Journal of Magnetic Resonance Imaging最新文献

{"title":"Saturation-Transfer-Based MRI of the Brain in Multiple Sclerosis Patients at 3T.","authors":"Ziyan Wang, Yingying Lin, Peng Cao, Pei Cai, Jiawen Wang, Huabin Zhang, Shihao Zeng, Chi Yan Lee, Chia-Wei Lee, Elaine Y P Lee, Kyongtae T Bae, Henry K F Mak, Kannie W Y Chan, Koon Ho Chan, Jianpan Huang","doi":"10.1002/jmri.70147","DOIUrl":"https://doi.org/10.1002/jmri.70147","url":null,"abstract":"<p><strong>Background: </strong>Multiple sclerosis (MS) is an autoimmune demyelinating disease that attacks myelin. MRI is an important imaging modality for diagnosis and monitoring in MS. However, the current standard MRI protocol for MS lacks sequences capable of detecting molecular changes.</p><p><strong>Purpose: </strong>To present a saturation-transfer-based MRI protocol, including chemical exchange saturation transfer (CEST) and magnetization transfer indirect spin labeling (MISL) sequences, for quantifying molecular changes and water exchange in the brain of MS patients.</p><p><strong>Study type: </strong>Prospective.</p><p><strong>Population: </strong>Fifty-two participants including 31 healthy controls (HC) (18 females and 13 males) and 21 MS patients (18 females and 3 males).</p><p><strong>Field strength/sequence: </strong>3D inversion-prepared gradient echo T1w, 3D fast spin echo T2w, 3D CUBE CEST and MISL at 3.0 T.</p><p><strong>Assessment: </strong>Multiple CEST contrasts between HC and MS groups were analyzed using double-step multi-pool Lorentzian fitting (DMPLF) and Lorentzian difference analysis (LDA) to evaluate and compare their diagnostic performance. MISL signals at -20 and -10 ppm were quantified by the normalized signal reduction in cerebrospinal fluid (CSF). T1w MRI was used to quantify brain volumes.</p><p><strong>Statistical tests: </strong>Unpaired Student's t-test, receiver operating characteristic (ROC) curve, area under the curve (AUC), and binary logistic regression analysis. p < 0.05 was considered statistically significant.</p><p><strong>Results: </strong>CEST detected decreased signals in the brain of MS patients using both DMPLF and LDA, with DMPLF demonstrating superior performance in differentiating MS from HC (AUC, 0.93; 95% CI: 0.86, 1.00). MS patients showed significantly lower whole brain MISL signals than HCs at both -20 ppm (0.04 ± 0.01 vs. 0.06 ± 0.02) and -10 ppm (0.06 ± 0.02 vs. 0.08 ± 0.02). MS patients showed a significant decrease (-6.57%) in brain tissue and an increase (+20.73%) in CSF volume ratios compared to HCs.</p><p><strong>Data conclusion: </strong>The saturation-transfer-based MRI framework can effectively evaluate molecular changes and CSF-tissue water exchange in the brains of MS patients.</p><p><strong>Evidence level: </strong>2.</p><p><strong>Technical efficacy: </strong>Stage 3.</p>","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145280382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reference Ranges for Cardiac Magnetic Resonance-Derived Atrioventricular Plane Displacement in Healthy Han Chinese Adults.","authors":"Bin Zhang, Fenghai Liu, Guoce Li, Jing Liang, Fan Yang, Li Zhang, Yazhen Zhao, Di Liu, Lan Zhang, Liqing Kang","doi":"10.1002/jmri.70146","DOIUrl":"https://doi.org/10.1002/jmri.70146","url":null,"abstract":"<p><strong>Background: </strong>Atrioventricular plane displacement (AVPD) and cardiac valve plane displacement (CVPD) are dominant contributors to the longitudinal component of ventricular pump function and vary with age; however, reference values are not available for Han Chinese adults.</p><p><strong>Purpose: </strong>To establish reference ranges for AVPD in healthy Han Chinese adult volunteers using cardiac magnetic resonance (MR).</p><p><strong>Study type: </strong>Prospective, single-center study.</p><p><strong>Population: </strong>Two hundred healthy adult volunteers (45.0 ± 14.5 years; 49.5% male) were recruited between May and July 2024.</p><p><strong>Field strength/sequence: </strong>3.0 Tesla MR imaging; steady-state free precession (SSFP).