Journal of Magnetic Resonance Imaging最新文献

{"title":"Editorial for “Multiparametric MRI‐Based Deep Learning Radiomics Model for Assessing 5‐Year Recurrence Risk in Non‐Muscle Invasive Bladder Cancer”","authors":"Iman Yazdani Nia, Bharath Ambale‐Venkatesh","doi":"10.1002/jmri.29592","DOIUrl":"https://doi.org/10.1002/jmri.29592","url":null,"abstract":"","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":"32 1","pages":""},"PeriodicalIF":4.4,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142185832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Same‐Day Repeatability and 28‐Day Reproducibility of Xenon MRI Ventilation in Children With Cystic Fibrosis in a Multi‐Site Trial","authors":"Laura L. Walkup, David J. Roach, Joseph W. Plummer, Matthew M. Willmering, Brandon Zanette, Giles Santyr, Sean B. Fain, Michael J. Rock, Jaime Mata, Deborah Froh, Sanja Stanojevic, Zackary I. Cleveland, Felix Ratjen, Jason C. Woods","doi":"10.1002/jmri.29605","DOIUrl":"https://doi.org/10.1002/jmri.29605","url":null,"abstract":"BackgroundMRI with xenon‐129 gas (Xe MRI) can assess airflow obstruction and heterogeneity in lung diseases. Specifically, Xe MRI may represent a sensitive modality for future therapeutic trials of cystic fibrosis (CF) therapies. The reproducibility of Xe MRI has not yet been assessed in the context of a multi‐site study.PurposeTo determine the same‐day repeatability and 28‐day reproducibility of Xe MRI in children with CF.Study TypeFour‐center prospective, longitudinal.PopulationThirty‐eight children (18 females, 47%), median interquartile range (IQR) age 12 (9–14) years old, with mild CF (forced expiratory volume in 1 second (FEV<jats:sub>1</jats:sub>) ≥85% predicted).Field Strength/Sequence3‐T, two‐dimensional (2D) gradient‐echo (GRE) sequence.AssessmentXe MRI, FEV<jats:sub>1</jats:sub>, and nitrogen multiple‐breath wash‐out for lung‐clearance index (LCI<jats:sub>2.5</jats:sub>) were performed. To assess same‐day reproducibility, Xe MRI was performed twice within the first visit, and procedures were repeated at 28 days. Xe hypoventilation was quantified using ventilation‐defect percentage (VDP) and reader‐defect volume (RDV). For VDP, hypoventilated voxels from segmented images were identified using a threshold of &lt;60% mean whole‐lung signal and expressed as a percentage of the lung volume. For RDV, hypoventilation was identified by two trained readers and expressed as a percentage.Statistical TestsInter‐site comparisons were conducted using Kruskal–Wallis nonparametric tests with Dunn's multiple‐comparisons tests. Differences for individuals were assessed using Wilcoxon matched‐pairs tests. Bland–Altman tests were used to evaluate same‐day repeatability, 28‐day reproducibility, and inter‐reader agreement. A <jats:italic>P</jats:italic>‐value ≤0.05 was considered significant.ResultsMedian FEV<jats:sub>1</jats:sub> %‐predicted was 96.8% (86%–106%), and median LCI<jats:sub>2.5</jats:sub> was 6.6 (6.3–7.4). Xe MRI had high same‐day reproducibility (mean VDP difference 0.12%, 95% limits of agreement [−3.2, 3.4]; mean RDV difference 0.42% [−2.5, 3.3]). At 28 days, 26/31 participants (84%) fell within the same‐day 95% limits of agreement.Data ConclusionXe MRI may offer excellent same‐day and short‐term reproducibility.Evidence Level2Technical EfficacyStage 2","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":"18 1","pages":""},"PeriodicalIF":4.4,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142185842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utilizing Radiomics of Peri‐Lesional Edema in T2‐FLAIR Subtraction Digital Images to Distinguish High‐Grade Glial Tumors From Brain Metastasis","authors":"Emin Demirel, Okan