Journal of Magnetic Resonance Imaging最新文献

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Evolving Myocardial Injury in Chronic Kidney Disease Assessed by Multiparameter Magnetic Resonance in a Rabbit Model.
IF 3.3 2区 医学
Journal of Magnetic Resonance Imaging Pub Date : 2025-03-20 DOI: 10.1002/jmri.29768
Shiqi Jin, Fan Wang, Huaibi Huo, Zhaoxin Tian, Shutong Liu, Ting Liu
{"title":"Evolving Myocardial Injury in Chronic Kidney Disease Assessed by Multiparameter Magnetic Resonance in a Rabbit Model.","authors":"Shiqi Jin, Fan Wang, Huaibi Huo, Zhaoxin Tian, Shutong Liu, Ting Liu","doi":"10.1002/jmri.29768","DOIUrl":"https://doi.org/10.1002/jmri.29768","url":null,"abstract":"<p><strong>Background: </strong>Early diagnosis and monitoring of chronic kidney disease (CKD)-related myocardial injury are crucial for improving outcomes.</p><p><strong>Purpose: </strong>To evaluate myocardial tissue characteristics and deformation during the occurrence and evolution of CKD in a rabbit model using multiparametric cardiac MRI.</p><p><strong>Study type: </strong>Longitudinal animal study.</p><p><strong>Population: </strong>A total of 26 rabbits (14 undergoing cationic bovine serum albumin (C-BSA) injection to induce CKD, 12 undergoing sham saline injection to serve as controls).</p><p><strong>Field strength/sequence: </strong>3, cine, T1 mapping, and T2 mapping sequences.</p><p><strong>Assessment: </strong>Cardiac MRI was performed at baseline, 4, 6, and 8 weeks in both groups. Global radial, circumferential, and longitudinal strain (GRS, GCS and GLS, respectively), native T1, T2, and extracellular volume (ECV) were assessed at each time point. Collagen volume fraction (CVF) was assessed, and immunohistochemical staining was performed using the IL-6 antibody. Pathology was used as a reference standard for comparison with MRI findings. The diagnostic accuracy of individual and combined MR parameters for detecting early CKD-related myocardial injury was determined.</p><p><strong>Statistical tests: </strong>Descriptive statistics, Spearman correlation (r), area under the receiver operating characteristic curve (AUC). A p-value < 0.05 was considered statistically significant.</p><p><strong>Results: </strong>Compared to controls, GLS was significantly lower, and ECV was significantly higher in the CKD group at 4 weeks post-injection. At 6 and 8 weeks, GLS was further reduced, and native T1, T2, and ECV values were significantly increased in the CKD group compared to controls. Myocardial native T1 and ECV were significantly positively correlated with CVF (r = 0.584 and 0.754, respectively), and T2 was significantly positively correlated with IL-6 (r = 0.661). The combination of native T1 and GLS showed superior diagnostic accuracy for detecting early CKD-related subclinical myocardial injury compared to single indicators (AUC = 0.846, 95% CI: 0.731-0.962).</p><p><strong>Conclusions: </strong>The appropriate combination of cardiac MRI-based features of strain, fibrosis, and inflammation may serve as an early marker of CKD-related myocardial injury.</p><p><strong>Evidence level: </strong>N/A.</p><p><strong>Technical efficacy: </strong>Stage 2.</p>","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143670070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Accelerated Abdominal MRI: A Review of Current Methods and Applications.
