Journal of Magnetic Resonance Imaging最新文献

{"title":"Restricted Spectrum Imaging for Diagnosis of High-Risk Metabolic Dysfunction-Associated Steatohepatitis.","authors":"Jie Yuan, Huamei Yan, Zhiwei Qin, Liping You, Guangda Liu, Wei Xu, Zheng Tu, Jinghao Zhang, Xuehua Sun, Wenli Tan","doi":"10.1002/jmri.70560","DOIUrl":"https://doi.org/10.1002/jmri.70560","url":null,"abstract":"<p><strong>Background: </strong>Conventional diffusion MRI inadequately characterizes heterogeneous microstructural changes in metabolic dysfunction-associated steatotic liver disease (MASLD). The optimal restricted spectrum imaging (RSI) model and value for high-risk metabolic dysfunction-associated steatohepatitis (MASH) remain unclear.</p><p><strong>Purpose: </strong>To optimize RSI modeling and evaluate its performance for high-risk MASH.</p><p><strong>Study type: </strong>Prospective cross-sectional study.</p><p><strong>Population: </strong>96 biopsy-proven MASLD participants (median age, 46 years [IQR: 36-58]; 51 women [53.1%]), including 64 with high-risk MASH.</p><p><strong>Field strength/sequence: </strong>3T; fat-suppressed single-shot echo-planar imaging with multi-b-value diffusion-weighted imaging, EPI-based MR elastography, and 3D chemical shift-encoded proton density fat-fraction imaging.</p><p><strong>Assessment: </strong>Two- to five-compartment RSI models were compared using Bayesian information criterion (BIC). RSI fractions, apparent diffusion coefficient, FIB-4, and MRI-based MASH score (MAST) were evaluated against histopathologic features and high-risk MASH.</p><p><strong>Statistical tests: </strong>Spearman correlation, Mann-Whitney U test, logistic regression, receiver operating characteristic analysis, DeLong test, bootstrap internal validation, decision curve analysis (thresholds, 0.20-0.60), and intraclass correlation coefficient (ICC). p < 0.05 was significant.</p><p><strong>Results: </strong>The five-compartment model showed the lowest BIC (1472.30; ΔBIC = 0). RSI measurements showed excellent inter-observer agreement (ICC, 0.955-0.994). RSI-C1 (r = 0.357) and RSI-C2 (r = 0.283) significantly correlated with steatosis; RSI-C2 (r = 0.273) and RSI-C5 (r = 0.282) with inflammation; and RSI-C2 (r = 0.326), RSI-C4 (r = 0.400), and RSI-C5 (r = 0.386) with fibrosis (all p < 0.05). The RSI-C2 + C4 + C5 model yielded an AUC of 0.800 for high-risk MASH, without significant difference versus FIB-4 (AUC = 0.707; p = 0.219) or MAST (AUC = 0.899; p = 0.146). Across thresholds of 0.20-0.60, RSI mean net benefit (0.504) exceeded FIB-4 (0.438) but not MAST (0.559).</p><p><strong>Data conclusion: </strong>RSI provides compartment-specific microstructural biomarkers associated with MASLD histology and may complement noninvasive tools for high-risk MASH assessment.</p><p><strong>Evidence level: </strong>2.</p><p><strong>Technical efficacy: </strong>Stage 2.</p>","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149081052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial for \"Pharmacokinetics and Pharmacodynamics of a Single Oral Dose of Ascelia-Manganese-Based MRI Contrast Agent (ACE-MBCA) in Adult Subjects With and Without Hepatic Impairment\".","authors":"Numan C Balci","doi":"10.1002/jmri.70555","DOIUrl":"https://doi.org/10.1002/jmri.70555","url":null,"abstract":"","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149074954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial for \"Preoperative Prediction of Ductal Carcinoma In Situ Upstaging Using Machine Learning-Based Peritumoral Breast MRI Radiomics\".","authors":"Simone Schiaffino, Andrea Cozzi","doi":"10.1002/jmri.70569","DOIUrl":"https://doi.org/10.1002/jmri.70569","url":null,"abstract":"","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149075016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Compressed Sensing-Accelerated Cartesian Real-Time Phase Contrast MRI With Shared Velocity Encoding: A Clinical Performance Evaluation.","authors":"Gang Yin, Yan Liang, Mi Li, Xinling Yang, Lin Chen, Kai Yang, Chen Cui, Xiuyu Chen, Jing An, Giese Daniel, Ning Jin, Shihua Zhao, Minjie Lu","doi":"10.1002/jmri.70553","DOIUrl":"https://doi.org/10.1002/jmri.70553","url":null,"abstract":"<p><strong>Background: </strong>Conventional segmented phase contrast (PC) MRI is the clinical reference standard for cardiovascular hemodynamic quantification, but prolonged acquisition times, mandatory breath-holding, and susceptibility to arrhythmia limit its utility in vulnerable populations.