Study on Hyperlipidemia Mechanism of Lotus Leaves by Network Pharmacology and Molecular Docking

Abstract

The main active chemical components and targets of lotus leaves were obtained though the TCMSP database and screened by ADME; The main targets of hyperlipidemia were obtained by Genecards, OMIM, TTD and DRUGBANK databases; Protein interactions were analyzed through the STRING database; Finding potential protein functions by constructing a PPI network; Metascape software was used to analyze “drug-component-target” and the biological processes and pathways involved. Build a“lotus leaves component-hyperlipemia target” network though Cytoscape3.7.1 software. Molecular docking verification was performed by Autodocktools software. The preliminary study shows that lotus leaves regulation of hyperlipidemia have a multicomponent, multi-target and multi-pathway mechanism, which provides data basis for traditional Chinese medicine to regulate hyperlipidemia.