Journal of Magnetic Resonance Imaging最新文献

{"title":"Editorial on \"Quantitative Analysis of Orbital Soft Tissues Using Three-Dimensional Fast Spin Echo With 2-Point Dixon-Based Fat Suppression Sequence: Its Association With Methylprednisolone Pulse Therapy Treatment Efficacy in Thyroid-Associated Ophthalmopathy\".","authors":"Sophie C Queler, Ek T Tan","doi":"10.1002/jmri.29744","DOIUrl":"https://doi.org/10.1002/jmri.29744","url":null,"abstract":"","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Participant Discomfort During 5 T MRI Examinations and Its Contributing Factors.","authors":"Suwei Liu, Limin Feng, Yali Li, Ming Ni, Chenyu Jiang, Huishu Yuan","doi":"10.1002/jmri.29766","DOIUrl":"https://doi.org/10.1002/jmri.29766","url":null,"abstract":"<p><strong>Background: </strong>5 T magnetic resonance imaging (MRI)-induced patient discomfort and the associated contributing factors remain unclear.</p><p><strong>Purpose: </strong>To assess the frequency of discomfort during 5 T MRI examinations and analyze the contributing factors that may lead to discomfort, understand the potential challenges, and improve patient experience with 5 T systems.</p><p><strong>Study type: </strong>Prospective study.</p><p><strong>Population: </strong>A total of 539 participants, comprising patients and healthy volunteers.</p><p><strong>Field strength/sequence: </strong>5.0 T.</p><p><strong>Assessment: </strong>Each participant completed a post-MRI examination tolerance questionnaire evaluating discomfort and overall examination experience. Each type of discomfort was analyzed separately to determine its relationship with the contributing factors. Further analysis identified specific elements that had the most significant impact within each factor and examined interdependencies among discomfort types.</p><p><strong>Statistical tests: </strong>Chi-square and Mann-Whitney U tests were used to compare the presence of discomfort across contributing factors. One-way analysis of variance or Kruskal-Wallis tests assessed the relationship between discomfort and contributing factors. Spearman's rank correlation evaluated interdependencies among different types of discomfort.</p><p><strong>Results: </strong>The rank order of discomfort was noise (13%), examination area heat (8.2%), and vertigo while moving (6.1%), whereas 72.8% (381/523) of participants reported no discomfort during the examination. Regarding the overall examination experience, less than 1% of the participants reported an unpleasant experience (2/539), 3% a neutral experience (17/539), and over 96.5% a pleasant experience (520/539). Additionally, space constraints, noise, paresthesia, examination area heat, whole-body heat, and overall examination experience were significantly influenced by different variables. Moreover, varying degrees of correlation were observed among different discomfort types.</p><p><strong>Data conclusion: </strong>The 5 T MRI system is clinically safe, with minimal reported discomfort. Optimization strategies addressing contributing factors could enhance patient comfort and facilitate broader adoption of 5 T MRI technology.</p><p><strong>Evidence level: </strong>2 TECHNICAL EFFICACY: Stage 2.</p>","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative Analysis of Orbital Soft Tissues Using Three-Dimensional Fast Spin Echo With 2-Point Dixon-Based Fat Suppression Sequence: Its Association With Methylprednisolone Pulse Therapy Treatment Efficacy in Thyroid-Associated Ophthalmopathy.","authors":"Yu Chen, Linhan Zhai, Weiqiang Liang, Yangyang Yin, Yali Zhao, Gang Yuan, Ban Luo, Haoyue Shao, Wang Baoyi, Qiuxia Wang, Jing Zhang","doi":"10.1002/jmri.29735","DOIUrl":"https://doi.org/10.1002/jmri.29735","url":null,"abstract":"<p><strong>Background: </strong>Three-dimensional fast spin echo with 2-point Dixon-based fat suppression (3D-FSE-Dixon) sequence may assess volume and water fraction (WF) of orbit.