Journal of Medical Science最新文献

{"title":"Molecular characterization of multiple myeloma","authors":"Buse Zeren Kiremitci, Elif Serap Gürler, Y. Kiraz","doi":"10.20883/medical.e656","DOIUrl":"https://doi.org/10.20883/medical.e656","url":null,"abstract":"Multiple myeloma (MM) is a hematologic malignancy that occurs when plasma cells, a type of white blood cell, grow out of control and start to overproduce antibodies that accumulates in blood and bone marrow. Despite the recent advance the survival rate for MM has not been increased significantly, which opens the need for identifying new molecular targets. This review article presents the most frequently observed gene mutations (KRAS (22.0%), NRAS (18.0%), DIS3 (9.3%), TTN (8.3%), ZNF717 (8.3%), TENT5C (7.3%), TP53 (7.3%) %), BRAF (6.3%), MUC16 (6.3%), RYR2 (5.4%), LRP1B (5.4%)) in MM patients and its rates, correlations, clinical significance, importance in the framework of MM disease and potential novel targets which are collected from the literature. The genes that are mutated in MM patients (211) taken from cBioportal data set. In conclusion, in the study conducted in MM patients, the 3 genes with the most frequent mutations were recorded as KRAS, NRAS and DIS3, respectively. In addition, in the context of our literature reviews and the data obtained, it appears that the TZNF717, TTN, MUC16, RYR2 genes need further study within the framework of MM.","PeriodicalId":16350,"journal":{"name":"Journal of Medical Science","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81671974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"E-scooters and the City – head to toe injuries","authors":"Justyna Kowalczewska, Szymon Rzepczyk, C. Żaba","doi":"10.20883/medical.e672","DOIUrl":"https://doi.org/10.20883/medical.e672","url":null,"abstract":"In the recent years electric scooters have become much more common. As the number of drivers increased, so did the number of accidents and injuries involving e-scooters. The most common are head and neck injuries, including open wounds of soft tissues, traumatic brain injuries (TBIs), fractures of the skull bones, and intracerebral hemorrhages (ICH). The second most frequent are injuries to both upper and lower limbs. Fractures of the spine and injuries to the chest and abdominal cavity are less common. Many injuries could be avoided by using helmets, not driving e-scooters under the influence of intoxicating substances, and systematizing the rules of using e- scooters among other road traffic users.","PeriodicalId":16350,"journal":{"name":"Journal of Medical Science","volume":"49 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73678992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Publication ethics of human studies in the light of the Declaration of Helsinki – a mini-review","authors":"N. Sawicka-Gutaj, Dawid Gruszczyński, P. Guzik, A. Mostowska, J. Walkowiak","doi":"10.20883/medical.e700","DOIUrl":"https://doi.org/10.20883/medical.e700","url":null,"abstract":"The Declaration of Helsinki is a set of ethical principles to be followed by scientists involved in medical research with humans or human cells and tissues. This Declaration defines how scientific research should be planned, carried out, documented, analysed, and published. \u0000We summarise and discuss some ethical issues related to publishing original articles, including clinical trials, review papers, and case reports based on the seventh revision of the Declaration of Helsinki. \u0000The principles of the Declaration of Helsinki refer most strongly to the publication of medical research results, in particular clinical trials, as original articles. Such papers must meet several ethical requirements, especially the study protocol transparency and the presentation of the results. For case reports, the bioethical aspects related to their publication are twofold - they must include informed and voluntary consent and the confidentiality of study participants. The review papers are of the least bioethical concern. However, whether patients' agreements with specific studies are valid if the data are used in meta-analyses is uncertain. \u0000Adherence to ethical policies and standards helps to ensure the highest possible quality of scientific publications. Responsibility for compliance with the Declaration of Helsinki lies not only with the authors preparing their manuscripts but also with the editorial board and reviewers, who must evaluate the ethical soundness of the submitted papers. The additional guidelines for the different