荷叶高脂血症机制的网络药理学与分子对接研究

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引用次数: 0

摘要

通过TCMSP数据库获得荷叶的主要活性化学成分和靶点,并通过ADME进行筛选;通过Genecards、OMIM、TTD和DRUGBANK数据库获得高脂血症的主要靶点;通过STRING数据库分析蛋白质相互作用;构建PPI网络寻找潜在的蛋白质功能;使用metscape软件分析“药物-组分-靶点”及其涉及的生物学过程和途径。通过Cytoscape3.7.1软件构建“荷叶成分-高脂血症靶点”网络。通过Autodocktools软件进行分子对接验证。初步研究表明,荷叶对高脂血症的调节具有多组分、多靶点、多通路的机制,为中药调节高脂血症提供了数据依据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Study on Hyperlipidemia Mechanism of Lotus Leaves by Network Pharmacology and Molecular Docking
The main active chemical components and targets of lotus leaves were obtained though the TCMSP database and screened by ADME; The main targets of hyperlipidemia were obtained by Genecards, OMIM, TTD and DRUGBANK databases; Protein interactions were analyzed through the STRING database; Finding potential protein functions by constructing a PPI network; Metascape software was used to analyze “drug-component-target” and the biological processes and pathways involved. Build a“lotus leaves component-hyperlipemia target” network though Cytoscape3.7.1 software. Molecular docking verification was performed by Autodocktools software. The preliminary study shows that lotus leaves regulation of hyperlipidemia have a multicomponent, multi-target and multi-pathway mechanism, which provides data basis for traditional Chinese medicine to regulate hyperlipidemia.
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