</p><p><strong>Assessment: </strong>All participants underwent 3.0 Tesla cardiac MR during breath-holding at end-expiration. AVPD for the left ventricle (LVAVPD) and right ventricle (RVAVPD) was quantified using three long-axis cine images with manually inputted points. LVAVPD (average (_avg), anterior (_ant), inferior (_inf), anterior-septal (_ant-sep), inferior-lateral (_inf-lat), inferior-septal (_inf-sep), anterior-lateral (_ant-lat)), as well as RVAVPD (average (_avg), right ventricular outflow tract (_rvot), and lateral (_lat)), were recorded.</p><p><strong>Statistical tests: </strong>Descriptive statistics; analysis of variance for age groups; multivariate linear regression; significance was set at p < 0.05.</p><p><strong>Results: </strong>Mean values were: LVAVPD_avg, 14.0 ± 1.5 mm; LVAVPD_ant, 12.5 ± 1.7 mm; LVAVPD_inf, 15.7 ± 2.1 mm; LVAVPD_ant-sep, 12.4 ± 2.0 mm; LVAVPD_inf-lat, 15.6 ± 2.3 mm; LVAVPD_inf-sep, 13.0 ± 1.9 mm; LVAVPD_ant-lat, 14.8 ± 2.0 mm; RVAVPD_avg, 18.7 ± 2.3 mm; RVAVPD_rvot, 20.7 ± 3.4 mm; RVAVPD_lat, 22.6 ± 3.0 mm. No significant sex differences were observed; however, significant differences were noted across the age groups (G_<45, G_45-60, and G_>60). Multivariate linear regression analysis identified age, end-diastolic volume (EDV), and end-diastolic volume index (EDVi) as significant independent determinants of AVPD.</p><p><strong>Data conclusion: </strong>This study presents both LVAVPD and RVAVPD reference ranges in healthy Han Chinese adults and demonstrates age-related changes and correlations with EDV, stroke volume (SV), and ejection fraction (EF). These findings support the clinical utility of AVPD in myocardial function assessment.</p><p><strong>Evidence level: </strong>N/A.</p><p><strong>Technical efficacy: </strong>Stage 1.</p>","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145274780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative MRI Values for Atrial and Ventricular Parameters in Altitude-Dwelling Youth.","authors":"Xiumei Xiao, Hui Xu","doi":"10.1002/jmri.70132","DOIUrl":"https://doi.org/10.1002/jmri.70132","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;The hypoxic environment on the Qinghai Plateau significantly exacerbates myocardial remodeling, with sex/ethnicity-specific variations in cardiac parameters among local youth. Current cardiac MRI reference values lack data from physiologically adapted populations on this plateau.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Purpose: &lt;/strong&gt;To establish sex- and ethnicity-specific normative reference values for cardiac structure and function in native Qinghai Plateau young adults and to analyze their correlations.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Study type: &lt;/strong&gt;Prospective.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Subjects: &lt;/strong&gt;101 healthy young volunteers (15-24 years) residing on the Qinghai Plateau, including 44 males and 57 females; 37 Han people (20 males and 17 females), 20 Tibetan people (3 males and 17 females); the remaining 44 people are from the Hui, Tu, Salar, and Mongolian ethnic groups.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Field strength/sequence: &lt;/strong&gt;Steady state free precession cine sequence at 3.0 T.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Assessment: &lt;/strong&gt;Circle CVI42 software was used to quantify cardiac chamber structural and functional parameters from cine images. All parameters were normalized to body surface area (BSA).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Statistical tests: &lt;/strong&gt;Sex- and ethnicity-specific reference ranges were defined as mean ± 1.96 SD. Sex/ethnicity group comparisons were assessed with independent samples t-tests. Correlations between parameters were visualized through correlation heatmaps. A p value &lt; 0.05 was considered significant.