types of studies facilitate the implementation of the Declaration principles.","PeriodicalId":16350,"journal":{"name":"Journal of Medical Science","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74062396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modern diagnostics in IgE-mediated cow’s milk allergy","authors":"J. Matysiak","doi":"10.20883/medical.e690","DOIUrl":"https://doi.org/10.20883/medical.e690","url":null,"abstract":"Cow's milk allergy (CMA) is the most common food allergy in infants and young children. Allergic reactions can vary from mild to severe, like an anaphylactic shock. In case of CMA diagnosis suspicion skin prick tests (SPT), immunoassays of specific IgE (sIgE) in blood serum (in vitro tests) and oral food challenge (OFC) tests can be performed.  SPT wheal diameter and the level of serum specific IgE to milk do not correlate with severity of clinical symptoms, while procedure of OFC is often difficult or even imposible in practice. Therefore component resolved-diagnostics (CRD) tests are a new diagnostic tool, which allows for a better correlation of laboratory test results with the observed clinical symptoms and indicate the triggering allergens.","PeriodicalId":16350,"journal":{"name":"Journal of Medical Science","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86348457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent developments in the use of activated charcoal in medicine","authors":"J. Hassen, Hamad Kalefa Abdulkadir","doi":"10.20883/medical.e647","DOIUrl":"https://doi.org/10.20883/medical.e647","url":null,"abstract":"One of the raw forms of graphite is activated charcoal which has an extensive surface area allowing for the adsorption of a wide range of chemicals. It possesses the strongest physical adsorption forces of the available materials, as well as the largest volume of adsorbing porosity. Activated charcoal acts as an adsorbent, collecting and storing substances in the gastrointestinal tract, reducing or blocking absorption in the bloodstream. The ingested toxins interact with charcoal by recycling toxins in the intestinal cavity. In cases where the drug has not been absorbed from the abdominal system, it is recirculated through the liver and intestines or by means of passive diffusion or active secretion. The article aims to review the most recent advances in the use of the activated charcoal, including the dose, how charcoal acts in the body, the mechanism of action, administration, contraindications, as well as the impact of various factors on the adsorption process. In addition, we also discussed numerous medical applications of activated charcoal.","PeriodicalId":16350,"journal":{"name":"Journal of Medical Science","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77259773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Thousand Words About Modern Medical Education: A Mini-Review Concerning the Theory of Education","authors":"M. Al-Jarshawi, A. Al-Imam","doi":"10.20883/medical.e636","DOIUrl":"https://doi.org/10.20883/medical.e636","url":null,"abstract":"The present article represents a mini-review and a reflective essay concerning modern medical education methods, as well as ways to adapt them to medical education's local conditions (disciplines), including basic medical sciences. We introduced Gagné's theory of learning and other theories – Constructivist, Experiential, and Humanistic – followed by Dennik's \"twelve tips\" for effective learning and Harden's ten questions for curriculum development. Outcome-based education (OBE) was discussed and related to relevant concepts within Miller's pyramid and Bloom's taxonomy. Harden's SPICES model was emphasized concerning education strategies while discussing the assessment of learning (AoL), assessment as learning (AaL), and assessment for learning (AfL). Finally, the authors advise exploring the adaptation of modern education methods for a specific discipline of basic medical sciences – Human Anatomy – by incorporating the abovementioned concepts and integrating different AfL and AaL assessment tools while conveying a graphical concept map for this scenario.","PeriodicalId":16350,"journal":{"name":"Journal of Medical Science","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84396626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluasi Waktu Tunggu Setelah Redesign dan Penerapan Lean Pharmacy Pada Pelayanan Farmasi Rawat Jalan","authors":"Fitri Yani, S. Maraiyuna, Azizah Vonna","doi":"10.55572/jms.v3i1.55","DOIUrl":"https://doi.org/10.55572/jms.v3i1.55","url":null,"abstract":"Waktu