Journal of Medical Science最新文献

{"title":"Penggunaan Minyak Kayu Putih untuk Membersihkan Sisa Perekat Plester pada Kulit Pasien di Ruang Rawat Inap RSUD dr.Zainoel Abidin","authors":"Trifandy ., Cut Nurfazmiati _, S. _","doi":"10.55572/jms.v4i1.72","DOIUrl":"https://doi.org/10.55572/jms.v4i1.72","url":null,"abstract":"Penggunaan plester bisa menyebabkan sisa perekat plester menempel dan tinggal di kulit yang dapat membuat perubahan performance kulit pasien, dan bagi umat muslim hal tersebut akan menghalangi air wudhu mengenai kulit. Penelitian ini merupakan penelitian kuasi eksperimen yang bertujuan untuk membuktikan secara ilmiah penggunaan minyak kayu putih dalam membersihkan sisa perekat plester yang menempel pada kulit pasien. Untuk itu dilakukan evaluasi lama waktu pembersihan sisa perekat plester menggunakan 2 jenis bahan yaitu minyak kayu putih, dan alkohol swab, selanjutnya dilakukan perbandingan antara kedua jenis bahan tersebut. Sampel penelitian berjumlah 60 pasien, terdiri atas 30 responden kelompok intervensi (minyak kayu putih) dan 30 responden kelompok kontrol (alkohol swab). Hasil penelitian menunjukkan rata-rata lama waktu pembersihan sisa perekat plester dengan minyak kayu putih 16,9117 detik, sedangkan dengan alkohol swab 25,4610 detik. Hasil uji Mann Whitney diperoleh p value 0,039, terdapat perbedaan lama waktu pembersihan sisa perekat plester antara minyak kayu putih dan alkohol swab dengan rerata selisih waktu 8,55 detik. Berdasarkan hal tersebut maka minyak kayu putih dapat direkomendasi sebagai bahan alternatif membersihkan sisa perekat plester yang melekat pada kulit pasien.","PeriodicalId":16350,"journal":{"name":"Journal of Medical Science","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84604882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pengembangan Sistem Informasi Farmasi untuk Memonitoring Penggunaan Antibiotik dengan Metode DDD/ATC","authors":"Syamsul Rizal _, Aris Wahyudi _, Ika Fitri Ramadhana _","doi":"10.55572/jms.v4i1.81","DOIUrl":"https://doi.org/10.55572/jms.v4i1.81","url":null,"abstract":"Tingginya penggunaan antibiotik akan meningkatkan potensi penggunaannya yang tidak rasional dan berdampak memunculkan masalah resistensi. Anatomical Therapeutic Chemical/Defined Daily Dose (ATC/DDD) merupakan metode untuk evaluasi penggunaan antibiotik terutama dari aspek kuantitas untuk menggambarkan pola penggunaan antibiotik yang banyak digunakan. Tujuan penelitian ini adalah untuk mengetahui profil penggunaan antibiotik berdasarkan jenis dan kuantitas yang dihitung berdasarkan metode ATC/DDD pada pasien rawat inap di RSUD dr Zainoel Abidin. Penelitian ini termasuk ke dalam penelitian Research and Development (R & D). Pengambilan data dilakukan secara prospektive dari bagian instalasi farmasi didapatkan data berupa jenis antibiotik yang digunakan beserta kuantitasnya, jumlah pasien rawat inap pertahun dan length of stay (LOS) pasien rawat inap di RSUD dr. Zainoel Abidin. Data penggunaan antibiotik kemudian diolah untuk mengetahui DDD/100 hari rawat. Data diolah dengan menggunakan pengembangan Sistem Informasi Rumah Sakit (SIMRS). Dari hasil penelitian diperoleh persen penggunaan antibiotik pada bulan Juli 2022 (69,30%) lebih tinggi dibandingkan bulan Agustus (67,83%) dan September 2022 (68,50%). Total DDD/100 hari rawat inap tertinggi pada bulan Agustus yaitu 41,70 DDD/100 hari rawat inap.","PeriodicalId":16350,"journal":{"name":"Journal of Medical Science","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90925326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hubungan Derajat Keparahan Area Vitiligo dengan Tingkat Depresi pada Pasien Vitiligo di Poliklinik Kulit dan Kelamin Rumah Sakit Umum Daerah dr. Zainoel Abidin Banda Aceh","authors":"Arie Hidayati _, Mimi Maulida _, Nanda Earlia _, Mahda Rizki Liana _","doi":"10.55572/jms.v4i1.75","DOIUrl":"https://doi.org/10.55572/jms.v4i1.75","url":null,"abstract":"Vitiligo menimbulkan perbedaan jelas antara kulit depigmentasi dan kulit normal yang menyebabkan pasien vitiligo sering menghadapi stigmatisasi dan masalah psikososial sehingga rentan terhadap depresi, kecemasan, dan