IF 3.3 2区 医学
Journal of Magnetic Resonance Imaging Pub Date : 2025-03-18 DOI: 10.1002/jmri.29750
Li Feng, Hersh Chandarana
{"title":"Accelerated Abdominal MRI: A Review of Current Methods and Applications.","authors":"Li Feng, Hersh Chandarana","doi":"10.1002/jmri.29750","DOIUrl":"10.1002/jmri.29750","url":null,"abstract":"<p><p>MRI is widely used for the diagnosis and management of various abdominal diseases involving organs such as the liver, pancreas, and kidneys. However, one major limitation of MRI is its relatively slow imaging speed compared to other modalities. In addition, respiratory motion poses a significant challenge in abdominal MRI, often requiring patients to hold their breath multiple times during an exam. This requirement can be particularly challenging for sick, elderly, and pediatric patients, who may have reduced breath-holding capacity. As a result, rapid imaging plays an important role in routine clinical abdominal MRI exams. Accelerated data acquisition not only reduces overall exam time but also shortens breath-hold durations, thereby improving patient comfort and compliance. Over the past decade, significant advancements in rapid MRI have led to the development of various accelerated imaging techniques for routine clinical use. These methods improve abdominal MRI by enhancing imaging speed, motion compensation, and overall image quality. Integrating these techniques into clinical practice also enables new applications that were previously challenging. This paper provides a concise yet comprehensive overview of rapid imaging techniques applicable to abdominal MRI and discusses their advantages, limitations, and potential clinical applications. By the end of this review, readers are expected to learn the latest advances in accelerated abdominal MRI and explore new frontiers in this evolving field. Evidence Level: N/A Technical Efficacy: Stage 5.</p>","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preoperative Assessment of Ki-67 Labeling Index in Pituitary Adenomas Using Delta-Radiomics Based on Dynamic Contrast-Enhanced MRI.
IF 3.3 2区 医学
Journal of Magnetic Resonance Imaging Pub Date : 2025-03-17 DOI: 10.1002/jmri.29764
Kaiyang Zhao, Chaoyue Chen, Yang Zhang, Zhouyang Huang, Yanjie Zhao, Qiang Yue, Jianguo Xu
{"title":"Preoperative Assessment of Ki-67 Labeling Index in Pituitary Adenomas Using Delta-Radiomics Based on Dynamic Contrast-Enhanced MRI.","authors":"Kaiyang Zhao, Chaoyue Chen, Yang Zhang, Zhouyang Huang, Yanjie Zhao, Qiang Yue, Jianguo Xu","doi":"10.1002/jmri.29764","DOIUrl":"https://doi.org/10.1002/jmri.29764","url":null,"abstract":"<p><strong>Background: </strong>Ki-67 labeling index (Ki-67 LI) is a proliferation marker that is correlated with aggressive behavior and prognosis of pituitary adenomas (PAs). Dynamic contrast-enhanced MRI (DCE-MRI) may potentially contribute to the preoperative assessment of Ki-67 LI.</p><p><strong>Purpose: </strong>To investigate the feasibility of assessing Ki-67 LI of PAs preoperatively using delta-radiomics based on DCE-MRI.</p><p><strong>Study type: </strong>Retrospective.</p><p><strong>Population: </strong>605 PA patients (female = 47.1%, average age = 52.2) from two centers (high Ki-67 LI (≥ 3%) = 229; low Ki-67 LI (< 3%) = 376), divided into a training set (n = 313), an internal validation set (n = 196), and an external validation set (n = 96).</p><p><strong>Field strength/sequence: </strong>1.5-T and 3-T, DCE-MRI.</p><p><strong>Assessment: </strong>This study developed a non-delta-radiomics model based on the non-delta-radiomic features directly extracted from four phases, a delta-radiomics model based on the delta-radiomic features, and a combined model integrating clinical parameters (Knosp grade and tumor diameter) with delta-radiomic features. U test, recursive feature elimination (RFE), and least absolute shrinkage and selection operator (LASSO) regression were utilized to select important radiomic features. Support vector machine (SVM), XGBoost (XGB), logistic regression (LR), and Gaussian naive Bayes (GNB) were utilized to develop the models.</p><p><strong>Statistical tests: </strong>Receiver operating characteristic (ROC) curve. Calibration curve. Decision curve analysis (DCA). Intraclass correlation coefficients (ICC). DeLong test for ROC curves. U test or t test for numerical variables. Fisher's test or Chi-squared test for categorical variables. A p-value < 0.05 was considered statistically significant.</p><p><strong>Results: </strong>The combined model demonstrated the best performance in preoperatively assessing the Ki-67 LI of PAs, achieving AUCs of 0.937 and 0.897 in the internal and external validation sets, respectively. The models based on delta-radiomic features outperformed the non-delta-radiomic model.</p><p><strong>Data conclusion: </strong>A delta-radiomics-based model using DCE-MRI may show high diagnostic performance for preoperatively assessing the Ki-67 LI status of PAs.</p><p><strong>Evidence level: </strong>3 Technical Efficacy: Stage 2.</p>","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Beyond Coronary Artery Lesions, Unmasking Myocardial Abnormalities via Cardiac Magnetic Resonance Imaging in Kawasaki Disease.
