Journal of Medical Virology最新文献_第6页

Exploration of the Pathogenicity and Inflammatory Mechanism of Wuxiang Virus: A Newly Identified Phlebovirus 新发现的静脉病毒乌香病毒的致病性和炎症机制探讨

IF 6.8 3区医学

Journal of Medical Virology Pub Date : 2025-05-20 DOI: 10.1002/jmv.70387

Xiaohui Yao, Qikai Yin, Yuke Zheng, Anqi Gu, Ruichen Wang, Shihong Fu, Weijia Zhang, Fan Li, Kai Nie, Qianqian Cui, Songtao Xu, Xiangdong Li, Huanyu Wang

{"title":"Exploration of the Pathogenicity and Inflammatory Mechanism of Wuxiang Virus: A Newly Identified Phlebovirus","authors":"Xiaohui Yao, Qikai Yin, Yuke Zheng, Anqi Gu, Ruichen Wang, Shihong Fu, Weijia Zhang, Fan Li, Kai Nie, Qianqian Cui, Songtao Xu, Xiangdong Li, Huanyu Wang","doi":"10.1002/jmv.70387","DOIUrl":"https://doi.org/10.1002/jmv.70387","url":null,"abstract":"<div>\u0000 \u0000 <p>WUXV is phlebovirus transmitted by sandflies, which can cause death in suckling mice and infect humans and chickens. However, little is known about the pathogenicity and pathogenic mechanisms of animals. Therefore, BALB/c WT mice and BALB/c nude mice were infected with WUXV. No fatal diseases occurred except for weight loss among the BALB/c WT mice, while BALB/c nude mice observed significant neurological symptoms and death. The virus nucleic acid was detected in the organs and blood of both mice. The blood routine showed a significant increase in RDW, and IgM, IgG, and neutralizing antibodies were detected in the serum of the BALB/c WT mice, which were significantly higher than those of BALB/c nude mice. The inflammatory factors in tissues, and pathological section results, indicate that WUXV caused severe inflammatory reactions. In addition, we found that WUXV activates the inflammatory pathway by activating TLR5 and TLR9. Inhibition of TLR5 and TLR9 can eliminate the activation of NF-κb and downstream inflammatory factors. In summary, we systematically studied the pathogenicity and pathogenesis of WUXV infection in mice with different immune states, and found that TLR5 in mammalian cells can serve as RNA sensor, expanding our understanding of the virus.</p></div>","PeriodicalId":16354,"journal":{"name":"Journal of Medical Virology","volume":"97 5","pages":""},"PeriodicalIF":6.8,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144091722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reactivation of Latent Herpesviruses and a Faulty Antiviral Response may Contribute to Chronic Multi-Symptom and Multi-System Illnesses in U.S. Military Veterans 潜伏疱疹病毒的再激活和错误的抗病毒反应可能导致美国退伍军人的慢性多症状和多系统疾病

IF 6.8 3区医学

Journal of Medical Virology Pub Date : 2025-05-20 DOI: 10.1002/jmv.70400

Brandon Cox, Paula Goolkasian, Irene Mena Palomo, Marshall V. Williams, Sean R. Maloney, Maria Eugenia Ariza

{"title":"Reactivation of Latent Herpesviruses and a Faulty Antiviral Response may Contribute to Chronic Multi-Symptom and Multi-System Illnesses in U.S. Military Veterans","authors":"Brandon Cox, Paula Goolkasian, Irene Mena Palomo, Marshall V. Williams, Sean R. Maloney, Maria Eugenia Ariza","doi":"10.1002/jmv.70400","DOIUrl":"https://doi.org/10.1002/jmv.70400","url":null,"abstract":"<p>Chronic multi-symptom illness (CMI) is a broad term utilized by the Department of Veterans Affairs to refer to complex conditions of unknown etiology where individuals experience symptoms that lack a clear medical diagnosis. In this study, we sought to determine if herpesvirus reactivation and the antiviral response could be involved in CMI. Longitudinal serology studies conducted in two military veteran cohorts diagnosed with CMI or Gulf War Illness (GWI) revealed an increased prevalence of IgG (55% and 83%, respectively) and IgM antibodies (80%–90% and 100%, respectively) to the deoxyuridine triphosphate nucleotidohydrolase (dUTPase) protein of multiple herpesviruses compared to age/gender-matched healthy controls (5% and 7% for IgG and IgM respectively, <i>p</i> < 0.001) by ELISA. Despite the ongoing viral reactivation in CMI veterans, IFN-γ levels surprisingly stayed mostly unchanged from healthy control levels, while in GWI were significantly upregulated. Interestingly, MCP-1/CCL-2 levels were significantly increased in some CMI veterans compared to GWI and healthy controls (<i>p</i> = 0.0009). Our data provide evidence suggesting aberrant antiviral response and immune dysfunction in CMI veterans and supports the premise that decreased serum levels of IFN-γ together with heightened MCP-1 and dUTPase antibodies to multiple herpesviruses may be useful to identify CMI veterans with deficient antiviral response.</p>","PeriodicalId":16354,"journal":{"name":"Journal of Medical Virology","volume":"97 5","pages":""},"PeriodicalIF":6.8,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jmv.70400","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144091769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reduction of Bacteroides fragilis in Gut Microbiome of Chronic Hepatitis B Patients Promotes Liver Injury 慢性乙型肝炎患者肠道微生物群中脆弱拟杆菌减少促进肝损伤

