{"title":"Age-, Body Surface Area-, and Sex-Specific Reference Values for Pericardial Adipose Tissue in Children: An MRI Study.","authors":"Shiganmo Azhe, Wei Bai, Ke Xu, Zhongqin Zhou, Lei Hu, Chuan Fu, Shengkun Peng, Xinrui Deng, Yaoji Zhu, Yifei Li, Yingkun Guo, Lizhi Zhang, Lingyi Wen","doi":"10.1002/jmri.70053","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Pericardial adipose tissue (PAT) is a cardiovascular disease risk factor in children, but normative data for PAT thickness, area, and volume are lacking.</p><p><strong>Purpose: </strong>To establish the percentile reference values for MRI PAT parameters in healthy Chinese children aged 3-18.</p><p><strong>Study type: </strong>Prospective.</p><p><strong>Subjects: </strong>218 healthy children divided into 3-10 years (n = 125, 62 males) and 10-18 years (n = 93, 53 males).</p><p><strong>Field strength/sequence: </strong>Balanced steady-state free-precession cine sequence at 3.0 T.</p><p><strong>Assessment: </strong>PAT thickness, area and volume.</p><p><strong>Statistical tests: </strong>Student's t-test, Mann-Whitney U test, Pearson correlation, the generalized additive model for location scale and shape, and intraclass correlation coefficients (ICC). A p value < 0.05 was considered statistically significant.</p><p><strong>Results: </strong>PAT volume showed no significant sex difference in the overall (boys: 32.7 ± 16.2 mL, girls: 28.2 ± 10.0 mL, p = 0.179) or childhood group (boys: 22.9 ± 7.9 vs. girls: 22.9 ± 6.6 mL, p = 0.954), but adolescent boys had a higher volume than girls (44.1 ± 15.9 vs. 36.9 ± 8.4 mL). PAT thickness at the right ventricular free wall (RVFW) was greater in boys across both age groups. PAT volume correlated strongly with age (r = 0.672) and BSA (r = 0.741). Age-specific percentile curves showed a progressive PAT volume increase with no clear plateau, with the most rapid growth between ages 10 and 14. BSA-specific curves revealed gradual PAT parameter increases, with steeper trends in boys. Good to excellent inter- and intra-observer agreement was observed for almost all PAT parameter measurements (95% CI > 0.75).</p><p><strong>Conclusion: </strong>This study proposes sex-, age-, and BSA-specific reference values for pericardial adipose tissue in healthy Chinese children and showed developmental patterns and sex differences that may have potential to inform future clinical and research applications.</p><p><strong>Evidence level: </strong>2.</p><p><strong>Technical efficacy: </strong>Stage 2.</p>","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.5000,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Magnetic Resonance Imaging","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/jmri.70053","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Pericardial adipose tissue (PAT) is a cardiovascular disease risk factor in children, but normative data for PAT thickness, area, and volume are lacking.
Purpose: To establish the percentile reference values for MRI PAT parameters in healthy Chinese children aged 3-18.
Study type: Prospective.
Subjects: 218 healthy children divided into 3-10 years (n = 125, 62 males) and 10-18 years (n = 93, 53 males).
Field strength/sequence: Balanced steady-state free-precession cine sequence at 3.0 T.
Assessment: PAT thickness, area and volume.
Statistical tests: Student's t-test, Mann-Whitney U test, Pearson correlation, the generalized additive model for location scale and shape, and intraclass correlation coefficients (ICC). A p value < 0.05 was considered statistically significant.
Results: PAT volume showed no significant sex difference in the overall (boys: 32.7 ± 16.2 mL, girls: 28.2 ± 10.0 mL, p = 0.179) or childhood group (boys: 22.9 ± 7.9 vs. girls: 22.9 ± 6.6 mL, p = 0.954), but adolescent boys had a higher volume than girls (44.1 ± 15.9 vs. 36.9 ± 8.4 mL). PAT thickness at the right ventricular free wall (RVFW) was greater in boys across both age groups. PAT volume correlated strongly with age (r = 0.672) and BSA (r = 0.741). Age-specific percentile curves showed a progressive PAT volume increase with no clear plateau, with the most rapid growth between ages 10 and 14. BSA-specific curves revealed gradual PAT parameter increases, with steeper trends in boys. Good to excellent inter- and intra-observer agreement was observed for almost all PAT parameter measurements (95% CI > 0.75).
Conclusion: This study proposes sex-, age-, and BSA-specific reference values for pericardial adipose tissue in healthy Chinese children and showed developmental patterns and sex differences that may have potential to inform future clinical and research applications.
期刊介绍：
The Journal of Magnetic Resonance Imaging (JMRI) is an international journal devoted to the timely publication of basic and clinical research, educational and review articles, and other information related to the diagnostic applications of magnetic resonance.
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