IF 3.3 2区 医学
Journal of Magnetic Resonance Imaging Pub Date : 2025-03-12 DOI: 10.1002/jmri.29760
Lingyi Wen, Zhongqin Zhou, Chuan Wang, Shiganmo Azhe, Kaiyu Zhou, Yingkun Guo
{"title":"Beyond Coronary Artery Lesions, Unmasking Myocardial Abnormalities via Cardiac Magnetic Resonance Imaging in Kawasaki Disease.","authors":"Lingyi Wen, Zhongqin Zhou, Chuan Wang, Shiganmo Azhe, Kaiyu Zhou, Yingkun Guo","doi":"10.1002/jmri.29760","DOIUrl":"https://doi.org/10.1002/jmri.29760","url":null,"abstract":"","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial for "Evaluating the Diagnostic Performance of MR Cytometry Imaging in Differentiating Benign and Malignant Breast Tumors".
IF 3.3 2区 医学
Journal of Magnetic Resonance Imaging Pub Date : 2025-03-12 DOI: 10.1002/jmri.29767
Lingzhi Hu, Rong Rong
{"title":"Editorial for \"Evaluating the Diagnostic Performance of MR Cytometry Imaging in Differentiating Benign and Malignant Breast Tumors\".","authors":"Lingzhi Hu, Rong Rong","doi":"10.1002/jmri.29767","DOIUrl":"https://doi.org/10.1002/jmri.29767","url":null,"abstract":"","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Kinetic Energy Measured by 4D Flow Cardiac MRI in Evaluating Intraventricular Hemodynamics: A Systematic Review. 通过 4D 流式心脏 MRI 测量动能以评估室内血流动力学:系统性综述。
IF 3.3 2区 医学
Journal of Magnetic Resonance Imaging Pub Date : 2025-03-12 DOI: 10.1002/jmri.29759
Jing Zhu, Xiaolin Mu, Wenjia Wang, Yang Song
{"title":"Kinetic Energy Measured by 4D Flow Cardiac MRI in Evaluating Intraventricular Hemodynamics: A Systematic Review.","authors":"Jing Zhu, Xiaolin Mu, Wenjia Wang, Yang Song","doi":"10.1002/jmri.29759","DOIUrl":"https://doi.org/10.1002/jmri.29759","url":null,"abstract":"<p><p>Four-dimensional flow cardiovascular magnetic resonance (4D Flow cardiac MRI) is an advanced non-invasive imaging technology, and its derived kinetic energy (KE) blood flow parameters have been confirmed as a potential biomarkers for assessing ventricular hemodynamics. This review synthesizes details on the methodology, clinical significance, and current status of studies focused on quantifying KE parameters of the ventricle using 4D Flow cardiac MRI, providing an objective foundation for further exploration of the value of KE in cardiac diseases.</p><p><strong>Study type: </strong>retrospective.</p><p><strong>Subjects: </strong>This review includes studies that utilized 4D Flow cardiac MRI in human subjects, focusing on the changes in KE parameters. Field Strength: 1.5T or 3T.</p><p><strong>Assessment: </strong>A systematic review was conducted to assess the literature on the intracardiac clinical applications of 4D Flow cardiac MRI. In September 2024, searches were performed in PubMed, Web of Science, SCIENCEDIRECT, and Springer Link databases using the keywords \"4D Flow cardiac MRI,\" \"ventricular kinetic energy,\" and \"intraventricular hemodynamics,\" covering a period of 10 years. The inclusion criteria for the literature were: (1) clinical trials with human subjects; (2) studies that addressed the value of 4D Flow cardiovascular magnetic resonance and its derived blood flow KE parameters