International Journal of Clinical and Medical Education Research最新文献

{"title":"Pink Gingiva is it the Needle or the Light!","authors":"","doi":"10.33140/ijcmer.02.04.05","DOIUrl":"https://doi.org/10.33140/ijcmer.02.04.05","url":null,"abstract":"Objectiv: Gingival depigmentation is an aesthetic periodontal procedure that is carried out to eliminate gingival hyperpigmentation. Numerous depigmentation modalities are used namely surgical scraping, gingival autograft, cryosurgery, electrosurgery, and lasers. Microneddling(MN) is a novel technique that is conservative involving the creation of micro wounds and has been tried for depigmentation. Material and Methods: A 23 yrs old female patient without any systemic conditions reported to the Outpatient Department of Periodontology, Krishnadevaraya College of dental sciences and Hospital, with the chief complaint of dark-colored gums. Depigmentation with micro needling was done in the lower anterior and laser in the upper anterior region. Result: There was a considerable reduction in the oral pigmentation scores (Dummett Oral Pigmentation Index) using both techniques in the first and the fourth week. The Visual Analogue Scale score showed lesser pain in the microneedling area. Conclusion: Depigmentation using microneedling and lasers is effective. Microneedling is a simple, economical, and viable option for the removal of gingival depigmentation.","PeriodicalId":162406,"journal":{"name":"International Journal of Clinical and Medical Education Research","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133342052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Quantitative Study on The Sociodemographic, Medical-Profile and Effect of Dialysis on the Quality of Life of Patients-The Case of Northern Region in Ghana","authors":"","doi":"10.33140/ijcmer.02.04.04","DOIUrl":"https://doi.org/10.33140/ijcmer.02.04.04","url":null,"abstract":"Background: End stage renal disease patients almost always end up requiring renal replacement therapy (RRT). The knowledge on sociodemographic characteristics and medical profile of patients with ESRD and the effects of dialysis on their quality of life is of immense importance to the effective planning and care of these patients. However, there is paucity of literature on this topic. Methods: A cross sectional survey was employed in this study. Objective: The study was meant to uncover knowledge on the sociodemographic characteristics, medical profile and the effects of dialysis on the quality of patients undergoing dialysis. Results: At a mean age of 42.9 years, (35.3%, n = 18) of participants were within 41 and 50 years (Mean = 42.9 years, SD 14.5, Min. 13 years, Max. 77 years). Majority (72.6%, n = 37) of the participants were males, meaning more males were on dialysis than females even though literature suggest that more females are diagnosed with renal conditions. Out of the total number, (29.4%, n = 15) of the participants had attained tertiary education while about 25.5% (n = 14) had no formal education and more than half of the participants earned below Ghc500 equivalent to 34 US dollars monthly. The ability to carry out activities of daily living are severely affected. Conclusion: Kidney failure has become a very common disease among the general public, causing devastating effects, hence there is the need to research into it for effective actions against it.","PeriodicalId":162406,"journal":{"name":"International Journal of Clinical and Medical Education Research","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126602109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Networks of Violence in the Covid-19 Era","authors":"","doi":"10.33140/ijcmer.02.04.03","DOIUrl":"https://doi.org/10.33140/ijcmer.02.04.03","url":null,"abstract":"Objective: From the review of the theories of the cycle of violence, gender violence and the social construction of masculine and feminine identities. Methodology: Carried out a non - experimental, exploratory and descriptive study with a nonrandom selection of students a public university with the aim of establishing a balance and a prospective expectation of violence. Results: The results show that of synaptic weights are explained by incoming, and outgoing latent layers on the pre-contemplation of violence, contemplation of aggressive relationships and personal change. Conclusion: Lines alluding to the kind of relationship research, negotiation and consensus decision making to warn couple conflicts.","PeriodicalId":162406,"journal":{"name":"International Journal of Clinical and Medical Education Research","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122602228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Hit of Two Earthquakes in Turkey-Syria: Mw=7,8 Giziantep-Mw=7,5 Kahramanmaras","authors":"","doi":"10.33140/ijcmer.02.04.01","DOIUrl":"https://doi.org/10.33140/ijcmer.02.04.01","url":null,"abstract":"Turkey-Syria were shaken by two large earthquakes Mw=7,8 and the other with Mw=7,5. The seismic moment shows the amount of energy accumulated due to the seismic gap in the region. Giving researchers a guideline on which they can rely on the different interpretations of data provided by different stations around the world. In addition to understanding the type of problem caused by the use