</p><p><strong>Purpose: </strong>To explore the association between 3D-FSE-Dixon based parameters and methylprednisolone pulse therapy (MPPT) efficacy in active moderate-to-severe thyroid-associated ophthalmopathy (TAO).</p><p><strong>Study type: </strong>Retrospective.</p><p><strong>Population: </strong>Fifty-nine TAO patients (29 females, 30 males, 49.1 ± 10.9 years) were included: 26 (15 females, 11 males, 48.4 ± 11.1 years) showed improvement and 33 (14 females, 19 males, 49.6 ± 10.9 years) did not.</p><p><strong>Field strength/sequence: </strong>3D-FSE-Dixon sequence of orbits at 3 T.</p><p><strong>Assessment: </strong>Manual segmentation delineated bony orbit (BO), whole orbit (WO), globe (GO), lacrimal gland (LG), and optic nerve (ON). Multi-dimensional threshold (MDT) identified orbital fat (OF). Extraocular muscles (ETM) were obtained by subtracting other tissues from WO. WF was calculated from water and in-phase images. Treatment efficacy, the clinical outcome, was assessed within 2 weeks after MPPT.</p><p><strong>Statistical tests: </strong>Unpaired t-test and Mann-Whitney U test compared normal and non-normal data, respectively. Paired t-test analyzed parameter changes pre- and post-MPPT. Multivariate logistic regression analysis identified factors independently associated with the efficacy of MPPT. Significance was set at P < 0.05.</p><p><strong>Results: </strong>Responsive group showed significantly higher pre-treatment WF (ETM, 0.86 ± 0.06 vs. 0.82 ± 0.07; OF, 0.21 ± 0.04 vs. 0.19 ± 0.02), with no difference in volume (OF: 21.34 ± 3.33 vs. 21.36 ± 3.46, P = 1.00; ETM: 13.48 ± 2.82 vs. 13.72 ± 3.45, P = 1.00) or volume ratio (OF/GO: 3.23 ± 0.50 vs. 3.26 ± 0.56, P = 1.00; ETM/GO: 2.06 ± 0.58 vs. 2.12 ± 0.64, P = 1.00). WF significantly decreased in responsive group (ETM, 0.86 ± 0.06 vs. 0.79 ± 0.05; OF, 0.21 ± 0.04 vs. 0.17 ± 0.03) but not decreased in unresponsive group (ETM, 0.81 ± 0.07 vs. 0.81 ± 0.07, P = 1.00; OF, 0.19 ± 0.02 vs. 0.190 ± 0.02, P = 1.00). ETM WF and disease duration can assess MPPT efficacy.</p><p><strong>Data conclusion: </strong>Higher ETM WF demonstrates better MPPT efficacy for TAO.</p><p><strong>Evidence level: </strong>4 TECHNICAL EFFICACY: Stage 4.</p>","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial for \"Participant Discomfort During 5T MRI Examinations and Its Contributing Factors\".","authors":"Hendrik Mattern","doi":"10.1002/jmri.29774","DOIUrl":"https://doi.org/10.1002/jmri.29774","url":null,"abstract":"","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toward a Refined PI-RADS: The Feasibility and Limitations of More Informative Metrics in Reviewing MRI Scans.","authors":"Omer Tarik Esengur, Hunter Stecko, Emma Stevenson, Baris Turkbey","doi":"10.1002/jmri.29754","DOIUrl":"https://doi.org/10.1002/jmri.29754","url":null,"abstract":"<p><p>The Prostate Imaging-Reporting and Data System (PI-RADS) is a widely-adopted framework for assessing prostate cancer risk using multiparametric MRI. However, as advancements in imaging and data analytics emerge, PI-RADS faces pressure to integrate novel quantitative techniques, enhanced imaging protocols, and artificial intelligence (AI) solutions to improve diagnostic accuracy. This review examines the recent innovations in advanced imaging, clinical, and AI methods that can provide more informative MRI scans and discuss their potential incorporation into PI-RADS. Techniques like multi-shot echo-planar imaging and reduced field-of-view DWI show promise in improving scan quality, but may present challenges with respect to technical complexity, cost, and standardization. Others, like restriction spectrum imaging and luminal water imaging, offer new possibilities for lesion characterization, yet remain difficult to implement consistently across clinical settings. In addition, integrating clinical parameters and AI-driven tools within PI-RADS could enhance risk stratification, but may introduce greater complexity, potentially impacting ease-of-use. We discuss the implications of these advancements for PI-RADS, balancing the potential diagnostic benefits with the challenges of maintaining accessibility and reproducibility in clinical practice. This review provides a comprehensive overview of how emerging MRI techniques and AI may redefine prostate cancer imaging standards. Evidence Level: 5. Technical Efficacy: Stage 5.