in quantifying ventricular blood flow. The exclusion criteria were: (1) animal experimental studies; (2) non-English core journal articles. Out of the 195 articles screened, 62 studies met the criteria for the systematic review. The included literature comprised 26 (41.9%) studies on 4D Flow cardiac MRI technology and blood flow parameter research, and 36 (58.1%) clinical application studies. KE measurement using 4D Flow cardiac MRI is a promising tool for evaluating ventricular hemodynamics. It provides clinicians with deeper insights into the physiological and pathological dynamics of ventricular blood flow, from healthy states to disease.</p>","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reliability of In Vivo Creatine-Weighted Chemical Exchange Saturation Transfer (CrCEST) MRI in Calf Skeletal Muscle of Healthy Volunteers at 3 T
IF 3.3 2区 医学
Journal of Magnetic Resonance Imaging Pub Date : 2025-03-11 DOI: 10.1002/jmri.29762
Kasturee Chakraborty PhD, Ritambhar Burman PhD, Sabah Nisar MSc, Saorla Miller BS, Zachary Loschinskey BS, Shengjie Wu MS, Yimei Li PhD, Asim K. Bag MBBS, MD, Ayaz Khan PhD, Chelsea Goodenough PhD, Neil Wilson PhD, Mohammad Haris PhD, Shana E. McCormack MD, MTR, Ravinder Reddy PhD, Kirsten Ness PT, PhD, Richard Finkel MD, Puneet Bagga PhD
{"title":"Reliability of In Vivo Creatine-Weighted Chemical Exchange Saturation Transfer (CrCEST) MRI in Calf Skeletal Muscle of Healthy Volunteers at 3 T","authors":"Kasturee Chakraborty PhD,&nbsp;Ritambhar Burman PhD,&nbsp;Sabah Nisar MSc,&nbsp;Saorla Miller BS,&nbsp;Zachary Loschinskey BS,&nbsp;Shengjie Wu MS,&nbsp;Yimei Li PhD,&nbsp;Asim K. Bag MBBS, MD,&nbsp;Ayaz Khan PhD,&nbsp;Chelsea Goodenough PhD,&nbsp;Neil Wilson PhD,&nbsp;Mohammad Haris PhD,&nbsp;Shana E. McCormack MD, MTR,&nbsp;Ravinder Reddy PhD,&nbsp;Kirsten Ness PT, PhD,&nbsp;Richard Finkel MD,&nbsp;Puneet Bagga PhD","doi":"10.1002/jmri.29762","DOIUrl":"https://doi.org/10.1002/jmri.29762","url":null,"abstract":"<p>(A) CrCEST<sub>asym</sub> MAPS OF A HUMAN CALF MUSCLE CAPTURED BEFORE AND AT 24-SECOND INTERVALS FOLLOWING 2 MINUTES OF MILD PLANTAR FLEXION EXERCISE (ARRANGED SEQUENTIALLY BY NUMBER). THE ERROR BARS INDICATE THE STANDARD DEVIATION OF CrCEST<sub>asym</sub> WITHIN EACH MUSCLE REGION. THE SEGMENTED ANATOMICAL IMAGE IS SITUATED IN THE LOWER RIGHT CORNER. (B) PLOT ILLUSTRATING THE TEMPORAL VARIATION OF THE MEAN CrCEST<sub>asym</sub> VALUES ACROSS THREE DISTINCT CALF MUSCLES (LG, MG, AND SOL, WHICH WERE DELINEATED FROM ANATOMICAL IMAGES (LOCATED IN THE BOTTOM RIGHT CORNER). SOLID LINES REPRESENT THE SPLINE INTERPOLATION THAT FITS THE DATA POINTS. BY CHAKRABORTY ET AL. (1681-1692)\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </p>","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":"61 4","pages":"spcone"},"PeriodicalIF":3.3,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jmri.29762","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143612381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluating the Diagnostic Performance of MR Cytometry Imaging in Differentiating Benign and Malignant Breast Tumors.