</p><p><strong>Purpose: </strong>To validate the clinical performance of compressed sensing-accelerated real-time (CSRT) PC MRI with shared velocity encoding (SVE) for fast, free-breathing cardiac flow assessment.</p><p><strong>Study type: </strong>Prospective.</p><p><strong>Population: </strong>63 patients (46 male/17 female, mean age 51.5 ± 15.1 years) with diverse cardiac disease.</p><p><strong>Field strength/sequence: </strong>3.0 T; single-shot RF-spoiled gradient echo sequence with SVE (free-breathing CSRT PC MRI) and velocity encoded segmented gradient echo sequence (breath-hold routine segmented (RS) PC MRI).</p><p><strong>Assessment: </strong>Hemodynamic parameters-peak velocity, peak flow rate, net flow rate, and peak mean velocity-were measured at the sinotubular junction plane for both CSRT and RS datasets. Scan time of the two sequences was recorded.</p><p><strong>Statistical tests: </strong>Pearson/Spearman correlation analysis, intraclass correlation coefficient (ICC), Bland-Altman analysis, paired t-test/Wilcoxon test. A p value < 0.05 was considered significant.</p><p><strong>Results: </strong>RS acquisition time was 16.0 ± 2.3 s; total imaging time including breath-hold instructions was 26.0 ± 2.3 s, whereas CSRT acquisition time was 10.0 s, yielding a statistically significant difference in scan duration. All hemodynamic parameters demonstrated strong significant correlation between CSRT PC and RS PC MRI (r ≥ 0.89) and good-to-excellent inter-method agreement (ICC ≥ 0.87). CSRT PC yielded significantly lower values for peak velocity (bias = -16.72 ± 11.48 cm/s [-13.31% ± 9.68%]), peak flow rate (bias = -36.28 ± 35.06 mL/s [-9.18% ± 8.98%]), and peak mean velocity (bias = -6.49 ± 7.06 cm/s [-11.02% ± 13.14%]) relative to the RS, but net flow rate was not significantly different between methods (bias = 0.15% ± 0.60 L/min [4.16% ± 17.28%, p = 0.058]).</p><p><strong>Data conclusions: </strong>CSRT PC provided satisfactory agreement with conventional RS PC while shortening scan time and enabling free-breathing acquisition.</p><p><strong>Evidence level: </strong>1.</p><p><strong>Technical efficacy: </strong>Stage 1.</p>","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149069752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial for \"Effects of Single and Multiple Dose Tiotropium/Olodaterol in Chronic Obstructive Pulmonary Disease on Alveolar Gas Exchange Measured by Hyperpolarized 129Xe MRI\".","authors":"Edwin J R van Beek","doi":"10.1002/jmri.70559","DOIUrl":"https://doi.org/10.1002/jmri.70559","url":null,"abstract":"","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149061907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preoperative Prediction of Ductal Carcinoma In Situ Upstaging Using Machine Learning-Based Peritumoral Breast MRI Radiomics.","authors":"K Ruwani M Fernando, Issam El Naqa, Mahmoud Abdalah, Dana Ataya, Marilyn M Bui, Jasmine R Brainerd, Yarelis De La Cruz, Olya Stringfield, Brian Czerniecki, Natarajan Raghunand, Lev Barinov, Amber C Simmons, Elizabeth S McDonald, Bethany L Niell","doi":"10.1002/jmri.70552","DOIUrl":"https://doi.org/10.1002/jmri.70552","url":null,"abstract":"<p><strong>Background: </strong>A subset of biopsy-confirmed ductal carcinoma in situ (DCIS) cases can be upstaged to invasive breast cancer at surgery. Preoperative identification of upstaging risk is essential for treatment planning.</p><p><strong>Purpose: </strong>To develop clinical and breast MRI radiomics models to preoperatively predict upstaging in DCIS.</p><p><strong>Study type: </strong>Retrospective and prospective.</p><p><strong>Population: </strong>Three hundred forty-five women (median age, 59 years [IQR, 49-67]) with 362 DCIS lesions diagnosed via core-needle biopsy (training: n = 216, internal testing: n = 53, external testing: n = 93).</p><p><strong>Field strength/sequences: </strong>1.5 T 3D T1-weighted spoiled gradient-echo MRI: pre-contrast non-fat-suppressed and dynamic contrast-enhanced (DCE) fat-suppressed sequences.