Journal of Magnetic Resonance Imaging最新文献

{"title":"Glycemic Influences on Hypertrophic Cardiomyopathy Myocardium: Insights From Cardiac MRI Feature Tracking.","authors":"Xin Peng, Huaibi Huo, Jin Gao, Xu Jiang, Yuli Yuan","doi":"10.1002/jmri.70031","DOIUrl":"https://doi.org/10.1002/jmri.70031","url":null,"abstract":"<p><strong>Background: </strong>Hypertrophic cardiomyopathy (HCM) is a genetic disorder associated with left ventricular hypertrophy and elevated cardiovascular risk. Emerging evidence suggests glycemic disturbances may exacerbate myocardial injury.</p><p><strong>Purpose: </strong>To evaluate the effects of prediabetes and diabetes on myocardium in patients with HCM using cardiac MRI feature tracking (FT).</p><p><strong>Study type: </strong>Retrospective.</p><p><strong>Population: </strong>One hundred thirty five participants (age: 58 ± 10 years; 60% male), divided into four subgroups according to the left ventricular maximal wall thickness (LVMWT) and hemoglobin A1c (HbA1c) level: 36 patients with HCM, 39 patients with prediabetes-HCM, 30 patients with diabetes-HCM, and 30 controls.</p><p><strong>Field strength/sequence: </strong>3.0 T/balanced steady-state free precession cine and phase-sensitive inversion-prepared late gadolinium enhancement (LGE) sequences.</p><p><strong>Assessment: </strong>The left ventricular global longitudinal strain (GLS), global circumferential strain (GCS), global radial strain (GRS), and their corresponding strain rates (GLSr, GCSr, GRSr), endocardial right ventricular GLS, as well as the presence and extent of replacement myocardial fibrosis, were assessed using Medis software and correlated with glycemic status (HbA1c and LVMWT).</p><p><strong>Statistical tests: </strong>Descriptive statistics, analysis of variance, Pearson/Spearman correlation coefficients (r), and stepwise regression. p < 0.05 indicated statistical significance.</p><p><strong>Results: </strong>LV-GRS was significantly lower in prediabetes and diabetes-HCM than HCM alone (62.7% ± 7.7% vs. 50.1% ± 5.6% vs. 43.4% ± 6.2%). LV-GLS and endocardial right ventricular GLS were also significantly reduced (LV-GLS: -23.2% ± 2.7% vs. -20.5% ± 3.6% vs. -18.1 ± 3.6; endo RV-GLS: -36.0% ± 6.7% vs. -30.9% ± 7.1% vs. -26.6 ± 7.0). After adjusting for age, sex, hypertension, and LV mass, LV-GRS remained significantly different across groups. Additionally, a significant negative correlation was observed between LV-GRS and HbA1c (r = -0.631), whereas a significant positive correlation was found between LV-GLS and LVMWT (r = 0.220).</p><p><strong>Data conclusions: </strong>Strain parameters derived from cardiac MRI FT may detect early myocardial damage in patients with HCM with prediabetes or diabetes, emphasizing the importance of early glycemic control.</p><p><strong>Evidence level: </strong>3.</p><p><strong>Technical efficacy: </strong>Stage 2.</p>","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144540512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Deep Learning-Based De-Artifact Diffusion Model for Removing Motion Artifacts in Knee MRI.","authors":"Yingchun Li, Tong Gong, Qing Zhou, Haodong Wang, Xiong Yan, Yu Xi, Zhenwei Shi, Wei Deng, Feng Shi, Yuting Wang","doi":"10.1002/jmri.70027","DOIUrl":"https://doi.org/10.1002/jmri.70027","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Motion artifacts are common for knee MRI, which usually lead to rescanning. Effective removal of motion artifacts would be clinically useful.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Purpose: &lt;/strong&gt;To construct an effective deep learning-based model to remove motion artifacts for knee MRI using real-world data.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Study type: &lt;/strong&gt;Retrospective.