</p>","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143719839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentary on the \"Effects of Static and Low-Frequency Magnetic Fields on Gene Expression\".","authors":"Dario A Bencardino, Maxim Zaitsev","doi":"10.1002/jmri.29765","DOIUrl":"https://doi.org/10.1002/jmri.29765","url":null,"abstract":"","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MRI4ALL: A Week-Long Hackathon for the Development of an Open-Source Ultra-Low-Field MRI System.","authors":"Kai Tobias Block, Chengtong Zhang, Vito Ciancia, Clarissa Cooley, Sairam Geethanath, Jason Stockmann, George Verghese, Leeor Alon","doi":"10.1002/jmri.29771","DOIUrl":"https://doi.org/10.1002/jmri.29771","url":null,"abstract":"<p><p>The goal of the MRI4ALL hackathon, which took place in October 2023, was to develop a functional low-field MRI scanner in just one week and to release all created source code and resources as open-source packages. The event was attended by 52 participants from 16 institutions who assembled the scanner on the last day of the hackathon. The scanner's magnetic B₀ field with a strength of 43 mT and a target field-of-view size of 11 cm³ was created with a Halbach array made from 990 N40UH permanent magnets, held in place using 3D printed ring formers. Gradient coils were fabricated by gluing enameled copper wire onto 3D printed holders with imprinted wire patterns. A solenoid coil for RF transmission and reception was built by winding 20 turns of Litz wire around a 3D printed cylinder. A Red Pitaya FPGA prototyping board running the MaRCoS framework was used to control the scanner components, and a GPA-FHDO amplifier board was used to drive the gradients. To simplify the scanner's operation, console software with an intuitive graphical user interface was developed in Python using the PyPulseq package for sequence calculations. Furthermore, the scanner was equipped with a cooling system, as well as options for passive and active shimming. After resolving several technical issues that arose during the assembly, the scanner is now able to acquire MR images with different sequences. While not suitable for real-world clinical applications, it can be utilized for educational purposes or as a low-cost prototyping platform. Moreover, it may serve as a reference design for future MRI development projects. All source code and resources are available on the project website mri4all.org, allowing other groups to replicate the scanner. EVIDENCE LEVEL: n/a TECHNICAL EFFICACY: Stage 1.</p>","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Body Position on Dynamic Apparent Diffusion Coefficient Changes During the Cardiac Cycle in the Human Brain.","authors":"Naoki Ohno, Tosiaki Miyati, Masatomo Uehara, Riho Okamoto, Mitsuhito Mase, Satoshi Kobayashi","doi":"10.1002/jmri.29758","DOIUrl":"https://doi.org/10.1002/jmri.29758","url":null,"abstract":"<p><strong>Background: </strong>Dynamic changes in the apparent diffusion coefficient (ΔADC) during the cardiac cycle reflect water molecule fluctuations in the brain and intracranial conditions. While body position strongly affects intracranial conditions, the relationship between ΔADC and body position has been less explored, as conventional MRI is typically performed only in the supine position.