of low-quality materials for the construction of buildings. The seismic moment that was calculated using the seismic moment formula can be found in the results where the moment graph is also evident; the peak seismic release at the time of the onset of the event, however many researchers will have discrepancies because they have reported the same ones that could be verified later","PeriodicalId":162406,"journal":{"name":"International Journal of Clinical and Medical Education Research","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114269989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurology and Neuroscience","authors":"R. K. Rodrigues, G. D. Costa, R. F. Castro, Ribeirão Preto, Zanon Zotin, M. C. Boston, MARibeirão, Preto Camilo, M. R. Pontes-Neto","doi":"10.33425/2692-7918","DOIUrl":"https://doi.org/10.33425/2692-7918","url":null,"abstract":"Fact There are three ways of knowing Perception Inference Validation","PeriodicalId":162406,"journal":{"name":"International Journal of Clinical and Medical Education Research","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122788267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on Hyperlipidemia Mechanism of Lotus Leaves by Network Pharmacology and Molecular Docking","authors":"","doi":"10.33140/ijcmer.02.02.02","DOIUrl":"https://doi.org/10.33140/ijcmer.02.02.02","url":null,"abstract":"The main active chemical components and targets of lotus leaves were obtained though the TCMSP database and screened by ADME; The main targets of hyperlipidemia were obtained by Genecards, OMIM, TTD and DRUGBANK databases; Protein interactions were analyzed through the STRING database; Finding potential protein functions by constructing a PPI network; Metascape software was used to analyze “drug-component-target” and the biological processes and pathways involved. Build a“lotus leaves component-hyperlipemia target” network though Cytoscape3.7.1 software. Molecular docking verification was performed by Autodocktools software. The preliminary study shows that lotus leaves regulation of hyperlipidemia have a multicomponent, multi-target and multi-pathway mechanism, which provides data basis for traditional Chinese medicine to regulate hyperlipidemia.","PeriodicalId":162406,"journal":{"name":"International Journal of Clinical and Medical Education Research","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131434134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytogenetic Analysis of Chronic Myeloid Leukemia in an Eastern Indian Population","authors":"","doi":"10.33140/ijcmer.02.02.03","DOIUrl":"https://doi.org/10.33140/ijcmer.02.02.03","url":null,"abstract":"Chronic myeloid leukaemia (CML) is a common translocation known as BCR-ABL1, also referred to as the Philadelphia chromosome, that affects the primitive hematopoietic stem cell. The GLOBOCAN 2020 report estimates that there will be roughly 19.3 million new cancer diagnoses and 10 million cancer-related deaths in 2020. A fusion oncoprotein called BCR-ABL1, a constitutively active tyrosine kinase that is essential for the development of CML, can be inhibited to slow the course of the illness. The bone marrow and peripheral blood pile up different forms of immature and mature granulocytes or blast cells. In the previous study of CML in India, the annual incidence was reported to be 0.8 to 2.2 per 100,000 population. In leukemia, the most, common type is CML in India. Therefore, chromosomal analysis of CML plays an essential aspect in diagnosing leukemia patients. In the current study, 130 CML cases from the Eastern Indian population ranging in age from 7 to 79 years were cytogenetically analysed (mean of 36). In the study population, the male to female ratio was 1.24:1, with 72 males (55.38%) and 58 women (44.61%) participating. 122 (93.7%) of the 130 cases could be successfully karyotyped, whereas 8 (6.3%) failed culture tests. Out of the 130 cases that were noted, 25 (19.25%) had karyotypes that were normal, while 97 (74.61%) had the Philadelphia (Ph’) chromosome, which has the distinctive translocation t(9;22); Ph’+ve. Furthermore, we conclude that while more advanced molecular techniques cannot entirely replace cytogenetics, which continues to be the focus of laboratory studies into the condition, they can be used in conjunction with it to help diagnose of chronic myeloid leukemia.","PeriodicalId":162406,"journal":{"name":"International Journal of Clinical and Medical Education Research","volume":"128 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132894333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prostate Carcinoma, what would be the best to do ?","authors":"","doi":"10.33140/ijcmer.02.01.04","DOIUrl":"https://doi.org/10.33140/ijcmer.02.01.04","url":null,"abstract":"Diagnosis and treatment of prostate cancer is a controversial topic. An ideal clarity has not been found to date. This concerns screening, risks, genetics as well as therapy. Another issue is the differential diagnosis to prostatitis. The aim should be freedom from schemata and instead strict individualization. to this end, it is important not to set a standard in terms of lowering testosterone to zero. There is a lack of age-related normal ranges for this purpose. If these exist, the real free testosterone can be individually