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Compared to females, males exhibited significantly larger cardiac parameters, including left atrial (LA) and right atrial (RA) diameters (p &lt; 0.05). In the four-chamber view, the left atrial area was larger in males (end-systolic 1688.57 ± 326.75 vs. 1562.68 ± 238.01 mm&lt;sup&gt;2&lt;/sup&gt;, p &lt; 0.05; end-diastolic 1178.18 ± 268.09 vs. 1018.81 ± 201.04 mm&lt;sup&gt;2&lt;/sup&gt;, p &lt; 0.05). The right atrial area was larger in males (end-systolic 1835.86 ± 360.73 vs. 1567.98 ± 276.84 mm&lt;sup&gt;2&lt;/sup&gt;, p &lt; 0.05; end-diastolic 1387.75 ± 319.39 vs. 1106.09 ± 228.78 mm&lt;sup&gt;2&lt;/sup&gt;, p &lt; 0.05). Males also had significantly higher left ventricular end-diastolic volume (LVEDV), left ventricular end-systolic volume (LVESV), stroke volume (LVSV), cardiac output (LVCO), and left ventricular mass (LVM) (p &lt; 0.05). After body surface area (BSA) normalization, males still had higher LVEDVi and LVESVi, while no significant difference was found in left ventricular ejection fraction (LVEF) (p = 0.334). Regarding ethnicity, there were no significant differences between Han and Tibetan participants in left ventricular volumes or systolic function (p &gt; 0.05), but Han individuals had significantly higher left ventricular mass and mass index (LVM 93.37 ± 15.82 vs. 63.72 ± 11.97 g, p &lt; 0.05; LVMI 44.60 ± 7.71 vs. 38.89 ± 4.72 g/m&lt;sup&gt;2&lt;/sup&gt;, p &lt; 0.05). Correlation heatmaps showed significant positive correlations (p &lt; 0.05) between body size (height, weight, BSA, BMI) and heart","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145251392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating Measurement Stability in Glioblastomas Using Magnetic Resonance Elastography: Repeatability and Interobserver Agreement.","authors":"Ancuta I Friismose, Jan S Aunan-Diop, Michael Pedersen, Rikke H Dahlrot, Frederik S G Harbo, Janni Jensen, Richard L Ehman, John Huston, Emi Hojo, Frantz R Poulsen, Ole Graumann, Bo Mussmann","doi":"10.1002/jmri.70145","DOIUrl":"https://doi.org/10.1002/jmri.70145","url":null,"abstract":"<p><strong>Background: </strong>Magnetic resonance elastography (MRE) has demonstrated potential in characterizing intracranial tumors, including glioblastoma. The influence of pathology on measurement consistency and interobserver agreement needs evaluation to promote MRE implementation as a quantitative biomarker.</p><p><strong>Purpose: </strong>To assess repeatability and interobserver agreement of absolute and normalized magnitude of the complex shear modulus (|G*|), storage modulus (G'), and loss modulus (G″) in glioblastoma.</p><p><strong>Study type: </strong>Prospective.</p><p><strong>Population: </strong>Thirteen adults (5 male, 8 female, mean age 66.23 years) with histopathologically confirmed glioblastoma.</p><p><strong>Field strength/sequence: </strong>3 T MRI, modified single-shot spin-echo echo-planar imaging.</p><p><strong>Assessment: </strong>Two same-session MRE acquisitions were performed with patient repositioning. The solid tumor component was independently segmented by 2 observers on contrast-enhanced T1-weighted images co-registered to MRE maps.</p><p><strong>Statistical tests: </strong>Repeatability was assessed using the repeatability coefficient, coefficient of variation, and Bland-Altman plots, and interobserver agreement by the intraclass correlation coefficient. The Wilcoxon signed-rank test compared parameters and coefficients of variation between tumor-normal-appearing white matter and absolute and normalized measurements. Significance was set at 0.05.</p><p><strong>Results: </strong>Tumor |G*| and G' showed repeatability coefficients of 0.07-0.08 kPa and 0.05 kPa, compared with 0.13 kPa (|G*|) and 0.15-0.16 kPa (G') for normalized measurements. Coefficients of variation in tumor regions were 1.42% ± 1.12%-1.60% ± 1.41% for |G*| and 1.19% ± 0.96%-2.08% ± 2.22% for G', significantly lower than normalized values (4.82% ± 4.49%-4.21% ± 4.27% for |G*|; 5.12% ± 5.04%-5.45% ± 4.53% for G'). Tumor |G*| and G' showed excellent interobserver agreement (intraclass correlation coefficients 0.97 and 0.95). Tumor G″ demonstrated higher variability than |G*| and G' (coefficients of variation 8.58% ± 7.69%-7.51% ± 6.73%), with no significant difference between absolute and normalized measurements (p = 0.14).