Dilek","doi":"10.1002/jmri.29572","DOIUrl":"https://doi.org/10.1002/jmri.29572","url":null,"abstract":"BackgroundDifferentiating high‐grade glioma (HGG) and isolated brain metastasis (BM) is important for determining appropriate treatment. Radiomics, utilizing quantitative imaging features, offers the potential for improved diagnostic accuracy in this context.PurposeTo differentiate high‐grade (grade 4) glioma and BM using machine learning models from radiomics data obtained from T2‐FLAIR digital subtraction images and the peritumoral edema area.Study TypeRetrospective.PopulationThe study included 1287 patients. Of these, 602 were male and 685 were female. Of the 788 HGG patients included in the study, 702 had solitary masses. Of the 499 BM patients included in the study, 112 had solitary masses. Initially, the model was developed and tested on solitary masses. Subsequently, the model was developed and tested separately for all patients (solitary and multiple masses).Field Strength/SequenceAxial T2‐weighted fast spin‐echo sequence (T2WI) and T2‐weighted fluid‐attenuated inversion recovery sequence (T2‐FLAIR), using 1.5‐T and 3.0‐T scanners.AssessmentRadiomic features were extracted from digitally subtracted T2‐FLAIR images in the area of peritumoral edema. The maximum relevance‐minimum redundancy (mRMR) method was then used for dimensionality reduction. The naive Bayes algorithm was used in model development. The interpretability of the model was explored using SHapley Additive exPlanations (SHAP).Statistical TestsChi‐square test, one‐way analysis of variance, and Kruskal–Wallis test were performed. The <jats:italic>P</jats:italic> values &lt;0.05 were considered statistically significant. The performance metrics include area under curve (AUC), sensitivity (SENS), and specificity (SPEC).ResultsThe mean age of HGG patients was 61.4 ± 13.2 years and 61.7 ± 12.2 years for BM patients. In the external validation cohort, the model achieved AUC: 0.991, SENS: 0.983, and SPEC: 0.922. The external cohort results for patients with solitary lesions were AUC: 0.987, SENS: 0.950, and SPEC: 0.922.Data ConclusionThe artificial intelligence model, developed with radiomics data from the peritumoral edema area in T2‐FLAIR digital subtraction images, might be able to differentiate isolated BM from HGG.Evidence Level3Technical EfficacyStage 2","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":"41 1","pages":""},"PeriodicalIF":4.4,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142185841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial for \"Simultaneous Increase of Mean Susceptibility and Mean Kurtosis in the Substantia Nigra as an MRI Neuroimaging Biomarker for Early-Stage Parkinson's Disease: A Systematic Review and Meta-Analysis\".","authors":"Rodolfo G Gatto, Hossam Youssef","doi":"10.1002/jmri.29601","DOIUrl":"https://doi.org/10.1002/jmri.29601","url":null,"abstract":"","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142154283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MRI Assessment of Cerebral White Matter Microvascular Hemodynamics Across the Adult Lifespan","authors":"Nikou L. Damestani PhD,&nbsp;John Jacoby BS,&nbsp;Christa B. Michel BS,&nbsp;Barnaly Rashid PhD,&nbsp;David H. Salat PhD,&nbsp;Meher R. Juttukonda PhD","doi":"10.1002/jmri.29606","DOIUrl":"https://doi.org/10.1002/jmri.29606","url":null,"abstract":"<p>EFFECT OF AGE ON (A) CBF, (B) ATT, AND (D) FA, WHERE (C) DEMONSTRATES THE OVERLAY OF THE CBF AND ATT MAPS FOR ASSOCIATIONS WITH AGE. RESULTS ARE PRESENTED AFTER MULTIPLE COMPARISONS CORRECTION (PTFCE &lt; 0.05) AND CONTROLLING FOR SEX. MORE WIDESPREAD ASSOCIATIONS WITH AGE ARE PREVALENT FOR ATT IN COMPARISON WITH CBF. DICE COEFFICIENT BETWEEN CBF DECREASING WITH AGE AND ATT INCREASING WITH AGE UPON THRESHOLDING AT PFWE &lt; 