{"title":"Age-, Body Surface Area-, and Sex-Specific Reference Values for Pericardial Adipose Tissue in Children: An MRI Study.","authors":"Shiganmo Azhe, Wei Bai, Ke Xu, Zhongqin Zhou, Lei Hu, Chuan Fu, Shengkun Peng, Xinrui Deng, Yaoji Zhu, Yifei Li, Yingkun Guo, Lizhi Zhang, Lingyi Wen","doi":"10.1002/jmri.70053","DOIUrl":"https://doi.org/10.1002/jmri.70053","url":null,"abstract":"<p><strong>Background: </strong>Pericardial adipose tissue (PAT) is a cardiovascular disease risk factor in children, but normative data for PAT thickness, area, and volume are lacking.</p><p><strong>Purpose: </strong>To establish the percentile reference values for MRI PAT parameters in healthy Chinese children aged 3-18.</p><p><strong>Study type: </strong>Prospective.</p><p><strong>Subjects: </strong>218 healthy children divided into 3-10 years (n = 125, 62 males) and 10-18 years (n = 93, 53 males).</p><p><strong>Field strength/sequence: </strong>Balanced steady-state free-precession cine sequence at 3.0 T.</p><p><strong>Assessment: </strong>PAT thickness, area and volume.</p><p><strong>Statistical tests: </strong>Student's t-test, Mann-Whitney U test, Pearson correlation, the generalized additive model for location scale and shape, and intraclass correlation coefficients (ICC). A p value < 0.05 was considered statistically significant.</p><p><strong>Results: </strong>PAT volume showed no significant sex difference in the overall (boys: 32.7 ± 16.2 mL, girls: 28.2 ± 10.0 mL, p = 0.179) or childhood group (boys: 22.9 ± 7.9 vs. girls: 22.9 ± 6.6 mL, p = 0.954), but adolescent boys had a higher volume than girls (44.1 ± 15.9 vs. 36.9 ± 8.4 mL). PAT thickness at the right ventricular free wall (RVFW) was greater in boys across both age groups. PAT volume correlated strongly with age (r = 0.672) and BSA (r = 0.741). Age-specific percentile curves showed a progressive PAT volume increase with no clear plateau, with the most rapid growth between ages 10 and 14. BSA-specific curves revealed gradual PAT parameter increases, with steeper trends in boys. Good to excellent inter- and intra-observer agreement was observed for almost all PAT parameter measurements (95% CI > 0.75).</p><p><strong>Conclusion: </strong>This study proposes sex-, age-, and BSA-specific reference values for pericardial adipose tissue in healthy Chinese children and showed developmental patterns and sex differences that may have potential to inform future clinical and research applications.</p><p><strong>Evidence level: </strong>2.</p><p><strong>Technical efficacy: </strong>Stage 2.</p>","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Assessment of Left Atrial Fibrosis With Cardiac MRI.","authors":"Monique Bernard","doi":"10.1002/jmri.70103","DOIUrl":"https://doi.org/10.1002/jmri.70103","url":null,"abstract":"","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Editorial for \"Saturated Multi-Delay Renal Arterial Spin Labeling Technique at 5 T MR: A Comparative Study With 3 T\".","authors":"L Qin, B Madore","doi":"10.1002/jmri.70107","DOIUrl":"https://doi.org/10.1002/jmri.70107","url":null,"abstract":"","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Editorial for \"Genetic Susceptibility to Cardio-Cerebrovascular Diseases and White Matter Integrity in Asymptomatic Older Adults: A UK Biobank Observational Cohort Study\".","authors":"Song Liu, Shuang Xia","doi":"10.1002/jmri.70100","DOIUrl":"https://doi.org/10.1002/jmri.70100","url":null,"abstract":"","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Editorial for \"Resilience and Brain Changes in Long-Term Ayahuasca Users: Insights From Psychometric and fMRI Pattern Recognition\".","authors":"Niels Bergsland","doi":"10.1002/jmri.70094","DOIUrl":"https://doi.org/10.1002/jmri.70094","url":null,"abstract":"","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Editorial for \"Assessment of Small Vessel Density Changes in Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalophy (CADASIL) by High-Resolution Black-Blood MRI\".","authors":"Satoshi Saito","doi":"10.1002/jmri.70095","DOIUrl":"https://doi.org/10.1002/jmri.70095","url":null,"abstract":"","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Editorial for \"Differentiating Benign Thyroid Nodules and Papillary Thyroid Carcinoma Using Time-Dependent Diffusion MRI: A Feasibility Study\".","authors":"Xiangyu Zhao, Lufan Chang","doi":"10.1002/jmri.70082","DOIUrl":"https://doi.org/10.1002/jmri.70082","url":null,"abstract":"","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yu Veronica Sui, Arjun V Masurkar, Timothy M Shepherd, Yang Feng, Thomas Wisniewski, Henry Rusinek, Mariana Lazar