</p><p><strong>Data conclusion: </strong>Tumor |G*| and G' are the most repeatable metrics in glioblastoma. Normalization reduces measurement repeatability due to normal-appearing white matter variability. The small sample size (n = 13) limits generalizability.</p><p><strong>Evidence level: </strong>2.</p><p><strong>Technical efficacy: </strong>Stage 2.</p>","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145251112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Intraocular Pressure Using Three-Dimensional MR Elastography in Ophthalmologically Normal Individuals","authors":"Zheng Gai,&nbsp;Yu Zeng,&nbsp;Juncheng Liang,&nbsp;Chen Zhang,&nbsp;Qijun Wu,&nbsp;Guangrui Chai,&nbsp;Yu Shi","doi":"10.1002/jmri.70135","DOIUrl":"https://doi.org/10.1002/jmri.70135","url":null,"abstract":"<p>Representative wave images of the <i>x</i>, <i>y</i>, and <i>z</i> components of the vector displacement field as well as elastograms at 90 Hz from four subjects. The intraocular pressure by Goldmann applanation tonometry and the stiffness of the anterior segment were 11 mmHg/2.22 kPa (right) and 10 mmHg/2.05 kPa (left) in the first subject; 14 mmHg/2.62 kPa (right) and 14 mmHg/2.60 kPa (left) in the second subject; 17 mmHg/3.22 kPa (right) and 17 mmHg/2.91 kPa (left) in the third subject; 17.3 mmHg/3.22 kPa (right) and 14.3 mmHg/2.57 kPa (left) in the fourth subject. The dashed lines overlaid on the wave images and elastograms represent the anterior segment and whole eye regions of interest. By Gai et al. (1483–1493)\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </p>","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":"62 5","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jmri.70135","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145243019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial for \"Use of Blood Oxygenation Level-Dependent MRI to Predict Clinical Outcomes After Endovascular Revascularization in Peripheral Artery Disease\".","authors":"Xinheng Zhang, Yuheng Huang, Hsin-Jung Yang","doi":"10.1002/jmri.70123","DOIUrl":"https://doi.org/10.1002/jmri.70123","url":null,"abstract":"","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145251161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety of MRI Examinations Under Sedation: A Nationwide Survey in Japan.","authors":"Shiori Amemiya, Masako Kataoka, Tsukasa Doi, Toshinori Hirai, Takayuki Obata, Kagayaki Kuroda","doi":"10.1002/jmri.70149","DOIUrl":"https://doi.org/10.1002/jmri.70149","url":null,"abstract":"<p><strong>Background: </strong>MRI is performed under sedation for patients requiring immobility or for those already sedated for clinical management. Although specialist guidelines advocate for anesthesiologist-led care, non-anesthesiologist-led adult sedation is a common practice worldwide. Furthermore, the increase in risk attributable to sedation has not been quantified.</p><p><strong>Purpose: </strong>To investigate MRI sedation practices in Japan to quantify associated risks and to identify key safety vulnerabilities.</p><p><strong>Study type: </strong>Survey.</p><p><strong>Subjects: </strong>Data were collected from 549 Japanese medical institutions.</p><p><strong>Assessment: </strong>A web-based questionnaire was distributed to members of major Japanese radiological societies to assess institutional policies, sedation management practices, safety measures, and historical adverse events. The survey primarily concerned deep sedation and general anesthesia in adults but also encompassed questions on minimal-to-moderate sedation and pediatric sedation.</p><p><strong>Statistical tests: </strong>Chi-squared test, Welch's t-test, Fisher's exact test were used. Odds ratios (ORs) were calculated based on the cumulative number of adverse events over 2 years to examine the increased risk from sedation. p < 0.05 was considered significant.