International Journal of Clinical and Medical Education Research最新文献

Application of ECMO in a Patient with Post-Cardiotomy Cardiogenic Shock Combined with Dextrocardia: Case Report ECMO在心脏切开术后心源性休克合并右位性心动过缓中的应用1例

International Journal of Clinical and Medical Education Research Pub Date : 2023-06-30 DOI: 10.33140/ijcmer.02.06.06

引用次数: 0

Primary Extranodal Non-Hodgkin Lymphoma of Cheek 原发性结外非霍奇金面颊淋巴瘤

International Journal of Clinical and Medical Education Research Pub Date : 2023-06-23 DOI: 10.33140/ijcmer.02.06.04

引用次数: 0

The Effect of MSCs with/without Silymarin Against Liver Fibrosis in HepG2 Cell Line with Focused on Caspase3, NFKβ, Apoptosis, Proliferation, Necrosis, and Collagen 含水飞蓟素/不含水飞蓟素的MSCs对HepG2细胞株肝纤维化的影响——以Caspase3、NFKβ、凋亡、增殖、坏死和胶原蛋白为重点

International Journal of Clinical and Medical Education Research Pub Date : 2023-06-23 DOI: 10.33140/ijcmer.02.06.03

Paulus Kusnanto, B. Purwanto, B. Wasita, V. Widyaningsih

{"title":"The Effect of MSCs with/without Silymarin Against Liver Fibrosis in HepG2 Cell Line with Focused on Caspase3, NFKβ, Apoptosis, Proliferation, Necrosis, and Collagen","authors":"Paulus Kusnanto, B. Purwanto, B. Wasita, V. Widyaningsih","doi":"10.33140/ijcmer.02.06.03","DOIUrl":"https://doi.org/10.33140/ijcmer.02.06.03","url":null,"abstract":"Background: Liver fibrosis is characterized by irreversible damage to the liver parenchyma. The mechanism of fibrosis is based on the activation of collagen, nuclear factor kappa (NF-kβ) activation, and inhibition of ne-crosis, apoptosis, caspase-3 and proliferation. The HepG2 cell line is an evolved human liver cancer cell that exhibits a human hormone response. Hepatocyte stem cells have antifibrotic, anti-inflammatory, and im-munomodulatory properties, can suppress apoptosis and necrosis, and promote proliferation. Methods: This is an experimental in vitro study using pre-test and post-test. Hepatocyte stem cells were obtained from the neonatal umbilical cord. The cell lines were divided into four groups. Analysis was performed on below variable including caspase-3, NF-kβ, necrosis, apoptosis, proliferation and cytopathological capacity. Results: Cytopathological studies of the hepG2 cell line showed fibroblast growth. Mesenchymal stem cells reduced NF-kβ activity, but not caspase 3 activity. Mesenchymal stem cells also significantly reduced apoptosis and necrotic activity, but silymarin was not significantly affected. Mesenchymal stem cells also significantly increased proliferation (p <0.001), but silymarin was not significantly affected. Conclusion: Mesenchymal stem cells significantly inhibited NF-kβ, necrosis, apoptosis, and proliferation ac-tivation, but caspase-3 inhibition was not significantly affected.","PeriodicalId":162406,"journal":{"name":"International Journal of Clinical and Medical Education Research","volume":"61 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114250542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating Errors and Improving Performance of ChatGPT 错误评估与改进ChatGPT的性能

International Journal of Clinical and Medical Education Research Pub Date : 2023-06-22 DOI: 10.33140/ijcmer.02.06.05

引用次数: 0

Gender Influence on Changes of Coagulation Factors in Fresh Frozen Plasma at Kisii Teaching and Referral Hospital 基思教学转诊医院新鲜冷冻血浆凝血因子变化的性别影响

International Journal of Clinical and Medical Education Research Pub Date : 2023-06-15 DOI: 10.33140/ijcmer.02.06..01