IF 3.3 2区 医学
Journal of Magnetic Resonance Imaging Pub Date : 2025-03-11 DOI: 10.1002/jmri.29757
Fan Liu, Lei Wu, Xinyi Luo, Sisi Li, Yishi Wang, Wen Zhong, Thorsten Feiweier, Junzhong Xu, Diwei Shi, Haihua Bao, Hua Guo
{"title":"Evaluating the Diagnostic Performance of MR Cytometry Imaging in Differentiating Benign and Malignant Breast Tumors.","authors":"Fan Liu, Lei Wu, Xinyi Luo, Sisi Li, Yishi Wang, Wen Zhong, Thorsten Feiweier, Junzhong Xu, Diwei Shi, Haihua Bao, Hua Guo","doi":"10.1002/jmri.29757","DOIUrl":"https://doi.org/10.1002/jmri.29757","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;MR cytometry is a class of diffusion-MRI-based methods that characterize tumor microstructures at the cellular level. It involves multicompartmental biophysical modeling of multi-b and multiple diffusion time data to generate microstructural parameters, which may improve differentiation of benign and malignant breast tumors.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Purpose: &lt;/strong&gt;To implement MR cytometry imaging with transcytolemmal water exchange (JOINT and EXCHANGE) to differentiate benign and malignant breast tumors, and to compare the classification efficacy of IMPULSED, JOINT, and EXCHANGE.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Study type: &lt;/strong&gt;Prospective.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Subjects: &lt;/strong&gt;115 patients with pathologically confirmed breast tumors (25 benign and 90 malignant).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Field strength/sequence: &lt;/strong&gt;3T; pulsed gradient spin-echo (PGSE) diffusion-weighted imaging (DWI) and oscillating gradient spin-echo (OGSE) DWI at 25 and 50 Hz.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Assessment: &lt;/strong&gt;Tumor regions were delineated by two radiologists on DWI. Time-dependent ADC and microstructural parameters (cell diameter &lt;math&gt; &lt;semantics&gt;&lt;mrow&gt;&lt;mi&gt;d&lt;/mi&gt;&lt;/mrow&gt; &lt;annotation&gt;$$ d $$&lt;/annotation&gt;&lt;/semantics&gt; &lt;/math&gt; , intracellular volume fraction &lt;math&gt; &lt;semantics&gt; &lt;mrow&gt;&lt;msub&gt;&lt;mi&gt;v&lt;/mi&gt; &lt;mtext&gt;in&lt;/mtext&gt;&lt;/msub&gt; &lt;/mrow&gt; &lt;annotation&gt;$$ {v}_{mathrm{in}} $$&lt;/annotation&gt;&lt;/semantics&gt; &lt;/math&gt; , water exchange rate constant &lt;math&gt; &lt;semantics&gt; &lt;mrow&gt;&lt;msub&gt;&lt;mi&gt;k&lt;/mi&gt; &lt;mtext&gt;in&lt;/mtext&gt;&lt;/msub&gt; &lt;/mrow&gt; &lt;annotation&gt;$$ {k}_{mathrm{in}} $$&lt;/annotation&gt;&lt;/semantics&gt; &lt;/math&gt; , extracellular diffusivity &lt;math&gt; &lt;semantics&gt; &lt;mrow&gt;&lt;msub&gt;&lt;mi&gt;D&lt;/mi&gt; &lt;mi&gt;ex&lt;/mi&gt;&lt;/msub&gt; &lt;/mrow&gt; &lt;annotation&gt;$$ {D}_{mathrm{ex}} $$&lt;/annotation&gt;&lt;/semantics&gt; &lt;/math&gt; and intracellular intrinsic diffusivity &lt;math&gt; &lt;semantics&gt; &lt;mrow&gt;&lt;msub&gt;&lt;mi&gt;D&lt;/mi&gt; &lt;mtext&gt;in&lt;/mtext&gt;&lt;/msub&gt; &lt;/mrow&gt; &lt;annotation&gt;$$ {D}_{mathrm{in}} $$&lt;/annotation&gt;&lt;/semantics&gt; &lt;/math&gt; ) were calculated. Classification performance was assessed in the original cohort and in an age-adjusted cohort (excluding older malignant patients to eliminate significant age differences).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Statistical tests: &lt;/strong&gt;Mann-Whitney U-tests compared benign and malignant tumor values. Multivariable logistic regression used a stepwise approach based on the likelihood ratio test. The area under the receiver operating characteristic (AUC) was computed and compared by using the DeLong test.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;In the full analysis (25 benign, 90 malignant), microstructural parameters from methods incorporating transcytolemmal water exchange (JOINT and EXCHANGE) demonstrated superior performance (AUC: ADC, 0.822; IMPULSED, 0.840; JOINT, 0.902; EXCHANGE, 0.905). Combining different metrics further improved classification (AUC: IMPULSED [ &lt;math&gt; &lt;semantics&gt;&lt;mrow&gt;&lt;mi&gt;d&lt;/mi&gt;&lt;/mrow&gt; &lt;annotation&gt;$$ d $$&lt;/annotation&gt;&lt;/semantics&gt; &lt;/math&gt; , &lt;math&gt; &lt;semantics&gt; &lt;mrow&gt;&lt;msub&gt;&lt;mi&gt;v&lt;/mi&gt; &lt;mtext&gt;in&lt;/mtext&gt;&lt;/msub&gt; &lt;/mrow&gt; &lt;annotation&gt;$$ {v}_{mathrm{in}} $$&lt;/annotation&gt;&lt;/","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial for "The Potential of Model-Free Parameters Derived From IVIM in Evaluating Pathological Indicators and Long-Term Survival in NPC".