</p><p><strong>Results: </strong>Adult MRI sedation management is typically led by attending physicians (84%) with limited consultation from anesthesiologists for sedation (9.0%) or radiologists for scan indication (5.1%). Safety infrastructure was often inadequate, with MRI-compatible ventilators (48%) or syringe pumps (29%) and capnometers (24%). In an analysis combining both pediatric and adult data, the ORs for the total sedated group versus non-sedated group were 62 (95% confidence interval, 54-73) for peripheral capillary oxygen saturation drop, 48 (32-72) for respiratory arrest, 15 (8.0-28) for cardiac arrest, 6.7 (2.0-23) for physical trauma, and 8.9 (4.0-20) for projectile accidents.</p><p><strong>Data conclusion: </strong>MRI examinations under sedation are associated with a substantially higher risk of adverse events. Developing and implementing a standardized protocol may mitigate these procedural risks.</p><p><strong>Level of evidence: 4: </strong></p><p><strong>Stage of technical efficacy: </strong>5.</p>","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145251337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing Quality and Adherence to PI-RADSv2.1 Minimum Technical Standards of Prostate MRI in NRG-GU005.","authors":"Stephanie Alley, Marion Tonneau, Damien Olivié, Clare M Tempany-Afdhal, Peter L Choyke, I Baris Turkbey, Uulke A van der Heide, Rodney J Ellis, Samuel Kadoury, Thomas P Boike, J Daniel Pennington, Arthur Frazier, Colleen A F Lawton, Nelson Leong, Alina M Mihai, Scott C Morgan, Abhishek A Solanki, Jeff M Michalski, Felix Y Feng, Howard M Sandler, Cynthia Menard","doi":"10.1002/jmri.70142","DOIUrl":"https://doi.org/10.1002/jmri.70142","url":null,"abstract":"<p><strong>Background: </strong>Multi-parametric MRI (mpMRI) datasets often vary between sites due to differences in acquisition protocols.</p><p><strong>Purpose: </strong>Evaluate adherence of multi-site mpMRI dataset to minimum technical standards (MTS) of PI-RADSv2.1.</p><p><strong>Study type: </strong>Prospective.</p><p><strong>Subjects: </strong>Six hundred patients (Age (years): ≤ 49 = 0.8%, 50-59 = 10.7%, 60-69 = 47.0%, ≥ 70 = 41.5%) with intermediate-risk prostate cancer (PCa) imaged across 124 institutions prior to radiotherapy.</p><p><strong>Field strength/sequence: </strong>3T, 1.5T, and 1.16T, T2-weighted (T2w): fast spin-echo, diffusion-weighted imaging (DWI): single-shot echo-planar imaging, and dynamic contrast-enhanced (DCE): T1-weighted 3D fast spoiled gradient echo.</p><p><strong>Assessment: </strong>Scanner vendors included Siemens, GE, Philips, Toshiba, and Hitachi. Degree of adherence to PIRADSv2.1 was determined as the proportion of datasets that met MTS. Mean and standard deviation of parameter values were calculated where applicable. Prostate imaging quality (PI-QUAL)v2 scores were assigned by one of three observers in 491 datasets. Evaluation of DICOM metadata consistency was performed.</p><p><strong>Statistical tests: </strong>Fisher's exact test to assess changes in MTS adherence over time and by field strength; Harrel's C-index to compare MTS adherence to PI-QUAL score. A p value of < 0.001 is considered statistically significant after Bonferroni correction.</p><p><strong>Results: </strong>Eighty-two percent of MTS showed greater than 75% adherence. Low adherence was found in the in-plane dimension (frequency-encoding direction) for T2w images (57%, mean = 0.45 ± 0.16 mm) and field of view (FOV) for DW images (62%, mean = 22.67 ± 4.70 cm). Only 50% of datasets used the recommended high b value image to compute the apparent diffusion coefficient map. Adherence improved significantly over time for one T2w and two DWI parameters; the adherence of FOV improved significantly at 3T for T2w and DWI sequences. C-index values for two T2w and two DWI parameters demonstrated a relationship between PI-RADS MTS and PI-QUAL score. Ten percent of anonymized datasets were stripped of some sequence information.