brought into the normal range, which would eliminate an important risk factor.","PeriodicalId":162406,"journal":{"name":"International Journal of Clinical and Medical Education Research","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121744283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SARS-CoV-2 ORF8 gene CAA=TAA and AAA=TAA Termination Codon Mutations found mostly in B.1.1.7 Variants was Independent of Popular L84S Point Mutations","authors":"","doi":"10.33140/ijcmer.01.06.01","DOIUrl":"https://doi.org/10.33140/ijcmer.01.06.01","url":null,"abstract":"Five VOCs of SARS-CoV-2 mainly caused million deaths worldwide and named as B.1.1.7 (U.K.), B.1.351 (South Africa), P.1 (Brazil), B.1.617.2 (India), and B.1.1.529 (Africa). In HIV mediated pathogenesis, small trans activator proteins (TAT, NEF, REV) modulate transcription of cellular genes. Similarly, preliminary reports indicated that corona virus ORF8 protein acts as histone mimics disrupting chromatic structure with many epigenetic changes and immune modulator functions. ORF8 protein had also some similarities to immunoglobulin domains and inhibited HMC-1 and IFN-beta functions. During evolution a 382-nucleotide deletion (∆382) in the ORF8 region of the corona virus genome leads to weak virus load and weak pathogenicity (accession no.MT374101). We BLAST searched deletion boundary and was selected few ORF8 protein truncated mutants. The C>T base change at 27972nt and another A>T base change at 28095nt created two termination codons (CAA=TAA and AAA=TAA) to produce 26AA and 67AA long ORF8 truncated proteins. Similar Blast-N search with oligonucleotides selected at the mutation boundaries gave many ORF8 mutants with distinct S24L, V32L, P38S, R52I, A65V, Y73C, L84S, K92E and V100L mutations with or without TAA termination mutations. Major mutations found in B.1.1.7 lineage which had spike 69HV and 145Y mutations and ORF1ab polyprotein 3675KSF deletion. However, one ORF8 mutant (accession no. OW221449) belongs to Omicron BA.2 variant with 24LPP spike deletion and others to Omicron BA.5 variants (accession nos. OP733645 and OP671680) with 24LPP and 69HV deletion in the spike protein. One termination codon mutant (accession no. OP711842) has also 63nt ORF7a/b deletions. Mutation did not change the hairpin structure in the ORF8 gene and ORF8 protein formed dimeric stable globular 3-D structure to interact with many host proteins. Clearly, generation of such abundant B.1.1.7 lineage ORF8 protein truncated mutants may be one of the causes for the extinction of Alpha variant of corona virus in 2021. Roles of ORF8 mutants as host proteins modulator were explained in light of other deletions and mutations in corona virus genome.","PeriodicalId":162406,"journal":{"name":"International Journal of Clinical and Medical Education Research","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126595897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"KNOWLEDGE AND UPTAKE OF TETANUS TOXOID VACCINE AND ASSOCIATED FACTORS AMONG REPRODUCTIVE AGE GROUP WOMEN IN HAYK TOWN SOUTH WOLLO, ETHIOPIA, CROSS-SECTIONAL STUDY","authors":"T. Alemayehu, S. Yimer, K. Getahun","doi":"10.1101/2022.12.20.22283731","DOIUrl":"https://doi.org/10.1101/2022.12.20.22283731","url":null,"abstract":"Background Tetanus is an acute, often fatal, disease caused by an exotoxin and highly potent neurotoxin, tetanospasm, Tetanus is a preventable disease by tetanus toxoid immunization, which is usually given to the reproductive women at the age between (15- 44) years in order to protect both mother and newborn in order to prevent maternal and neonatal tetanus For lifelong protection from tetanus a woman needs a total of five tetanus toxoid doses Objective: To assess the level of knowledge uptake and associated factors of completing tetanus toxoid vaccine among reproductive age women in Hayk town, SouthWollo, Amhara, Ethiopia in 2020. Methods and materials: A community based cross-sectional study conducted in Hayk town, South Wollo Amhara, Ethiopia, from November to December on 2020. Data collected using structured and pretested questionnaire, entered in to Epi Data version 3.1 and exported to statistical package for social science version 25.0 for analysis. Result: Magnitude of uptake of TT2 immunization at Hayk town was 71.2%, have taken at least two doses of TT. But only 35(8.5%) had completed 5 doses of TT according to EPI schedule. Nearly half of 182(44%) of women in the reproductive age group had knowledge on complete TT5 immunization. Educational status, having sort of info on TT5 and knowledge about TT are significantly associated factors for full dose of TT according to EPI schedule. Conclusion: Fair proportions of women had uptake of TT2, but very low proportion for complete dose of TT5 according to expanded program on Immunization. Most of study participants have inadequate knowledge on TT vaccine. Educational status, having sort of info on TT5 and knowledge about TT are significantly associated factors for completing full dose of TT according to EPI schedule.","PeriodicalId":162406,"journal":{"name":"International Journal of Clinical and Medical Education Research","volume":"150 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121293983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}