Cognition-Eye-Brain Connection in Alzheimer's Disease Spectrum Revealed by Multimodal Imaging.

IF 3.3 2区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Yan Shi, Tingting Shen, Su Yan, Jianwen Liang, Tianyunxi Wei, Yijin Huang, Rong Gao, Ning Zheng, Renpuchi Ci, Min Zhang, Xiaoying Tang, Yuanyuan Qin, Wenzhen Zhu
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引用次数: 0

Abstract

Background: The connection between cognition, eye, and brain remains inconclusive in Alzheimer's disease (AD) spectrum disorders.

Purpose: To explore the relationship between cognitive function, retinal biometrics, and brain alterations in the AD spectrum.

Study type: Prospective.

Subjects: Healthy control (HC) (n = 16), subjective cognitive decline (SCD) (n = 35), mild cognitive impairment (MCI) (n = 18), and AD group (n = 7).

Field strength/sequence: 3-T, 3D T1-weighted Brain Volume (BRAVO) and resting-state functional MRI (fMRI).

Assessment: In all subgroups, cortical thickness was measured from BRAVO and segmented using the Desikan-Killiany-Tourville (DKT) atlas. The fractional amplitude of low-frequency fluctuations (FALFF) and regional homogeneity (ReHo) were measured in fMRI using voxel-based analysis. The eye was imaged by optical coherence tomography angiography (OCTA), with the deep learning model FARGO segmenting the foveal avascular zone (FAZ) and retinal vessels. FAZ area and perimeter, retinal blood vessels curvature (RBVC), thicknesses of the retinal nerve fiber layer (RNFL) and ganglion cell layer-inner plexiform layer (GCL-IPL) were calculated. Cognition-eye-brain associations were compared across the HC group and each AD spectrum stage using multivariable linear regression.

Statistical tests: Multivariable linear regression analysis. Statistical significance was set at p < 0.05 with FWE correction for fMRI and p < 1/62 (Bonferroni-corrected) for structural analyses.

Results: Reductions of FALFF in temporal regions, especially the left superior temporal gyrus (STG) in MCI patients, were linked to decreased RNFL thickness and increased FAZ area significantly. In AD patients, reduced ReHo values in occipital regions, especially the right middle occipital gyrus (MOG), were significantly associated with an enlarged FAZ area. The SCD group showed widespread cortical thickening significantly associated with all aforementioned retinal biometrics, with notable thickening in the right fusiform gyrus (FG) and right parahippocampal gyrus (PHG) correlating with reduced GCL-IPL thickness.

Data conclusion: Brain function and structure may be associated with cognition and retinal biometrics across the AD spectrum. Specifically, cognition-eye-brain connections may be present in SCD.

Evidence level: 2.

Technical efficacy: 3.

多模态成像揭示阿尔茨海默病谱系中的认知-眼-脑连接。
背景:认知、眼睛和大脑之间的联系在阿尔茨海默病(AD)谱系障碍中仍然没有定论。目的:探讨AD患者认知功能、视网膜生物特征与大脑改变之间的关系。研究类型:前瞻性。研究对象:健康对照组(HC) (n = 16)、主观认知衰退组(SCD) (n = 35)、轻度认知障碍组(MCI) (n = 18)和AD组(n = 7)。场强/序列:3-T, 3D t1加权脑容量(BRAVO)和静息状态功能MRI (fMRI)。评估:在所有亚组中,从BRAVO测量皮质厚度,并使用Desikan-Killiany-Tourville (DKT)图谱进行分割。低频波动分数幅值(FALFF)和区域均匀性(ReHo)在fMRI中使用基于体素的分析测量。采用光学相干断层血管造影(OCTA)对眼睛进行成像,深度学习模型FARGO对中央凹无血管区(FAZ)和视网膜血管进行分割。计算FAZ面积和周长、视网膜血管曲率(RBVC)、视网膜神经纤维层(RNFL)和神经节细胞层-内丛状层(GCL-IPL)厚度。使用多变量线性回归比较HC组和AD频谱各阶段的认知-眼-脑关联。统计检验:多变量线性回归分析。结果:MCI患者颞区,特别是左侧颞上回(STG)的FALFF减少与RNFL厚度减少和FAZ面积增加显著相关。在AD患者中,枕区ReHo值降低,特别是右侧枕中回(MOG),与FAZ面积扩大显著相关。SCD组显示广泛的皮质增厚与上述所有视网膜生物特征显著相关,其中右侧梭状回(FG)和右侧海马旁回(PHG)的增厚与GCL-IPL厚度降低相关。数据结论:AD患者的大脑功能和结构可能与认知和视网膜生物特征有关。具体来说,认知-眼-脑连接可能存在于SCD中。证据等级:2。技术功效:
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来源期刊
CiteScore
9.70
自引率
6.80%
发文量
494
审稿时长
2 months
期刊介绍: The Journal of Magnetic Resonance Imaging (JMRI) is an international journal devoted to the timely publication of basic and clinical research, educational and review articles, and other information related to the diagnostic applications of magnetic resonance.
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