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Subjects: &lt;/strong&gt;Model construction: 90 consecutive patients (1997 2D slices) who had knee MRI images with motion artifacts paired with immediately rescanned images without artifacts served as ground truth. Internal test dataset: 25 patients (795 slices) from another period; external test dataset: 39 patients (813 slices) from another hospital.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Field strength/sequence: &lt;/strong&gt;3-T/1.5-T knee MRI with T1-weighted imaging, T2-weighted imaging, and proton-weighted imaging.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Assessment: &lt;/strong&gt;A deep learning-based supervised conditional diffusion model was constructed. Objective metrics (root mean square error [RMSE], peak signal-to-noise ratio [PSNR], structural similarity [SSIM]) and subjective ratings were used for image quality assessment, which were compared with three other algorithms (enhanced super-resolution [ESR], enhanced deep super-resolution, and ESR using a generative adversarial network). Diagnostic performance of the output images was compared with the rescanned images.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Statistical tests: &lt;/strong&gt;The Kappa Test, Pearson chi-square test, Fredman's rank-sum test, and the marginal homogeneity test. A p value &lt; 0.05 was considered statistically significant.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Subjective ratings showed significant improvements in the output images compared to the input, with no significant difference from the ground truth. The constructed method demonstrated the smallest RMSE (11.44  &lt;math&gt; &lt;semantics&gt;&lt;mrow&gt;&lt;mo&gt;±&lt;/mo&gt;&lt;/mrow&gt; &lt;annotation&gt;$$ pm $$&lt;/annotation&gt;&lt;/semantics&gt; &lt;/math&gt;  5.47 in the validation cohort; 13.95  &lt;math&gt; &lt;semantics&gt;&lt;mrow&gt;&lt;mo&gt;±&lt;/mo&gt;&lt;/mrow&gt; &lt;annotation&gt;$$ pm $$&lt;/annotation&gt;&lt;/semantics&gt; &lt;/math&gt;  4.32 in the external test cohort), the largest PSNR (27.61  &lt;math&gt; &lt;semantics&gt;&lt;mrow&gt;&lt;mo&gt;±&lt;/mo&gt;&lt;/mrow&gt; &lt;annotation&gt;$$ pm $$&lt;/annotation&gt;&lt;/semantics&gt; &lt;/math&gt;  3.20 in the validation cohort; 25.64  &lt;math&gt; &lt;semantics&gt;&lt;mrow&gt;&lt;mo&gt;±&lt;/mo&gt;&lt;/mrow&gt; &lt;annotation&gt;$$ pm $$&lt;/annotation&gt;&lt;/semantics&gt; &lt;/math&gt;  2.67 in the external test cohort) and SSIM (0.97  &lt;math&gt; &lt;semantics&gt;&lt;mrow&gt;&lt;mo&gt;±&lt;/mo&gt;&lt;/mrow&gt; &lt;annotation&gt;$$ pm $$&lt;/annotation&gt;&lt;/semantics&gt; &lt;/math&gt;  0.04 in the validation cohort; 0.94  &lt;math&gt; &lt;semantics&gt;&lt;mrow&gt;&lt;mo&gt;±&lt;/mo&gt;&lt;/mrow&gt; &lt;annotation&gt;$$ pm $$&lt;/annotation&gt;&lt;/semantics&gt; &lt;/math&gt;  0.04 in the external test cohort) compared to the other three algorithms. The output images achieved comparable diagnostic capability as the ground truth for multiple anatomical structures.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Data conclusion: &lt;/strong&gt;The constructed model exhibited feasibility and effectiveness, and outperformed multiple other algorithms","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aortic Function in a Longitudinal 4D Flow MRI Study in Marfan Syndrome Patients Receiving Resveratrol.","authors":"Daan Bosshardt, Mitzi M van Andel, E M Schrauben, Roland R J van Kimmenade, Arthur J Scholte, Moniek G J P Cox, Daniëlle Robbers-Visser, Aeilko H Zwinderman, Barbara J M Mulder, Aart J Nederveen, Vivian de Waard, Maarten Groenink, Pim van Ooij","doi":"10.1002/jmri.70021","DOIUrl":"https://doi.org/10.1002/jmri.70021","url":null,"abstract":"<p><strong>Background: </strong>New treatment strategies are required to reduce aortic events in Marfan syndrome (MFS). Resveratrol is a dietary supplement that intervenes in aortic wall cellular metabolism and may benefit MFS patients.