{"title":"儿童心包脂肪组织的年龄、体表面积和性别特异性参考值：一项MRI研究。","authors":"Shiganmo Azhe, Wei Bai, Ke Xu, Zhongqin Zhou, Lei Hu, Chuan Fu, Shengkun Peng, Xinrui Deng, Yaoji Zhu, Yifei Li, Yingkun Guo, Lizhi Zhang, Lingyi Wen","doi":"10.1002/jmri.70053","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Pericardial adipose tissue (PAT) is a cardiovascular disease risk factor in children, but normative data for PAT thickness, area, and volume are lacking.</p><p><strong>Purpose: </strong>To establish the percentile reference values for MRI PAT parameters in healthy Chinese children aged 3-18.</p><p><strong>Study type: </strong>Prospective.</p><p><strong>Subjects: </strong>218 healthy children divided into 3-10 years (n = 125, 62 males) and 10-18 years (n = 93, 53 males).</p><p><strong>Field strength/sequence: </strong>Balanced steady-state free-precession cine sequence at 3.0 T.</p><p><strong>Assessment: </strong>PAT thickness, area and volume.</p><p><strong>Statistical tests: </strong>Student's t-test, Mann-Whitney U test, Pearson correlation, the generalized additive model for location scale and shape, and intraclass correlation coefficients (ICC). A p value < 0.05 was considered statistically significant.</p><p><strong>Results: </strong>PAT volume showed no significant sex difference in the overall (boys: 32.7 ± 16.2 mL, girls: 28.2 ± 10.0 mL, p = 0.179) or childhood group (boys: 22.9 ± 7.9 vs. girls: 22.9 ± 6.6 mL, p = 0.954), but adolescent boys had a higher volume than girls (44.1 ± 15.9 vs. 36.9 ± 8.4 mL). PAT thickness at the right ventricular free wall (RVFW) was greater in boys across both age groups. PAT volume correlated strongly with age (r = 0.672) and BSA (r = 0.741). Age-specific percentile curves showed a progressive PAT volume increase with no clear plateau, with the most rapid growth between ages 10 and 14. BSA-specific curves revealed gradual PAT parameter increases, with steeper trends in boys. Good to excellent inter- and intra-observer agreement was observed for almost all PAT parameter measurements (95% CI > 0.75).</p><p><strong>Conclusion: </strong>This study proposes sex-, age-, and BSA-specific reference values for pericardial adipose tissue in healthy Chinese children and showed developmental patterns and sex differences that may have potential to inform future clinical and research applications.</p><p><strong>Evidence level: </strong>2.</p><p><strong>Technical efficacy: </strong>Stage 2.</p>","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.5000,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Age-, Body Surface Area-, and Sex-Specific Reference Values for Pericardial Adipose Tissue in Children: An MRI Study.\",\"authors\":\"Shiganmo Azhe, Wei Bai, Ke Xu, Zhongqin Zhou, Lei Hu, Chuan Fu, Shengkun Peng, Xinrui Deng, Yaoji Zhu, Yifei Li, Yingkun Guo, Lizhi Zhang, Lingyi Wen\",\"doi\":\"10.1002/jmri.70053\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Pericardial adipose tissue (PAT) is a cardiovascular disease risk factor in children, but normative data for PAT thickness, area, and volume are lacking.</p><p><strong>Purpose: </strong>To establish the percentile reference values for MRI PAT parameters in healthy Chinese children aged 3-18.</p><p><strong>Study type: </strong>Prospective.</p><p><strong>Subjects: </strong>218 healthy children divided into 3-10 years (n = 125, 62 males) and 10-18 years (n = 93, 53 males).</p><p><strong>Field strength/sequence: </strong>Balanced steady-state free-precession cine sequence at 3.0 T.</p><p><strong>Assessment: </strong>PAT thickness, area and volume.</p><p><strong>Statistical tests: </strong>Student's t-test, Mann-Whitney U test, Pearson correlation, the generalized additive model for location scale and shape, and intraclass correlation coefficients (ICC). A p value < 0.05 was considered statistically significant.</p><p><strong>Results: </strong>PAT volume showed no significant sex difference in the overall (boys: 32.7 ± 16.2 mL, girls: 28.2 ± 10.0 mL, p = 0.179) or childhood group (boys: 22.9 ± 7.9 vs. girls: 22.9 ± 6.6 mL, p = 0.954), but adolescent boys had a higher volume than girls (44.1 ± 15.9 vs. 36.9 ± 8.4 mL). PAT thickness at the right ventricular free wall (RVFW) was greater in boys across both age groups. PAT volume correlated strongly with age (r = 0.672) and BSA (r = 0.741). Age-specific percentile curves showed a progressive PAT volume increase with no clear plateau, with the most rapid growth between ages 10 and 14. BSA-specific curves revealed gradual PAT parameter increases, with steeper trends in boys. Good to excellent inter- and intra-observer agreement was observed for almost all PAT parameter measurements (95% CI > 0.75).