tunggu pelayanan menurut World Health Organization (WHO) merupakan acuan penilaian sistem kerja yang baik dari suatu fasilitas kesehatan. Waktu tunggu obat adalah jumlah waktu mulai pasien menyerahkan resep sampai dengan menerima obat jadi. Farmasi merupakan unit pelayanan terakhir yang akan dikunjungi pasien yang berobat rawat jalan di Rumah Sakit. Standar yang ditetapkan oleh Menteri Kesehatan untuk pelayanan resep non racik adalah 30 menit untuk satu resep, sementara dari hasil evaluasi di depo farmasi rawat jalan tahun 2021 diketahui waktu tunggu pelayanan resep masih di atas standar. Beberapa intervensi untuk menurunkan lamanya waktu tunggu telah dilakukan selama beberapa tahun ke belakang. Namun, intervensi tersebut tidak terdokumentasi dengan baik dan hasil dari intervensi tidak terukur secara jelas, sehingga tidak bisa dijadikan sebagai referensi dalam perbaikan berkelanjutan berikutnya. Penelitian ini merupakan upaya perbaikan yang dilakukan dengan menerapkan konsep lean pharmacy di depo farmasi rawat jalan. Jenis penelitian yang digunakan adalah kuantitatif dengan metode penelitian quasi experimental dengan one group pretest posttest design yang bertujuan untuk menguji perbaikan waktu tunggu dan kepuasan pasien setelah diterapkan konsep Lean pharmacy. Beberapa intervensi diterapkan yaitu merubah tahapan prosedur pelayanan resep pada tahapan awal, memisahkan tanggung jawab petugas berdasarkan kategori jenis resep, menambah unit set komputer untuk resep cito dan eksekutif, merevisi SOP pelayanan resep kronis dan non kronis, memfasilitasi pasien dengan informasi alur pelayanan resep dalam bentuk standing banner dan melakukan sosialisasi perubahan sistem dan motivasi penguatan kinerja kepada staf di depo farmasi rawat jalan. Hasil yang diperoleh pada penelitian waktu tunggu pelayanan resep kronik di Depo Farmasi Rawat Jalan RSUDZA sebelum dilakukan intervensi adalah selama 1 jam 26 menit (86 menit) dan meningkat lebih cepat setelah dilakukannya intervensi menjadi 56 menit (p-value 0,000). Hasil penelitian kepuasan pasien sebelum dilakukan intervensi yaitu waktu tunggu pelayanan resep di depo farmasi rawat jalan terjadi penurunan waktu yang signifikan (p-value 0,000) sebesar 30 menit setelah dilakukan intervensi dengan melakukan rediesign pelayanan farmasi.","PeriodicalId":16350,"journal":{"name":"Journal of Medical Science","volume":"236 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77556469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluasi Response Time Seksio Emergensi Kategori I Terhadap Luaran Maternal dan Neonatal Dengan Tersedianya Alur Pelayanan Seksio Sesarea Emergensi Di RSUDZA Juli-Oktober 2021","authors":"Cut Meurah Yeni, H. Hasanuddin, Cut Rika Maharani, Nurul Fadhliati Maulida Maulida","doi":"10.55572/jms.v3i1.57","DOIUrl":"https://doi.org/10.55572/jms.v3i1.57","url":null,"abstract":"Angka seksio sesarea (SC) mengalami kenaikan dua kali lipat di seluruh dunia yaitu 12,1% pada tahun 2010 dan 21,1 % pada tahun 2015 di 169 negara. The American College of Obstetricians and Gynecologists (ACOG) dan the National Institute of Clinical Excellence (NICE) membuat ketentuan standar baku emas bahwa response time  SC emergensi atau disebut juga decision-to-delivery interval (DDI) pada kelahiran yaitu <30 menit. Tujuan pelitian ini untuk mengetahui gambaran response time  SC emergensi kategori 1 di RSUDZA setelah pembuatan alur pelayanan SC emergensi.  Rancangan penelitian ini adalah kohort prospektif, dengan melihat data pasien yang memenuhi kriteria inklusi dan ekslusi di RSUDZA dari periode Juli sampai Oktober 2021. Luaran cut of point rerata response time, luaran maternal dan neonatal. Data dianalisis dengan menggunakan software SPSS 23.  Didapatkan 19 kasus yang memenuhi kriteria dari total 23 kasus SC emergensi kategori 1. Rerata response time  SC emergensi kategori 1 adalah 36,29±8,59 (28-50 menit). Ada tidaknya demam, perlu tidaknya rawatan pasca operasi di ICU, serta kematian ibu memiliki hubungan yang erat dengan response time SC emergensi kategori I (p<0,05). Skor APGAR, perlu tidaknya bantuan pernapasan seperti CPAP dan intubasi, perlu tidaknya rawatan di NICU, serta kematian bayi memiliki hubungan yang erat dengan response time  SC  emergensi Kategori I (p<0,05). Response time  SC <30 menit memiliki pengaruh yang signifikan terhadap luaran maternal dan neonatal dengan tersedianya alur SC emergensi di RSUDZA.","PeriodicalId":16350,"journal":{"name":"Journal of Medical