</p><p><strong>Purpose: </strong>To evaluate whether treatment with Resveratrol affects aorta hemodynamics derived from 4D flow MRI in MFS.</p><p><strong>Study type: </strong>Prospective single-arm open-label multicenter trial.</p><p><strong>Population: </strong>46 MFS patients (mean age 36 ± 9 years, 23 female), 20 with and 26 without a history of aortic root surgery (RR and native MFS), and 25 age- and sex-matched healthy controls.</p><p><strong>Field strength/sequence: </strong>3T, temporally resolved 3D phase contrast (4D flow MRI) and 3D mDixon sequences.</p><p><strong>Assessment: </strong>MFS patients underwent 4D flow MRI before (baseline) and after 1 year of 500 mg daily Resveratrol treatment (follow-up). Velocity magnitude and wall shear stress (WSS) in six regions in the thoracic aorta were evaluated. Incidence maps showing abnormal hemodynamics compared to healthy controls were generated. Pulse wave velocity (PWV) was assessed in 45 subjects. The relationships between MRI parameters and annual aortic growth from the 3D mDixon scans and age were investigated.</p><p><strong>Statistical tests: </strong>Student's paired and unpaired t-tests, Fisher's exact tests, McNemar's exact test, and Pearson correlation coefficients (r). Statistical significance was defined as p < 0.05.</p><p><strong>Results: </strong>No significant changes in any of the hemodynamic parameters were observed: inner descending aorta WSS (Pa), native: from 1.08 ± 0.21 to 1.08 ± 0.17, p = 0.818, RR: from 1.02 ± 0.29 to 0.98 ± 0.21, p = 0.270; velocity (m/s), native: from 0.64 ± 0.10 to 0.65 ± 0.10, p = 0.359, RR: 0.68 ± 0.15, to 0.67 ± 0.12, p = 0.629; abnormally directed WSS incidence: native: from 17 (65%) to 14 (54%), p = 0.453, RR: 13 (65%) to 13 (65%), p = 1.000; PWV (m/s) native: from 7.7 ± 1.9 to 7.9 ± 1.8, p = 0.582, RR: 9.2 ± 1.6 to 8.2 ± 3.2, p = 0.184. PWV correlated with age in RR MFS patients (r = 0.59, n = 19).</p><p><strong>Data conclusion: </strong>No significant changes in aortic hemodynamics derived from 4D flow MRI were observed after 1 year of Resveratrol treatment.</p><p><strong>Evidence level: </strong>1.</p><p><strong>Technical efficacy: </strong>Stage 4.</p>","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of Field Strength, Sex, and Age on Pseudo-Continuous Arterial Spin Labeling and T₁ Mapping in the Kidney.","authors":"Leyre Garcia-Ruiz, Rebeca Echeverria-Chasco, Verónica Aramendía-Vidaurreta, Sergio M Solis-Barquero, Nuria Garcia-Fernandez, José María Mora-Gutiérrez, Marta Vidorreta, Gorka Bastarrika, Maria A Fernández-Seara","doi":"10.1002/jmri.70009","DOIUrl":"https://doi.org/10.1002/jmri.70009","url":null,"abstract":"<p><strong>Background: </strong>Pseudo-continuous arterial spin labeling (PCASL) and T₁ mapping have been used for renal imaging at 1.5 T and 3 T. However, direct comparisons between field strengths, age, and sex are lacking.</p><p><strong>Purpose: </strong>To assess the effects of field strength, age, and sex on renal perfusion and T₁ values and measure reproducibility.</p><p><strong>Study type: </strong>Prospective.</p><p><strong>Population: </strong>Sixteen healthy volunteers (eight females, age 41.8 ± 13.3 years) underwent same-day scans at 1.5 T and 3 T, repeated 1 week later.</p><p><strong>Field strength/sequence: </strong>1.5 T/3 T multi-delay PCASL with spin-echo EPI readout, inversion-recovery T₁ mapping, B₀ and B₁ mapping.