Journal of Magnetic Resonance Imaging最新文献

{"title":"Editorial for \"Impact of Different Degrees of Liver Iron Concentration on MRI Feature Assessment and LI-RADS v2018 Category Assignment for Hepatocellular Carcinoma\".","authors":"Andreu F Costa","doi":"10.1002/jmri.70453","DOIUrl":"10.1002/jmri.70453","url":null,"abstract":"","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":"1382-1383"},"PeriodicalIF":4.3,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148471109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial for \"Effect of Visualized Respiratory Training on Patient Cooperation and Image Quality in Gadoxetic Acid Disodium-Enhanced Liver MRI: A Randomized Controlled Trial\".","authors":"Tej Mehta, Caleb Heiberger, Robert Liddell","doi":"10.1002/jmri.70427","DOIUrl":"10.1002/jmri.70427","url":null,"abstract":"","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":"1396-1397"},"PeriodicalIF":4.3,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148387616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond the Heart: Hepatic Extracellular Volume Assessment in Patients With Cardiovascular Disease.","authors":"Kenichiro Suwa, Yuichiro Maekawa","doi":"10.1002/jmri.70452","DOIUrl":"10.1002/jmri.70452","url":null,"abstract":"","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":"1472-1473"},"PeriodicalIF":4.3,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13667327/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148437003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-Throughput Quantitative Chemical Shift-Encoded MRI of the Liver.","authors":"Garrett C Fullerton, Jiayi Tang, Jitka Starekova, Julius F Heidenreich, Ali Pirasteh, David T Harris, Daiki Tamada, Collin J Buelo, Dan W Rettmann, Diego Hernando, Scott B Reeder","doi":"10.1002/jmri.70429","DOIUrl":"10.1002/jmri.70429","url":null,"abstract":"<p><strong>Background: </strong>Access to MRI is limited by lengthy exam times and inefficient utilization. Focused protocols can reduce exam times, but workflow variability and inefficient room turnaround contribute to conservative scheduling with long exam slots.</p><p><strong>Purpose: </strong>To develop and evaluate a high-throughput clinical MRI suite architecture and workflow, using an AI-prescribed free-breathing chemical shift-encoded (CSE) MRI exam to quantify liver proton density fat fraction (PDFF) in under 5 min of total MRI room time.</p><p><strong>Study type: </strong>Prospective.</p><p><strong>Subjects: </strong>24 healthy volunteers in two cohorts: 12 research staff (7 women/5 men; age 26.8 ± 5.8 years) and 12 community volunteers (6 women/6 men; age 41.3 ± 13.5 years).</p><p><strong>Field strength/sequence: </strong>1.5 T; free-breathing 2D multi-echo gradient echo CSE-MRI.</p><p><strong>Assessment: </strong>Each participant underwent three nonconsecutive CSE-MRI exams in a continuously queued workflow to characterize timing and PDFF repeatability. Workflow intervals were recorded from timestamped video review and image metadata. Staff cohort exams included two CSE-MRI acquisitions to assess within-exam repeatability, while community cohort exams included one to simulate clinical practice. Three radiologists (8/13/14 years of experience) independently evaluated AI-automated prescriptions for complete liver coverage and rated CSE-MRI image quality (five-point Likert scale).</p><p><strong>Statistical tests: </strong>Student's t-tests; Gwet's AC2; repeatability coefficients (RCs) with bootstrap 95% confidence intervals; Bland-Altman analysis. p < 0.05 was significant.</p><p><strong>Results: </strong>Diagnostic image quality was achieved in all 72 exams (median PDFF Likert score 5/5, inter-rater AC2 ≥ 0.86). Total MRI room times averaged 4:09 ± 0:14 min (staff) and 3:35 ± 0:34 min (community). Turnaround times averaged under 2 min, enabling throughput of 16.1 exams per hour in the community cohort. Automated prescription achieved complete liver coverage in all exams. PDFF RCs were 0.78% (staff within-exam), 0.99% (staff between-exam), and 1.21% (community between-exam) absolute PDFF.</p><p><strong>Data conclusion: </strong>The proposed high-throughput MRI workflow achieved over 16 exams per hour with highly repeatable liver fat quantification, demonstrating a framework for improving MRI utilization and access.</p><p><strong>Evidence level: </strong>1.</p><p><strong>Stage of technical efficacy: </strong>2.