</p><p><strong>Data conclusion: </strong>Results show promise for mpMRI standardization in characterization of PCa and identify key parameters that remain variable across datasets and institutions.</p><p><strong>Evidence level: </strong>1.</p><p><strong>Technical efficacy: </strong>Stage 2.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov: NCT03367702.</p>","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145251683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Young Investigator Awards Winners","authors":"","doi":"10.1002/jmri.70036","DOIUrl":"https://doi.org/10.1002/jmri.70036","url":null,"abstract":"","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":"62 5","pages":"1513-1515"},"PeriodicalIF":3.5,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145243020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of Large Language Models in TN Staging and Treatment Response Evaluation for Patients With Nasopharyngeal Carcinoma: A Comparative Performance Analysis of ChatGPT-4o-Latest and DeepSeek-V3-0324.","authors":"Yifan Yang, Fan Yang, Shengsheng Xiao, Kaiqi Hou, Kexin Chen, Zaiyi Liu, Changhong Liang, Xiaobo Chen, Guangyi Wang","doi":"10.1002/jmri.70140","DOIUrl":"https://doi.org/10.1002/jmri.70140","url":null,"abstract":"<p><strong>Background: </strong>Accurate tumor staging and treatment response evaluation (TRE) are critical for nasopharyngeal carcinoma (NPC) clinical decisions. Conventional methods relying on manual imaging analysis are expertise-dependent, time-consuming, and prone to inter-observer variability and errors.</p><p><strong>Purpose: </strong>To assess the performance of two large language models (LLMs): ChatGPT-4o-latest and DeepSeek-V3-0324 in automating T, N staging and TRE for NPC patients.</p><p><strong>Study type: </strong>Retrospective.</p><p><strong>Population: </strong>Three hundred seven NPC patients from three centers (mean age: 45.5 ± 11.3 years; 216 men, 91 women).</p><p><strong>Field strength/sequence: </strong>All imaging was conducted using 3.0T or 1.5T scanners. The imaging sequence included axial T1-weighted fast spin-echo, T2-weighted fast spin-echo, T2-weighted fat-suppressed spin-echo, and Contrast-Enhanced T1-weighted fast spin-echo.</p><p><strong>Assessment: </strong>Two radiologists established the reference standards for TN staging at baseline and for TRE at two time points: post-induction chemotherapy (TRE-1) and post-concurrent chemoradiotherapy (TRE-2), based on the 9th version of AJCC/UICC guidelines and the RECIST1.1 criteria. LLMs were via few-shot chain-of-thought prompting and tested on 277 patients with 831 reports. Additionally, four radiologists independently assessed 68 cases both with and without the assistance of LLMs and compared the performance and efficiency in both conditions.</p><p><strong>Statistical tests: </strong>McNemar-Bowker test, Wilcoxon signed-rank test. p < 0.05 was considered statistically significant.</p><p><strong>Results: </strong>DeepSeek-V3-0324 significantly outperformed GPT-4o-latest in TRE-1 staging (96.5% vs. 82.9%, p < 0.001). For T staging (95.3% vs. 93.5%, p = 0.24), N staging (93.8% vs. 89.6%, p = 0.265), and TRE-2 (94.9% vs. 93.2%, p = 0.556), the accuracy between DeepSeek-V3-0324 and ChatGPT-4o-latest showed no significant difference. DeepSeek-V3-0324 also showed stronger agreement with expert annotation (κ = 0.85-0.90), compared to ChatGPT-4o-latest (κ = 0.49-0.86). Significant improvements in time efficiency were observed across all radiologists with LLM assistance (p < 0.001).</p><p><strong>Data conclusion: </strong>LLMs, particularly DeepSeek-V3-0324, can automate NPC TN staging and TRE with high accuracy, enhancing clinical efficiency. LLMs integration may improve diagnostic consistency, especially for junior clinicians.</p><p><strong>Level of evidence: 3: </strong></p><p><strong>Technical efficacy: </strong>Stage 4.</p>","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145225442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}