</p><p><strong>Conclusion: </strong>This study proposes sex-, age-, and BSA-specific reference values for pericardial adipose tissue in healthy Chinese children and showed developmental patterns and sex differences that may have potential to inform future clinical and research applications.</p><p><strong>Evidence level: </strong>2.</p><p><strong>Technical efficacy: </strong>Stage 2.</p>\",\"PeriodicalId\":16140,\"journal\":{\"name\":\"Journal of Magnetic Resonance Imaging\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":3.5000,\"publicationDate\":\"2025-08-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Magnetic Resonance Imaging\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1002/jmri.70053\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Magnetic Resonance Imaging","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/jmri.70053","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
引用次数: 0
摘要
背景：心包脂肪组织（PAT）是儿童心血管疾病的危险因素，但缺乏关于PAT厚度、面积和体积的规范数据。目的：建立中国3-18岁健康儿童MRI PAT参数的百分位数参考值。研究类型：前瞻性。研究对象：218名健康儿童，分为3-10岁（男125例，男62例）和10-18岁（男93例，男53例）。场强/序列：3.0 T平衡稳态自由进动序列。评估：PAT的厚度、面积和体积。统计检验：学生t检验、Mann-Whitney U检验、Pearson相关、位置规模和形状的广义相加模型、类内相关系数（ICC）。结果：PAT体积在总体上（男孩：32.7±16.2 mL，女孩：28.2±10.0 mL, p = 0.179）和儿童期组（男孩：22.9±7.9 vs女孩：22.9±6.6 mL, p = 0.954）无显著性差异，但青春期男孩体积高于女孩（44.1±15.9 vs 36.9±8.4 mL）。在两个年龄组中，男孩右心室游离壁（RVFW）的PAT厚度都更大。PAT体积与年龄（r = 0.672）和BSA （r = 0.741）呈正相关。不同年龄的百分位曲线显示PAT体积呈进行性增加，没有明显的平台，在10 - 14岁之间增长最快。bsa特异性曲线显示PAT参数逐渐增加，男孩的趋势更陡峭。几乎所有PAT参数测量的观察者之间和观察者内部的一致性都达到了极好的水平（95% CI > 0.75）。结论：本研究提出了中国健康儿童心包脂肪组织的性别、年龄和bsa特异性参考值，并显示了发育模式和性别差异，这可能为未来的临床和研究应用提供潜在的信息。证据等级：2。技术功效：第二阶段。
Age-, Body Surface Area-, and Sex-Specific Reference Values for Pericardial Adipose Tissue in Children: An MRI Study.
Background: Pericardial adipose tissue (PAT) is a cardiovascular disease risk factor in children, but normative data for PAT thickness, area, and volume are lacking.
Purpose: To establish the percentile reference values for MRI PAT parameters in healthy Chinese children aged 3-18.
Study type: Prospective.
Subjects: 218 healthy children divided into 3-10 years (n = 125, 62 males) and 10-18 years (n = 93, 53 males).
Field strength/sequence: Balanced steady-state free-precession cine sequence at 3.0 T.
Assessment: PAT thickness, area and volume.
Statistical tests: Student's t-test, Mann-Whitney U test, Pearson correlation, the generalized additive model for location scale and shape, and intraclass correlation coefficients (ICC). A p value < 0.05 was considered statistically significant.
Results: PAT volume showed no significant sex difference in the overall (boys: 32.7 ± 16.2 mL, girls: 28.2 ± 10.0 mL, p = 0.179) or childhood group (boys: 22.9 ± 7.9 vs. girls: 22.9 ± 6.6 mL, p = 0.954), but adolescent boys had a higher volume than girls (44.1 ± 15.9 vs. 36.9 ± 8.4 mL). PAT thickness at the right ventricular free wall (RVFW) was greater in boys across both age groups. PAT volume correlated strongly with age (r = 0.672) and BSA (r = 0.741). Age-specific percentile curves showed a progressive PAT volume increase with no clear plateau, with the most rapid growth between ages 10 and 14. BSA-specific curves revealed gradual PAT parameter increases, with steeper trends in boys. Good to excellent inter- and intra-observer agreement was observed for almost all PAT parameter measurements (95% CI > 0.75).
Conclusion: This study proposes sex-, age-, and BSA-specific reference values for pericardial adipose tissue in healthy Chinese children and showed developmental patterns and sex differences that may have potential to inform future clinical and research applications.
期刊介绍：
The Journal of Magnetic Resonance Imaging (JMRI) is an international journal devoted to the timely publication of basic and clinical research, educational and review articles, and other information related to the diagnostic applications of magnetic resonance.
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