</p><p><strong>Assessment: </strong>Multi-delay PCASL was employed to calculate renal blood flow (RBF) and arterial transit time (ATT) maps; single-delay PCASL (PLD = 1.3 s) assessed RBF and technical parameters. Cortical and medullary RBF, ATT, and T₁ were compared between field strengths, age, and sex groups. Reproducibility and inter-observer agreement were evaluated.</p><p><strong>Statistical tests: </strong>Shapiro-Wilk test, analysis of variance, Levene test, Box M-test, Pearson's correlation, within-subject coefficient of variation (wsCV), and intraclass correlation coefficient (ICC). P-value < 0.05 was significant.</p><p><strong>Results: </strong>3 T yielded significantly higher cortical T₁ (1356.02 ± 3.72 vs. 1023.29 ± 39.30 ms), and lower RBF (310.63 ± 52.72 vs. 347.65 ± 54.08 [mL/min/100 g]) than 1.5 T. Eight older (≥ 40 years) participants had significantly lower cortical RBF (1.5 T: 312.23 ± 37.59 vs. 383.06 ± 43.91 [mL/min/100 g]). Females showed significantly shorter ATT (1.5 T: 0.75 ± 0.11 s vs. 0.96 ± 0.22 s) and longer medullary T₁ (1.5 T: 1388.12 ± 33.68 ms vs. 1308.97 ± 28.52 ms). T₁ showed excellent reproducibility and inter-observer agreement (wsCV: < 2%, ICC: > 0.8). Cortical RBF was reproducible (wsCV: ~10%, ICC: > 0.7) with strong inter-observer agreement (wsCV: < 2.5%, ICC > 0.95). Medullary RBF had good inter-observer agreement (wsCV: < 4.7%, ICC: > 0.75) but poor reproducibility (wsCV: 15.78%-19.38%).</p><p><strong>Data conclusion: </strong>Cortical perfusion parameters and T₁ were reproducible. However, age, sex, and field strength affect the values, requiring consideration in renal imaging.</p><p><strong>Evidence level: </strong>Level 2.</p><p><strong>Technical efficacy: </strong>Stage 1.</p>","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MRI Assessment of Energy Loss Within the Thoracic Aorta and Its Impact on Cardiac Function in Fontan Patients After Aortic Reconstruction.","authors":"Yujiro Ide, Dominik Gabbert, Jan Hinnerk Hansen, Anselm Uebing, Inga Voges","doi":"10.1002/jmri.70025","DOIUrl":"https://doi.org/10.1002/jmri.70025","url":null,"abstract":"<p><strong>Background: </strong>In Fontan patients undergoing aortic reconstruction, concerns regarding the impact of aortic function on ventricular function exist.</p><p><strong>Purpose: </strong>4D Flow MRI was used to compare energy loss (EL) within the thoracic aorta in patients with and without aortic reconstruction.</p><p><strong>Study type: </strong>Retrospective case control.</p><p><strong>Population: </strong>Eighty-nine patients underwent 4D Flow MRI: group A (n = 36), Fontan patients without aortic reconstruction (9.9 (1.0-26.7) years since Fontan completion); group B (n = 42), Fontan patients with aortic reconstruction (11.8 (1.0-26.4) years since Fontan completion); and group C (n = 11), patients with biventricular circulation without aortic reconstruction.</p><p><strong>Field strength/sequence: </strong>Balanced SSFP cine and time-resolved 3D phase contrast (4D Flow) sequences at 1.5 T or 3 T.</p><p><strong>Assessment: </strong>Peak and average aortic EL in the thoracic aorta as well as peak aortic velocity and flow volume were assessed. Correlations between EL indexed to aortic forward flow volume and volumetric ventricular parameters and peak aortic velocity were assessed.</p><p><strong>Statistical tests: </strong>Kruskal-Wallis test, chi-square test and Spearman's correlation coefficient were used.</p><p><strong>Results: </strong>Peak and average EL were significantly larger in group B than in groups A and C (peak EL (mW); A: 1.45 (0.22-9.81), B: 3.09 (0.51-12.49), C: 2.10 (1.20-3.45); average EL (mW); A: 0.46 (0.07-2.63), B: 1.13 (0.13-4.67), C: 0.76 (0.40-1.98)). Group B had significantly larger ventricular end-diastolic volume index (EDVi, 108 mL/m²) and end-systolic volume index (ESVi, 53 mL/m²), significantly lower ejection fraction (EF, 51%) and significantly greater end-diastolic myocardial mass (MM, 50 g/m²) of the systemic ventricle than group A (EDVi: 86 mL/m², ESVi: 34 mL/m², EF: 58%, end-diastolic MM: 43 g/m²). In Fontan patients, indexed average aortic EL correlated positively with aortic peak velocity (R = 0.68) and with years after Fontan completion (R = 0.60).