C. O. Ogolla, Rodgers N Demba

{"title":"Gender Influence on Changes of Coagulation Factors in Fresh Frozen Plasma at Kisii Teaching and Referral Hospital","authors":"C. O. Ogolla, Rodgers N Demba","doi":"10.33140/ijcmer.02.06..01","DOIUrl":"https://doi.org/10.33140/ijcmer.02.06..01","url":null,"abstract":"Background: Fresh frozen plasma is a critical substitute therapy in management of bleeding. Increased risk of venous thrombosis has been described to be associated with high plasma levels of several coagulation factors. Objective: The objective was to evaluate gender influence on changes of coagulation factors in fresh frozen plasma at Kisii Teaching and Referral Hospital. Methodology: This study was a longitudinal study involving time series analysis of fresh frozen plasma stored at -18°C for five weeks. A sample of 180 ml plasma was obtained from the blood centrifuged at 4000rpm which was aliquoted into three parts each containing 60ml. The first aliquot was used to assess the changes in coagulation factors in FFP at baseline during the first week of sample collection, the second aliquot was used to assess the changes in coagulation factors in FFP storage at -18°C temp after three weeks of storage, the third aliquot was used to assess the changes in coagulation factors in FFP storage at -18°C temp after five weeks of storage. Coagulation factor analysis was performed using Erba Mannheim ECL 105 coagulation analyzer, India factor results recorded. Thawing for subsequent coagulation factor analysis and serial testing of stored cryoprecipitate and fresh frozen plasma was done using Stericox Plasma Thawing Bath at 37°C, for 45 mins before before analyzing the samples. Standard storage conditions for the aliquots were monitored and maintained to ensure homogeneity. Results: The findings showed no significant association between gender and FFP with p-values for three sampled weeks of the study with [0.333, 0.345 and 0.940] respectively greater than 0.05 standard alpha values. This means that, the coagulation factors in FFP were not affected by the gender of the blood donor. Conclusion: There was no influence of gender on coagulation factors in fresh frozen plasma during storage at -18°C for 5 weeks at Kisii Teaching and Referral Hospital, Kisii County","PeriodicalId":162406,"journal":{"name":"International Journal of Clinical and Medical Education Research","volume":"48 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133650788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effectiveness of the Comprehensive Community-Based Intervention on Maternal and Child Health in Bangladesh 孟加拉国以社区为基础的妇幼保健综合干预措施的有效性

International Journal of Clinical and Medical Education Research Pub Date : 2023-06-15 DOI: 10.33140/ijcmer.02.06.02

Ziaul Matin, Minjoon Kim, F. Bari, A. Sayem, S. Sharmin, A. Abdullah, Md. Abdul Halim, A. Rahman

{"title":"Effectiveness of the Comprehensive Community-Based Intervention on Maternal and Child Health in Bangladesh","authors":"Ziaul Matin, Minjoon Kim, F. Bari, A. Sayem, S. Sharmin, A. Abdullah, Md. Abdul Halim, A. Rahman","doi":"10.33140/ijcmer.02.06.02","DOIUrl":"https://doi.org/10.33140/ijcmer.02.06.02","url":null,"abstract":"The current study looked at the influence of a community intervention on maternal and child health in five Bangladeshi districts. To determine the impact on the intervention, data was acquired through a baseline and end-of-project review. A quasi-experimental design was used in this investigation, which included a baseline and end line survey with the same variables. The research was carried out in two geo demographic groups of districts including plain land districts with easy access to services, such as Tangail and Khulna, and hard to reach locations, such as Netrakona, Cox's Bazar, and Bandarban. Program impact on uptake of maternal and child health services, as defined by the health services/behaviors for the index pregnancy, was analyzed using difference-in-difference analysis. All programs that provided information and counseling to women and their families, often in conjunction with other program measures, increased the number of women who received ANC from a medically certified person during their pregnancy significantly. The community-based programs also resulted in a significant increase in the use of neonatal and child health services. The findings of this study serve as a foundation for maternal and newborn health policies as well as intervention evaluation in both easily accessible and difficult-to-access places.","PeriodicalId":162406,"journal":{"name":"International Journal of Clinical and Medical Education Research","volume":"121 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121537457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unmasking the Truth: Progressive Multifocal Leukoencephalopathy–Immune Reconstitution Inflammatory Syndrome (PML-IRIS) in a 36-year Old Male with HIV, A Case Report 揭露真相:一名36岁男性HIV感染者的进行性多灶性白质脑病-免疫重建炎症综合征(PML-IRIS)一例报告

International Journal of Clinical and Medical Education Research Pub Date : 2023-05-29 DOI: 10.33140/ijcmer.02.05.04