IF 6.8 3区医学

Journal of Medical Virology Pub Date : 2025-05-20 DOI: 10.1002/jmv.70395

Qiuhong You, Kaifeng Wang, Zhou Zhao, Heqi Zhou, Zhixian Lan, Hongyan Liang, Rui Deng, Wanying Li, Sheng Shen, Routing Wang, Kaikai Zhang, Dekai Zheng, Jian Sun

{"title":"Reduction of Bacteroides fragilis in Gut Microbiome of Chronic Hepatitis B Patients Promotes Liver Injury","authors":"Qiuhong You, Kaifeng Wang, Zhou Zhao, Heqi Zhou, Zhixian Lan, Hongyan Liang, Rui Deng, Wanying Li, Sheng Shen, Routing Wang, Kaikai Zhang, Dekai Zheng, Jian Sun","doi":"10.1002/jmv.70395","DOIUrl":"https://doi.org/10.1002/jmv.70395","url":null,"abstract":"<div>\u0000 \u0000 <p>In chronic hepatitis B (CHB) patients under antiviral treatment, liver injury, as evidenced by elevated alanine transaminase (ALT), is associated with unfavorable outcomes and needs effective treatment. The interaction between gut microbiota and liver injury in CHB patients remains unclear. Using a case-control design, 28 cases with elevated ALT and 28 matched controls with normal ALT were randomly selected from CHB patients with viral control. Clinical characteristics were comparable between groups. Metagenomic sequencing revealed that <i>Bacteroides fragilis</i> was decreased in cases and exhibited the greatest disparity between cases and controls. Mice colonized by gut microbiota from cases exhibited more severe liver damage in both LPS-induced and MCD diet-induced liver injury models, and had a lower abundance of <i>B. fragilis</i> compared to mice colonized by gut microbiota from controls. Oral gavage of <i>B. fragilis</i> improved both LPS-induced and MCD diet-induced liver injury. Metabolomics analysis revealed that the levels of 7-Ketolithocholic acid (7-Keto-LCA) were positively correlated with <i>B. fragilis</i> and significantly increased in the cultural supernatant of <i>B. fragilis</i>. Consistently, 7-Keto-LCA exerted protective effects against both LPS-induced and MCD diet-induced liver damage. Targeting gut microbiota might be a promising therapeutic treatment for alleviation residual liver inflammation in CHB patients with viral control.</p></div>","PeriodicalId":16354,"journal":{"name":"Journal of Medical Virology","volume":"97 5","pages":""},"PeriodicalIF":6.8,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144091729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Improving Detection of CIN2+ and CIN3+ Lesions: Evaluation of E6/E7 mRNA, P16, and Ki-67, Individually and in Combination 提高CIN2+和CIN3+病变的检出率：单独和联合评估E6/E7 mRNA、P16和Ki-67