</p><p><strong>Data conclusion: </strong>Fontan patients who underwent aortic reconstruction had increased aortic EL, even in the absence of significant residual aortic stenosis.</p><p><strong>Evidence level: </strong>Level 3.</p><p><strong>Technical efficacy: </strong>Stage 3.</p>","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial for \"Quantitative Evaluation of Carotid Artery Stenosis by Multi-VENC 4D Flow MRI: Incorporating Turbulent Kinetic Energy for Clinical Validity\".","authors":"Petter Dyverfeldt","doi":"10.1002/jmri.70018","DOIUrl":"https://doi.org/10.1002/jmri.70018","url":null,"abstract":"","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial for \"Perivascular Space Burden in Children With Autism Spectrum Disorder Correlates With Neurodevelopmental Severity\".","authors":"Jose Bernal, Inga Menze","doi":"10.1002/jmri.70026","DOIUrl":"https://doi.org/10.1002/jmri.70026","url":null,"abstract":"","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognition-Eye-Brain Connection in Alzheimer's Disease Spectrum Revealed by Multimodal Imaging.","authors":"Yan Shi, Tingting Shen, Su Yan, Jianwen Liang, Tianyunxi Wei, Yijin Huang, Rong Gao, Ning Zheng, Renpuchi Ci, Min Zhang, Xiaoying Tang, Yuanyuan Qin, Wenzhen Zhu","doi":"10.1002/jmri.70003","DOIUrl":"https://doi.org/10.1002/jmri.70003","url":null,"abstract":"<p><strong>Background: </strong>The connection between cognition, eye, and brain remains inconclusive in Alzheimer's disease (AD) spectrum disorders.</p><p><strong>Purpose: </strong>To explore the relationship between cognitive function, retinal biometrics, and brain alterations in the AD spectrum.</p><p><strong>Study type: </strong>Prospective.</p><p><strong>Subjects: </strong>Healthy control (HC) (n = 16), subjective cognitive decline (SCD) (n = 35), mild cognitive impairment (MCI) (n = 18), and AD group (n = 7).</p><p><strong>Field strength/sequence: </strong>3-T, 3D T1-weighted Brain Volume (BRAVO) and resting-state functional MRI (fMRI).</p><p><strong>Assessment: </strong>In all subgroups, cortical thickness was measured from BRAVO and segmented using the Desikan-Killiany-Tourville (DKT) atlas. The fractional amplitude of low-frequency fluctuations (FALFF) and regional homogeneity (ReHo) were measured in fMRI using voxel-based analysis. The eye was imaged by optical coherence tomography angiography (OCTA), with the deep learning model FARGO segmenting the foveal avascular zone (FAZ) and retinal vessels. FAZ area and perimeter, retinal blood vessels curvature (RBVC), thicknesses of the retinal nerve fiber layer (RNFL) and ganglion cell layer-inner plexiform layer (GCL-IPL) were calculated. Cognition-eye-brain associations were compared across the HC group and each AD spectrum stage using multivariable linear regression.</p><p><strong>Statistical tests: </strong>Multivariable linear regression analysis. Statistical significance was set at p < 0.05 with FWE correction for fMRI and p < 1/62 (Bonferroni-corrected) for structural analyses.</p><p><strong>Results: </strong>Reductions of FALFF in temporal regions, especially the left superior temporal gyrus (STG) in MCI patients, were linked to decreased RNFL thickness and increased FAZ area significantly. In AD patients, reduced ReHo values in occipital regions, especially the right middle occipital gyrus (MOG), were significantly associated with an enlarged FAZ area. The SCD group showed widespread cortical thickening significantly associated with all aforementioned retinal biometrics, with notable thickening in the right fusiform gyrus (FG) and right parahippocampal gyrus (PHG) correlating with reduced GCL-IPL thickness.