0.05 = 0.8045, INDICATING HIGH OVERLAP OF THESE MEASURES OF HEMODYNAMICS. LOWER FA WAS GENERALLY ASSOCIATED WITH INCREASING AGE, THOUGH HIGHER FA WAS ASSOCIATED WITH INCREASING AGE IN THE SURROUNDING RETROLENTICULAR PART OF THE INTERNAL CAPSULE. BY DAMESTANI ET AL. (1549–1562)\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </p>","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":"60 4","pages":"spcone"},"PeriodicalIF":3.3,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jmri.29606","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142165367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial for \"Initial Experience of Metabolic Imaging With Hyperpolarized [1-¹³C]pyruvate MRI in Kidney Transplant Patients\".","authors":"Malene Aastrup, Uffe Kjærgaard, Christoffer Laustsen","doi":"10.1002/jmri.29582","DOIUrl":"https://doi.org/10.1002/jmri.29582","url":null,"abstract":"","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142145778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial for \"Clear Cell Renal Cell Carcinoma: Characterizing the Phenotype of Von Hippel-Lindau Mutation Using MRI\".","authors":"Taek Min Kim","doi":"10.1002/jmri.29603","DOIUrl":"https://doi.org/10.1002/jmri.29603","url":null,"abstract":"","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142140292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal Multiparametric Quantitative MRI Evaluation of Acute and Chronic Multiple Sclerosis Paramagnetic Rim Lesions.","authors":"Ahmed M Elkady, Colm Elliott, Dumitru Fetco, David Araujo, Zahra Karimaghaloo, Marco Ganzetti, David Clayton, Licinio Craveiro, Agne Kazlauskaite, Sridar Narayanan, Douglas L Arnold, David A Rudko","doi":"10.1002/jmri.29583","DOIUrl":"https://doi.org/10.1002/jmri.29583","url":null,"abstract":"<p><strong>Background: </strong>Multiple sclerosis (MS) paramagnetic rim lesions (PRLs) are markers of chronic active biology and exhibit complex iron and myelin changes that may complicate quantification when using conventional MRI approaches.</p><p><strong>Purpose: </strong>To conduct a multiparametric MRI analysis of PRLs.</p><p><strong>Study type: </strong>Retrospective/longitudinal.</p><p><strong>Subjects: </strong>Ninety-five progressive MS subjects with at least one persistent PRL who were enrolled in the CONSONANCE trial.</p><p><strong>Field strength/sequence: </strong>3-T/Susceptibility-weighted, T1-weighted, T2-weighted, and fluid-attenuated inversion recovery.</p><p><strong>Assessment: </strong>Acute/chronic PRLs and non-PRLs were measured at screening, 24, 48, and 96 weeks using quantitative magnetic susceptibility (QS), R2*, and standardized T1w/T2w ratio (sT1w/T2w). PRL analyses were performed for whole lesion, core, and rim. The correlations between PRL core and rim sT1w/T2w, QS, and R2* were assessed.</p><p><strong>Statistical tests: </strong>Linear mixed models. A P-value <0.05 was considered significant.</p><p><strong>Results: </strong>There was a significant decrease in sT1w/T2w (-0.24 ± -5.3 × 10^-3) and R2* (-3.6 ± 2.2 Hz) but a significant increase in QS (+21 ± 1.3 ppb) using whole-lesion analysis of chronic PRLs compared to non-PRLs at screening. Tissue damage accumulated at the 96-week time point was more evident in acute/chronic PRLs compared to acute/chronic non-PRLs (ΔsT1w/T2w = -0.21/-0.24 ± 0.033/0.0053; ΔR2* = -4.4/-3.6 ± 1.4/2.2 Hz). New, acute PRL sT1w/T2w significantly increased in lesion core (+4.3 × 10^-3 ± 1.2 × 10^-4) and rim (+5.6 × 10^-3 ± 1.2 × 10^-4) 24 weeks post lesion inception, suggestive of partial recovery. Chronic PRLs, contrastingly, showed significant decreases in sT1w/T2w over the initial 24 weeks for both core (-2.1 × 10^-4 ± 2.0 × 10^-5) and rim (-2.4 × 10^-4 ± 2.0 × 10^-5), indicative of irreversible tissue damage. Significant positive correlations between PRL core and rim sT1w/T2w (R² = 0.53), R2* (R² = 0.69) and QS (R² = 0.52) were observed.