</p><p><strong>Assessments: </strong>Clinical and radiomics features were extracted from radiologist-segmented lesions on DCE breast MRI. Seven machine learning algorithms were evaluated across clinical-only (demographic and clinicopathologic variables), radiomics-only (whole-lesion/peritumoral), and combined models, using nested cross-validation and internal and external testing. Feature importance was assessed using Shapley additive explanation (SHAP).</p><p><strong>Statistical tests: </strong>Mann-Whitney, Chi-square, DeLong tests; area under the receiver operating characteristic curve (AUC), sensitivity, negative predictive value (NPV).</p><p><strong>Results: </strong>The clinical model achieved AUC 0.70 (95% CI: 0.51-0.89), with 36% sensitivity and 84% NPV. A multilayer perceptron integrating clinical and peritumoral radiomics non-significantly increased AUC to 0.75 (95% CI: 0.58-0.92; ΔAUC = +0.05; False Discovery Rate p-adj = 0.65), improving sensitivity to 82% (Δ = +46%) and NPV to 92% (Δ = +8%). On external testing, AUC was 0.63 (95% CI: 0.50-0.76) with no significant change over the clinical baseline (ΔAUC = -0.03; FDR p-adj = 0.857) but demonstrated superior sensitivity (68%; Δ = +30%) and NPV (84%; Δ = +3%). SHAP identified peritumoral center-of-mass shift as the dominant predictor.</p><p><strong>Data conclusion: </strong>Clinical-peritumoral modeling did not significantly improve discrimination over the clinical baseline but showed higher NPV and sensitivity, suggesting the tumor microenvironment may provide complementary information for upstaging risk stratification.</p><p><strong>Level of evidence: 3: </strong></p><p><strong>Technical efficacy: </strong>Stage 2.</p>","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149039207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial for \"Limbic Structural Alterations and Structural Covariance Across Prodromal Phenotypes and Early Parkinson's Disease\".","authors":"James T Grist","doi":"10.1002/jmri.70547","DOIUrl":"https://doi.org/10.1002/jmri.70547","url":null,"abstract":"","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149061947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Single and Multiple Dose Tiotropium/Olodaterol in Chronic Obstructive Pulmonary Disease on Alveolar Gas Exchange Measured by Hyperpolarized ¹²⁹Xe MRI.","authors":"Agilo L Kern, Thomas Kayser, Robin A Müller, Andreas Voskrebenzev, Filip Klimeš, Frank Wacker, Jens M Hohlfeld, Jens Vogel-Claussen","doi":"10.1002/jmri.70558","DOIUrl":"https://doi.org/10.1002/jmri.70558","url":null,"abstract":"<p><strong>Background: </strong>Long-acting muscarinic antagonists/long-acting beta adrenoreceptor agonists lead to lung deflation and improved microvascular perfusion in hyperinflated chronic obstructive pulmonary disease (COPD), but with an unclear time course.</p><p><strong>Purpose: </strong>To investigate the effect of inhalation of tiotropium/olodaterol (TIO/OLO) on MRI measures of gas uptake and microvascular blood volume after single and multiple doses.</p><p><strong>Study type: </strong>Prospective, randomized, investigator-blinded, placebo-controlled single-dose crossover study with open-label multiple-dose extension.</p><p><strong>Population: </strong>31 participants with COPD and lung hyperinflation (residual volume > 135% predicted, ≥ 10 pack-years smoking).</p><p><strong>Fieldstrength/sequence: </strong>1.5 T/Interleaved 3D radial gas and dissolved-phase MRI using multi-echo FLASH, high-resolution spectroscopy, chemical shift saturation recovery spectroscopy.</p><p><strong>Assessment: </strong>Ratios of ¹²⁹Xe in membrane tissues (M) to gas (M-Gas), red blood cells (RBC) to gas (RBC-Gas), RBC to M (RBC-M) were calculated from dissolved-phase imaging. Dissolved-phase apparent transverse relaxation times (T₂*) from high-resolution spectra were also calculated, and septal wall thickness and surface-volume ratio (S/V) were assessed by fitting a model of xenon exchange functions. Parameters were compared for single-dose (5 μg/5 μg TIO/OLO) versus placebo using saline, and single-dose versus multiple-dose (daily 5 μg/5 μg TIO/OLO for 14 days) treatments.</p><p><strong>Statistical tests: </strong>Linear mixed models with contrasts of estimated marginal means, significance level 0.05.