IF 6.8 3区医学

Journal of Medical Virology Pub Date : 2025-05-20 DOI: 10.1002/jmv.70405

Yingmei Huang, Feng Liang, Jianyong Huang, Hongmian Jiang, Jing Chen, Baoli Xie

{"title":"Improving Detection of CIN2+ and CIN3+ Lesions: Evaluation of E6/E7 mRNA, P16, and Ki-67, Individually and in Combination","authors":"Yingmei Huang, Feng Liang, Jianyong Huang, Hongmian Jiang, Jing Chen, Baoli Xie","doi":"10.1002/jmv.70405","DOIUrl":"https://doi.org/10.1002/jmv.70405","url":null,"abstract":"<div>\u0000 \u0000 <p>Cytology screening has lower cervical precancer sensitivity than HPV DNA testing, which lacks specificity. To overcome this limitation, we assessed the diagnostic performance of E6/E7 mRNA, P16, and Ki-67, both alone and in combination, in detecting cervical intraepithelial neoplasia grade 2 or higher (CIN2+). A total of 403 cervical samples were collected from the First People's Hospital of Nanning between January 2019 and January 2024, and each biomarker was evaluated for its diagnostic accuracy. E6/E7 mRNA showed moderate performance, with 68.2% sensitivity and 61.8% specificity in detecting CIN2+ lesions. P16 exhibited superior performance, achieving 82.2% sensitivity and 90.1% specificity. Although Ki-67 showed the highest sensitivity at 95%, it had the lowest specificity at 27.2%. The combination of P16 and Ki-67 yielded the best diagnostic results, with 90% sensitivity and 79.8% specificity for CIN2+, representing a significant enhancement over individual biomarkers. These findings highlight the superior accuracy of P16, especially when combined with Ki-67, in detecting both CIN2+ and CIN3+ lesions. This approach improves high-risk lesion detection by reducing false negatives. Incorporating P16/Ki-67 biomarkers enhances screening sensitivity/specificity and clinical outcomes.</p>\u0000 </div>","PeriodicalId":16354,"journal":{"name":"Journal of Medical Virology","volume":"97 5","pages":""},"PeriodicalIF":6.8,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144091770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk-Based Triage Strategy by Extended HPV Genotyping for Women With LSIL Cytology: A Real-World Study 扩展HPV基因分型对LSIL细胞学女性的基于风险的分诊策略：一项现实世界的研究

IF 6.8 3区医学

Journal of Medical Virology Pub Date : 2025-05-20 DOI: 10.1002/jmv.70404

Chun Ye, Yi Liu, Huiru Huang, Ruizhe Chen, Ying Li, Xiaofei Zhang, Yunfeng Fu, Liang Feng, Xiao Li

{"title":"Risk-Based Triage Strategy by Extended HPV Genotyping for Women With LSIL Cytology: A Real-World Study","authors":"Chun Ye, Yi Liu, Huiru Huang, Ruizhe Chen, Ying Li, Xiaofei Zhang, Yunfeng Fu, Liang Feng, Xiao Li","doi":"10.1002/jmv.70404","DOIUrl":"https://doi.org/10.1002/jmv.70404","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 <p>To evaluate the immediate risk of (pre)cancer for cytology low-grade squamous intraepithelial lesion (LSIL) women infected with or without specific HPV genotype and develop a risk-based management strategy. A total of 4567 LSIL women with extended HPV genotyping and colposcopy results were enrolled according to the inclusive and exclusive criteria. The distribution and immediate cervical intraepithelial neoplasia grade 2 or worse and 3+ or worse (CIN2+/3+) risks of specific HPV genotypes were assessed using Minimum Estimate, Any Type Estimate, and Hierarchical Attribution Estimate. A risk-based strategy was further established and evaluated. CIN2+/3+ were 729/328 cases, including 691/317 in 3398 HPV-positive and 38/11 in 1169 HPV-negative women. HPV16, 52, 58, and 18 were the most prevalent genotypes in both HPV-positive and CIN2+/3+ cases. HPV16, 73, and 33 carried the highest immediate CIN2+/3+ risk. A risk-based strategy was established, which suggested Group A (HPV 16, 33, 45, 31, 18, 58, 52, 35, 73, 82; with immediate CIN3+ risk of 4.08%–22.12%) for immediate colposcopy, Group B (HPV 59, 66, 56, 53) for 6-month follow-up or p16/Ki-67 dual stain or DNA methylation triage, while Group C (HPV 51, 68, 39, 26) for 1-year HPV repeat testing. Compared with conventional strategy, this new strategy showed significantly higher specificity (CIN2+: 52.16% vs. 29.47%, <i>χ</i><sup>2</sup> = 409.136, <i>p</i> < 0.001; CIN3+: 48.45% vs. 27.32%, <i>χ</i><sup>2</sup> = 402.395, <i>p</i> < 0.001) but similar sensitivity, which could reduce immediate colposcopy referrals by 19.82%. A risk-based triage strategy for LSIL women with extended HPV genotyping could effectively reduce unnecessary colposcopies and maintain high efficacy for CIN2+/3+ detection.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16354,"journal":{"name":"Journal of Medical Virology","volume":"97 5","pages":""},"PeriodicalIF":6.8,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jmv.70404","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144091771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neurovascular Barrier Protection in COVID-19: Emerging Therapeutic Targets From SARS-CoV-2 Pathogenesis COVID-19的神经血管屏障保护：来自SARS-CoV-2发病机制的新治疗靶点