{"title":"Associations Between Hippocampal Transverse Relaxation Time and Amyloid PET in Cognitively Normal Aging Adults.","authors":"Yu Veronica Sui, Arjun V Masurkar, Timothy M Shepherd, Yang Feng, Thomas Wisniewski, Henry Rusinek, Mariana Lazar","doi":"10.1002/jmri.70097","DOIUrl":"10.1002/jmri.70097","url":null,"abstract":"<p><strong>Background: </strong>Identifying early neuropathological changes in Alzheimer's disease (AD) is important for improving treatment efficacy. Among quantitative MRI measures, transverse relaxation time (T2) has been shown to reflect tissue microstructure relevant in aging and neurodegeneration; however, findings regarding T2 changes in both normal aging and AD have been inconsistent. The association between T2 and amyloid-beta (Aβ) accumulation, a hallmark of AD pathology, is also unclear, particularly in cognitively normal individuals who may be in preclinical stages of the disease.</p><p><strong>Purpose: </strong>To investigate longitudinal hippocampal T2 changes in a cognitively normal cohort of older adults and their association with global Aβ accumulation.</p><p><strong>Study type: </strong>Retrospective, longitudinal.</p><p><strong>Subjects: </strong>56 cognitively normal adults between 55 and 90 years of age (17 males and 39 females).</p><p><strong>Field strength/sequence: </strong>3 Tesla; multi-echo spin echo sequence for T2 mapping; 18F-florbetaben positron emission tomography for Aβ measurement.</p><p><strong>Assessment: </strong>Bilateral hippocampal T2 and volume were extracted to relate to Aβ PET measurements. To understand variations in AD risk, participants were separated into Aβ-high and Aβ-low subgroups using a predetermined threshold.</p><p><strong>Statistical tests: </strong>Linear mixed-effect models and general linear models were used. A p-value < 0.025 was considered significant to account for bilateral comparisons.</p><p><strong>Results: </strong>Older age was associated with increased T2 in the bilateral hippocampus (left: β = 0.30, right: β = 0.25) and smaller hippocampal volume on the left (β = -0.12). In the Aβ-low subgroup, both longitudinal T2 increase rates (β = 0.65) in the left hippocampus and bilateral cross-sectional T2 (left: β = 0.64, right: β = 0.46) were positively correlated with Aβ PET, independent of hippocampal volume.</p><p><strong>Data conclusion: </strong>This study provided in vivo evidence linking hippocampal T2 to Aβ accumulation in cognitively normal aging individuals, suggesting that quantitative T2 may be sensitive to microstructural changes accompanying early Aβ pathology, such as neuroinflammation, demyelination, and reduced tissue integrity.</p><p><strong>Evidence level: </strong>3.</p><p><strong>Technical efficacy: </strong>Stage 2.</p>","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12426994/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Editorial for \"Time-Dependent Diffusion MRI-Based Microstructural Mapping for Characterizing HER2-Zero, -Low, -Ultralow and -Positive Breast Cancers\".","authors":"Simone Schiaffino, Andrea Leoncini","doi":"10.1002/jmri.70078","DOIUrl":"https://doi.org/10.1002/jmri.70078","url":null,"abstract":"","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Response to Letter to the Editor Regarding: \"Potential Time and Recall Benefits for Adaptive AI-Based Breast Cancer MRI Screening\".","authors":"Luuk Balkenende, Ritse M Mann","doi":"10.1002/jmri.70098","DOIUrl":"https://doi.org/10.1002/jmri.70098","url":null,"abstract":"","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}