</p><p><strong>Purpose: </strong>To investigate ΔADC and mean ADC (ADC_mean) of the brain in supine and sitting positions using a multi-posture MRI system.</p><p><strong>Study type: </strong>Prospective.</p><p><strong>Subjects: </strong>Nine healthy volunteers (all males; mean age, 23.5 years).</p><p><strong>Field strength/sequence: </strong>0.4 T, electrocardiographically synchronized single-shot diffusion echo-planar imaging sequence with b-values of 0 and 500 s/mm².</p><p><strong>Assessment: </strong>ADC maps were generated at multiple cardiac phases in each subject in the sitting and supine positions. For each position, an ADC_mean map was then generated as the voxel-wise mean ADC across all phases, and a ΔADC map was generated as the voxel-wise maximum difference in ADC across phases. ΔADC and ADC_mean were measured in 2 frontal and 2 occipital lobe regions and averaged. ΔADC, ADC_mean, and heart rate (HR) were compared between supine and sitting positions.</p><p><strong>Statistical tests: </strong>Wilcoxon signed-rank test. Significance was set at p < 0.05.</p><p><strong>Results: </strong>Both ΔADC and ADC_mean were significantly higher in the sitting position compared with the supine position (ΔADC: 0.84 ± 0.06 × 10^-3 mm²/s vs. 0.68 ± 0.05 × 10^-3 mm²/s; ADC_mean: 0.87 ± 0.02 × 10^-3 mm²/s vs. 0.79 ± 0.06 × 10^-3 mm²/s, respectively). These increases were consistent across all participants. In addition, HR was significantly higher in the sitting position compared with the supine position (73.8 ± 8.4 bpm vs. 58.1 ± 3.7 bpm).</p><p><strong>Data conclusion: </strong>ΔADC and ADC_mean of the brain are significantly higher in the sitting position than in the supine position.</p><p><strong>Evidence level: </strong>2. Technical Efficacy: Stage 1.</p>","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143670066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional MRI and Tumor Vasculature Correlation in Ewing Sarcoma Xenografts: A Prospective Study Based on MRI-Pathology Co-Alignment.","authors":"Xiaoge Liu, Kai Zhang, Yutong Song, Xiyang Deng, Juan Tao, Yajie Liu, Chengjiang Xu, Guijiao Qin, Yasmin Mushtaq, Shaowu Wang","doi":"10.1002/jmri.29770","DOIUrl":"https://doi.org/10.1002/jmri.29770","url":null,"abstract":"<p><strong>Background: </strong>Limited studies have evaluated vascular markers of Ewing sarcoma (ES) using MRI.</p><p><strong>Purpose: </strong>To explore the correlation between tumor vascular markers and MRI perfusion parameters in ES xenografts based on MRI-pathology co-alignment.</p><p><strong>Study type: </strong>Prospective.</p><p><strong>Animal model: </strong>Thirty-four ES xenograft models were established in female athymic nude mice using the human-derived A673 cell line.</p><p><strong>Field strength/sequence: </strong>3 T MRI, T₁-weighted (T1w) with fast spin echo sequence, T2w with fast recovery fast spin echo sequence, intravoxel incoherent motion (IVIM) with echo-planar diffusion-weighted sequence, and dynamic contrast-enhanced MRI (DCE-MRI) with the liver acquisition with volume acceleration sequence.</p><p><strong>Assessment: </strong>IVIM parameters (D, D*, and f), DCE-MRI semiquantitative parameters (maximum slope of increase [MSI], contrast-enhancement ratio [CER], and initial area under the gadolinium curve [iAUGC]), and DCE-MRI quantitative parameters (K_trans, K_ep, and V_e). The expression of vascular endothelial growth factor (VEGF), microvessel density (MVD), and vascular mimicry (VM) was evaluated by immunohistochemical staining.</p><p><strong>Statistical tests: </strong>Intraclass correlation coefficient (ICC), bootstrap resampling, Fisher's Z transformation, Pearson or Spearman correlation analysis, receiver operating characteristic curve (ROC) analysis, and DeLong's test. p < 0.05 was considered statistically significant.