Journal of Magnetic Resonance Imaging最新文献

{"title":"Editorial for \"Quantitative Analysis of Small Intestinal Motility in 3D Cine-MRI Using Centerline-Aware Motion Estimation.","authors":"Aysegul Sagir Kahraman, Bayram Kahraman","doi":"10.1002/jmri.29596","DOIUrl":"https://doi.org/10.1002/jmri.29596","url":null,"abstract":"","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142120049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial for \"Spontaneous Brain Activity Abnormalities in Patients With Temporal Lobe Epilepsy: A Meta-Analysis of 1474 Patients\".","authors":"Elza Azri Othman","doi":"10.1002/jmri.29570","DOIUrl":"https://doi.org/10.1002/jmri.29570","url":null,"abstract":"","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142108062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spontaneous Brain Activity Abnormalities in Patients With Temporal Lobe Epilepsy: A Meta-Analysis of 1474 Patients.","authors":"Shu Xiao, Zibin Yang, Zitao Lin, Liqing Chen, Weiming Liao, Jurong Wang, Cuihua Gao, Jianjun Lu, Yang Song, Sulian Su, Guihua Jiang","doi":"10.1002/jmri.29568","DOIUrl":"https://doi.org/10.1002/jmri.29568","url":null,"abstract":"<p><strong>Background: </strong>Abnormalities in resting-state functional brain activity have been detected in patients with temporal lobe epilepsy (TLE). The results of individual neuroimaging studies of TLE, however, are frequently inconsistent due to small and heterogeneous samples, analytical flexibility, and publication bias toward positive findings.</p><p><strong>Purpose: </strong>To investigate the most consistent regions of resting-state functional brain activity abnormality in patients with TLE through a quantitative meta-analysis of published neuroimaging data.</p><p><strong>Study type: </strong>Meta-analysis.</p><p><strong>Subjects: </strong>Exactly 1474 TLE patients (716 males and 758 females) from 31 studies on resting-state functional brain activity were included in this study.</p><p><strong>Field strength/sequence: </strong>Studies utilizing 1.5 T or 3 T MR scanners were included for meta-analysis. Resting-state functional MRI using gradient echo-planar imaging, T1-weighted imaging.</p><p><strong>Assessment: </strong>PubMed, Web of Science, Chinese National Knowledge Infrastructure, and WanFang databases were searched to identify studies investigating amplitude of low-frequency fluctuation (ALFF), fractional ALFF (fALFF), and regional homogeneity (ReHo) at the whole-brain level between patients with TLE and healthy controls (HCs).</p><p><strong>Statistical tests: </strong>Seed-based d Mapping with Permutation of Subject Images, standard randomization tests and meta-regression analysis were used. Results were significant if P < 0.05 with family-wise error corrected.</p><p><strong>Results: </strong>Patients with TLE displayed resting-state functional brain activity which was a significant increase in the right hippocampus, and significant decrease in the right angular gurus and right precuneus. Additionally, the meta-regression analysis demonstrated that age (P = 0.231), sex distribution (P = 0.376), and illness duration (P = 0.184), did not show significant associations with resting state functional brain activity in patients with TLE.</p><p><strong>Data conclusion: </strong>Common alteration patterns of spontaneous brain activity were identified in the right hippocampus and default-model network regions in patients with TLE. These findings may contribute to understanding of the underlying mechanism for potentially effective intervention of TLE.</p><p><strong>Level of evidence: 1: </strong></p><p><strong>Technical efficacy stage: </strong>Stage 2.</p>","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142108077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Letter to Editor Regarding \"Influence of Morphological Changes on Dural Venous Sinuses Hemodynamics\".","authors":"Chihang Dai, Zhenchang Wang, Pengfei Zhao","doi":"10.1002/jmri.29591","DOIUrl":"https://doi.org/10.1002/jmri.29591","url":null,"abstract":"","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142108075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of Morphological Changes on Dural Venous Sinuses Hemodynamics.","authors":"Juan J Cardona, Aaron S Dumont, Joe Iwanaga, R Shane Tubbs","doi":"10.1002/jmri.29590","DOIUrl":"https://doi.org/10.1002/jmri.29590","url":null,"abstract":"","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142108063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial for \"Assessment of Tumor Cell Invasion and Radiotherapy Response in Experimental Glioma by Magnetic Resonance Elastography\".","authors":"James R Ewing","doi":"10.1002/jmri.29577","DOIUrl":"https://doi.org/10.1002/jmri.29577","url":null,"abstract":"","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142108061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reliability of In Vivo Creatine-Weighted Chemical Exchange Saturation Transfer (CrCEST) MRI in Calf Skeletal Muscle of Healthy Volunteers at 3 T.","authors":"Kasturee Chakraborty, Ritambhar Burman, Sabah Nisar, Saorla Miller, Zachary Loschinskey, Shengjie Wu, Yimei Li, Asim K Bag, Ayaz Khan, Chelsea Goodenough, Neil Wilson, Mohammad Haris, Shana E McCormack, Ravinder Reddy, Kirsten Ness, Richard Finkel, Puneet Bagga","doi":"10.1002/jmri.29566","DOIUrl":"10.1002/jmri.29566","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Skeletal muscle mitochondrial oxidative phosphorylation (mtOXPHOS) is important for ATP generation and its dysfunction leads to exercise intolerance. Phosphorus magnetic resonance spectroscopy (&lt;sup&gt;31&lt;/sup&gt;P-MRS) is a useful, noninvasive technique for mtOXPHOS assessment but has limitations. Creatine-weighted chemical exchange saturation transfer (CrCEST) MRI is a potential alternative to assess muscle bioenergetics.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Purpose: &lt;/strong&gt;To evaluate the interscan repeatability, intra- and interobserver reproducibility of CrCEST during mild plantar flexion exercise.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Study type: &lt;/strong&gt;Retrospective.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Subjects: &lt;/strong&gt;Twenty healthy volunteers (age 37.6 ± 12.4 years, 11 females).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Field strength/sequence: &lt;/strong&gt;3 T/CEST imaging using gradient echo readout.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Assessment: &lt;/strong&gt;τCrCEST (postexercise Cr recovery time) was assessed in two scans for each participant, following mild plantar flexion exercises targeting the medial gastrocnemius (MG), lateral gastrocnemius (LG), and soleus (Sol) muscles. Three observers measured τCrCEST for interobserver reproducibility. Three readings by one observer were used to measure intraobserver reproducibility. Two scans were used for within-participant interscan repeatability.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Statistical tests: &lt;/strong&gt;Paired t tests, intraclass correlation coefficient (ICC), and Pearson correlation were conducted. Bland-Altman plots were used to analyze the interobserver variability. A P-value of 0.05 was considered statistically significant.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;There was excellent intra- (ICC &lt;math&gt; &lt;semantics&gt;&lt;mrow&gt;&lt;mo&gt;∈&lt;/mo&gt; &lt;mfenced&gt;&lt;mrow&gt;&lt;mn&gt;0.94&lt;/mn&gt; &lt;mo&gt;-&lt;/mo&gt; &lt;mn&gt;0.98&lt;/mn&gt;&lt;/mrow&gt; &lt;/mfenced&gt; &lt;/mrow&gt; &lt;annotation&gt;$$ in left[0.94-0.98right] $$&lt;/annotation&gt;&lt;/semantics&gt; &lt;/math&gt; ) and interobserver (ICC &lt;math&gt; &lt;semantics&gt;&lt;mrow&gt;&lt;mo&gt;∈&lt;/mo&gt; &lt;mfenced&gt;&lt;mrow&gt;&lt;mn&gt;0.9&lt;/mn&gt; &lt;mo&gt;-&lt;/mo&gt; &lt;mn&gt;0.98&lt;/mn&gt;&lt;/mrow&gt; &lt;/mfenced&gt; &lt;/mrow&gt; &lt;annotation&gt;$$ in left[0.9-0.98right] $$&lt;/annotation&gt;&lt;/semantics&gt; &lt;/math&gt; ) reproducibility, with moderate interscan repeatability for τCrCEST in LG and MG (ICC &lt;math&gt; &lt;semantics&gt;&lt;mrow&gt;&lt;mo&gt;∈&lt;/mo&gt; &lt;mfenced&gt;&lt;mrow&gt;&lt;mn&gt;0.54&lt;/mn&gt; &lt;mo&gt;-&lt;/mo&gt; &lt;mn&gt;0.74&lt;/mn&gt;&lt;/mrow&gt; &lt;/mfenced&gt; &lt;/mrow&gt; &lt;annotation&gt;$$ in left[0.54-0.74right] $$&lt;/annotation&gt;&lt;/semantics&gt; &lt;/math&gt; ) and poor-to-moderate interscan repeatability in Sol (ICC &lt;math&gt; &lt;semantics&gt;&lt;mrow&gt;&lt;mo&gt;∈&lt;/mo&gt; &lt;mfenced&gt;&lt;mrow&gt;&lt;mn&gt;0.24&lt;/mn&gt; &lt;mo&gt;-&lt;/mo&gt; &lt;mn&gt;0.53&lt;/mn&gt;&lt;/mrow&gt; &lt;/mfenced&gt; &lt;/mrow&gt; &lt;annotation&gt;$$ in left[0.24-0.53right] $$&lt;/annotation&gt;&lt;/semantics&gt; &lt;/math&gt; ). Excellent interobserver reproducibility was confirmed by Bland-Altman plots (fixed bias P-value &lt;math&gt; &lt;semantics&gt;&lt;mrow&gt;&lt;mo&gt;∈&lt;/mo&gt; &lt;mfenced&gt;&lt;mrow&gt;&lt;mn&gt;0.08&lt;/mn&gt; &lt;mo&gt;-&lt;/mo&gt; &lt;mn&gt;0.87&lt;/mn&gt;&lt;/mrow&gt; &lt;/mfenced&gt; &lt;/mrow&gt; &lt;annotation&gt;$$ in left[0.08-0.87right] $$&lt;/annotation&gt;&lt;/semantics&gt; &lt;/math&gt; ).