</p>","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":"1398-1410"},"PeriodicalIF":4.3,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13660437/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148421648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial for \"Effect of 37°C Pre-Warmed Versus Room Temperature Gadoxetic Acid Disodium Contrast Medium on Patient Comfort and Image Quality in Liver MRI: A Prospective, Double-Blind, Self-Controlled Before-and-After Study\".","authors":"Michael R Torkzad, Pardeep Mittal","doi":"10.1002/jmri.70446","DOIUrl":"10.1002/jmri.70446","url":null,"abstract":"","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":"1422-1423"},"PeriodicalIF":4.3,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148471091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrashort Echo Time Magnetization Transfer MRI for Cortical Bone Collagen Assessment and Its Association With Mineralization in Type 1 Diabetes.","authors":"Minzhi Pei, Chuanyun Jiang, Weiyin Vivian Liu, Kejun Wang, Michael Carl, Yufan Gao, Yunfei Zha","doi":"10.1002/jmri.70457","DOIUrl":"https://doi.org/10.1002/jmri.70457","url":null,"abstract":"<p><strong>Background: </strong>Type 1 diabetes mellitus (T1DM) increases fracture risk beyond bone mineral density (BMD), implicating matrix quality. Whether ultrashort echo time magnetization transfer (UTE-MT) MRI can track collagen alterations in T1DM and their associations with mineralization is unknown.</p><p><strong>Purpose: </strong>To evaluate UTE-MT-derived magnetization transfer ratio (MTR) for monitoring in vivo cortical collagen alterations in T1DM and to investigate its associations with mineralization and multiscale bone properties.</p><p><strong>Study type: </strong>Longitudinal animal model.</p><p><strong>Animal model: </strong>18 male New Zealand white rabbits (Age: 5-6 months) randomized to diabetic (n = 12) and control (n = 6) groups.</p><p><strong>Field strength/sequence: </strong>3 T/3D gradient-echo UTE-MT sequence.</p><p><strong>Assessment: </strong>UTE-MT MRI was performed at baseline (week 0) and weeks 12, 16, and 20 post-alloxan induction. Cortical MTR was calculated from paired MT-on/off images and quantified over cortical regions of interest. Reference measurements at the terminal time point (week 20) included micro-CT (cortical porosity [CtPo]), histomorphometry (mineral apposition rate [MAR], bone formation rate [BFR/BS]), fourier transform infrared spectroscopy (FT-IR) (collagen cross-linking), liquid chromatography-tandem mass spectrometry (LC-MS/MS) (hydroxyproline [Hyp]), histology (collagen maturation), and mechanical testing.</p><p><strong>Statistical tests: </strong>The t-tests/Mann-Whitney U for endpoint cross-sectional comparisons, linear mixed-effects model for longitudinal MTR, Pearson correlations (r) for associations; p < 0.05 was considered significant.</p><p><strong>Results: </strong>Cortical MTR declined in T1DM rabbits, becoming significantly lower than controls at week 12 and lowest at week 20. At termination, T1DM group demonstrated significantly higher CtPo (1.345 ± 0.270% vs. 0.591 ± 0.233%), elevated NE-xLR, reduced MAR, BFR/BS, Hyp, ECR, and collagen maturation (1.705 ± 0.548 vs. 5.474 ± 1.455). Mechanical properties (elastic modulus [E], yield strength [YS], toughness) were significantly lower in the T1DM group, with reductions of 44.1%, 35.2%, and 63.2% relative to controls, respectively. MTR at week 20 correlated positively with Hyp, ECR, collagen maturation, mineralization, and mechanical parameters (r = 0.562 to 0.900), and negatively with NE-xLR via partial correlation (r = -0.616) and CtPo (r = -0.826).</p><p><strong>Data conclusions: </strong>UTE-MT-derived MTR enables in vivo tracking of cortical collagen dynamics in T1DM.</p><p><strong>Evidence level: </strong>1.</p><p><strong>Technical efficacy: </strong>Stage 2.</p>","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149182292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Cardiac MRI-Derived Epicardial Adipose Tissue Index With Adverse Clinical Outcomes in Heart Failure With Preserved Ejection Fraction.","authors":"Siying Ma, Lujie Qian, Kaihua Lou, Qiuhui Hu, Xi Hu, Feidan Yu, Lingjie Zhang, Qi Wang, Yiyuan Gao, Hongjie Hu","doi":"10.1002/jmri.70554","DOIUrl":"https://doi.org/10.1002/jmri.70554","url":null,"abstract":"<p><strong>Background: </strong>The clinical relevance of the epicardial adipose tissue index (EATI) is increasingly recognized, but its association with clinical outcomes in patients with heart failure with preserved ejection fraction (HFpEF) remains inadequately investigated.