stres. Tujuan penelitian ini adalah untuk mengetahui hubungan antara derajat keparahan vitiligo dengan tingkat depresi pasien vitiligo. Penelitian ini merupakan penelitian analitik observasional dengan desain cross-sectional. Pengumpulan data menggunakan teknik consecutive sampling dan pengisian kuesioner Back Depression Scale pada Juli hingga Oktober 2022 di Poliklinik Kulit dan Kelamin Rumah Sakit Umum Daerah dr.Zainoel Abidin Banda Aceh. Kriteria inklusi meliputi pasien dengan diagnosis vitiligo, usia 13-80 tahun, dan bersedia mengikuti penelitian; sedangkan kriteria eksklusi adalah pasien vitiligo yang telah didiagnosa dengan depresi, dan telah atau dalam proses pengobatan depresi.  Didapatkan hasil dari 31 sampel sebanyak 48,4% laki-laki, 51,6% perempuan, usia rata-rata 36 tahun, 32,4% merupakan siswa dan mahasiswa, guru/dosen dan PNS masing-masing 12,9%.  Jenis klinis vitiligo localized sebesar 58,1 %, vulgaris 29%, dan acrofacial 12,9%. Sebanyak 74,2% telah mengalami vitiligo selama 1-5 tahun, 54,6% telah mendapatkan pengobatan selama 1-5 tahun; 64,5% dengan riwayat pengobatan topikal dan fototerapi.  Mayoritas (93,5%) pasien vitiligo tidak memiliki riwayat autoimun lainnya, 87,1% memiliki tingkat keparahan vitiligo ringan, 6,5% vitiligo sedang, dan 6,5% vitiligo berat. Sebagian besar pasien (93,5%) tidak mengalami depresi, dan 6,5% menderita depresi ringan. Berdasarkan analisa bivariat didapatkan hubungan yang lemah antara derajat keparahan vitiligo dengan tingkat depresi (p= 0.66), sehingga disimpulkan bahwa tidak terdapat hubungan antara derajat keparahan vitiligo dengan terjadinya depresi.","PeriodicalId":16350,"journal":{"name":"Journal of Medical Science","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74865989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analisis Kelembapan Kulit pada Pasien Anak dengan Penyakit Jantung Bawaan Di RSUDZA Banda Aceh","authors":"Vella _, Herlina Dimiati _, Elfa Wirdani Fitri _","doi":"10.55572/jms.v4i1.73","DOIUrl":"https://doi.org/10.55572/jms.v4i1.73","url":null,"abstract":"Kulit adalah organ terbesar dalam tubuh manusia dan bertindak sebagai pertahanan tubuh terhadap agen eksternal seperti mikroorganisme, radiasi UV, dan rangsangan fisik dan kimia. Salah satu parameter yang paling sering digunakan dalam menilai fungsi sawar kulit, baik pada kulit sehat maupun pada penyakit tertentu, adalah dengan melakukan penilaian kelembapan ataupun hidrasi kulit dengan menggunakan trans-epidermal water loss (TEWL) dan skin capacitance (Scap). Terdapat berbagai penyakit yang disertai gangguan kelembapan kulit seperti dermatitis atopik, psoriasis, penyakit metabolik lainnya seperti ginjal, diabetes melitus hingga penyakit jantung. Tujuan penelitian ini adalah untuk menganalisis kelembapan kulit pada pasien anak dengan penyakit jantung bawaan (PJB) di RSUDZA Banda Aceh. Penelitian ini merupakan penelitian analitik observasional dengan desain cross sectional yang dilakukan pada 37 pasien anak dengan PJB yang berobat pada poliklinik jantung anak RSUDZA Banda Aceh serta memenuhi kriteria inklusi dan ekslusi dengan metode total sampling dalam kurun waktu 3 bulan.  Status kelembapan kulit di area dahi, pipi, leher, ekstremitas atas dan bawah dinilai dengan menggunakan alat Tewameter dan Corneometer yang dianalisis menggunakan uji T tidak berpasangan. Hasil penelitian menunjukkan bahwa dari 37 sampel, 72.9% merupakan PJB tipe non-sianotik, dimana jenis kelamin terbanyak pada kelompok PJB sianotik adalah laki-laki (70%) sedangkan kelompok non-sianotik yang terbanyak adalah perempuan (51.9%). Kedua kelompok didominasi oleh anak usia 1 sampai 5 tahun (PJB sianotik, 70%; PJB non-sianotik 70.4%) dengan berat badan lahir ≥ 2500 gr (PJB sianotik, 60%; PJB non-sianotik 74.1%). Nilai TEWL kelompok PJB sianotik lebih tinggi dibandingkan kelompok non-sianotik dan nilai Scap kelompok PJB sianotik lebih rendah dibandingkan kelompok non-sianotik sehingga dapat disimpulkan pasien anak dengan PJB sianotik memiliki kelembapan kulit yang lebih buruk dibandingkan anak dengan PJB non sianotik (p<0.05).","PeriodicalId":16350,"journal":{"name":"Journal of Medical