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Data conclusion: &lt;/strong&gt;CrCEST MRI shows promise in assessing muscle bioenergetics by evaluati","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142108074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Z-Spectral MRI Quantifies the Mass and Metabolic Activity of Adipose Tissues With Fat-Water-Fraction and Amide-Proton-Transfer Contrasts.","authors":"Zimeng Cai, Qiaoling Zhong, Daming Zhang, Yanqiu Feng, Qian Wang, Yuanbo Yang, Yongzhou Xu, Changhong Liang, Zaiyi Liu, Kejia Cai","doi":"10.1002/jmri.29598","DOIUrl":"10.1002/jmri.29598","url":null,"abstract":"<p><strong>Background: </strong>Brown adipose tissue (BAT) is metabolically activatable and plays an important role in obesity and metabolic diseases. With reduced fat-water-fraction (FWF) compared with white adipose tissue (WAT), BAT mass and its functional activation may be quantified with Z-spectra MRI, with built-in FWF and the metabolic amide proton transfer (APT) contrasts.</p><p><strong>Purpose: </strong>To investigate if Z-spectral MRI can quantify the mass and metabolic activity of adipose tissues.</p><p><strong>Study type: </strong>Prospective.</p><p><strong>Subjects: </strong>Seven groups of 8-week-old male rats, including two groups (n = 7 per group) for in vivo MRI study and five groups (n = 5 per group) for ex vivo validation; 12 young and healthy volunteers with 6 male and 6 female.</p><p><strong>Field strength/sequence: </strong>The 7 T small animal and 3 T clinical systems, T₂-weighted imaging, Rapid Acquisition with Relaxation Enhancement (RARE) readout based chemical exchange saturation transfer (CEST) Z-spectral MRI sequence.</p><p><strong>Assessment: </strong>Quantified FWF and APT from Z-spectra in rats before and after norepinephrine (NE) stimulation and in healthy human subjects; ex vivo measurements of total proteins in BAT from rats.</p><p><strong>Statistical tests: </strong>Two-tailed unpaired Student's t-tests and repeated measures ANOVA. P-value <0.05 was considered significant.</p><p><strong>Results: </strong>Decreased FWF (from 39.6% ± 7.2% before NE injection to 16.4% ± 7.2% 120 minutes after NE injection, P < 0.0001) and elevated APT (from 1.1% ± 0.5% before NE injection to 2.9% ± 0.5% 120 minutes after NE injection, P < 0.0001) signals in BAT were observed with in vivo Z-spectral MRI in rats injected with NE at 7 T MRI. At clinical 3 T, Z-spectral MRI was used to quantify the FWF (58.5% ± 7.2% in BAT and 73.7% ± 6.5% in WAT with P < 0.0001) and APT (2.6% ± 0.8% in BAT and 0.9% ± 0.3% in WAT with P < 0.0001) signals in healthy volunteers. APT signals of BAT were negatively correlated with the BMI in humans (r = 0.71).</p><p><strong>Data conclusion: </strong>Endogenous Z-spectral MRI was demonstrated to simultaneously quantify BAT mass and function based on its FWF and APT contrasts.</p><p><strong>Level of evidence: 2: </strong></p><p><strong>Technical efficacy stage: </strong>1.</p>","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142108078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simultaneous Increase of Mean Susceptibility and Mean Kurtosis in the Substantia Nigra as an MRI Neuroimaging Biomarker for Early-Stage Parkinson's Disease: A Systematic Review and Meta-Analysis.","authors":"Sana Mohammadi, Sadegh Ghaderi, Hossein Mohammadi, Farzad Fatehi","doi":"10.1002/jmri.29569","DOIUrl":"https://doi.org/10.1002/jmri.29569","url":null,"abstract":"<p><strong>Background: </strong>Parkinson's disease (PD) is the second most common neurodegenerative disorder. Early detection is crucial for treatment and slowing disease progression.</p><p><strong>Hypothesis: </strong>Simultaneous alterations in mean susceptibility (MS) from quantitative susceptibility mapping (QSM) and mean kurtosis (MK) from diffusion kurtosis imaging (DKI) can serve as reliable neuroimaging biomarkers for early-stage PD (ESPD) in the basal ganglia nuclei, including the substantia nigra (SN), putamen (PUT), globus pallidus (GP), and caudate nucleus (CN).</p><p><strong>Study type: </strong>Systematic review and meta-analysis.</p><p><strong>Population: </strong>One hundred eleven patients diagnosed with ESPD and 81 healthy controls (HCs) were included from four studies that utilized both QSM and DKI in both subject groups.