Antibody and B-Cell Responses to PHH-1V81 XBB.1.16-Adapted SARS-CoV-2 Booster Vaccination Are Associated With Variant Neutralization

IF 4.6 3区医学 Q1 VIROLOGY

Journal of Medical Virology Pub Date : 2025-08-29 DOI:10.1002/jmv.70583

Cèlia Torres, Alfons Jiménez, Meritxell Deulofeu, Antoni Prenafeta, Carlota Dobaño, Gemma Moncunill, Laura Ferrer, Luis M. Molinos-Albert

引用次数: 0

Abstract

Immune escape by SARS-CoV-2 emerging variants jeopardizes vaccine effectiveness, necessitating new immunization strategies. Here, we assessed the antibody B-cell response in 40 individuals receiving either the PHH-1V81 XBB.1.16- or BNT162b2 XBB.1.5-adapted vaccine boosters. Both immunizations significantly increased ancestral-reactive B cells cross-recognizing the vaccine variant. Notably, XBB.1.16 cross-reactive B cells were associated with neutralizing responses, reinforcing the potential of PHH-1V81 as a strong boosting candidate against emerging variants.

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抗体和b细胞对PHH-1V81 xbb .1.16适应的SARS-CoV-2加强疫苗的反应与变异中和有关

SARS-CoV-2新变体的免疫逃逸危及疫苗的有效性，需要新的免疫策略。在这里，我们评估了40名接受PHH-1V81 XBB.1.16-或BNT162b2 xbb .1.5适应疫苗增强剂的个体的抗体b细胞反应。两种免疫都显著增加了祖先反应性B细胞交叉识别疫苗变体。值得注意的是，XBB.1.16交叉反应性B细胞与中和反应相关，增强了PHH-1V81作为抗新变体的强大增强候选物的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Medical Virology 医学-病毒学

CiteScore

23.20

自引率

2.40%

发文量

777

审稿时长

1 months

期刊介绍： The Journal of Medical Virology focuses on publishing original scientific papers on both basic and applied research related to viruses that affect humans. The journal publishes reports covering a wide range of topics, including the characterization, diagnosis, epidemiology, immunology, and pathogenesis of human virus infections. It also includes studies on virus morphology, genetics, replication, and interactions with host cells. The intended readership of the journal includes virologists, microbiologists, immunologists, infectious disease specialists, diagnostic laboratory technologists, epidemiologists, hematologists, and cell biologists. The Journal of Medical Virology is indexed and abstracted in various databases, including Abstracts in Anthropology (Sage), CABI, AgBiotech News & Information, National Agricultural Library, Biological Abstracts, Embase, Global Health, Web of Science, Veterinary Bulletin, and others.