Science","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74586249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pengaruh Daun Kelor Untuk Pencegahan Infertilitas Akibat Trauma Fisik Testis","authors":"Dahril _, Jufriady Ismi _, A. .","doi":"10.55572/jms.v4i1.91","DOIUrl":"https://doi.org/10.55572/jms.v4i1.91","url":null,"abstract":"Trauma testis menjadi penyebab tersering ketiga dari nyeri skrotum akut yang dapat mengakibatkan berbagai tingkat kerusakan testis, sehingga dapat menyebabkan infertilitas. Trauma testis merupakan faktor risiko infertilitas terkait dengan adanya peningkatan radikal bebas, inflamasi yang berdampak pada penurunan kualitas sperma, dan kerusakan Blood Testis Barrier (BTB). Lima dari 9 testis yang mengalami trauma menjadi atrofi. Salah satu tatalaksana yang dapat dilakukan untuk mengatasi hal tersebut adalah dengan pemberian antioksidan. Tanaman kelor (Moringa oleifera)  mengandung beberapa senyawa antioksidan seperti senyawa golongan alkaloid, flavonoid, tanin, vitamin C, vitamin E, dan steroid. Diharapkan daun kelor juga dapat melindungi sel sperma dari oksidan bebas akibat trauma testis dan secara tidak langsung menjadi salah satu pilihan terapi infertilitas. Penelitian ini merupakan penelitian eksperimental menggunakan rancangan the post-test only control group design. Setelah dilakukan adaptasi selama 2 minggu, dibuat perlakuan torsio testis pada 30 ekor tikus rattus novergicus yang dibagi  ke dalam 5 kelompok perlakuan, kemudian dilakukan analisis sperma. Analisis data perbedaan antar kelompok menggunakan uji analisis of variance (ANNOVA) satu arah. Hasil penelitian menemukan konsentrasi spermatozoa (39.80 ± 17.88 x106 spermatozoa/ml) pada kelompok dosis 800 mg lebih tinggi dibandingkan kelompok dosis 400 mg (27.94 ± 14.76 x106 spermatozoa/ml), dan kelompok dosis 200 mg (25.32 ± 19.33 x106 spermatozoa/mL). Hal ini menunjukkan bahwa pemberian ekstrak tanaman kelor dosis 800 mg lebih berpengaruh atau mampu mempertahankan konsentrasi spermatozoa tikus wistar pada torsio testis dibanding  dosis 400 mg dan 200 mg. Penelitian ini menyimpulkan daun kelor memiliki potensi dalam tatalaksana infertilitas terkait trauma testis.","PeriodicalId":16350,"journal":{"name":"Journal of Medical Science","volume":"112 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74505849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of autoimmune thyroiditis on primary hyperparathyroidism","authors":"Stefanos Chatzidakis, D. Lamnisos, V. Constantinides, A. Kyriacou, A. Economides, P. Economides","doi":"10.20883/medical.e737","DOIUrl":"https://doi.org/10.20883/medical.e737","url":null,"abstract":"Aim. Primary hyperparathyroidism (PHPT) often coexists with thyroid diseases. Current guidelines advise preoperative ultrasound (US) examination of the thyroid gland for thyroid nodular disease or concomitant malignancy but not evaluation for autoimmune thyroiditis (AIT). The impact of autoimmune thyroiditis on the clinical presentation and intraoperative course of PHPT is not clear.\u0000Material and methods. We retrospectively assessed the medical records of 21 patients with PHPT who underwent parathyroidectomy. Clinical, biochemical, ultrasonographic and intraoperative data were evaluated.\u0000Results. There was a longer duration of parathyroidectomy in patients with AIT than in those without (113.3 min vs. 93.9 min, P=0.03). A lower rate of kidney stones was noted in patients with autoimmune thyroiditis (44.4% vs. 0%, P=0.03). Patients with AIT were more symptomatic, but this was not significant. There was no difference between the two groups in the prevalence of osteoporosis or thyroid nodular disease.\u0000Conclusions. A significantly longer duration of parathyroidectomy was seen in PHPT patients with AIT. Patients with PHPT undergoing surgery should be investigated for autoimmune thyroiditis, as this may affect surgical planning.","PeriodicalId":16350,"journal":{"name":"Journal of Medical Science","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75795046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of dietary habits among Polish women with Hashimoto's disease","authors":"K. Skoracka, E. Swora-Cwynar, Aleksandra Królczyk, M. Kałużna, K. Ziemnicka, M. Ruchała, A. Dobrowolska, I. Krela-kaźmierczak","doi":"10.20883/medical.e735","DOIUrl":"https://doi.org/10.20883/medical.e735","url":null,"abstract":"Introduction. Selected dietary components are crucial for a properly functioning thyroid gland. Therefore a healthy and balanced diet is  crucial for treating patients with Hashimoto's disease.