Jon Stewart, H. Dy1, S. SamanthaAnne, M. Gutierrez1Ryan, Llorin2 Mercedes, D. Leon, Dizon3 Eric, Gerard Maglaya3 Hans, F. Ludwig, Damian1, Jon Stewart Dy, Gutier - rez

{"title":"Unmasking the Truth: Progressive Multifocal Leukoencephalopathy–Immune Reconstitution Inflammatory Syndrome (PML-IRIS) in a 36-year Old Male with HIV, A Case Report","authors":"Jon Stewart, H. Dy1, S. SamanthaAnne, M. Gutierrez1Ryan, Llorin2 Mercedes, D. Leon, Dizon3 Eric, Gerard Maglaya3 Hans, F. Ludwig, Damian1, Jon Stewart Dy, Gutier - rez","doi":"10.33140/ijcmer.02.05.04","DOIUrl":"https://doi.org/10.33140/ijcmer.02.05.04","url":null,"abstract":"Progressive Multifocal Leukoencephalopathy Immune Reconstitution Inflammatory Syndrome (PMLIRIS) is the subacute onset of neurological deficits that appeared or was exacerbated after initiation antiretroviral therapy (ART) for treatment of PML. It is due to severe neuroinflammation with reestablishment of immunocompetence. Approximately 25% of patients with HIV and PML develop IRIS. Clinical trials on the treatment of PML-IRIS is lacking with only limited evidence supporting the use of investigative therapies such as corticosteroids and Maraviroc. We report a case of a 36-year old Filipino male, known hypertensive and diagnosed with HIV, who presented with memory problems. He was eventually treated as a case of PML-IRIS on the 3rd week after initiation of ART. He was treated with a course of intravenous Dexamethasone, oral Mefloquine and intravenous immunoglobulin, and ART was continued. Clinical outcome in our patient shows an overall improvement of symptoms and no deterioration of neurologic deficits.","PeriodicalId":162406,"journal":{"name":"International Journal of Clinical and Medical Education Research","volume":"76 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115556685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oxygenation Needs of the Bronchopneumonia Patient in the Pediatric Room at Parepare Hospital, Parepare City, Indonesia 印度尼西亚帕帕雷市帕帕雷医院儿科病房支气管肺炎患者的氧合需求

International Journal of Clinical and Medical Education Research Pub Date : 2023-05-27 DOI: 10.33140/ijcmer.02.05.03

引用次数: 0

The Role of Diffusible Signal Factors in Quorum Sensing for Improved Biocontrol Techniques 扩散性信号因子在群体感应中对改进生物防治技术的作用

International Journal of Clinical and Medical Education Research Pub Date : 2023-05-10 DOI: 10.33140/ijcmer.02.05.02

A. Yetgi̇n

{"title":"The Role of Diffusible Signal Factors in Quorum Sensing for Improved Biocontrol Techniques","authors":"A. Yetgi̇n","doi":"10.33140/ijcmer.02.05.02","DOIUrl":"https://doi.org/10.33140/ijcmer.02.05.02","url":null,"abstract":"Quorum sensing (QS) is a mechanism by which bacteria communicate with each other to coordinate group behavior. One important aspect of QS is the production and detection of diffusible signal factors (DSFs), which are small molecules that can diffuse across bacterial membranes and trigger various responses. DSFs have been shown to play a crucial role in regulating a wide range of biological processes, including biofilm formation, virulence, and antibiotic resistance. In recent years, researchers have started to explore the potential of DSFs in biocontrol applications, where they can be used to interfere with the communication and coordination of pathogenic bacteria. This review discusses the role of DSFs in QS and how they can be utilized to develop improved biocontrol techniques. We also discuss the various strategies that have been developed to interfere with DSF-mediated QS, such as using DSF analogs or enzymes that degrade DSFs. We highlight some of the promising applications of DSFs in biocontrol, including their use as biocontrol agents as part of plant microbiomes. We argue that DSFs represent a promising avenue for developing novel and effective biocontrol strategies that can help address some of the most pressing challenges in agriculture and healthcare.","PeriodicalId":162406,"journal":{"name":"International Journal of Clinical and Medical Education Research","volume":"50 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124257832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Networks of Risks Perceptions in the Literature from 2020 to 2023 2020 - 2023年文献中的风险感知网络

International Journal of Clinical and Medical Education Research Pub Date : 2023-05-10 DOI: 10.33140/ijcmer.02.05.01

引用次数: 0