IF 3.3 2区 医学
Journal of Magnetic Resonance Imaging Pub Date : 2025-03-10 DOI: 10.1002/jmri.29727
Nico Sollmann
{"title":"Editorial for \"The Potential of Model-Free Parameters Derived From IVIM in Evaluating Pathological Indicators and Long-Term Survival in NPC\".","authors":"Nico Sollmann","doi":"10.1002/jmri.29727","DOIUrl":"https://doi.org/10.1002/jmri.29727","url":null,"abstract":"","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of Occult Liver Metastases in Pancreatic Adenocarcinoma by Diffusion-Weighted Related Magnetic Resonance Imaging.
IF 3.3 2区 医学
Journal of Magnetic Resonance Imaging Pub Date : 2025-03-10 DOI: 10.1002/jmri.29747
Fangqing Wang, Xinghua Xu, Yinghui Chen, Jianwei Xu, Weiwei Ji, Dexin Yu
{"title":"Evaluation of Occult Liver Metastases in Pancreatic Adenocarcinoma by Diffusion-Weighted Related Magnetic Resonance Imaging.","authors":"Fangqing Wang, Xinghua Xu, Yinghui Chen, Jianwei Xu, Weiwei Ji, Dexin Yu","doi":"10.1002/jmri.29747","DOIUrl":"https://doi.org/10.1002/jmri.29747","url":null,"abstract":"<p><strong>Background: </strong>Occult liver metastases in patients with pancreatic ductal adenocarcinoma (PDAC) affects treatment strategies and prognosis. Diffusion-weighted imaging (DWI), including non-Gaussian DWI may help to evaluate tumor biological behavior.</p><p><strong>Purpose: </strong>To evaluate the diagnostic value of DWI parameters in predicting occult liver metastases in patients with PDAC.</p><p><strong>Study type: </strong>Prospective.</p><p><strong>Population: </strong>115 participants with pathologically confirmed PDAC (male = 71, mean age = 59.8 ± 9.9 years). Occult liver metastasis was defined as those detected by CT or MRI within 6 months of pancreatectomy.</p><p><strong>Field strength/sequence: </strong>DWI, intravoxel incoherent motion (IVIM) imaging and diffusion kurtosis imaging (DKI) echo planar imaging sequences at 1.5 T.</p><p><strong>Assessment: </strong>Apparent diffusion coefficient (ADC), pure diffusion coefficient (D), pseudo-diffusion coefficient (D*), perfusion fraction (f), mean apparent diffusion (MD) and mean kurtosis (MK) were measured. In addition, age, sex, body mass index, neutrophil-to-lymphocyte ratio (NLR) and carbohydrate antigen 19-9 (CA 19-9) level were recorded.</p><p><strong>Statistical tests: </strong>Logistic regression analysis, area under the receiver operating characteristic curve (AUC), DeLong test. Two tailed P value < 0.05 was considered significant. Results 23 of 115 (20%) participants had occult liver metastases. Multivariable analysis revealed D [odds ratio (OR) = 0.220], NLR (OR = 1.391) and CA19-9 level (OR = 1.002) were independent risk factors for occult liver metastases. The AUCs were 0.772 for the combination of NLR and CA19-9 level, and 0.848 for the combination of D, NLR and CA19-9 level, without significant difference between the two models (P = 0.055).</p><p><strong>Data conclusion: </strong>A combination of D, NLR and CA19-9 level may be useful in the prediction of occult liver metastases in patients with PDAC.</p><p><strong>Evidence level: </strong>2.</p><p><strong>Technical efficacy: </strong>Stage 2.</p>","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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