\u0000Aim. This study aims to evaluate the dietary habits of women suffering from autoimmune thyroiditis.\u0000Material and methods. A questionnaire study was conducted in a group of 58 women with Hashimoto's disease and among 42 women without autoimmune thyroiditis using the Food Frequency Questionnaire (FFQ-6). To assess compliance with the normal distribution, we used the Shapiro-Wilk test. The comparative assessment was made using the Student's t-test and Mann-Whitney test. The Chi-square test was used to assess the relationship between the response and the group. A p-value of less than 0.05 was considered significant.\u0000Results. The study showed no significant differences in dietary habits between the two groups. Only 29% (n=15) of women with HT declared daily consumption of fruits vs 31% (n=12) in the control group (p=0.3800), and only 2% (n=1) declared consuming berries daily vs. 5% (n=2), (p=0.5270). The consumption of the recommended several portions of vegetables per day was declared by only 22% (n=11) of women with HT vs 28% (n=11) in the control group (p=0.3983). 42% (n=24) of women with HT vs 38.5% (n=16) of controls reported eating cruciferous vegetables several times a week (p=0.8241). 14% (n=8) of women with HT vs 19% (n=8) of women in the control group declared daily consumption of green leafy vegetables (p=0.3653). Most people in the study group consume nuts and seeds several times a month, and those in the control group several times a week. Most HT respondents also declare not to consume the recommended amount of fish.\u0000Conclusions. The diet of patients with Hashimoto's disease does not differ significantly from that of non-Hashimoto's disease patients. Considering the study results and current scientific knowledge, it seems necessary to undertake educational activities for patients with Hashimoto's disease to increase patient awareness of the impact of diet on the course of the disease.","PeriodicalId":16350,"journal":{"name":"Journal of Medical Science","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89657871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of PD-L1 in triple negative breast cancer","authors":"Gina James Keorges","doi":"10.20883/medical.e806","DOIUrl":"https://doi.org/10.20883/medical.e806","url":null,"abstract":"Introduction: The second leading cause of cancer deaths in women is breast cancer. Breast cancer awareness has increased due to mammography screenings. The aim of study is to evaluate the prevalence of PD-L1 expression in TNBC cases and to correlate it with clinicopathological parameters. Method: PDL1 expression is measured by immunohistochemical technique using Dako kits, PD-L1 IHC 22C3 pharm Dx, on 44 paraffin block samples from Duhok municipal labs. If the specimen has a combined positive score (CPS) of 10 or higher, it expresses PD-L1. Age groups, grades, kinds, stages, and PDL1, lymph node involvement are studied. Results: 44 cross-sectional patients, mean and SD (47.7±14) years old. (54.5%) of patients in middle age group, (63.6%) at grade III, majority (88.6%) have IDC type and (75%) have negative PDL1, (63.6%) have KI69 less than 20, (70.5%) at stage T2, and (45.5%) have N1 lymph node involvement. There is significant association between PDL1 and Ki67, (100%) of patients with positive PDL1 have Ki67 more than 20 while (15.2%) of patients with negative PDL1 have Ki67 more than 20. Conclusion: 75% of middle-aged individuals with grade III had negative PDL1. All PDL1-positive patients have Ki67 above 20. Different research employ 1%, 5%, or 10% cutoff values, which affects PDL1. \u0000 ","PeriodicalId":16350,"journal":{"name":"Journal of Medical