Science","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82077615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pengaruh Intervensi Prosedur Layanan Terhadap Waktu Tunggu (Model Intervensi) dan Tingkat Kepuasan Masyarakat Pada Layanan Kesehatan Poliklinik THT-KL RSUDZA Banda Aceh","authors":"Teuku Husni TR Husni, Benny Kurnia, Safarianti Safarianti","doi":"10.55572/jms.v3i1.53","DOIUrl":"https://doi.org/10.55572/jms.v3i1.53","url":null,"abstract":"Upaya peningkatan layanan melalui percepatan waktu tunggu pasien dipoliklinik THT-KL dilakukan dengan mempercepat durasi layanan pasien menjadi ≤60 menit yang dihitung dari mulai saat pasien mendaftar ulang di nurse station poliklinik THT-KL hingga pasien selesai diperiksa oleh dokter dan meninggalkan poliklinik. Upaya lainnya adalah melalui pengembangan model layanan baru melalui perubahan alur/prosedur layanan. Studi ini bertujuan menganalisis pengaruh intervensi prosedur layanan terhadap waktu tunggu (model intervensi) dan tingkat kepuasan pasien pasien yang berobat dipoliklinik THT-KL Penelitian ini adalah penelitian eksperimental analitik dengan jenis eksperimen quasi dan rancangan penelitian Post Test Only Control Group Design. Sampel diambil menggunakan metode Accidental Sampling dengan jumlah responden 82 pasien. Hasil Penelitian didapatkan bahwa rata-rata waktu tunggu pasien di poliklinik THT-KL RSUDZA pre intervensi adalah 49 menit dan waktu tunggu post intervensi adalah 54 menit. Hasil analisis uji Mann Whitney didapatkan P value= 0,176. Hasil analisis uji chi-square yang dilakukan untuk mengetahui pengaruh intervensi prosedur layanan pada tingkat kepuasan pasien didapatkan P value= 0,061. Hal ini menunjukkan bahwa intervensi prosedur layanan dipoliklinik THT-KL tidak mempunyai pengaruh yang bermakna pada waktu tunggu layanan model intervensi dan tingkat kepuasan pasien/masyarakat. Hal ini diduga karena adanya keterbatasan dalam penelitian berupa variasi jenis tindakan yang didapat pasien dan pengukuran dilakukan pada subjek yang berbeda.","PeriodicalId":16350,"journal":{"name":"Journal of Medical Science","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83866272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pengaruh Pemberian Ketoprofen Supposituria terhadap Penurunan Intensitas Nyeri saat Pelepasan Kateter Uretra Menetap","authors":"Jufriady Ismy, Andreas Andreas, Y. Aulia","doi":"10.55572/jms.v3i1.54","DOIUrl":"https://doi.org/10.55572/jms.v3i1.54","url":null,"abstract":"Kateter urin adalah selang yang dimasukkan ke dalam kandung kemih untuk mengalirkan urine. Kateter ini biasanya dimasukkan melalui uretra ke dalam kandung kemih. Pemberian ketoprofen digunakan untuk mengurangi intensitas nyeri pada saat pelepasan kateter. Tujuan dari penelitian ini adalah untuk mengetahui efektivitas pemberian Ketoprofen pada pasien saat pelepasan kateter urin. Tujuan jangka panjang dari penelitian ini adalah mendapatkan suatu metode intervensi pendukung manajemen nyeri yang dapat dilakukan oleh perawat di ruang rawat bedah sehingga dapat meningkatkan kepuasan pasien terhadap pelayanan yang diberikan. Penelitian ini merupakan penelitian uji klinis (clinical trials) desain paralel. Uji klinis adalah penelitian eksperimental terencana yang dilakukan pada manusia. Peneliti pada penelitian uji klinis akan memberikan perlakuan atau intervensi pada 60 peserta atau subjek penelitian. Terdapat 2 kelompok penelitian yang akan dinilai. Terdapat 30 sampel akan diberikan perlakuan ketoprofen supposituria, dan 30 sampel sebagai kelompok kontrol. Pengambilan sampel menggunakan teknik consecutive sampling dengan kriteria inklusi: 1) Pasien diruang rawat bedah dan memakai kateter; 2) masa pemasangan kateter tidak lebih dari 3 hari; 3) pasien diatas 18 tahun; 4) pasien tidak menjalani operasi pada uretra vesica urinaria. Hasil penelitian menggunakan normalitas data menggunakan uji kolmogorov-smirnov menunjukkan bahwa nilai p-value < 0.05 pada masing-masing kelompok, maka dapat disimpulkan bahwa data berdistribusi tidak normal. Dari analisis uji Mann Whitney ditemukan pengaruh yang signifikan pada pemberian ketoprofen terhadap penurunan skala nyeri (p <0.05). Kami akan mensosialisasikan kepada devisi Bagian Urologi/ KSM Ilmu Bedah RSUDZA/FKUSK untuk menjadikan hasil penelitian ini menjadi standar operasional prosedur (SOP) yang harus di jalankan pada pasien-pasien yang dilakukan pelepasan kateter.","PeriodicalId":16350,"journal":{"name":"Journal of Medical Science","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91123981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}