IF 6.8 3区医学

Journal of Medical Virology Pub Date : 2025-05-20 DOI: 10.1002/jmv.70413

Qisen Chen, Kun Tan

引用次数: 0

Emergence of Antigenic Variants in Bovine H5N1 Influenza Viruses

IF 6.8 3区医学

Journal of Medical Virology Pub Date : 2025-05-14 DOI: 10.1002/jmv.70394

Kei Miyakawa, Makoto Ota, Kaori Sano, Fumitaka Momose, Noriko Kishida, Tomoko Arita, Yasushi Suzuki, Masayuki Shirakura, Hideki Asanuma, Shinji Watanabe, Hideki Hasegawa

{"title":"Emergence of Antigenic Variants in Bovine H5N1 Influenza Viruses","authors":"Kei Miyakawa, Makoto Ota, Kaori Sano, Fumitaka Momose, Noriko Kishida, Tomoko Arita, Yasushi Suzuki, Masayuki Shirakura, Hideki Asanuma, Shinji Watanabe, Hideki Hasegawa","doi":"10.1002/jmv.70394","DOIUrl":"https://doi.org/10.1002/jmv.70394","url":null,"abstract":"<div>\u0000 \u0000 <p>The recent emergence of the H5N1 influenza virus in dairy cattle has raised significant public health concerns. Using a previously established pseudovirus-based neutralization assay, we evaluated the impact of emerging hemagglutinin (HA) mutations on the efficacy of current candidate vaccine viruses (CVVs). Neutralization analysis revealed that the cow-derived H5N1 virus showed up to a 2.2-fold reduction in sensitivity compared to the CVV homologous neutralization titers. Among the 1,453 HA sequences analyzed from cow-derived H5N1 viruses, we identified four major mutations (E2K, D104G, V147M, and S336N) that emerged after the initial isolation, with 134 isolates (9.22%) harboring all four mutations. These multi-mutation variants exhibited up to a 3.3-fold reduction compared with the CVV homologous neutralization titers. Single-mutation analysis demonstrated that the D104G mutation, present in 47.8% of sequences, markedly contributed to antibody escape. Our findings highlight the importance of continued surveillance and antigenic evaluation of emerging variants for pandemic preparedness strategies.</p>\u0000 </div>","PeriodicalId":16354,"journal":{"name":"Journal of Medical Virology","volume":"97 5","pages":""},"PeriodicalIF":6.8,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143944652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influenza A Virus Induces Autophagosome by Inhibiting LTCC/Calpain 2/LC3A Signaling to Promote Viral Replication 甲型流感病毒通过抑制LTCC/Calpain 2/LC3A信号诱导自噬体促进病毒复制

IF 6.8 3区医学

Journal of Medical Virology Pub Date : 2025-05-13 DOI: 10.1002/jmv.70393

Lu Tian, Xueer Liu, Fengqing Zheng, Zhihui Ren, Tian Li, Zelin Zhang, Lihong Zhu, Weiqiang Chen, Kangsheng Li, Jiangtao Sheng