</p><p><strong>Purpose: </strong>To evaluate the association between cardiac MRI-derived EATI and major adverse cardiovascular events (MACE) in patients with HFpEF.</p><p><strong>Study type: </strong>Retrospective.</p><p><strong>Population: </strong>Two hundred sixty-five patients with HFpEF (135 male; mean age 55 years).</p><p><strong>Field strength/sequence: </strong>1.5 T/balanced steady-state free precession.</p><p><strong>Assessment: </strong>EATI was quantified on cardiac MRI cine images. MACE was defined as cardiac death or readmission for heart failure.</p><p><strong>Statistical tests: </strong>Welch t-test or Mann-Whitney U test, Cox proportional hazards regression, Kaplan-Meier analysis with log-rank test, and global χ² model comparison. A p value < 0.05 was considered significant.</p><p><strong>Results: </strong>During a median follow-up of 33 months (22-65), 42 patients experienced MACE. EATI was significantly higher in the MACE group than in the no-MACE group (33.65 ± 13.91 vs. 26.13 ± 11.28 mL/m², Z = -3.52, effect size r = -0.22). EATI was independently associated with MACE (multivariable HR = 1.04 [95% CI: 1.01-1.06]). Kaplan-Meier survival analysis confirmed that patients with low EATI had significantly higher event-free survival rate. A model combining EATI with other clinical and conventional imaging risk factors (χ² = 42.3) showed significantly improved model discrimination for identifying patients at risk of MACE compared with models with clinical variables (χ² = 26.0) or clinical and conventional imaging variables (χ² = 34.3).</p><p><strong>Data conclusion: </strong>Cardiac MRI-derived EATI was independently associated with MACE in patients with HFpEF and showed favorable discriminatory performance compared with clinical and conventional imaging risk factors.</p><p><strong>Evidence level: </strong>3.</p><p><strong>Technical efficacy: </strong>Stage 5.</p>","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149181731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MRI of Total Hip Arthroplasty: Successful Ripple Artifact Reduction Using Wavelet Domain Filtering","authors":"Jeanette C. Deck,&nbsp;Sophia S. Goller,&nbsp;Georg W. Kajdi,&nbsp;Adrian A. Marth,&nbsp;Patrick Zingg,&nbsp;Constantin von Deuster,&nbsp;Reto Sutter","doi":"10.1002/jmri.70448","DOIUrl":"10.1002/jmri.70448","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Slice encoding for metal artifact correction (SEMAC) is used in MRI for total hip arthroplasties for metal artifact reduction. However, ripple artifacts often arise near the implant, impairing diagnosis in affected regions.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Hypothesis&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Applying a wavelet domain filter (WD-Filter) might reduce ripple artifacts and improve image quality.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Study Type&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Retrospective.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Subjects&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;100 patients with primary total hip arthroplasty (female: 51, mean age: (64 ± 13) years; male: 49, mean age: (65 ± 13) years) who underwent clinically indicated MRI using compressed sensing SEMAC.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Field Strength/Sequences&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;1.5 T; compressed sensing-accelerated turbo spin-echo (TSE)-based SEMAC sequence.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Assessment&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Three readers rated 250 ripple artifacts before and after applying the WD-filter. 4-point Likert scales were used for the intensity of ripple artifacts (Likert-RA, “none”: 1, “mild”: 2, “moderate”: 3, “severe”: 4) and the image quality (Likert-IQ, “poor”: 1, “moderate”: 2, “good”: 3, “excellent”: 4). The relative reduction of the signal intensity standard deviation (&lt;span&gt;&lt;/span&gt;&lt;math&gt;\u0000 &lt;semantics&gt;\u0000 &lt;mrow&gt;\u0000 &lt;mi&gt;Δ&lt;/mi&gt;\u0000 &lt;mi&gt;S&lt;/mi&gt;\u0000 &lt;msub&gt;\u0000 &lt;mi&gt;D&lt;/mi&gt;\u0000 &lt;mi&gt;ROI&lt;/mi&gt;\u0000 &lt;/msub&gt;\u0000 &lt;/mrow&gt;\u0000 &lt;/semantics&gt;&lt;/math&gt;) was measured in a region of interest (ROI) containing the ripple artifact.