirefractory RSV-induced HLH patient. Tocilizumab appears to be a promising therapeutic option and is well-tolerated.

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来源期刊

Journal of Medical Virology 医学-病毒学

CiteScore

23.20

自引率

2.40%

发文量

777

审稿时长

1 months

期刊介绍： The Journal of Medical Virology focuses on publishing original scientific papers on both basic and applied research related to viruses that affect humans. The journal publishes reports covering a wide range of topics, including the characterization, diagnosis, epidemiology, immunology, and pathogenesis of human virus infections. It also includes studies on virus morphology, genetics, replication, and interactions with host cells. The intended readership of the journal includes virologists, microbiologists, immunologists, infectious disease specialists, diagnostic laboratory technologists, epidemiologists, hematologists, and cell biologists. The Journal of Medical Virology is indexed and abstracted in various databases, including Abstracts in Anthropology (Sage), CABI, AgBiotech News & Information, National Agricultural Library, Biological Abstracts, Embase, Global Health, Web of Science, Veterinary Bulletin, and others.