{"title":"Influenza A Virus Induces Autophagosome by Inhibiting LTCC/Calpain 2/LC3A Signaling to Promote Viral Replication","authors":"Lu Tian, Xueer Liu, Fengqing Zheng, Zhihui Ren, Tian Li, Zelin Zhang, Lihong Zhu, Weiqiang Chen, Kangsheng Li, Jiangtao Sheng","doi":"10.1002/jmv.70393","DOIUrl":"https://doi.org/10.1002/jmv.70393","url":null,"abstract":"<div>\u0000 \u0000 <p><span>l</span>-type voltage-gated calcium channels (LTCC), which are accountable for the influx of extracellular Ca<sup>2+</sup>, have been discovered to play a crucial regulatory role in the process of autophagy. However, the regulatory role of LTCC in autophagy process induced by influenza A virus (IAV) infection remains largely unknown. Here, we found that IAV (H1N1/PR8) induced autophagosome accumulation consistent with previous studies but blocked the fusion of autophagosomes with lysosomes. Meanwhile, viral infection led to a persistent decline of the cytoplasmic calcium signal in A549 cells. Interestingly, activation of LTCC partially restored the cytoplasmic calcium signal, impeded the formation of autophagosomes, and hindered the replication of IAV. Conversely, hindering LTCC or suppressing Cav1.3, the primary isoform of LTCC in A549 cells, significantly enhanced autophagosome formation and IAV replication. Mechanistically, calpain 2, a calcium-dependent cysteine protease, mediated the inhibition of LTCC/Cav1.3 on autophagosome formation and IAV replication by cleaving the carboxyl-terminal (112-118aa) of Microtubule-associated protein 1 light chain 3A(MAP1LC3A). Our findings reveal that IAV infection inhibits the LTCC/Cav1.3-calpain 2-LC3A axis to induce autophagosome formation, contributing to better understanding of viral infection process and providing potential target for combating IAV infection.</p></div>","PeriodicalId":16354,"journal":{"name":"Journal of Medical Virology","volume":"97 5","pages":""},"PeriodicalIF":6.8,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143938785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development and Characterization of an Inducible Bacterial Artificial Chromosome System for Studying Lytic Replication and Pathogenesis of Kaposi's Sarcoma-Associated Herpesvirus 用于研究卡波西肉瘤相关疱疹病毒裂解复制和发病机制的可诱导细菌人工染色体系统的建立和表征

IF 6.8 3区医学

Journal of Medical Virology Pub Date : 2025-05-13 DOI: 10.1002/jmv.70392

Xue Xu, Peixian Dong, Wenwei Li, Xiaoqian Wang, Zizhen Ming, Zhenshan Liu, Fanxiu Zhu, Qiming Liang

{"title":"Development and Characterization of an Inducible Bacterial Artificial Chromosome System for Studying Lytic Replication and Pathogenesis of Kaposi's Sarcoma-Associated Herpesvirus","authors":"Xue Xu, Peixian Dong, Wenwei Li, Xiaoqian Wang, Zizhen Ming, Zhenshan Liu, Fanxiu Zhu, Qiming Liang","doi":"10.1002/jmv.70392","DOIUrl":"https://doi.org/10.1002/jmv.70392","url":null,"abstract":"<div>\u0000 \u0000 <p>Bacterial artificial chromosome (BAC) is widely used to manipulate herpesvirus genome and generate recombinant virus. Here, we developed a new KSHV BACmid, namely as iBAC, by replacing the EGFP with TET3G transactivator under EF1α promoter and inserted Tet response elements in the promoter of RTA in the original KSHV BAC16 clone and characterized KSHV lytic replication in SLK-iBAC cells. SLK-iBAC cells developed more efficient lytic replication and generated more progeny virus than iSLK-BAC16 cells upon the same conditions of doxycycline treatment. Since SLK-iBAC cells only occupied hygromycin selection marker, it is convenient to generate cellular gene knockout via lentivirus-mediated CRISPR-Cas9 or stably express viral or cellular gene via lentivirus followed by antibiotic selection, making iBAC system a better tool to identify cellular targets of viral proteins in the context of virus infection or study the role of viral or cellular genes for KSHV lytic replication and pathogenesis. In addition, iBAC is color-free and can be utilized to track subcellular localization of viral proteins or colocalization between different viral proteins by introducing fusing fluorescent proteins into the BAC backbone. Therefore, the new KSHV iBAC is a powerful inducible tool to study KSHV lytic replication and pathogenesis in cell model.</p></div>","PeriodicalId":16354,"journal":{"name":"Journal of Medical Virology","volume":"97 5","pages":""},"PeriodicalIF":6.8,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143938789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Response to the Korea National Committee on Immunization Programs' Letter 对韩国国家免疫规划委员会信函的答复

IF 6.8 3区医学

Journal of Medical Virology Pub Date : 2025-05-13 DOI: 10.1002/jmv.70401

Joowon Lee

引用次数: 0