</p><p><strong>Data conclusion: </strong>Multiparametric assessment of PRLs has the potential to be a valuable tool for assessing complex iron and myelin changes in chronic active PRLs of progressive MS patients.</p><p><strong>Level of evidence: </strong>2 TECHNICAL EFFICACY: Stage 3.</p>","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142140295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial for \"Disturbed Dynamic Brain Activity and Neurovascular Coupling in End-Stage Renal Disease Assessed With MRI\".","authors":"Dinil Sasi Sankaralayam","doi":"10.1002/jmri.29595","DOIUrl":"https://doi.org/10.1002/jmri.29595","url":null,"abstract":"","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142140293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Initial Experience of Metabolic Imaging With Hyperpolarized [1-¹³C]pyruvate MRI in Kidney Transplant Patients.","authors":"Xiaoxi Liu, Ying-Chieh Lai, Di Cui, Shiang-Cheng Kung, Meyeon Park, Zoltan Laszik, Peder E Z Larson, Zhen J Wang","doi":"10.1002/jmri.29580","DOIUrl":"10.1002/jmri.29580","url":null,"abstract":"<p><strong>Background: </strong>Kidney transplant is the treatment of choice for patients with end-stage renal disease. Early detection of allograft injury is important to delay or prevent irreversible damage.</p><p><strong>Purpose: </strong>To investigate the feasibility of hyperpolarized (HP) [1-¹³C]pyruvate MRI for assessing kidney allograft metabolism.</p><p><strong>Study type: </strong>Prospective.</p><p><strong>Subjects: </strong>Six participants (mean age, 45.2 ± 12.4 years, two females) scheduled for kidney allograft biopsy and five patients (mean age, 59.6 ± 10.4 years, two females) with renal cell carcinoma (RCC).</p><p><strong>Field strength/sequence: </strong>Three Tesla, T2-weighted fast spin echo, multi-echo gradient echo, single shot diffusion-weighted echo-planar imaging, and time-resolved HP ¹³C metabolite-selective imaging.</p><p><strong>Assessment: </strong>Five of the six kidney allograft participants underwent biopsy after MRI. Estimated glomerular filtration rate (eGFR) and urine protein-to-creatine ratio (uPCR) were collected within 4 weeks of MRI. Kidney metabolism was quantified from HP [1-¹³C]pyruvate MRI using the lactate-to-pyruvate ratio in allograft kidneys and non-tumor bearing kidneys from RCC patients.</p><p><strong>Statistical tests: </strong>Descriptive statistics (mean ± SD).</p><p><strong>Results: </strong>Biopsy was performed a mean of 9 days (range 5-19 days) after HP [1-¹³C]pyruvate MRI. Three biopsies were normal, one showed low-grade fibrosis and one showed moderate microvascular inflammation. All had stable functioning allografts with eGFR >60 mL/min/1.73 m² and normal uPCR. One participant who did not undergo biopsy had reduced eGFR of 49 mL/min/1.73 m² and elevated uPCR. The mean lactate-to-pyruvate ratio was 0.373 in participants with normal findings (N = 3) and 0.552 in participants with abnormal findings (N = 2). The lactate-to-pyruvate ratio was highest (0.847) in the participant with reduced eGFR and elevated uPRC. Native non-tumor bearing kidneys had a mean lactate-to-pyruvate ratio of 0.309.</p><p><strong>Data conclusion: </strong>Stable allografts with normal findings at biopsy showed lactate-to-pyruvate ratios similar to native non-tumor bearing kidneys, whereas allografts with abnormal findings showed higher lactate-to-pyruvate ratios.</p><p><strong>Evidence level: </strong>2 TECHNICAL EFFICACY: Stage 2.</p>","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142140294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}