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Statistical Tests&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Inter-reader agreement was assessed with Fleiss' kappa, with 95% confidence intervals. Differences between pre- and post-filter ratings (Likert-RA and Likert-IQ) were evaluated using the Wilcoxon signed-rank test, while &lt;span&gt;&lt;/span&gt;&lt;math&gt;\u0000 &lt;semantics&gt;\u0000 &lt;mrow&gt;\u0000 &lt;mi&gt;Δ&lt;/mi&gt;\u0000 &lt;mi&gt;S&lt;/mi&gt;\u0000 &lt;msub&gt;\u0000 &lt;mi&gt;D&lt;/mi&gt;\u0000 ","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":"64 5","pages":"1326-1336"},"PeriodicalIF":4.3,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jmri.70448","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148421680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial for \"Association of Cardiac MRI-Derived Epicardial Adipose Tissue Index With Adverse Clinical Outcomes in Heart Failure With Preserved Ejection Fraction\".","authors":"Han Jia, Yinsu Zhu","doi":"10.1002/jmri.70556","DOIUrl":"https://doi.org/10.1002/jmri.70556","url":null,"abstract":"","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149181855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Deep Gray Matter Iron Deposition Dysregulation and Cognitive Performance in Type 2 Diabetes Mellitus Patients: A Quantitative Susceptibility Mapping Study","authors":"Kun Wang,&nbsp;Jiahe Wang,&nbsp;Ziyu Diao,&nbsp;Xin Tan,&nbsp;Shijun Qiu,&nbsp;Jie An","doi":"10.1002/jmri.70432","DOIUrl":"10.1002/jmri.70432","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Type 2 diabetes (T2DM) heightens cognitive impairment risk, yet the mechanisms remain unclear. Hyperglycemia-induced iron dysregulation in deep gray matter (DGM) nuclei may be a crucial mechanism.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Purpose&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;To investigate DGM iron deposition in T2DM using Quantitative Susceptibility Mapping (QSM) and determine its association with cognitive function.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Study Type&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Prospective.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Population&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;One hundred and fifteen T2DM patients (59.13% male, 53.04 ± 10.12 years) and 176 healthy controls (29.55% male, 50.18 ± 9.41 years).&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Field Strength/Sequence&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;3 T; 3D T1-weighted and 3D multi-echo gradient-echo sequences.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Assessment&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The magnetic susceptibility of eight bilateral DGM nuclei was quantitatively assessed via QSM. Comprehensive evaluations were conducted for all participants, covering demographic and clinical characteristics, and a battery of multidimensional neuropsychological tests.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Statistical Tests&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Group differences in DGM magnetic susceptibility were assessed using two-sample &lt;i&gt;t&lt;/i&gt;-tests. Partial correlation and multiple linear regression analyses were performed to examine associations between regional susceptibility and both cognitive and clinical variables. Mediation and moderation analyses were conducted to examine the relationships between various clinical factors, DGM susceptibility, and cognitive function. A corrected &lt;i&gt;p&lt;/i&gt; &lt; 0.05 was considered statistically significant.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;T2DM patients showed significantly increased magnetic susceptibility in the thalamus, putamen, substantia nigra, and right red nucleus, while the caudate nucleus showed reduced susceptibility. Iron content in the caudate nucleus positively correlated with MoCA (&lt;i&gt;r&lt;/i&gt; = 0.193) and CDT (&lt;i&gt;r&lt;/i&gt; = 0.196), whereas putamen iron deposition negatively correlated with AVLT-immediate (&lt;i&gt;r&lt;/i&gt; = −0.211) and AVLT-delay (&lt;i&gt;r&lt;/i&gt; = −0.187) and positively correlated with G","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":"64 5","pages":"1295-1308"},"PeriodicalIF":4.3,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jmri.70432","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148375948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}