</p><p><strong>Results: </strong>K_trans, K_ep, f, and D* values showed significant correlations with VEGF (r = 0.697, 0.630, 0.781, 0.695, respectively). D*, f, K_trans, MSI, and CER values showed significant correlations with MVD (r = 0.42, 0.554, 0.486, 0.461, 0.416, respectively). D and f values showed significant correlations with VM (r = -0.552, 0.384, respectively). K_trans, f, D*, and K_ep values were good diagnostics in distinguishing between high- and low-expression groups of VEGF (AUC = 0.833-0.954). D* and D values were good diagnostics in distinguishing between high- and low-expression groups of MVD and VM (AUC = 0.727, 0.739, respectively).</p><p><strong>Data conclusion: </strong>IVIM and DCE-MRI can be utilized to assess tumor vasculature in ES xenografts.</p><p><strong>Evidence level: </strong>1.</p><p><strong>Technical efficacy: </strong>Stage 3.</p>","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143670073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evolving Myocardial Injury in Chronic Kidney Disease Assessed by Multiparameter Magnetic Resonance in a Rabbit Model.","authors":"Shiqi Jin, Fan Wang, Huaibi Huo, Zhaoxin Tian, Shutong Liu, Ting Liu","doi":"10.1002/jmri.29768","DOIUrl":"https://doi.org/10.1002/jmri.29768","url":null,"abstract":"<p><strong>Background: </strong>Early diagnosis and monitoring of chronic kidney disease (CKD)-related myocardial injury are crucial for improving outcomes.</p><p><strong>Purpose: </strong>To evaluate myocardial tissue characteristics and deformation during the occurrence and evolution of CKD in a rabbit model using multiparametric cardiac MRI.</p><p><strong>Study type: </strong>Longitudinal animal study.</p><p><strong>Population: </strong>A total of 26 rabbits (14 undergoing cationic bovine serum albumin (C-BSA) injection to induce CKD, 12 undergoing sham saline injection to serve as controls).</p><p><strong>Field strength/sequence: </strong>3, cine, T1 mapping, and T2 mapping sequences.</p><p><strong>Assessment: </strong>Cardiac MRI was performed at baseline, 4, 6, and 8 weeks in both groups. Global radial, circumferential, and longitudinal strain (GRS, GCS and GLS, respectively), native T1, T2, and extracellular volume (ECV) were assessed at each time point. Collagen volume fraction (CVF) was assessed, and immunohistochemical staining was performed using the IL-6 antibody. Pathology was used as a reference standard for comparison with MRI findings. The diagnostic accuracy of individual and combined MR parameters for detecting early CKD-related myocardial injury was determined.</p><p><strong>Statistical tests: </strong>Descriptive statistics, Spearman correlation (r), area under the receiver operating characteristic curve (AUC). A p-value < 0.05 was considered statistically significant.</p><p><strong>Results: </strong>Compared to controls, GLS was significantly lower, and ECV was significantly higher in the CKD group at 4 weeks post-injection. At 6 and 8 weeks, GLS was further reduced, and native T1, T2, and ECV values were significantly increased in the CKD group compared to controls. Myocardial native T1 and ECV were significantly positively correlated with CVF (r = 0.584 and 0.754, respectively), and T2 was significantly positively correlated with IL-6 (r = 0.661). The combination of native T1 and GLS showed superior diagnostic accuracy for detecting early CKD-related subclinical myocardial injury compared to single indicators (AUC = 0.846, 95% CI: 0.731-0.962).</p><p><strong>Conclusions: </strong>The appropriate combination of cardiac MRI-based features of strain, fibrosis, and inflammation may serve as an early marker of CKD-related myocardial injury.</p><p><strong>Evidence level: </strong>N/A.</p><p><strong>Technical efficacy: </strong>Stage 2.</p>","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143670070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}