</p><p><strong>Results: </strong>Compared with placebo, single-dose treatment significantly increased RBC-Gas and septal thickness but not RBC-M (p = 0.06), M-Gas (p = 0.16), RBC T₂* (p = 0.13), M T₂* (p = 0.09) and S/V (p = 0.47). Multiple-dose treatment significantly increased RBC-Gas, M-Gas and M T₂* compared with single-dose treatment, but not RBC-M (p = 0.82), RBC T₂* (p = 0.48), septal thickness (p = 0.61), and S/V (p = 0.49).</p><p><strong>Data conclusion: </strong>Single-dose TIO/OLO increased ¹²⁹Xe in RBC-Gas. Multiple-dose treatment increased M-Gas and further increased RBC-Gas compared to single-dose treatment.</p><p><strong>Technical efficacy: </strong>Stage 4.</p><p><strong>Evidence level: </strong>2.</p>","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149030752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of Anatomical Location and Reader Experience With the Diagnostic Performance of Multiparametric MRI-Derived VI-RADS for Muscle Invasive Bladder Cancer: A Multicenter Multireader Study.","authors":"Xiangyu Wang, Feng Sun, Jingjun Hu, Xiaodan Huang, Shiying Du, Zhi Wen, Fan Lin","doi":"10.1002/jmri.70557","DOIUrl":"https://doi.org/10.1002/jmri.70557","url":null,"abstract":"<p><strong>Background: </strong>The associations of tumor location and reader experience with Vesical Imaging-Reporting and Data System (VI-RADS) performance remain unclear.</p><p><strong>Purpose: </strong>To evaluate the associations of tumor location and reader experience with VI-RADS performance in detecting muscle-invasive bladder cancer (MIBC).</p><p><strong>Study type: </strong>Retrospective.</p><p><strong>Subjects: </strong>A total of 543 patients (464 males; mean age, 67.0 ± 12.1 years) with bladder cancer.</p><p><strong>Field strength/sequence: </strong>1.5 T and 3.0 T, T2-weighted image with turbo spin-echo, diffusion-weighted imaging using single-shot echo planar imaging, and three-dimensional T1-weighted spoiled gradient echo sequence.</p><p><strong>Assessment: </strong>Four radiologists (two with 15 and 10 years of experience and two with < 5 years of experience) independently assigned VI-RADS scores. Histopathology was the reference standard. Diagnostic performance of VI-RADS ≥ 3 for identifying MIBC was assessed across seven anatomical locations: trigone, ureteral orifice, neck, lateral wall, dome, anterior and posterior walls.</p><p><strong>Statistical tests: </strong>Weighted kappa, Generalized estimating equation (GEE) models, the independent samples t-test or Mann-Whitney U test, the chi-square test, ROC analysis and DeLong test. Benjamini-Hochberg false discovery rate (FDR)-adjust p < 0.05 was considered statistically significant.</p><p><strong>Results: </strong>Of 543 patients, 168 (30.9%) had MIBC. Inter-reader agreement was excellent (κ = 0.943-0.986). Adjusted GEE models showed lower accuracy (OR, 0.624; 95% CI: 0.518-0.751) for inexperienced readers. Tumor location was not associated with overall accuracy (global p = 0.295), and the location-by-experience interaction was nonsignificant (global p = 0.469). The ureteral orifice showed the highest false-negative rates (24/82 [29.3%] and 32/82 [39.0%], respectively) in experienced and inexperienced readers, whereas the dome showed the highest false-positive rates (10/58 [17.2%] and 15/58 [25.9%], respectively). Only the lateral-wall false-positive rate differed significantly by experience (6.1% vs. 14.8%, respectively).</p><p><strong>Data conclusion: </strong>Reader experience was independently associated with overall VI-RADS performance, whereas tumor location was not associated with overall accuracy. Descriptive analyses identified location-specific diagnostic pitfalls.</p><p><strong>Level of evidence: 3: </strong></p><p><strong>Technical efficacy stage: </strong>2.</p>","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149025121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial for \"Associations of Anatomical Location and Reader Experience With the Diagnostic Performance of Multiparametric MRI-Derived VI-RADS for Muscle Invasive Bladder Cancer: A Multicenter Multireader Study\".","authors":"Yoshiko Ueno, Keitaro Sofue, Takamichi Murakami","doi":"10.1002/jmri.70561","DOIUrl":"https://doi.org/10.1002/jmri.70561","url":null,"abstract":"","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149025119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}