Science","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78580227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formulation of a radiological scoring system to prognosticate patients with primary intracerebral haemorrhage","authors":"Krishna Kumar, H. Gopalan, Jayalakshmi Jayaprakash","doi":"10.20883/medical.e724","DOIUrl":"https://doi.org/10.20883/medical.e724","url":null,"abstract":"Background. Primary intracerebral haemorrhage is a neurological condition associated with high morbidity and mortality. Outcome prediction is necessary to allocate the available resources in such cases judicially. Our study aims to identify the radiological predictors of in-hospital mortality based on a plain CT study of the brain at admission and to develop a prognostic scoring system based on them.\u0000Material and methods. We collected the clinical and radiological data from 182 consecutive patients who presented with primary spontaneous ICH. Bivariate analysis of radiological predictors of in-hospital mortality was undertaken using unadjusted logistic regression. Those variables found to have significance were put into a multivariate logistic regression model. The Results of multivariate logistic regression were treated as a foundation for developing the scoring system.  \u0000Results. The mortality rate in our series was 23.6% (N = 43). After multivariate analysis, Midline shift (MLS), presence or absence of intraventricular haemorrhage (IVH), Volume of ICH and Location of haematoma were significant predictors of mortality. Based on the identified radiological variables, a five-score prognostic scoring system (AUROC = 0.925, 95% CI 0.887–0.964)) was developed, with higher scores indicating higher mortality.\u0000Conclusions. The established scoring system, MIVL, may help physicians to do better patient counselling regarding outcomes.","PeriodicalId":16350,"journal":{"name":"Journal of Medical Science","volume":"267 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75084768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A simple model of human walking","authors":"L. Campanelli","doi":"10.20883/medical.e817","DOIUrl":"https://doi.org/10.20883/medical.e817","url":null,"abstract":"Aim. We investigate Alexander’s inverted pendulum model, the simplest mathematical model of human walking. Although it successfully explains some kinematic features of human walking, such as the velocity of the body's centre of mass, it does not account for others, like the vertical reaction force and the maximum walking speed. This paper aims to minimally extend Alexander’s model in such a way as to make it a viable and quantitative model of human walking for clinical biomechanics.Material and methods. In order to compare the predictions of Alexander’s model with experimental data on walking, we incorporate in it a robust phenomenological relation between stride frequency and stride length derived in the literature, and we introduce a step-angle dependent muscle force along the pendulum. We then analytically solve the pendulum's motion equation and find the corresponding analytical expression for the average walking speed.Results. The values of the average walking speed for different heights predicted by our model are in excellent agreement with the ones obtained in treadmill experiments. Moreover, it successfully predicts the observed walking-running transition speed, which occurs when the stride length equals the height of an individual. Finally, our extended model satisfactorily reproduces the experimentally observed ground reaction forces in the midstance and terminal stance phases. Consequently, the predicted value of the (height-dependent) maximum walking speed is in reasonable agreement with the one obtained in more sophisticated models of human walking.Conclusions. Augmented with our minimal extensions, Alexander’s model becomes an effective and realistic model of human walking applicable in clinical investigations of the human gate.","PeriodicalId":16350,"journal":{"name":"Journal of Medical Science","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88444431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}