</p><p><strong>Data conclusion: </strong>Brain function and structure may be associated with cognition and retinal biometrics across the AD spectrum. Specifically, cognition-eye-brain connections may be present in SCD.</p><p><strong>Evidence level: </strong>2.</p><p><strong>Technical efficacy: </strong>3.</p>","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial for \"Non-Invasive Assessment of Carotid Perivascular Adipose Tissue Phenotyping and Calcific Burden Using MRI Fat Fraction and R2* Mappings: Validation Against CTA\".","authors":"Michael L Wood","doi":"10.1002/jmri.70017","DOIUrl":"https://doi.org/10.1002/jmri.70017","url":null,"abstract":"","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perivascular Space Burden in Children With Autism Spectrum Disorder Correlates With Neurodevelopmental Severity.","authors":"Giulia Frigerio, Gloria Rizzato, Denis Peruzzo, Tommaso Ciceri, Elisa Mani, Fabiola Lanteri, Valentina Mariani, Massimo Molteni, Nivedita Agarwal","doi":"10.1002/jmri.70023","DOIUrl":"https://doi.org/10.1002/jmri.70023","url":null,"abstract":"<p><strong>Background: </strong>Cerebral perivascular spaces (PVS) are involved in cerebrospinal fluid (CSF) circulation and clearance of metabolic waste in adult humans. A high number of PVS has been reported in autism spectrum disorder (ASD) but its relationship with CSF and disease severity is unclear.</p><p><strong>Purpose: </strong>To quantify PVS in children with ASD through MRI.</p><p><strong>Study type: </strong>Retrospective.</p><p><strong>Population: </strong>Sixty six children with ASD (mean age: 4.7 ± 1.5 years; males/females: 59/7).</p><p><strong>Field strength/sequence: </strong>3T, 3D T1-weighted GRE and 3D T2-weighted turbo spin echo sequences.</p><p><strong>Assessment: </strong>PVS were segmented using a weakly supervised PVS algorithm. PVS count, white matter-perivascular spaces (WM-PVS_tot) and normalized volume (WM-PVS_voln) were analyzed in the entire white matter. Six regions: frontal, parietal, limbic, occipital, temporal, and deep WM (WM-PVS_sr). WM, GM, CSF, and extra-axial CSF (eaCSF) volumes were also calculated. Autism Diagnostic Observation Schedule, Wechsler Intelligence Scale, and Griffiths Mental Developmental scales were used to assess clinical severity and developmental quotient (DQ).</p><p><strong>Statistical tests: </strong>Kendall correlation analysis (continuous variables) and Friedman (categorical variables) tests were used to compare medians of PVS variables across different WM regions. Post hoc pairwise comparisons with Wilcoxon tests were used to evaluate distributions of PVS in WM regions. Generalized linear models were employed to assess DQ, clinical severity, age, and eaCSF volume in relation to PVS variables. A p-value < 0.05 indicated statistical significance.</p><p><strong>Results: </strong>Severe DQ (β = 0.0089), mild form of autism (β = -0.0174), and larger eaCSF (β = 0.0082) volume was significantly associated with greater WM-PVS_tot count. WM-PVS_voln was predominantly affected by normalized eaCSF volume (eaCSF_voln) (β = 0.0242; adjusted for WM volumes). The percentage of WM-PVS_sr was higher in the frontal areas (32%) and was lowest in the temporal regions (11%).</p><p><strong>Data conclusion: </strong>PVS count and volume in ASD are associated with eaCSF_voln. PVS count is related to clinical severity and DQ. PVS count was higher in frontal regions and lower in temporal regions.</p><p><strong>Evidence level: </strong>4.</p><p><strong>Technical efficacy: </strong>Stage 3.</p>","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}