</p><p><strong>Field strength/sequence: </strong>Three-dimensional multi-echo gradient echo sequence for QSM and spin echo planar imaging sequence for DKI at 3 Tesla.</p><p><strong>Assessment: </strong>A systematic review and meta-analysis using PRISMA guidelines searched PubMed, Web of Science, and Scopus.</p><p><strong>Statistical tests: </strong>Random-effects model, standardized mean difference (SMD) to compare MS and MK between ESPD patients and HCs, I² statistic for heterogeneity, Newcastle-Ottawa Scale (NOS) for risk of bias, and Egger's test for publication bias. A P-value <0.05 was considered significant.</p><p><strong>Results: </strong>MS values were significantly higher in SN (SMD 0.72, 95% CI 0.31 to 1.12), PUT (SMD 0.68, 95% CI 0.29 to 1.07), and GP (SMD 0.53, 95% CI 0.19 to 0.87) in ESPD patients compared to HCs. CN did not show a significant difference in MS values (P = 0.15). MK values were significantly higher only in SN (SMD = 0.72, 95% CI 0.16 to 1.27). MK values were not significantly different in PUT (P = 1.00), GP (P = 0.97), and CN (P = 0.59). Studies had high quality (NOS 7-8) and no publication bias (P = 0.967).</p><p><strong>Data conclusion: </strong>Simultaneous use of MS and MK may be useful as an early neuroimaging biomarker for ESPD detection and its differentiation from HCs, with significant differences observed in the SN.</p><p><strong>Evidence level: </strong>2 TECHNICAL EFFICACY: Stage 2.</p>","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142108076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative Analysis of Small Intestinal Motility in 3D Cine-MRI Using Centerline-Aware Motion Estimation.","authors":"Louis D van Harten, Catharina S de Jonge, Femke Struik, Jaap Stoker, Ivana Išgum","doi":"10.1002/jmri.29571","DOIUrl":"https://doi.org/10.1002/jmri.29571","url":null,"abstract":"<p><strong>Background: </strong>Currently available tools for noninvasive motility quantification of the small intestine are limited to dynamic 2D MRI scans, which are limited in their ability to differentiate between types of intestinal motility.</p><p><strong>Purpose: </strong>To develop a method for quantification and characterization of small intestinal motility in 3D, capable of differentiating motile, non-motile and peristaltic motion patterns.</p><p><strong>Study type: </strong>Prospective.</p><p><strong>Subjects: </strong>Fourteen healthy volunteers (127 small intestinal segments) and 10 patients with Crohn's disease (87 small intestinal segments).</p><p><strong>Field strength/sequence: </strong>3.0 T, 3D balanced fast field echo sequence, 1 volume per second.</p><p><strong>Assessment: </strong>Using deformable image registration between subsequent volumes, the local velocity within the intestinal lumen was quantified. Average velocity and average absolute velocity along intestinal segments were used with linear classifiers to differentiate motile from non-motile intestines, as well as erratic motility from peristalsis. The mean absolute velocity of small intestinal content was compared between healthy volunteers and Crohn's disease patients, and the discriminative power of the proposed motility metrics for detecting motility and peristalsis was determined. The consensus of two observers was used as referenced standard.</p><p><strong>Statistical tests: </strong>Student's t-test to assess differences between groups; area under the receiver operating characteristic curve (AUC) to assess discriminative ability. P < 0.001 was considered significant.</p><p><strong>Results: </strong>A significant difference in the absolute velocity of intestinal content between Crohn's patients and healthy volunteers was observed (median [IQR] 1.06 [0.61, 1.56] mm/s vs. 1.84 [1.37, 2.43] mm/s), which was consistent with manual reference annotations of motile activity. The proposed method had a strong discriminative performance for detecting non-motile intestines (AUC 0.97) and discernible peristalsis (AUC 0.81).</p><p><strong>Data conclusion: </strong>Analysis of 3D cine-MRI using centerline-aware motion estimation has the potential to allow noninvasive characterization of small intestinal motility and peristaltic motion in 3D.</p><p><strong>Evidence level: </strong>3 TECHNICAL EFFICACY: Stage 2.</p>","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142108064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}